Mineral preference in rats treated with muscimol into the lateral parabrachial nucleus
Autor(a) principal: | |
---|---|
Data de Publicação: | 2020 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.neulet.2020.134989 http://hdl.handle.net/11449/201737 |
Resumo: | Injection of muscimol, a GABAA receptor agonist, into the lateral parabrachial nucleus (LPBN) induces 0.3 M NaCl intake in rats. In the present work, we investigated whether such an effect applies to hypertonic (0.3 M) mineral solutions in general or is selective to sodium solutions in a 240 min intake test. Muscimol injection (0.5 nmol/0.2 μL) compared to vehicle injection into the LPBN of adult hydrated rats produced a preferential ingestion of 0.3 M NaCl (25.3 ± 10.2 mL) followed by a 0.3 M NaHCO3 intake (11.7 ± 5.6 mL), with no significant effect on water, KCl and CaCl2 intake. Only the effect of muscimol on NaCl intake (19.0 ± 10.4 mL) persisted in cell-dehydrated rats, with hardly any effect on water or other mineral solutions. The results suggest that the LPBN controls the ingestion of hypertonic NaCl and NaHCO3. They also suggest a selective mechanisms involving the LPBN to check hypertonic sodium intake. |
id |
UNSP_0d169cebf569bbd35aa2b14b7fadb37d |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/201737 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Mineral preference in rats treated with muscimol into the lateral parabrachial nucleusBicarbonateDehydrationFluid intakeGABAParabrachial nucleusReceptorsSodium appetiteInjection of muscimol, a GABAA receptor agonist, into the lateral parabrachial nucleus (LPBN) induces 0.3 M NaCl intake in rats. In the present work, we investigated whether such an effect applies to hypertonic (0.3 M) mineral solutions in general or is selective to sodium solutions in a 240 min intake test. Muscimol injection (0.5 nmol/0.2 μL) compared to vehicle injection into the LPBN of adult hydrated rats produced a preferential ingestion of 0.3 M NaCl (25.3 ± 10.2 mL) followed by a 0.3 M NaHCO3 intake (11.7 ± 5.6 mL), with no significant effect on water, KCl and CaCl2 intake. Only the effect of muscimol on NaCl intake (19.0 ± 10.4 mL) persisted in cell-dehydrated rats, with hardly any effect on water or other mineral solutions. The results suggest that the LPBN controls the ingestion of hypertonic NaCl and NaHCO3. They also suggest a selective mechanisms involving the LPBN to check hypertonic sodium intake.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Department of Basic Sciences School of Dentistry Sao Paulo State University (UNESP), Rodovia Marechal Rondom, Km 527Department of Physiology and Pathology School of Dentistry UNESPDepartment of Basic Sciences School of Dentistry Sao Paulo State University (UNESP), Rodovia Marechal Rondom, Km 527Department of Physiology and Pathology School of Dentistry UNESPUniversidade Estadual Paulista (Unesp)Callera, João Carlos [UNESP]De Luca, Laurival Antonio [UNESP]Menani, José Vanderlei [UNESP]2020-12-12T02:40:29Z2020-12-12T02:40:29Z2020-07-13info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.neulet.2020.134989Neuroscience Letters, v. 731.1872-79720304-3940http://hdl.handle.net/11449/20173710.1016/j.neulet.2020.1349892-s2.0-85084385421Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengNeuroscience Lettersinfo:eu-repo/semantics/openAccess2021-10-22T21:10:02Zoai:repositorio.unesp.br:11449/201737Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-22T21:10:02Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Mineral preference in rats treated with muscimol into the lateral parabrachial nucleus |
title |
Mineral preference in rats treated with muscimol into the lateral parabrachial nucleus |
spellingShingle |
Mineral preference in rats treated with muscimol into the lateral parabrachial nucleus Callera, João Carlos [UNESP] Bicarbonate Dehydration Fluid intake GABA Parabrachial nucleus Receptors Sodium appetite |
title_short |
Mineral preference in rats treated with muscimol into the lateral parabrachial nucleus |
title_full |
Mineral preference in rats treated with muscimol into the lateral parabrachial nucleus |
title_fullStr |
Mineral preference in rats treated with muscimol into the lateral parabrachial nucleus |
title_full_unstemmed |
Mineral preference in rats treated with muscimol into the lateral parabrachial nucleus |
title_sort |
Mineral preference in rats treated with muscimol into the lateral parabrachial nucleus |
author |
Callera, João Carlos [UNESP] |
author_facet |
Callera, João Carlos [UNESP] De Luca, Laurival Antonio [UNESP] Menani, José Vanderlei [UNESP] |
author_role |
author |
author2 |
De Luca, Laurival Antonio [UNESP] Menani, José Vanderlei [UNESP] |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Callera, João Carlos [UNESP] De Luca, Laurival Antonio [UNESP] Menani, José Vanderlei [UNESP] |
dc.subject.por.fl_str_mv |
Bicarbonate Dehydration Fluid intake GABA Parabrachial nucleus Receptors Sodium appetite |
topic |
Bicarbonate Dehydration Fluid intake GABA Parabrachial nucleus Receptors Sodium appetite |
description |
Injection of muscimol, a GABAA receptor agonist, into the lateral parabrachial nucleus (LPBN) induces 0.3 M NaCl intake in rats. In the present work, we investigated whether such an effect applies to hypertonic (0.3 M) mineral solutions in general or is selective to sodium solutions in a 240 min intake test. Muscimol injection (0.5 nmol/0.2 μL) compared to vehicle injection into the LPBN of adult hydrated rats produced a preferential ingestion of 0.3 M NaCl (25.3 ± 10.2 mL) followed by a 0.3 M NaHCO3 intake (11.7 ± 5.6 mL), with no significant effect on water, KCl and CaCl2 intake. Only the effect of muscimol on NaCl intake (19.0 ± 10.4 mL) persisted in cell-dehydrated rats, with hardly any effect on water or other mineral solutions. The results suggest that the LPBN controls the ingestion of hypertonic NaCl and NaHCO3. They also suggest a selective mechanisms involving the LPBN to check hypertonic sodium intake. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T02:40:29Z 2020-12-12T02:40:29Z 2020-07-13 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.neulet.2020.134989 Neuroscience Letters, v. 731. 1872-7972 0304-3940 http://hdl.handle.net/11449/201737 10.1016/j.neulet.2020.134989 2-s2.0-85084385421 |
url |
http://dx.doi.org/10.1016/j.neulet.2020.134989 http://hdl.handle.net/11449/201737 |
identifier_str_mv |
Neuroscience Letters, v. 731. 1872-7972 0304-3940 10.1016/j.neulet.2020.134989 2-s2.0-85084385421 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Neuroscience Letters |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965336572788736 |