Genotipagem do locus ABO (9q34.1) em doadores de sangue da região noroeste do estado de São Paulo

Detalhes bibliográficos
Autor(a) principal: Mattos, Luiz C.
Data de Publicação: 2001
Outros Autores: Sancbez, Fábio E., Cintra, Juliana R., Salles, Andréa B. C. F., Bonini-Domingos, Cláudia R. [UNESP], Moreira, Haroldo Wilson [UNESP]
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S1516-84842001000100003
http://hdl.handle.net/11449/66692
Resumo: The advances of molecular genetics enabled us to understand the molecular basis of the ABO locus. Considering Us importance as a genetic marker and its applications, the aim of this study was to verify the distribution of the ABO genotypes in a Brazilian population from the Northwest region of the Sào Paulo Stale, Brazil. The genomic DNA was extracted from three hundred and twenty four healthy Brazilian blood donors (O ] 50; A 118; B 32 and AB 24) and analyzed by PCR amplification followed by restriction enzyme digestion. Fourteen genotypes were identified and the relative frequencies of the O , O , O , A and B genes ivere estimated at 44.6%, 16.9%, 4.1%, 25.3% and 9.1%, respectively. Tloese results demonstrate that the ABO locus presents a high polymorphism as revealed by molecular analysis.
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spelling Genotipagem do locus ABO (9q34.1) em doadores de sangue da região noroeste do estado de São PauloLocus ABO (9q 34.1) genotyping in blood donors in the state of Sao Paulo, BrazilABO genesABO genotypesBlood donorsThe advances of molecular genetics enabled us to understand the molecular basis of the ABO locus. Considering Us importance as a genetic marker and its applications, the aim of this study was to verify the distribution of the ABO genotypes in a Brazilian population from the Northwest region of the Sào Paulo Stale, Brazil. The genomic DNA was extracted from three hundred and twenty four healthy Brazilian blood donors (O ] 50; A 118; B 32 and AB 24) and analyzed by PCR amplification followed by restriction enzyme digestion. Fourteen genotypes were identified and the relative frequencies of the O , O , O , A and B genes ivere estimated at 44.6%, 16.9%, 4.1%, 25.3% and 9.1%, respectively. Tloese results demonstrate that the ABO locus presents a high polymorphism as revealed by molecular analysis.Departamento de Biologia Molecular Faculdade de Medicina de Sào José do Rio Preto, SPLaboralório de Imunogenélica Molecular Hemocenlro de Sào José do Rio Prelo, SPDepartamento de Biologia Ibilce-Unesp - Sào José do Rio Prelo, SPDepartamento de Anälises Clínicas Faculdade de Ciências Farmacêulicas Unesp, Araraquara, SPDepartamento de Biologia Molecular Faculdade de Medicina de Sào José do Rio Prêta, Avenida Brigadeiro Faria Lima, 5416, 15090-000 Sào josé do Rio Preto, SPDepartamento de Biologia Ibilce-Unesp - Sào José do Rio Prelo, SPDepartamento de Anälises Clínicas Faculdade de Ciências Farmacêulicas Unesp, Araraquara, SPFaculdade de Medicina de São José do Rio Preto (FAMERP)Universidade Estadual Paulista (Unesp)Mattos, Luiz C.Sancbez, Fábio E.Cintra, Juliana R.Salles, Andréa B. C. F.Bonini-Domingos, Cláudia R. [UNESP]Moreira, Haroldo Wilson [UNESP]2014-05-27T11:20:21Z2014-05-27T11:20:21Z2001-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article15-22application/pdfhttp://dx.doi.org/10.1590/S1516-84842001000100003Revista Brasileira de Hematologia e Hemoterapia, v. 23, n. 1, p. 15-22, 2001.1516-8484http://hdl.handle.net/11449/6669210.1590/S1516-84842001000100003S1516-848420010001000032-s2.0-301444331602-s2.0-30144433160.pdf32794280661767190000-0002-4603-9467Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporRevista Brasileira de Hematologia e Hemoterapia0,335info:eu-repo/semantics/openAccess2023-10-26T06:05:15Zoai:repositorio.unesp.br:11449/66692Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-10-26T06:05:15Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Genotipagem do locus ABO (9q34.1) em doadores de sangue da região noroeste do estado de São Paulo
Locus ABO (9q 34.1) genotyping in blood donors in the state of Sao Paulo, Brazil
title Genotipagem do locus ABO (9q34.1) em doadores de sangue da região noroeste do estado de São Paulo
spellingShingle Genotipagem do locus ABO (9q34.1) em doadores de sangue da região noroeste do estado de São Paulo
Mattos, Luiz C.
ABO genes
ABO genotypes
Blood donors
title_short Genotipagem do locus ABO (9q34.1) em doadores de sangue da região noroeste do estado de São Paulo
title_full Genotipagem do locus ABO (9q34.1) em doadores de sangue da região noroeste do estado de São Paulo
title_fullStr Genotipagem do locus ABO (9q34.1) em doadores de sangue da região noroeste do estado de São Paulo
title_full_unstemmed Genotipagem do locus ABO (9q34.1) em doadores de sangue da região noroeste do estado de São Paulo
title_sort Genotipagem do locus ABO (9q34.1) em doadores de sangue da região noroeste do estado de São Paulo
author Mattos, Luiz C.
author_facet Mattos, Luiz C.
Sancbez, Fábio E.
Cintra, Juliana R.
Salles, Andréa B. C. F.
Bonini-Domingos, Cláudia R. [UNESP]
Moreira, Haroldo Wilson [UNESP]
author_role author
author2 Sancbez, Fábio E.
Cintra, Juliana R.
Salles, Andréa B. C. F.
Bonini-Domingos, Cláudia R. [UNESP]
Moreira, Haroldo Wilson [UNESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Faculdade de Medicina de São José do Rio Preto (FAMERP)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Mattos, Luiz C.
Sancbez, Fábio E.
Cintra, Juliana R.
Salles, Andréa B. C. F.
Bonini-Domingos, Cláudia R. [UNESP]
Moreira, Haroldo Wilson [UNESP]
dc.subject.por.fl_str_mv ABO genes
ABO genotypes
Blood donors
topic ABO genes
ABO genotypes
Blood donors
description The advances of molecular genetics enabled us to understand the molecular basis of the ABO locus. Considering Us importance as a genetic marker and its applications, the aim of this study was to verify the distribution of the ABO genotypes in a Brazilian population from the Northwest region of the Sào Paulo Stale, Brazil. The genomic DNA was extracted from three hundred and twenty four healthy Brazilian blood donors (O ] 50; A 118; B 32 and AB 24) and analyzed by PCR amplification followed by restriction enzyme digestion. Fourteen genotypes were identified and the relative frequencies of the O , O , O , A and B genes ivere estimated at 44.6%, 16.9%, 4.1%, 25.3% and 9.1%, respectively. Tloese results demonstrate that the ABO locus presents a high polymorphism as revealed by molecular analysis.
publishDate 2001
dc.date.none.fl_str_mv 2001-12-01
2014-05-27T11:20:21Z
2014-05-27T11:20:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1516-84842001000100003
Revista Brasileira de Hematologia e Hemoterapia, v. 23, n. 1, p. 15-22, 2001.
1516-8484
http://hdl.handle.net/11449/66692
10.1590/S1516-84842001000100003
S1516-84842001000100003
2-s2.0-30144433160
2-s2.0-30144433160.pdf
3279428066176719
0000-0002-4603-9467
url http://dx.doi.org/10.1590/S1516-84842001000100003
http://hdl.handle.net/11449/66692
identifier_str_mv Revista Brasileira de Hematologia e Hemoterapia, v. 23, n. 1, p. 15-22, 2001.
1516-8484
10.1590/S1516-84842001000100003
S1516-84842001000100003
2-s2.0-30144433160
2-s2.0-30144433160.pdf
3279428066176719
0000-0002-4603-9467
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Revista Brasileira de Hematologia e Hemoterapia
0,335
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 15-22
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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