Structure/activity of PtII/N,N-Disubstituted-N’-acylthiourea complexes: Anti-tumor and anti-mycobacterium tuberculosis activities

• Autor(a) principal: Plutín, Ana M.
• Data de Publicação: 2018
• Outros Autores: Alvarez, Anislay, Mocelo, Raúl, Ramos, Raúl, Sánchez, Osmar C., Castellano, Eduardo E., da Silva, Monize M., Villarreal, Wilmer, Colina-Vegas, Legna, Pavan, Fernando R. [UNESP], Batista, Alzir A.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.21577/0103-5053.20170222; http://hdl.handle.net/11449/179828
• topic: Mycobacterium tuberculosis; Platinum(II); Tumor cells

The syntheses, characterization, cytotoxicity against tumor cells and anti-Mycobacterium tuberculosis activity assays of PtII/PPh3/N,N-disubstituted-N’-acylthioureas complexes with general formulae [Pt(PPh3)2(L)]PF6, PPh3 = triphenylphosphine; L = N,N-disubstituted-N’-acylthiourea, are here reported. The complexes were characterized by elemental analysis, molar conductivity, infrared (IR), nuclear magnetic resonance (NMR) (1H, 13C{1H} and 31P{1H}) spectroscopy. The 31P{1H} NMR data are consistent with the presence of two PPh3 ligands cis to each other position, and one N,N-disubstituted-N’-acylthiourea coordinated to the metal through O and S, in a chelate form. The structures of the complexes were determined by X-ray crystallography, forming distorted square-planar structures. The complexes were tested in human cell lines carcinomas and also screened with respect to their anti-Mycobacterium tuberculosis activity (H37RvATCC 27294). It was found that complexes with N,N-disubstituted-N’-acylthiourea containing open and small chains as R2 groups show higher cytotoxic and higher anti-Mycobacterium tuberculosis activity than those containing rings in this position.