Interaction of central angiotensin II and aldosterone on sodium intake and blood pressure
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.brainres.2019.06.018 http://hdl.handle.net/11449/190425 |
Resumo: | Recent studies demonstrated an important natriorexigenic mechanism activated by aldosterone acting in the hindbrain. Studies have also shown that aldosterone effects are intensified by angiotensin II (ANG II) and vice-versa. Thus, the aim of the present work was to test if angiotensinergic mechanisms in the forebrain are involved on sodium appetite to aldosterone infused into the 4th V and also if aldosterone into the 4th V might facilitate ingestive and cardiovascular responses to central ANG II. Male Holtzman rats with stainless steel cannulas implanted into the 4th ventricle (4th V) and lateral ventricle (LV) had access to 1.8% NaCl during 2 h/day. Chronic infusion of aldosterone (100 ng/h) into the 4th V for 7 days strongly increased 1.8% NaCl intake (16.1 ± 2.2 ml/2h/day). Losartan (AT1 receptor antagonist, 50 µg/1 µl) acutely injected into the LV reduced 1.8% NaCl intake induced by aldosterone infusion into the 4th V (8.8 ± 2.3 ml/2h/day). The pressor response to ANG II (50 ng/1 µl) into the LV increased in rats treated with aldosterone into the 4th V (45 ± 5 mmHg, vs. vehicle infusion: 26 ± 4 mmHg). Similarly, fluid intake (water + 1.8% NaCl) also increased when rats receiving aldosterone infusion were treated with ANG II acutely into the LV. These results suggest that forebrain angiotensinergic mechanisms are important for sodium intake produced by aldosterone acting in the hindbrain. In addition, aldosterone in the hindbrain produces sensitization of the central pressor mechanisms activated by ANG II acting in the forebrain. |
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Interaction of central angiotensin II and aldosterone on sodium intake and blood pressureAldosteroneAngiotensinArterial pressureAT1 receptorsSodium intakeRecent studies demonstrated an important natriorexigenic mechanism activated by aldosterone acting in the hindbrain. Studies have also shown that aldosterone effects are intensified by angiotensin II (ANG II) and vice-versa. Thus, the aim of the present work was to test if angiotensinergic mechanisms in the forebrain are involved on sodium appetite to aldosterone infused into the 4th V and also if aldosterone into the 4th V might facilitate ingestive and cardiovascular responses to central ANG II. Male Holtzman rats with stainless steel cannulas implanted into the 4th ventricle (4th V) and lateral ventricle (LV) had access to 1.8% NaCl during 2 h/day. Chronic infusion of aldosterone (100 ng/h) into the 4th V for 7 days strongly increased 1.8% NaCl intake (16.1 ± 2.2 ml/2h/day). Losartan (AT1 receptor antagonist, 50 µg/1 µl) acutely injected into the LV reduced 1.8% NaCl intake induced by aldosterone infusion into the 4th V (8.8 ± 2.3 ml/2h/day). The pressor response to ANG II (50 ng/1 µl) into the LV increased in rats treated with aldosterone into the 4th V (45 ± 5 mmHg, vs. vehicle infusion: 26 ± 4 mmHg). Similarly, fluid intake (water + 1.8% NaCl) also increased when rats receiving aldosterone infusion were treated with ANG II acutely into the LV. These results suggest that forebrain angiotensinergic mechanisms are important for sodium intake produced by aldosterone acting in the hindbrain. In addition, aldosterone in the hindbrain produces sensitization of the central pressor mechanisms activated by ANG II acting in the forebrain.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)University of IowaDepartment of Physiology and Pathology School of Dentistry São Paulo State University (UNESP)Department of Physiology School of Medicine of Ribeirao Preto University of Sao PauloDepartment of Pharmacology and Physiology Saint Louis UniversityDepartment of Neurology University of IowaDepartment of Physiology University of MelbourneDepartment of Physiology and Pathology School of Dentistry São Paulo State University (UNESP)Universidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Saint Louis UniversityUniversity of IowaUniversity of MelbourneGasparini, S. [UNESP]Melo, M. R. [UNESP]Nascimento, P. A. [UNESP]Andrade-Franzé, G. M.F. [UNESP]Antunes- Rodrigues, J.Yosten, G. L.C.Menani, J. V. [UNESP]Samson, W. K.Colombari, E. [UNESP]2019-10-06T17:12:47Z2019-10-06T17:12:47Z2019-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.brainres.2019.06.018Brain Research, v. 1720.1872-62400006-8993http://hdl.handle.net/11449/19042510.1016/j.brainres.2019.06.0182-s2.0-85067623063Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrain Researchinfo:eu-repo/semantics/openAccess2021-10-22T21:16:17Zoai:repositorio.unesp.br:11449/190425Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-22T21:16:17Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Interaction of central angiotensin II and aldosterone on sodium intake and blood pressure |
title |
Interaction of central angiotensin II and aldosterone on sodium intake and blood pressure |
spellingShingle |
Interaction of central angiotensin II and aldosterone on sodium intake and blood pressure Gasparini, S. [UNESP] Aldosterone Angiotensin Arterial pressure AT1 receptors Sodium intake |
title_short |
Interaction of central angiotensin II and aldosterone on sodium intake and blood pressure |
title_full |
Interaction of central angiotensin II and aldosterone on sodium intake and blood pressure |
title_fullStr |
Interaction of central angiotensin II and aldosterone on sodium intake and blood pressure |
title_full_unstemmed |
Interaction of central angiotensin II and aldosterone on sodium intake and blood pressure |
title_sort |
Interaction of central angiotensin II and aldosterone on sodium intake and blood pressure |
author |
Gasparini, S. [UNESP] |
author_facet |
Gasparini, S. [UNESP] Melo, M. R. [UNESP] Nascimento, P. A. [UNESP] Andrade-Franzé, G. M.F. [UNESP] Antunes- Rodrigues, J. Yosten, G. L.C. Menani, J. V. [UNESP] Samson, W. K. Colombari, E. [UNESP] |
author_role |
author |
author2 |
Melo, M. R. [UNESP] Nascimento, P. A. [UNESP] Andrade-Franzé, G. M.F. [UNESP] Antunes- Rodrigues, J. Yosten, G. L.C. Menani, J. V. [UNESP] Samson, W. K. Colombari, E. [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) Saint Louis University University of Iowa University of Melbourne |
dc.contributor.author.fl_str_mv |
Gasparini, S. [UNESP] Melo, M. R. [UNESP] Nascimento, P. A. [UNESP] Andrade-Franzé, G. M.F. [UNESP] Antunes- Rodrigues, J. Yosten, G. L.C. Menani, J. V. [UNESP] Samson, W. K. Colombari, E. [UNESP] |
dc.subject.por.fl_str_mv |
Aldosterone Angiotensin Arterial pressure AT1 receptors Sodium intake |
topic |
Aldosterone Angiotensin Arterial pressure AT1 receptors Sodium intake |
description |
Recent studies demonstrated an important natriorexigenic mechanism activated by aldosterone acting in the hindbrain. Studies have also shown that aldosterone effects are intensified by angiotensin II (ANG II) and vice-versa. Thus, the aim of the present work was to test if angiotensinergic mechanisms in the forebrain are involved on sodium appetite to aldosterone infused into the 4th V and also if aldosterone into the 4th V might facilitate ingestive and cardiovascular responses to central ANG II. Male Holtzman rats with stainless steel cannulas implanted into the 4th ventricle (4th V) and lateral ventricle (LV) had access to 1.8% NaCl during 2 h/day. Chronic infusion of aldosterone (100 ng/h) into the 4th V for 7 days strongly increased 1.8% NaCl intake (16.1 ± 2.2 ml/2h/day). Losartan (AT1 receptor antagonist, 50 µg/1 µl) acutely injected into the LV reduced 1.8% NaCl intake induced by aldosterone infusion into the 4th V (8.8 ± 2.3 ml/2h/day). The pressor response to ANG II (50 ng/1 µl) into the LV increased in rats treated with aldosterone into the 4th V (45 ± 5 mmHg, vs. vehicle infusion: 26 ± 4 mmHg). Similarly, fluid intake (water + 1.8% NaCl) also increased when rats receiving aldosterone infusion were treated with ANG II acutely into the LV. These results suggest that forebrain angiotensinergic mechanisms are important for sodium intake produced by aldosterone acting in the hindbrain. In addition, aldosterone in the hindbrain produces sensitization of the central pressor mechanisms activated by ANG II acting in the forebrain. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-06T17:12:47Z 2019-10-06T17:12:47Z 2019-10-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.brainres.2019.06.018 Brain Research, v. 1720. 1872-6240 0006-8993 http://hdl.handle.net/11449/190425 10.1016/j.brainres.2019.06.018 2-s2.0-85067623063 |
url |
http://dx.doi.org/10.1016/j.brainres.2019.06.018 http://hdl.handle.net/11449/190425 |
identifier_str_mv |
Brain Research, v. 1720. 1872-6240 0006-8993 10.1016/j.brainres.2019.06.018 2-s2.0-85067623063 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brain Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1797789570939486208 |