Flavonoids with gastroprotective activity

Detalhes bibliográficos
Autor(a) principal: De Lira Mota, Kelly Samara
Data de Publicação: 2009
Outros Autores: Dias, Guilherme Eduardo Nunes, Pinto, Meri Emili Ferreira, Luiz-Ferreira, Ânderson, Souza-Brito, Alba Regina Monteiro, Hiruma-Lima, Clélia Akiko [UNESP], Barbosa-Filho, José Maria, Batista, Leônia Maria
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.3390/molecules14030979
http://hdl.handle.net/11449/70947
Resumo: Peptic ulcers are a common disorder of the entire gastrointestinal tract that occurs mainly in the stomach and the proximal duodenum. This disease is multifactorial and its treatment faces great difficulties due to the limited effectiveness and severe side effects of the currently available drugs. The use of natural products for the prevention and treatment of different pathologies is continuously expanding throughout the world. This is particularly true with regards to flavonoids, which represent a highly diverse class of secondary metabolites with potentially beneficial human health effects that is widely distributed in the plant kingdom and currently consumed in large amounts in the diet. They display several pharmacological properties in the gastroprotective area, acting as anti-secretory, cytoprotective and antioxidant agents. Besides their action as gastroprotectives, flavonoids also act in healing of gastric ulcers and additionally these polyphenolic compounds can be new alternatives for suppression or modulation of peptic ulcers associated with H. pylori. In this review, we have summarized the literature on ninety-five flavonoids with varying degrees of antiulcerogenic activity, confirming that flavonoids have a therapeutic potential for the more effective treatment of peptic ulcers.
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spelling Flavonoids with gastroprotective activityFlavonoidsGastroprotective activityNatural products.Peptic ulcersflavonoidphenol derivativepolyphenolsprotective agenthumanpeptic ulcerreviewHumansPeptic UlcerPhenolsProtective AgentsPeptic ulcers are a common disorder of the entire gastrointestinal tract that occurs mainly in the stomach and the proximal duodenum. This disease is multifactorial and its treatment faces great difficulties due to the limited effectiveness and severe side effects of the currently available drugs. The use of natural products for the prevention and treatment of different pathologies is continuously expanding throughout the world. This is particularly true with regards to flavonoids, which represent a highly diverse class of secondary metabolites with potentially beneficial human health effects that is widely distributed in the plant kingdom and currently consumed in large amounts in the diet. They display several pharmacological properties in the gastroprotective area, acting as anti-secretory, cytoprotective and antioxidant agents. Besides their action as gastroprotectives, flavonoids also act in healing of gastric ulcers and additionally these polyphenolic compounds can be new alternatives for suppression or modulation of peptic ulcers associated with H. pylori. In this review, we have summarized the literature on ninety-five flavonoids with varying degrees of antiulcerogenic activity, confirming that flavonoids have a therapeutic potential for the more effective treatment of peptic ulcers.Laboratório de Tecnologia Farmacêutica Prof. Delby Fernandes de Medeiros - LTF Universidade Federal da Paraíba - UFPB, Cx. Postal 5009, 58051-970, João Pessoa, PBLaboratório de Produtos Naturais Universidade Estadual de Campinas - UNICAMP, Cx. Postal 6109, 13083-970, Campinas, SPDepartamento de Fisiologia Instituto de Biosciência Universidade Estadual de São Paulo-UNESP, c.p. 510, Zip Code: 18618-000, Botucatu, SPDepartamento de Fisiologia Instituto de Biosciência Universidade Estadual de São Paulo-UNESP, c.p. 510, Zip Code: 18618-000, Botucatu, SPUniversidade Federal da Paraíba (UFPB)Universidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (Unesp)De Lira Mota, Kelly SamaraDias, Guilherme Eduardo NunesPinto, Meri Emili FerreiraLuiz-Ferreira, ÂndersonSouza-Brito, Alba Regina MonteiroHiruma-Lima, Clélia Akiko [UNESP]Barbosa-Filho, José MariaBatista, Leônia Maria2014-05-27T11:23:52Z2014-05-27T11:23:52Z2009-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article979-1012application/pdfhttp://dx.doi.org/10.3390/molecules14030979Molecules, v. 14, n. 3, p. 979-1012, 2009.1420-3049http://hdl.handle.net/11449/7094710.3390/molecules140309792-s2.0-634491040702-s2.0-63449104070.pdf38145049013868440000-0002-8645-3777Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMolecules3.0980,855info:eu-repo/semantics/openAccess2024-01-22T06:24:29Zoai:repositorio.unesp.br:11449/70947Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-01-22T06:24:29Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Flavonoids with gastroprotective activity
title Flavonoids with gastroprotective activity
spellingShingle Flavonoids with gastroprotective activity
De Lira Mota, Kelly Samara
Flavonoids
Gastroprotective activity
Natural products.
Peptic ulcers
flavonoid
phenol derivative
polyphenols
protective agent
human
peptic ulcer
review
Humans
Peptic Ulcer
Phenols
Protective Agents
title_short Flavonoids with gastroprotective activity
title_full Flavonoids with gastroprotective activity
title_fullStr Flavonoids with gastroprotective activity
title_full_unstemmed Flavonoids with gastroprotective activity
title_sort Flavonoids with gastroprotective activity
author De Lira Mota, Kelly Samara
author_facet De Lira Mota, Kelly Samara
Dias, Guilherme Eduardo Nunes
Pinto, Meri Emili Ferreira
Luiz-Ferreira, Ânderson
Souza-Brito, Alba Regina Monteiro
Hiruma-Lima, Clélia Akiko [UNESP]
Barbosa-Filho, José Maria
Batista, Leônia Maria
author_role author
author2 Dias, Guilherme Eduardo Nunes
Pinto, Meri Emili Ferreira
Luiz-Ferreira, Ânderson
Souza-Brito, Alba Regina Monteiro
Hiruma-Lima, Clélia Akiko [UNESP]
Barbosa-Filho, José Maria
Batista, Leônia Maria
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal da Paraíba (UFPB)
Universidade Estadual de Campinas (UNICAMP)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv De Lira Mota, Kelly Samara
Dias, Guilherme Eduardo Nunes
Pinto, Meri Emili Ferreira
Luiz-Ferreira, Ânderson
Souza-Brito, Alba Regina Monteiro
Hiruma-Lima, Clélia Akiko [UNESP]
Barbosa-Filho, José Maria
Batista, Leônia Maria
dc.subject.por.fl_str_mv Flavonoids
Gastroprotective activity
Natural products.
Peptic ulcers
flavonoid
phenol derivative
polyphenols
protective agent
human
peptic ulcer
review
Humans
Peptic Ulcer
Phenols
Protective Agents
topic Flavonoids
Gastroprotective activity
Natural products.
Peptic ulcers
flavonoid
phenol derivative
polyphenols
protective agent
human
peptic ulcer
review
Humans
Peptic Ulcer
Phenols
Protective Agents
description Peptic ulcers are a common disorder of the entire gastrointestinal tract that occurs mainly in the stomach and the proximal duodenum. This disease is multifactorial and its treatment faces great difficulties due to the limited effectiveness and severe side effects of the currently available drugs. The use of natural products for the prevention and treatment of different pathologies is continuously expanding throughout the world. This is particularly true with regards to flavonoids, which represent a highly diverse class of secondary metabolites with potentially beneficial human health effects that is widely distributed in the plant kingdom and currently consumed in large amounts in the diet. They display several pharmacological properties in the gastroprotective area, acting as anti-secretory, cytoprotective and antioxidant agents. Besides their action as gastroprotectives, flavonoids also act in healing of gastric ulcers and additionally these polyphenolic compounds can be new alternatives for suppression or modulation of peptic ulcers associated with H. pylori. In this review, we have summarized the literature on ninety-five flavonoids with varying degrees of antiulcerogenic activity, confirming that flavonoids have a therapeutic potential for the more effective treatment of peptic ulcers.
publishDate 2009
dc.date.none.fl_str_mv 2009-03-01
2014-05-27T11:23:52Z
2014-05-27T11:23:52Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.3390/molecules14030979
Molecules, v. 14, n. 3, p. 979-1012, 2009.
1420-3049
http://hdl.handle.net/11449/70947
10.3390/molecules14030979
2-s2.0-63449104070
2-s2.0-63449104070.pdf
3814504901386844
0000-0002-8645-3777
url http://dx.doi.org/10.3390/molecules14030979
http://hdl.handle.net/11449/70947
identifier_str_mv Molecules, v. 14, n. 3, p. 979-1012, 2009.
1420-3049
10.3390/molecules14030979
2-s2.0-63449104070
2-s2.0-63449104070.pdf
3814504901386844
0000-0002-8645-3777
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Molecules
3.098
0,855
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 979-1012
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1799965694929928192

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