The Influence of Nanostructured Hydroxyapatite Surface in the Early Stages of Osseointegration: A Multiparameter Animal Study in Low-Density Bone
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.2147/IJN.S280957 http://hdl.handle.net/11449/205489 |
Resumo: | Background and Objective: The success rates of dental implants in low-density bone have been reported as a challenge, especially for early or immediate loading in the maxilla posterior area. Nanoscale architecture affects the roughness, surface area, surface energy of the implant and can enhance osseointegration. This study aimed to evaluate the implant-surface topography and biomechanical, histomorphometric, and histological bone responses to a new nanostructured hydroxyapatite surface placed in the iliac crest of sheep. Methods: Ten female sheep (2-4 years) received 30 implants (n=10/group): HAnano® coated (Epikut Plus®, S.I.N. Implant System, Sao Paulo, SP, Brazil), SLActive (BLX®, Straumann, Basel, Switzerland), and TiUnite (NobelActive®, Nobel Biocare, Göteborg, Sweden) surfaces. Scanning electron microscopy with energy-dispersive spectroscopy evaluated the implant surface topography, the insertion torque value, and resonance frequency analysis evaluated the primary stability, bone-implant contact, and bone-area fraction occupancy were evaluated after 14 and 28 days after implant placement. Results: The surface morphology was considerably comparable between the implant groups'; however, the TiUnite® group presented a remarkable different surface. The SLActive® and TiUnite® groups presented an insertion torque average of 74 (±8.9) N/cm that was similar to that of HAnano® 72 (±8.3) N/cm (p >0.05). The resonance frequency evaluated with Osstell®/SmartPeg® or Penguin®/MulTipeg® showed similar results when assessing implants from the same group. BIC and BAFO significantly increased (p<0.05) throughout the experimental periods to all groups, but BIC and BAFO values were similar among the implants at the same time point. After 4 weeks, bone-implant contact was higher than 80% of the total length analyzed. New bone occupies around 60% of analyzed area around the implants. Conclusion: HAnano® coated surface promoted comparable osseointegration as SLActive and TiUnite in the sheep model. The three tested surfaces showed comparable osseointegration at the early stages of low-density bone repair in the sheep model. |
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The Influence of Nanostructured Hydroxyapatite Surface in the Early Stages of Osseointegration: A Multiparameter Animal Study in Low-Density Bonebone responsedental implant surfacehydroxyapatitenanotechnologyosseointegrationsheepBackground and Objective: The success rates of dental implants in low-density bone have been reported as a challenge, especially for early or immediate loading in the maxilla posterior area. Nanoscale architecture affects the roughness, surface area, surface energy of the implant and can enhance osseointegration. This study aimed to evaluate the implant-surface topography and biomechanical, histomorphometric, and histological bone responses to a new nanostructured hydroxyapatite surface placed in the iliac crest of sheep. Methods: Ten female sheep (2-4 years) received 30 implants (n=10/group): HAnano® coated (Epikut Plus®, S.I.N. Implant System, Sao Paulo, SP, Brazil), SLActive (BLX®, Straumann, Basel, Switzerland), and TiUnite (NobelActive®, Nobel Biocare, Göteborg, Sweden) surfaces. Scanning electron microscopy with energy-dispersive spectroscopy evaluated the implant surface topography, the insertion torque value, and resonance frequency analysis evaluated the primary stability, bone-implant contact, and bone-area fraction occupancy were evaluated after 14 and 28 days after implant placement. Results: The surface morphology was considerably comparable between the implant groups'; however, the TiUnite® group presented a remarkable different surface. The SLActive® and TiUnite® groups presented an insertion torque average of 74 (±8.9) N/cm that was similar to that of HAnano® 72 (±8.3) N/cm (p >0.05). The resonance frequency evaluated with Osstell®/SmartPeg® or Penguin®/MulTipeg® showed similar results when assessing implants from the same group. BIC and BAFO significantly increased (p<0.05) throughout the experimental periods to all groups, but BIC and BAFO values were similar among the implants at the same time point. After 4 weeks, bone-implant contact was higher than 80% of the total length analyzed. New bone occupies around 60% of analyzed area around the implants. Conclusion: HAnano® coated surface promoted comparable osseointegration as SLActive and TiUnite in the sheep model. The three tested surfaces showed comparable osseointegration at the early stages of low-density bone repair in the sheep model.Oral Surgery Department Universidade Veiga de Almeida RJOral Surgery Department Universidade Iguaçu RJPost-Graduation Program in Dentistry Universidade Veiga de Almeida RJClinical Research Laboratory Dentistry School Universidade Federal Fluminense RJOrthodontics Department Dentistry School Universidade Federal Fluminense RJOral Surgery Department Universidade Federal Fluminense RJDental Research Division Dentistry School Universidade PaulistaLaboratory of Bioassays and Cell Dynamics IBB-UNESPNational Institute of Metrology Quality and Technology (INMETRO) RJLaboratory of Bioassays and Cell Dynamics IBB-UNESPRJUniversidade Federal Fluminense (UFF)Universidade PaulistaUniversidade Estadual Paulista (Unesp)Sartoretto, Suelen CristinaCalasans-Maia, JoseResende, RodrigoCâmara, EduardoGhiraldini, BrunaBarbosa Bezerra, Fabio Jose [UNESP]Granjeiro, Jose MauroCalasans-Maia, Monica Diuana2021-06-25T10:16:13Z2021-06-25T10:16:13Z2020-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article8803-8817http://dx.doi.org/10.2147/IJN.S280957International journal of nanomedicine, v. 15, p. 8803-8817.1178-2013http://hdl.handle.net/11449/20548910.2147/IJN.S2809572-s2.0-85096348326Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational journal of nanomedicineinfo:eu-repo/semantics/openAccess2021-10-23T14:40:28Zoai:repositorio.unesp.br:11449/205489Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T14:40:28Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
The Influence of Nanostructured Hydroxyapatite Surface in the Early Stages of Osseointegration: A Multiparameter Animal Study in Low-Density Bone |
title |
The Influence of Nanostructured Hydroxyapatite Surface in the Early Stages of Osseointegration: A Multiparameter Animal Study in Low-Density Bone |
spellingShingle |
The Influence of Nanostructured Hydroxyapatite Surface in the Early Stages of Osseointegration: A Multiparameter Animal Study in Low-Density Bone Sartoretto, Suelen Cristina bone response dental implant surface hydroxyapatite nanotechnology osseointegration sheep |
title_short |
The Influence of Nanostructured Hydroxyapatite Surface in the Early Stages of Osseointegration: A Multiparameter Animal Study in Low-Density Bone |
title_full |
The Influence of Nanostructured Hydroxyapatite Surface in the Early Stages of Osseointegration: A Multiparameter Animal Study in Low-Density Bone |
title_fullStr |
The Influence of Nanostructured Hydroxyapatite Surface in the Early Stages of Osseointegration: A Multiparameter Animal Study in Low-Density Bone |
title_full_unstemmed |
The Influence of Nanostructured Hydroxyapatite Surface in the Early Stages of Osseointegration: A Multiparameter Animal Study in Low-Density Bone |
title_sort |
The Influence of Nanostructured Hydroxyapatite Surface in the Early Stages of Osseointegration: A Multiparameter Animal Study in Low-Density Bone |
author |
Sartoretto, Suelen Cristina |
author_facet |
Sartoretto, Suelen Cristina Calasans-Maia, Jose Resende, Rodrigo Câmara, Eduardo Ghiraldini, Bruna Barbosa Bezerra, Fabio Jose [UNESP] Granjeiro, Jose Mauro Calasans-Maia, Monica Diuana |
author_role |
author |
author2 |
Calasans-Maia, Jose Resende, Rodrigo Câmara, Eduardo Ghiraldini, Bruna Barbosa Bezerra, Fabio Jose [UNESP] Granjeiro, Jose Mauro Calasans-Maia, Monica Diuana |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
RJ Universidade Federal Fluminense (UFF) Universidade Paulista Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Sartoretto, Suelen Cristina Calasans-Maia, Jose Resende, Rodrigo Câmara, Eduardo Ghiraldini, Bruna Barbosa Bezerra, Fabio Jose [UNESP] Granjeiro, Jose Mauro Calasans-Maia, Monica Diuana |
dc.subject.por.fl_str_mv |
bone response dental implant surface hydroxyapatite nanotechnology osseointegration sheep |
topic |
bone response dental implant surface hydroxyapatite nanotechnology osseointegration sheep |
description |
Background and Objective: The success rates of dental implants in low-density bone have been reported as a challenge, especially for early or immediate loading in the maxilla posterior area. Nanoscale architecture affects the roughness, surface area, surface energy of the implant and can enhance osseointegration. This study aimed to evaluate the implant-surface topography and biomechanical, histomorphometric, and histological bone responses to a new nanostructured hydroxyapatite surface placed in the iliac crest of sheep. Methods: Ten female sheep (2-4 years) received 30 implants (n=10/group): HAnano® coated (Epikut Plus®, S.I.N. Implant System, Sao Paulo, SP, Brazil), SLActive (BLX®, Straumann, Basel, Switzerland), and TiUnite (NobelActive®, Nobel Biocare, Göteborg, Sweden) surfaces. Scanning electron microscopy with energy-dispersive spectroscopy evaluated the implant surface topography, the insertion torque value, and resonance frequency analysis evaluated the primary stability, bone-implant contact, and bone-area fraction occupancy were evaluated after 14 and 28 days after implant placement. Results: The surface morphology was considerably comparable between the implant groups'; however, the TiUnite® group presented a remarkable different surface. The SLActive® and TiUnite® groups presented an insertion torque average of 74 (±8.9) N/cm that was similar to that of HAnano® 72 (±8.3) N/cm (p >0.05). The resonance frequency evaluated with Osstell®/SmartPeg® or Penguin®/MulTipeg® showed similar results when assessing implants from the same group. BIC and BAFO significantly increased (p<0.05) throughout the experimental periods to all groups, but BIC and BAFO values were similar among the implants at the same time point. After 4 weeks, bone-implant contact was higher than 80% of the total length analyzed. New bone occupies around 60% of analyzed area around the implants. Conclusion: HAnano® coated surface promoted comparable osseointegration as SLActive and TiUnite in the sheep model. The three tested surfaces showed comparable osseointegration at the early stages of low-density bone repair in the sheep model. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-01-01 2021-06-25T10:16:13Z 2021-06-25T10:16:13Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.2147/IJN.S280957 International journal of nanomedicine, v. 15, p. 8803-8817. 1178-2013 http://hdl.handle.net/11449/205489 10.2147/IJN.S280957 2-s2.0-85096348326 |
url |
http://dx.doi.org/10.2147/IJN.S280957 http://hdl.handle.net/11449/205489 |
identifier_str_mv |
International journal of nanomedicine, v. 15, p. 8803-8817. 1178-2013 10.2147/IJN.S280957 2-s2.0-85096348326 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
International journal of nanomedicine |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
8803-8817 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964732570992640 |