Previous short-term use of testosterone propionate enhances muscle hypertrophy in Wistar rats submitted to ladder-based resistance training
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.tice.2022.101741 http://hdl.handle.net/11449/234034 |
Resumo: | To investigate the effects of the previous administration of testosterone propionate (TP) on the morphology of the gastrocnemius muscle of Wistar rats submitted to ladder-based resistance training (LRT). Twenty-eight rats were divided equally into groups: initial control (CI), 4-week TP (CT4), 4-week TP + LRT (TRT), and placebo + LRT (RT). The rats from the CT4 and TRT groups were treated with TP for four weeks (10 mg/kg/week). TRT and RT trained for ten weeks. The rodents were euthanized at the end of the experiment, and gastrocnemius muscle, prostate, and left and right testicles were collected. There was no statistical difference between the RT and TRT for final volume load. The prostate mass of the TRT and RT groups was statistically heavier than the CT4 group (P < 0.01). The TRT group's prostate/body mass ratio was statistically different from the CT4 group (P < 0.05). The TRT group was shown to have larger type I, type II, and mean fCSA fibers than all other groups (P < 0.001). Regarding the nuclei/fiber ratio (N/f), the CT4, RT, and TRT groups had higher values than CI (P < 0.01). In addition, the RT group showed a higher N/f ratio than CT4 (P < 0.001) but lower than TRT (P < 0.001). In conclusion, short-term TP administration before resistance training can elicit a greater N/f ratio and size of the mean fCSA of the Gastrocnemius muscle of young adult Wistar rats than resistance training alone. |
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Repositório Institucional da UNESP |
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Previous short-term use of testosterone propionate enhances muscle hypertrophy in Wistar rats submitted to ladder-based resistance trainingExerciseMorphologySkeletal muscleSteroidsTestosteroneTo investigate the effects of the previous administration of testosterone propionate (TP) on the morphology of the gastrocnemius muscle of Wistar rats submitted to ladder-based resistance training (LRT). Twenty-eight rats were divided equally into groups: initial control (CI), 4-week TP (CT4), 4-week TP + LRT (TRT), and placebo + LRT (RT). The rats from the CT4 and TRT groups were treated with TP for four weeks (10 mg/kg/week). TRT and RT trained for ten weeks. The rodents were euthanized at the end of the experiment, and gastrocnemius muscle, prostate, and left and right testicles were collected. There was no statistical difference between the RT and TRT for final volume load. The prostate mass of the TRT and RT groups was statistically heavier than the CT4 group (P < 0.01). The TRT group's prostate/body mass ratio was statistically different from the CT4 group (P < 0.05). The TRT group was shown to have larger type I, type II, and mean fCSA fibers than all other groups (P < 0.001). Regarding the nuclei/fiber ratio (N/f), the CT4, RT, and TRT groups had higher values than CI (P < 0.01). In addition, the RT group showed a higher N/f ratio than CT4 (P < 0.001) but lower than TRT (P < 0.001). In conclusion, short-term TP administration before resistance training can elicit a greater N/f ratio and size of the mean fCSA of the Gastrocnemius muscle of young adult Wistar rats than resistance training alone.Department of Physical Education Laboratory of Morphoquantitative Studies and Immunohistochemistry Universidade São Judas TadeuDepartment of Physical Education Laboratory of Morphology and Physical Activity São Paulo State University “Júlio de Mesquita Filho,”Department of Morphology Federal University of São PauloDepatment of Physical Education Laboratory of Human Moviment Universidade São Judas TadeuDepartment of Physical Education Laboratory of Morphology and Physical Activity São Paulo State University “Júlio de Mesquita Filho,”Universidade São Judas TadeuUniversidade Estadual Paulista (UNESP)Universidade de São Paulo (USP)Lourenço, ÍtaloKrause Neto, WalterAmorim, Laura dos Santos PortellaOrtiz, Vagner Moraes MunhozGeraldo, Vitor LopesFerreira, Gabriel Henrique da Silvade Lima, Jackson TorresMassoni, Amanda Alves RibeiroOliveira, Beatriz MassensiniAnaruma, Carlos Alberto [UNESP]Ciena, Adriano Polican [UNESP]Gama, Eliane FlorencioCaperuto, Érico Chagas2022-05-01T12:40:48Z2022-05-01T12:40:48Z2022-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.tice.2022.101741Tissue and Cell, v. 75.1532-30720040-8166http://hdl.handle.net/11449/23403410.1016/j.tice.2022.1017412-s2.0-85123211532Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengTissue and Cellinfo:eu-repo/semantics/openAccess2022-05-01T12:40:48Zoai:repositorio.unesp.br:11449/234034Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-05-01T12:40:48Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Previous short-term use of testosterone propionate enhances muscle hypertrophy in Wistar rats submitted to ladder-based resistance training |
title |
Previous short-term use of testosterone propionate enhances muscle hypertrophy in Wistar rats submitted to ladder-based resistance training |
spellingShingle |
Previous short-term use of testosterone propionate enhances muscle hypertrophy in Wistar rats submitted to ladder-based resistance training Lourenço, Ítalo Exercise Morphology Skeletal muscle Steroids Testosterone |
title_short |
Previous short-term use of testosterone propionate enhances muscle hypertrophy in Wistar rats submitted to ladder-based resistance training |
title_full |
Previous short-term use of testosterone propionate enhances muscle hypertrophy in Wistar rats submitted to ladder-based resistance training |
title_fullStr |
Previous short-term use of testosterone propionate enhances muscle hypertrophy in Wistar rats submitted to ladder-based resistance training |
title_full_unstemmed |
Previous short-term use of testosterone propionate enhances muscle hypertrophy in Wistar rats submitted to ladder-based resistance training |
title_sort |
Previous short-term use of testosterone propionate enhances muscle hypertrophy in Wistar rats submitted to ladder-based resistance training |
author |
Lourenço, Ítalo |
author_facet |
Lourenço, Ítalo Krause Neto, Walter Amorim, Laura dos Santos Portella Ortiz, Vagner Moraes Munhoz Geraldo, Vitor Lopes Ferreira, Gabriel Henrique da Silva de Lima, Jackson Torres Massoni, Amanda Alves Ribeiro Oliveira, Beatriz Massensini Anaruma, Carlos Alberto [UNESP] Ciena, Adriano Polican [UNESP] Gama, Eliane Florencio Caperuto, Érico Chagas |
author_role |
author |
author2 |
Krause Neto, Walter Amorim, Laura dos Santos Portella Ortiz, Vagner Moraes Munhoz Geraldo, Vitor Lopes Ferreira, Gabriel Henrique da Silva de Lima, Jackson Torres Massoni, Amanda Alves Ribeiro Oliveira, Beatriz Massensini Anaruma, Carlos Alberto [UNESP] Ciena, Adriano Polican [UNESP] Gama, Eliane Florencio Caperuto, Érico Chagas |
author2_role |
author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade São Judas Tadeu Universidade Estadual Paulista (UNESP) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Lourenço, Ítalo Krause Neto, Walter Amorim, Laura dos Santos Portella Ortiz, Vagner Moraes Munhoz Geraldo, Vitor Lopes Ferreira, Gabriel Henrique da Silva de Lima, Jackson Torres Massoni, Amanda Alves Ribeiro Oliveira, Beatriz Massensini Anaruma, Carlos Alberto [UNESP] Ciena, Adriano Polican [UNESP] Gama, Eliane Florencio Caperuto, Érico Chagas |
dc.subject.por.fl_str_mv |
Exercise Morphology Skeletal muscle Steroids Testosterone |
topic |
Exercise Morphology Skeletal muscle Steroids Testosterone |
description |
To investigate the effects of the previous administration of testosterone propionate (TP) on the morphology of the gastrocnemius muscle of Wistar rats submitted to ladder-based resistance training (LRT). Twenty-eight rats were divided equally into groups: initial control (CI), 4-week TP (CT4), 4-week TP + LRT (TRT), and placebo + LRT (RT). The rats from the CT4 and TRT groups were treated with TP for four weeks (10 mg/kg/week). TRT and RT trained for ten weeks. The rodents were euthanized at the end of the experiment, and gastrocnemius muscle, prostate, and left and right testicles were collected. There was no statistical difference between the RT and TRT for final volume load. The prostate mass of the TRT and RT groups was statistically heavier than the CT4 group (P < 0.01). The TRT group's prostate/body mass ratio was statistically different from the CT4 group (P < 0.05). The TRT group was shown to have larger type I, type II, and mean fCSA fibers than all other groups (P < 0.001). Regarding the nuclei/fiber ratio (N/f), the CT4, RT, and TRT groups had higher values than CI (P < 0.01). In addition, the RT group showed a higher N/f ratio than CT4 (P < 0.001) but lower than TRT (P < 0.001). In conclusion, short-term TP administration before resistance training can elicit a greater N/f ratio and size of the mean fCSA of the Gastrocnemius muscle of young adult Wistar rats than resistance training alone. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-05-01T12:40:48Z 2022-05-01T12:40:48Z 2022-04-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.tice.2022.101741 Tissue and Cell, v. 75. 1532-3072 0040-8166 http://hdl.handle.net/11449/234034 10.1016/j.tice.2022.101741 2-s2.0-85123211532 |
url |
http://dx.doi.org/10.1016/j.tice.2022.101741 http://hdl.handle.net/11449/234034 |
identifier_str_mv |
Tissue and Cell, v. 75. 1532-3072 0040-8166 10.1016/j.tice.2022.101741 2-s2.0-85123211532 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Tissue and Cell |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965706324803584 |