Immunohistochemical and morphological features of a small bowel leiomyoma in a black crested macaque (Macaca nigra)
Autor(a) principal: | |
---|---|
Data de Publicação: | 2012 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1186/1746-6148-8-97 http://hdl.handle.net/11449/13048 |
Resumo: | Background: Spontaneous gastrointestinal neoplasms in non-human primates are commonly seen in aged individuals. Due to genetic similarities between human and non-human primates, scientists have shown increasing interest in terms of comparative oncology studies.Case presentation: The present study is related to a case of an intestinal leiomyoma in a black crested macaque (Macaca nigra), kept on captivity by Mateca a Zoo, Pereira City, Colombia. The animal had abdominal distension, anorexia, vomiting, diarrhea and behavioral changes. Clinical examination showed an increased volume in the upper right abdominal quadrant caused by a neoplastic mass. The patient died during the surgical procedure. Necropsy revealed several small nodules in the peritoneum with adhesion to different portions of the small and large intestines, liver, stomach and diaphragm. Tissue samples were collected, routinely processed and stained by H&E. Microscopic examination revealed a mesenchymal tumor limited to tunica muscularis, resembling normal smooth muscle cells. Neoplastic cells were positive for alpha-smooth muscle actin and vimentin, and negative for cytokeratin AE1/AE3 by immunohistochemistry. Those morphological and immunohistochemical findings allowed to diagnose the intestinal leiomyoma referred above.Conclusion: Neoplastic diseases in primates have multifaceted causes. Their manifestations are understudied, leading to a greater difficulty in detection and measurement of the real impact provides by this disease. |
id |
UNSP_097818386d63758465f7b12d9667dc0d |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/13048 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Immunohistochemical and morphological features of a small bowel leiomyoma in a black crested macaque (Macaca nigra)NeoplasmSmall bowelMacacaMonkeyLeiomyomaIntestineBackground: Spontaneous gastrointestinal neoplasms in non-human primates are commonly seen in aged individuals. Due to genetic similarities between human and non-human primates, scientists have shown increasing interest in terms of comparative oncology studies.Case presentation: The present study is related to a case of an intestinal leiomyoma in a black crested macaque (Macaca nigra), kept on captivity by Mateca a Zoo, Pereira City, Colombia. The animal had abdominal distension, anorexia, vomiting, diarrhea and behavioral changes. Clinical examination showed an increased volume in the upper right abdominal quadrant caused by a neoplastic mass. The patient died during the surgical procedure. Necropsy revealed several small nodules in the peritoneum with adhesion to different portions of the small and large intestines, liver, stomach and diaphragm. Tissue samples were collected, routinely processed and stained by H&E. Microscopic examination revealed a mesenchymal tumor limited to tunica muscularis, resembling normal smooth muscle cells. Neoplastic cells were positive for alpha-smooth muscle actin and vimentin, and negative for cytokeratin AE1/AE3 by immunohistochemistry. Those morphological and immunohistochemical findings allowed to diagnose the intestinal leiomyoma referred above.Conclusion: Neoplastic diseases in primates have multifaceted causes. Their manifestations are understudied, leading to a greater difficulty in detection and measurement of the real impact provides by this disease.Univ Caldas, Fac Agr Sci, Vet Pathol Res Grp, Manizales, ColombiaUniv Estadual Paulista, UNESP, Dept Vet Clin, Lab Invest & Comparat Pathol, Botucatu, SP, BrazilUniv Caldas, Anim Hlth Dept, Manizales, ColombiaUniv Estadual Paulista, UNESP, Botucatu Med Sch, Dept Pathol, Botucatu, SP, BrazilNatl Assoc Small Anim Clinicians Anclivepa, Vet Serv, Publ Vet Hosp, Dept Diagnost Pathol, São Paulo, BrazilUniv Estadual Paulista, UNESP, Dept Vet Clin, Lab Invest & Comparat Pathol, Botucatu, SP, BrazilUniv Estadual Paulista, UNESP, Botucatu Med Sch, Dept Pathol, Botucatu, SP, BrazilBiomed Central Ltd.Univ CaldasUniversidade Estadual Paulista (Unesp)Natl Assoc Small Anim Clinicians AnclivepaAristizabal-Arbelaez, MonicaMejia-Restrepo, JulianMontoya-Florez, Mauricio [UNESP]Grandi, Fabrizio [UNESP]Pedraza-Ordonez, Francisco [UNESP]2014-05-20T13:37:38Z2014-05-20T13:37:38Z2012-06-29info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article7application/pdfhttp://dx.doi.org/10.1186/1746-6148-8-97Bmc Veterinary Research. London: Biomed Central Ltd., v. 8, p. 7, 2012.1746-6148http://hdl.handle.net/11449/1304810.1186/1746-6148-8-97WOS:000312219200001WOS000312219200001.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBMC Veterinary Research1.9580,934info:eu-repo/semantics/openAccess2023-10-27T06:12:59Zoai:repositorio.unesp.br:11449/13048Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-10-27T06:12:59Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Immunohistochemical and morphological features of a small bowel leiomyoma in a black crested macaque (Macaca nigra) |
title |
Immunohistochemical and morphological features of a small bowel leiomyoma in a black crested macaque (Macaca nigra) |
spellingShingle |
Immunohistochemical and morphological features of a small bowel leiomyoma in a black crested macaque (Macaca nigra) Aristizabal-Arbelaez, Monica Neoplasm Small bowel Macaca Monkey Leiomyoma Intestine |
title_short |
Immunohistochemical and morphological features of a small bowel leiomyoma in a black crested macaque (Macaca nigra) |
title_full |
Immunohistochemical and morphological features of a small bowel leiomyoma in a black crested macaque (Macaca nigra) |
title_fullStr |
Immunohistochemical and morphological features of a small bowel leiomyoma in a black crested macaque (Macaca nigra) |
title_full_unstemmed |
Immunohistochemical and morphological features of a small bowel leiomyoma in a black crested macaque (Macaca nigra) |
title_sort |
Immunohistochemical and morphological features of a small bowel leiomyoma in a black crested macaque (Macaca nigra) |
author |
Aristizabal-Arbelaez, Monica |
author_facet |
Aristizabal-Arbelaez, Monica Mejia-Restrepo, Julian Montoya-Florez, Mauricio [UNESP] Grandi, Fabrizio [UNESP] Pedraza-Ordonez, Francisco [UNESP] |
author_role |
author |
author2 |
Mejia-Restrepo, Julian Montoya-Florez, Mauricio [UNESP] Grandi, Fabrizio [UNESP] Pedraza-Ordonez, Francisco [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Univ Caldas Universidade Estadual Paulista (Unesp) Natl Assoc Small Anim Clinicians Anclivepa |
dc.contributor.author.fl_str_mv |
Aristizabal-Arbelaez, Monica Mejia-Restrepo, Julian Montoya-Florez, Mauricio [UNESP] Grandi, Fabrizio [UNESP] Pedraza-Ordonez, Francisco [UNESP] |
dc.subject.por.fl_str_mv |
Neoplasm Small bowel Macaca Monkey Leiomyoma Intestine |
topic |
Neoplasm Small bowel Macaca Monkey Leiomyoma Intestine |
description |
Background: Spontaneous gastrointestinal neoplasms in non-human primates are commonly seen in aged individuals. Due to genetic similarities between human and non-human primates, scientists have shown increasing interest in terms of comparative oncology studies.Case presentation: The present study is related to a case of an intestinal leiomyoma in a black crested macaque (Macaca nigra), kept on captivity by Mateca a Zoo, Pereira City, Colombia. The animal had abdominal distension, anorexia, vomiting, diarrhea and behavioral changes. Clinical examination showed an increased volume in the upper right abdominal quadrant caused by a neoplastic mass. The patient died during the surgical procedure. Necropsy revealed several small nodules in the peritoneum with adhesion to different portions of the small and large intestines, liver, stomach and diaphragm. Tissue samples were collected, routinely processed and stained by H&E. Microscopic examination revealed a mesenchymal tumor limited to tunica muscularis, resembling normal smooth muscle cells. Neoplastic cells were positive for alpha-smooth muscle actin and vimentin, and negative for cytokeratin AE1/AE3 by immunohistochemistry. Those morphological and immunohistochemical findings allowed to diagnose the intestinal leiomyoma referred above.Conclusion: Neoplastic diseases in primates have multifaceted causes. Their manifestations are understudied, leading to a greater difficulty in detection and measurement of the real impact provides by this disease. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-06-29 2014-05-20T13:37:38Z 2014-05-20T13:37:38Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1186/1746-6148-8-97 Bmc Veterinary Research. London: Biomed Central Ltd., v. 8, p. 7, 2012. 1746-6148 http://hdl.handle.net/11449/13048 10.1186/1746-6148-8-97 WOS:000312219200001 WOS000312219200001.pdf |
url |
http://dx.doi.org/10.1186/1746-6148-8-97 http://hdl.handle.net/11449/13048 |
identifier_str_mv |
Bmc Veterinary Research. London: Biomed Central Ltd., v. 8, p. 7, 2012. 1746-6148 10.1186/1746-6148-8-97 WOS:000312219200001 WOS000312219200001.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
BMC Veterinary Research 1.958 0,934 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
7 application/pdf |
dc.publisher.none.fl_str_mv |
Biomed Central Ltd. |
publisher.none.fl_str_mv |
Biomed Central Ltd. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1797789532923363328 |