Genetic heterogeneity of white markings in Quarter Horses
Autor(a) principal: | |
---|---|
Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.livsci.2020.103935 http://hdl.handle.net/11449/198455 |
Resumo: | White markings are very common in several horse breeds. These patterns are used for breed characterization, for the identification of animals (records) and might be associated with anomalies such as skin problems and deafness. The aim of the study was to perform genome-wide association analysis to identify genomic regions associated with the presence of white markings on the head and legs of Quarter Horses. The horses were from racing lineage and raised in Brazil. Records of 342 individuals and genotypes of 360 animals, genotyped for 63k, were used in a genome-wide association study, using the single-step procedure. Traits under analyses were presence of white markings on the head, forelegs, and hind legs. Few genomic regions influencing the traits were identified. Only one region containing the MC1R gene has been reported previously. The remaining genomic regions were detected for the first time in the present study. Within the genomic windows, some candidate genes were pointed out: ZEB2, KYNU, SLC36A1, STX12, MAP3K6, and GJB2. Markings in horses are characterized by genetic heterogeneity. It means that different genes can give origin to the same phenotype depending on the population. Candidate genes were, herein, described. It will permit future fine mapping studies in Quarter Horses in order to identify their causal mutations and also the development of molecular markers. |
id |
UNSP_0e63cf50aadbb1bcd9f98ebff6f9cca3 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/198455 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Genetic heterogeneity of white markings in Quarter HorsesEquus caballusHeadLegsSNPSpotWhite markings are very common in several horse breeds. These patterns are used for breed characterization, for the identification of animals (records) and might be associated with anomalies such as skin problems and deafness. The aim of the study was to perform genome-wide association analysis to identify genomic regions associated with the presence of white markings on the head and legs of Quarter Horses. The horses were from racing lineage and raised in Brazil. Records of 342 individuals and genotypes of 360 animals, genotyped for 63k, were used in a genome-wide association study, using the single-step procedure. Traits under analyses were presence of white markings on the head, forelegs, and hind legs. Few genomic regions influencing the traits were identified. Only one region containing the MC1R gene has been reported previously. The remaining genomic regions were detected for the first time in the present study. Within the genomic windows, some candidate genes were pointed out: ZEB2, KYNU, SLC36A1, STX12, MAP3K6, and GJB2. Markings in horses are characterized by genetic heterogeneity. It means that different genes can give origin to the same phenotype depending on the population. Candidate genes were, herein, described. It will permit future fine mapping studies in Quarter Horses in order to identify their causal mutations and also the development of molecular markers.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Federal da Bahia (UFBA)Universidade Federal Rural do Rio de Janeiro (UFRRJ)Universidade Estadual Paulista (Unesp)Universidade Estadual Paulista (Unesp)FAPESP: 2014/20207-1Universidade Federal da Bahia (UFBA)Universidade Federal Rural do Rio de Janeiro (UFRRJ)Universidade Estadual Paulista (Unesp)Maciel, S. V.S.A.de Queiroz, V. H.O.de Oliveira, C. A.A.de Godói, F. N.Pereira, G. L. [UNESP]Curi, R. A. [UNESP]Costa, R. B.de Camargo, G. M.F.2020-12-12T01:13:23Z2020-12-12T01:13:23Z2020-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.livsci.2020.103935Livestock Science, v. 232.1871-1413http://hdl.handle.net/11449/19845510.1016/j.livsci.2020.1039352-s2.0-85078542357Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengLivestock Scienceinfo:eu-repo/semantics/openAccess2021-10-22T12:11:21Zoai:repositorio.unesp.br:11449/198455Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-22T12:11:21Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Genetic heterogeneity of white markings in Quarter Horses |
title |
Genetic heterogeneity of white markings in Quarter Horses |
spellingShingle |
Genetic heterogeneity of white markings in Quarter Horses Maciel, S. V.S.A. Equus caballus Head Legs SNP Spot |
title_short |
Genetic heterogeneity of white markings in Quarter Horses |
title_full |
Genetic heterogeneity of white markings in Quarter Horses |
title_fullStr |
Genetic heterogeneity of white markings in Quarter Horses |
title_full_unstemmed |
Genetic heterogeneity of white markings in Quarter Horses |
title_sort |
Genetic heterogeneity of white markings in Quarter Horses |
author |
Maciel, S. V.S.A. |
author_facet |
Maciel, S. V.S.A. de Queiroz, V. H.O. de Oliveira, C. A.A. de Godói, F. N. Pereira, G. L. [UNESP] Curi, R. A. [UNESP] Costa, R. B. de Camargo, G. M.F. |
author_role |
author |
author2 |
de Queiroz, V. H.O. de Oliveira, C. A.A. de Godói, F. N. Pereira, G. L. [UNESP] Curi, R. A. [UNESP] Costa, R. B. de Camargo, G. M.F. |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal da Bahia (UFBA) Universidade Federal Rural do Rio de Janeiro (UFRRJ) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Maciel, S. V.S.A. de Queiroz, V. H.O. de Oliveira, C. A.A. de Godói, F. N. Pereira, G. L. [UNESP] Curi, R. A. [UNESP] Costa, R. B. de Camargo, G. M.F. |
dc.subject.por.fl_str_mv |
Equus caballus Head Legs SNP Spot |
topic |
Equus caballus Head Legs SNP Spot |
description |
White markings are very common in several horse breeds. These patterns are used for breed characterization, for the identification of animals (records) and might be associated with anomalies such as skin problems and deafness. The aim of the study was to perform genome-wide association analysis to identify genomic regions associated with the presence of white markings on the head and legs of Quarter Horses. The horses were from racing lineage and raised in Brazil. Records of 342 individuals and genotypes of 360 animals, genotyped for 63k, were used in a genome-wide association study, using the single-step procedure. Traits under analyses were presence of white markings on the head, forelegs, and hind legs. Few genomic regions influencing the traits were identified. Only one region containing the MC1R gene has been reported previously. The remaining genomic regions were detected for the first time in the present study. Within the genomic windows, some candidate genes were pointed out: ZEB2, KYNU, SLC36A1, STX12, MAP3K6, and GJB2. Markings in horses are characterized by genetic heterogeneity. It means that different genes can give origin to the same phenotype depending on the population. Candidate genes were, herein, described. It will permit future fine mapping studies in Quarter Horses in order to identify their causal mutations and also the development of molecular markers. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T01:13:23Z 2020-12-12T01:13:23Z 2020-02-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.livsci.2020.103935 Livestock Science, v. 232. 1871-1413 http://hdl.handle.net/11449/198455 10.1016/j.livsci.2020.103935 2-s2.0-85078542357 |
url |
http://dx.doi.org/10.1016/j.livsci.2020.103935 http://hdl.handle.net/11449/198455 |
identifier_str_mv |
Livestock Science, v. 232. 1871-1413 10.1016/j.livsci.2020.103935 2-s2.0-85078542357 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Livestock Science |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965548434423808 |