Developing new radiotherapy techniques using linac based gamma radiation sources
Main Author: | |
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Publication Date: | 2007 |
Other Authors: | , , , , , , , |
Format: | Conference object |
Language: | eng |
Source: | Repositório Institucional da UNESP |
Download full: | http://www.ans.org/store/i_700330 http://hdl.handle.net/11449/70159 |
Summary: | A major challenge in cancer radiotherapy is to deliver a lethal dose of radiation to the target volume while minimizing damage to the surrounding normal tissue. We have proposed a model on how treatment efficacy might be improved by interfering with biological responses to DNA damage using exogenous electric fields as a strategy to drastically reduce radiation doses in cancer therapy. This approach is demonstrated at this Laboratory through case studies with prokaryotes (bacteria) and eukaryotes (yeast) cells, in which cellkilling rates induced by both gamma radiation and exogenous electric fields were measured. It was found that when cells exposed to gamma radiation are immediately submitted to a weak electric field, cell death increases more than an order of magnitude compared to the effect of radiation alone. This finding suggests, although does not prove, that DNA damage sites are reached and recognized by means of long-range electric DNA-protein interaction, and that exogenous electric fields could destructively interfere with this process. As a consequence, DNA repair is avoided leading to massive cell death. Here we are proposing the use this new technique for the design and construction of novel radiotherapy facilities associated with linac generated gamma beams under controlled conditions of dose and beam intensity. |
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Developing new radiotherapy techniques using linac based gamma radiation sourcesCell deathDNADosimetryElectric field effectsElectric field measurementElectric fieldsGamma raysGenesLinear acceleratorsNucleic acidsOrganic acidsQuantum opticsRadiotherapyTheorem provingBeam intensitiesBiological responsesCancer therapiesCase studiesControlled conditionsDesign and constructionsDna damagesDna repairsGamma radiation sourcesGamma radiationsLethal dosesNew techniquesNormal tissuesProtein interactionsRadiation dosesTarget volumesRadiationA major challenge in cancer radiotherapy is to deliver a lethal dose of radiation to the target volume while minimizing damage to the surrounding normal tissue. We have proposed a model on how treatment efficacy might be improved by interfering with biological responses to DNA damage using exogenous electric fields as a strategy to drastically reduce radiation doses in cancer therapy. This approach is demonstrated at this Laboratory through case studies with prokaryotes (bacteria) and eukaryotes (yeast) cells, in which cellkilling rates induced by both gamma radiation and exogenous electric fields were measured. It was found that when cells exposed to gamma radiation are immediately submitted to a weak electric field, cell death increases more than an order of magnitude compared to the effect of radiation alone. This finding suggests, although does not prove, that DNA damage sites are reached and recognized by means of long-range electric DNA-protein interaction, and that exogenous electric fields could destructively interfere with this process. As a consequence, DNA repair is avoided leading to massive cell death. Here we are proposing the use this new technique for the design and construction of novel radiotherapy facilities associated with linac generated gamma beams under controlled conditions of dose and beam intensity.Physics Institute University of São Paulo, São Paulo, SPUNISA University of Santo Amaro, São Paulo, SPESALQ University of São Paulo, Piracicaba, SPInstitute for Biomedical Sciences University of São Paulo, São Paulo, SPSão Paulo State University UNESP, Botucatu, SPMedical Physics Group Santa Cruz State University, Ilhéus, BASão Paulo State University UNESP, Botucatu, SPUniversidade de São Paulo (USP)University of Santo AmaroUniversidade Estadual Paulista (Unesp)Santa Cruz State UniversityArruda-Neto, J. D TBittencourt-Oliveira, M. C.Schenberg, A. C GSilva, E. C.Mesa, J.Rodrigues, T. E.Garcia, F.Louvison, M.Paula, C. R.2014-05-27T11:22:43Z2014-05-27T11:22:43Z2007-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObject398-404http://www.ans.org/store/i_7003308th International Topical Meeting on Nuclear Applications and Utilization of Accelerators, ACCAPP'07, p. 398-404.http://hdl.handle.net/11449/701592-s2.0-58349095158Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPeng8th International Topical Meeting on Nuclear Applications and Utilization of Accelerators, ACCAPP'07info:eu-repo/semantics/openAccess2021-10-23T21:37:57Zoai:repositorio.unesp.br:11449/70159Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T21:37:57Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Developing new radiotherapy techniques using linac based gamma radiation sources |
title |
Developing new radiotherapy techniques using linac based gamma radiation sources |
spellingShingle |
Developing new radiotherapy techniques using linac based gamma radiation sources Arruda-Neto, J. D T Cell death DNA Dosimetry Electric field effects Electric field measurement Electric fields Gamma rays Genes Linear accelerators Nucleic acids Organic acids Quantum optics Radiotherapy Theorem proving Beam intensities Biological responses Cancer therapies Case studies Controlled conditions Design and constructions Dna damages Dna repairs Gamma radiation sources Gamma radiations Lethal doses New techniques Normal tissues Protein interactions Radiation doses Target volumes Radiation |
title_short |
Developing new radiotherapy techniques using linac based gamma radiation sources |
title_full |
Developing new radiotherapy techniques using linac based gamma radiation sources |
title_fullStr |
Developing new radiotherapy techniques using linac based gamma radiation sources |
title_full_unstemmed |
Developing new radiotherapy techniques using linac based gamma radiation sources |
title_sort |
Developing new radiotherapy techniques using linac based gamma radiation sources |
author |
Arruda-Neto, J. D T |
author_facet |
Arruda-Neto, J. D T Bittencourt-Oliveira, M. C. Schenberg, A. C G Silva, E. C. Mesa, J. Rodrigues, T. E. Garcia, F. Louvison, M. Paula, C. R. |
author_role |
author |
author2 |
Bittencourt-Oliveira, M. C. Schenberg, A. C G Silva, E. C. Mesa, J. Rodrigues, T. E. Garcia, F. Louvison, M. Paula, C. R. |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) University of Santo Amaro Universidade Estadual Paulista (Unesp) Santa Cruz State University |
dc.contributor.author.fl_str_mv |
Arruda-Neto, J. D T Bittencourt-Oliveira, M. C. Schenberg, A. C G Silva, E. C. Mesa, J. Rodrigues, T. E. Garcia, F. Louvison, M. Paula, C. R. |
dc.subject.por.fl_str_mv |
Cell death DNA Dosimetry Electric field effects Electric field measurement Electric fields Gamma rays Genes Linear accelerators Nucleic acids Organic acids Quantum optics Radiotherapy Theorem proving Beam intensities Biological responses Cancer therapies Case studies Controlled conditions Design and constructions Dna damages Dna repairs Gamma radiation sources Gamma radiations Lethal doses New techniques Normal tissues Protein interactions Radiation doses Target volumes Radiation |
topic |
Cell death DNA Dosimetry Electric field effects Electric field measurement Electric fields Gamma rays Genes Linear accelerators Nucleic acids Organic acids Quantum optics Radiotherapy Theorem proving Beam intensities Biological responses Cancer therapies Case studies Controlled conditions Design and constructions Dna damages Dna repairs Gamma radiation sources Gamma radiations Lethal doses New techniques Normal tissues Protein interactions Radiation doses Target volumes Radiation |
description |
A major challenge in cancer radiotherapy is to deliver a lethal dose of radiation to the target volume while minimizing damage to the surrounding normal tissue. We have proposed a model on how treatment efficacy might be improved by interfering with biological responses to DNA damage using exogenous electric fields as a strategy to drastically reduce radiation doses in cancer therapy. This approach is demonstrated at this Laboratory through case studies with prokaryotes (bacteria) and eukaryotes (yeast) cells, in which cellkilling rates induced by both gamma radiation and exogenous electric fields were measured. It was found that when cells exposed to gamma radiation are immediately submitted to a weak electric field, cell death increases more than an order of magnitude compared to the effect of radiation alone. This finding suggests, although does not prove, that DNA damage sites are reached and recognized by means of long-range electric DNA-protein interaction, and that exogenous electric fields could destructively interfere with this process. As a consequence, DNA repair is avoided leading to massive cell death. Here we are proposing the use this new technique for the design and construction of novel radiotherapy facilities associated with linac generated gamma beams under controlled conditions of dose and beam intensity. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-12-01 2014-05-27T11:22:43Z 2014-05-27T11:22:43Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/conferenceObject |
format |
conferenceObject |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.ans.org/store/i_700330 8th International Topical Meeting on Nuclear Applications and Utilization of Accelerators, ACCAPP'07, p. 398-404. http://hdl.handle.net/11449/70159 2-s2.0-58349095158 |
url |
http://www.ans.org/store/i_700330 http://hdl.handle.net/11449/70159 |
identifier_str_mv |
8th International Topical Meeting on Nuclear Applications and Utilization of Accelerators, ACCAPP'07, p. 398-404. 2-s2.0-58349095158 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
8th International Topical Meeting on Nuclear Applications and Utilization of Accelerators, ACCAPP'07 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
398-404 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1799964722768904192 |