Water-Soluble Glutamic Acid Derivatives Produced in Culture by Penicillium solitum IS1-A from King George Island, Maritime Antarctica

• Autor(a) principal: Rodriguez, Julie P. G.
• Data de Publicação: 2020
• Outros Autores: Bernardi, Darlon I., Gubiani, Juliana R., Oliveira, Juliana Magalhaes de, Morais-Urano, Raquel P., Bertonha, Ariane F., Bandeira, Karin F., Bulla, Jairo I. Q., Sette, Lara D. [UNESP], Ferreira, Antonio G., Batista, Joao M., Silva, Thayna de Souza, Santos, Raquel Alves dos, Martins, Carlos H. G., Lira, Simone P., Cunha, Marcos G. da, Trivella, Daniela B. B., Grazzia, Nathalia, Gomes, Natalia E. S., Gadelha, Fernanda, Miguel, Danilo C., Cauz, Ana Carolina G., Brocchi, Marcelo, Berlinck, Roberto G. S.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1021/acs.jnatprod.9b00635; http://hdl.handle.net/11449/196539

A new method of screening was developed to generate 770 organic and water-soluble fractions from extracts of nine species of marine sponges, from the growth media of 18 species of marine-derived fungi, and from the growth media of 13 species of endophytic fungi. The screening results indicated that water-soluble fractions displayed significant bioactivity in cytotoxic, antibiotic, anti-Leishmania, anti-Trypanosoma cruzi, and inhibition of proteasome assays. Purification of water-soluble fractions from the growth medium of Penicillium solitum IS1-A provided the new glutamic acid derivatives solitumine A (1), solitumine B (2), and solitumidines A-D (3-6). The structures of compounds 1-6 have been established by analysis of spectroscopic data, chemical derivatizations, and vibrational circular dichroism calculations. Although no biological activity could be observed for compounds 1-6, the new structures reported for 1-6 indicate that the investigation of water-soluble natural products represents a relevant strategy in finding new secondary metabolites.