Longitudinal assessment of maternal-fetal Doppler parameters and maternal plasma level of matrix metalloproteinases 2 and 9
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3109/14767058.2016.1152247 http://hdl.handle.net/11449/172712 |
Resumo: | Objective: To assess the behavior as well as the comparison between maternal circulating level of biochemical markers (matrix metalloproteinases - MMP-9 and MMP-2) and maternal-fetal Doppler parameters in all three trimesters of pregnancy. Methods: We performed a prospective longitudinal study with 33 healthy pregnant women in three periods of pregnancy: A1 (12w0–14w6d), A2 (22w0d–24w6d) and A3 (34w0d and 36w6d). The following maternal Doppler parameters were assessed: mean pulsatility index (PI) uterine artery, resistance index (RI) umbilical artery and RI middle cerebral artery. The maternal plasma concentrations of MMP-2 and MMP-9 were determined by enzyme immunoassay (ELISA). To compare two (A2 and A3) and three assessments (A1, A2 and A3), we used the paired Student t test and linear regression, respectively. To compare the biomechanical markers and maternal-fetal Doppler parameter, we used the Spearman correlation coefficient (ρ). Results: We observed a significant decrease of PI uterine artery Doppler over the three trimesters of pregnancy (p < 0.01) and RI umbilical artery Doppler overt second to three trimester of pregnancy (p < 0.05). We did not observe significant difference in the maternal plasma level of MMP-2 and MMP-9 between the three trimesters. We did not also observe significant correlation between biochemical markers and maternal-fetal Doppler parameters. Conclusion: Maternal circulating level of MMPs did not modify throughout pregnancy and it did not show correlation with maternal-fetal Doppler parameters. |
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Longitudinal assessment of maternal-fetal Doppler parameters and maternal plasma level of matrix metalloproteinases 2 and 9Biochemical markersDopplermatrix metalloproteinasespregnancyObjective: To assess the behavior as well as the comparison between maternal circulating level of biochemical markers (matrix metalloproteinases - MMP-9 and MMP-2) and maternal-fetal Doppler parameters in all three trimesters of pregnancy. Methods: We performed a prospective longitudinal study with 33 healthy pregnant women in three periods of pregnancy: A1 (12w0–14w6d), A2 (22w0d–24w6d) and A3 (34w0d and 36w6d). The following maternal Doppler parameters were assessed: mean pulsatility index (PI) uterine artery, resistance index (RI) umbilical artery and RI middle cerebral artery. The maternal plasma concentrations of MMP-2 and MMP-9 were determined by enzyme immunoassay (ELISA). To compare two (A2 and A3) and three assessments (A1, A2 and A3), we used the paired Student t test and linear regression, respectively. To compare the biomechanical markers and maternal-fetal Doppler parameter, we used the Spearman correlation coefficient (ρ). Results: We observed a significant decrease of PI uterine artery Doppler over the three trimesters of pregnancy (p < 0.01) and RI umbilical artery Doppler overt second to three trimester of pregnancy (p < 0.05). We did not observe significant difference in the maternal plasma level of MMP-2 and MMP-9 between the three trimesters. We did not also observe significant correlation between biochemical markers and maternal-fetal Doppler parameters. Conclusion: Maternal circulating level of MMPs did not modify throughout pregnancy and it did not show correlation with maternal-fetal Doppler parameters.Department of Obstetrics and Gynecology Ribeirão Preto Medical School University of Sao Paulo (FMRP-USP)Department of Obstetrics Paulista School of Medicine–Federal University of São Paulo (EPM-UNIFESP)Departament of Physiology and Biophysics University of Mississipi Medical CenterDepartament of Pharmacology Ribeirão Preto Medical School University of Sao Paulo (FMRP-USP)Departament of Pharmacology Botucatu Medical School São Paulo State University (UNESP)Departament of Pharmacology Botucatu Medical School São Paulo State University (UNESP)Universidade de São Paulo (USP)University of Mississipi Medical CenterUniversidade Estadual Paulista (Unesp)Jorge Neto, Salim DemétrioMachado, Jackeline Souza RangelAraujo Júnior, EdwardPalei, Ana Carolina TaveirosAmaral, Lorena MachadoTanus-Santos, José EduardoMarcolin, Alessandra CristinaDuarte, GeraldoSandrim, Valéria Cristina [UNESP]Cavalli, Ricardo Carvalho2018-12-11T17:01:52Z2018-12-11T17:01:52Z2016-12-16info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article3967-3970http://dx.doi.org/10.3109/14767058.2016.1152247Journal of Maternal-Fetal and Neonatal Medicine, v. 29, n. 24, p. 3967-3970, 2016.1476-49541476-7058http://hdl.handle.net/11449/17271210.3109/14767058.2016.11522472-s2.0-84961207949Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Maternal-Fetal and Neonatal Medicine0,7140,714info:eu-repo/semantics/openAccess2021-10-23T08:05:28Zoai:repositorio.unesp.br:11449/172712Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T08:05:28Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Longitudinal assessment of maternal-fetal Doppler parameters and maternal plasma level of matrix metalloproteinases 2 and 9 |
title |
Longitudinal assessment of maternal-fetal Doppler parameters and maternal plasma level of matrix metalloproteinases 2 and 9 |
spellingShingle |
Longitudinal assessment of maternal-fetal Doppler parameters and maternal plasma level of matrix metalloproteinases 2 and 9 Jorge Neto, Salim Demétrio Biochemical markers Doppler matrix metalloproteinases pregnancy |
title_short |
Longitudinal assessment of maternal-fetal Doppler parameters and maternal plasma level of matrix metalloproteinases 2 and 9 |
title_full |
Longitudinal assessment of maternal-fetal Doppler parameters and maternal plasma level of matrix metalloproteinases 2 and 9 |
title_fullStr |
Longitudinal assessment of maternal-fetal Doppler parameters and maternal plasma level of matrix metalloproteinases 2 and 9 |
title_full_unstemmed |
Longitudinal assessment of maternal-fetal Doppler parameters and maternal plasma level of matrix metalloproteinases 2 and 9 |
title_sort |
Longitudinal assessment of maternal-fetal Doppler parameters and maternal plasma level of matrix metalloproteinases 2 and 9 |
author |
Jorge Neto, Salim Demétrio |
author_facet |
Jorge Neto, Salim Demétrio Machado, Jackeline Souza Rangel Araujo Júnior, Edward Palei, Ana Carolina Taveiros Amaral, Lorena Machado Tanus-Santos, José Eduardo Marcolin, Alessandra Cristina Duarte, Geraldo Sandrim, Valéria Cristina [UNESP] Cavalli, Ricardo Carvalho |
author_role |
author |
author2 |
Machado, Jackeline Souza Rangel Araujo Júnior, Edward Palei, Ana Carolina Taveiros Amaral, Lorena Machado Tanus-Santos, José Eduardo Marcolin, Alessandra Cristina Duarte, Geraldo Sandrim, Valéria Cristina [UNESP] Cavalli, Ricardo Carvalho |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) University of Mississipi Medical Center Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Jorge Neto, Salim Demétrio Machado, Jackeline Souza Rangel Araujo Júnior, Edward Palei, Ana Carolina Taveiros Amaral, Lorena Machado Tanus-Santos, José Eduardo Marcolin, Alessandra Cristina Duarte, Geraldo Sandrim, Valéria Cristina [UNESP] Cavalli, Ricardo Carvalho |
dc.subject.por.fl_str_mv |
Biochemical markers Doppler matrix metalloproteinases pregnancy |
topic |
Biochemical markers Doppler matrix metalloproteinases pregnancy |
description |
Objective: To assess the behavior as well as the comparison between maternal circulating level of biochemical markers (matrix metalloproteinases - MMP-9 and MMP-2) and maternal-fetal Doppler parameters in all three trimesters of pregnancy. Methods: We performed a prospective longitudinal study with 33 healthy pregnant women in three periods of pregnancy: A1 (12w0–14w6d), A2 (22w0d–24w6d) and A3 (34w0d and 36w6d). The following maternal Doppler parameters were assessed: mean pulsatility index (PI) uterine artery, resistance index (RI) umbilical artery and RI middle cerebral artery. The maternal plasma concentrations of MMP-2 and MMP-9 were determined by enzyme immunoassay (ELISA). To compare two (A2 and A3) and three assessments (A1, A2 and A3), we used the paired Student t test and linear regression, respectively. To compare the biomechanical markers and maternal-fetal Doppler parameter, we used the Spearman correlation coefficient (ρ). Results: We observed a significant decrease of PI uterine artery Doppler over the three trimesters of pregnancy (p < 0.01) and RI umbilical artery Doppler overt second to three trimester of pregnancy (p < 0.05). We did not observe significant difference in the maternal plasma level of MMP-2 and MMP-9 between the three trimesters. We did not also observe significant correlation between biochemical markers and maternal-fetal Doppler parameters. Conclusion: Maternal circulating level of MMPs did not modify throughout pregnancy and it did not show correlation with maternal-fetal Doppler parameters. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-12-16 2018-12-11T17:01:52Z 2018-12-11T17:01:52Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3109/14767058.2016.1152247 Journal of Maternal-Fetal and Neonatal Medicine, v. 29, n. 24, p. 3967-3970, 2016. 1476-4954 1476-7058 http://hdl.handle.net/11449/172712 10.3109/14767058.2016.1152247 2-s2.0-84961207949 |
url |
http://dx.doi.org/10.3109/14767058.2016.1152247 http://hdl.handle.net/11449/172712 |
identifier_str_mv |
Journal of Maternal-Fetal and Neonatal Medicine, v. 29, n. 24, p. 3967-3970, 2016. 1476-4954 1476-7058 10.3109/14767058.2016.1152247 2-s2.0-84961207949 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Maternal-Fetal and Neonatal Medicine 0,714 0,714 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
3967-3970 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964692965228544 |