Chitosan/nanocellulose-based bionanocomposite films for controlled betamethasone and silver sulfadiazine delivery
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1002/app.50468 http://hdl.handle.net/11449/205836 |
Resumo: | Bionanocomposite films based on chitosan and nanocellulose (nanocrystals or nanofibrils) have gained considerable attention for biomedical applications, especially for wound dressings. However, the development of these films as controlled drug release dressings is still under-exploited. Therefore, this work aimed to design chitosan/nanocellulose-based bionanocomposite films, loaded by betamethasone or silver sulfadiazine, as functional dressings. The films were obtained by solvent casting and characterized by physicochemical, mechanical, barrier properties, in vitro drug release, and antimicrobial activity. The nanocellulose type, physical state, and content caused influence on the film's properties providing different physical, barrier, and drug release profiles. They are semi-occlusive and mechanically resistant; the drug release is controlled, and possesses antimicrobial activity. In conclusion, the developed biodegradable bionanocomposite films are promising as active dressings for controlled drug delivery in the wound site and have specific applications according to their features to treat inflamed and purulent wounds, non-infectious dry wounds, and infectious wounds. |
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Chitosan/nanocellulose-based bionanocomposite films for controlled betamethasone and silver sulfadiazine deliverybiodegradablebiomedical applicationsdrug delivery systemsBionanocomposite films based on chitosan and nanocellulose (nanocrystals or nanofibrils) have gained considerable attention for biomedical applications, especially for wound dressings. However, the development of these films as controlled drug release dressings is still under-exploited. Therefore, this work aimed to design chitosan/nanocellulose-based bionanocomposite films, loaded by betamethasone or silver sulfadiazine, as functional dressings. The films were obtained by solvent casting and characterized by physicochemical, mechanical, barrier properties, in vitro drug release, and antimicrobial activity. The nanocellulose type, physical state, and content caused influence on the film's properties providing different physical, barrier, and drug release profiles. They are semi-occlusive and mechanically resistant; the drug release is controlled, and possesses antimicrobial activity. In conclusion, the developed biodegradable bionanocomposite films are promising as active dressings for controlled drug delivery in the wound site and have specific applications according to their features to treat inflamed and purulent wounds, non-infectious dry wounds, and infectious wounds.Department of Pharmaceutical Sciences State University of São Paulo – UNESPDepartment of Pharmaceutical Sciences State University of Ponta Grossa – UEPGDepartment of Materials Engineering State University of Ponta Grossa – UEPGDepartment of Pharmaceutical Sciences State University of São Paulo – UNESPUniversidade Estadual Paulista (Unesp)Universidade Estadual de Ponta Grossa (UEPG)Riccio, Bruno Vincenzo Fiod [UNESP]Klosowski, Ana BeatrizPrestes, Eduardode Sousa, Taynara Barbosade Assunção Morais, Laís CarolineLemes, Bruna MikulisBeltrame, Flávio LuísCampos, Patrícia MazurekiFerrari, Priscileila Colerato2021-06-25T10:22:07Z2021-06-25T10:22:07Z2021-06-05info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1002/app.50468Journal of Applied Polymer Science, v. 138, n. 21, 2021.1097-46280021-8995http://hdl.handle.net/11449/20583610.1002/app.504682-s2.0-85100377139Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Applied Polymer Scienceinfo:eu-repo/semantics/openAccess2021-10-22T18:20:58Zoai:repositorio.unesp.br:11449/205836Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-22T18:20:58Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Chitosan/nanocellulose-based bionanocomposite films for controlled betamethasone and silver sulfadiazine delivery |
title |
Chitosan/nanocellulose-based bionanocomposite films for controlled betamethasone and silver sulfadiazine delivery |
spellingShingle |
Chitosan/nanocellulose-based bionanocomposite films for controlled betamethasone and silver sulfadiazine delivery Riccio, Bruno Vincenzo Fiod [UNESP] biodegradable biomedical applications drug delivery systems |
title_short |
Chitosan/nanocellulose-based bionanocomposite films for controlled betamethasone and silver sulfadiazine delivery |
title_full |
Chitosan/nanocellulose-based bionanocomposite films for controlled betamethasone and silver sulfadiazine delivery |
title_fullStr |
Chitosan/nanocellulose-based bionanocomposite films for controlled betamethasone and silver sulfadiazine delivery |
title_full_unstemmed |
Chitosan/nanocellulose-based bionanocomposite films for controlled betamethasone and silver sulfadiazine delivery |
title_sort |
Chitosan/nanocellulose-based bionanocomposite films for controlled betamethasone and silver sulfadiazine delivery |
author |
Riccio, Bruno Vincenzo Fiod [UNESP] |
author_facet |
Riccio, Bruno Vincenzo Fiod [UNESP] Klosowski, Ana Beatriz Prestes, Eduardo de Sousa, Taynara Barbosa de Assunção Morais, Laís Caroline Lemes, Bruna Mikulis Beltrame, Flávio Luís Campos, Patrícia Mazureki Ferrari, Priscileila Colerato |
author_role |
author |
author2 |
Klosowski, Ana Beatriz Prestes, Eduardo de Sousa, Taynara Barbosa de Assunção Morais, Laís Caroline Lemes, Bruna Mikulis Beltrame, Flávio Luís Campos, Patrícia Mazureki Ferrari, Priscileila Colerato |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Estadual de Ponta Grossa (UEPG) |
dc.contributor.author.fl_str_mv |
Riccio, Bruno Vincenzo Fiod [UNESP] Klosowski, Ana Beatriz Prestes, Eduardo de Sousa, Taynara Barbosa de Assunção Morais, Laís Caroline Lemes, Bruna Mikulis Beltrame, Flávio Luís Campos, Patrícia Mazureki Ferrari, Priscileila Colerato |
dc.subject.por.fl_str_mv |
biodegradable biomedical applications drug delivery systems |
topic |
biodegradable biomedical applications drug delivery systems |
description |
Bionanocomposite films based on chitosan and nanocellulose (nanocrystals or nanofibrils) have gained considerable attention for biomedical applications, especially for wound dressings. However, the development of these films as controlled drug release dressings is still under-exploited. Therefore, this work aimed to design chitosan/nanocellulose-based bionanocomposite films, loaded by betamethasone or silver sulfadiazine, as functional dressings. The films were obtained by solvent casting and characterized by physicochemical, mechanical, barrier properties, in vitro drug release, and antimicrobial activity. The nanocellulose type, physical state, and content caused influence on the film's properties providing different physical, barrier, and drug release profiles. They are semi-occlusive and mechanically resistant; the drug release is controlled, and possesses antimicrobial activity. In conclusion, the developed biodegradable bionanocomposite films are promising as active dressings for controlled drug delivery in the wound site and have specific applications according to their features to treat inflamed and purulent wounds, non-infectious dry wounds, and infectious wounds. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T10:22:07Z 2021-06-25T10:22:07Z 2021-06-05 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1002/app.50468 Journal of Applied Polymer Science, v. 138, n. 21, 2021. 1097-4628 0021-8995 http://hdl.handle.net/11449/205836 10.1002/app.50468 2-s2.0-85100377139 |
url |
http://dx.doi.org/10.1002/app.50468 http://hdl.handle.net/11449/205836 |
identifier_str_mv |
Journal of Applied Polymer Science, v. 138, n. 21, 2021. 1097-4628 0021-8995 10.1002/app.50468 2-s2.0-85100377139 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Applied Polymer Science |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965571301769216 |