Changes in Electrical Brain Activity and Cognitive Functions Following Mild to Moderate COVID-19: A one-Year Prospective Study After Acute Infection
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1177/15500594221103834 http://hdl.handle.net/11449/241109 |
Resumo: | The coronavirus disease 2019 (COVID-19) can disrupt various brain functions. Over a one-year period, we aimed to assess brain activity and cognitive function in 53 COVID-19 patients and 30 individuals without COVID-19 (or asymptomatic). The Montreal Cognitive Assessment, Trail Making Test Parts A and B (TMT-A and B), and Digit Span Test were used to assess cognitive function. Cognitive variables and electroencephalography (EEG) data (activity, mobility, and complexity) were compared between the groups at rest and during cognitive demand (F3-F7, Fz-F3, Fz-F4, and F4-F8). There was a reduction in F3-F7 activity during the TMT-B in the COVID-19 group at 6-12 months compared to the controls (p = 0.01) at baseline (p = 0.03), a reduction in signal complexity at F3-F7 at rest in the COVID-19 group at baseline and 6-12 months compared to the controls (p < 0.001), and a reduction in Fz-F4 activity at rest from 6-12 months in the post-COVID group compared to baseline (p = 0.02) and 3-6 months (p = 0.04). At 6-12 months, there was a time increase in TMT-A in the COVID-19 group compared to that in the controls (p = 0.04). Some correlations were found between EEG data and cognitive test in both groups. In conclusion, there was a reduction in brain activity at rest in the Fz-F4 areas and during high cognitive demands in the F3-F7 areas. A reduction in signal complexity in F3-F7 at rest was found in the COVID-19 group at 6-12 months after acute infection. Furthermore, individuals with COVID-19 experience long-term changes in cognitive function. |
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Changes in Electrical Brain Activity and Cognitive Functions Following Mild to Moderate COVID-19: A one-Year Prospective Study After Acute InfectioncognitionCOVID-19electroencephalographySARS-CoV-2The coronavirus disease 2019 (COVID-19) can disrupt various brain functions. Over a one-year period, we aimed to assess brain activity and cognitive function in 53 COVID-19 patients and 30 individuals without COVID-19 (or asymptomatic). The Montreal Cognitive Assessment, Trail Making Test Parts A and B (TMT-A and B), and Digit Span Test were used to assess cognitive function. Cognitive variables and electroencephalography (EEG) data (activity, mobility, and complexity) were compared between the groups at rest and during cognitive demand (F3-F7, Fz-F3, Fz-F4, and F4-F8). There was a reduction in F3-F7 activity during the TMT-B in the COVID-19 group at 6-12 months compared to the controls (p = 0.01) at baseline (p = 0.03), a reduction in signal complexity at F3-F7 at rest in the COVID-19 group at baseline and 6-12 months compared to the controls (p < 0.001), and a reduction in Fz-F4 activity at rest from 6-12 months in the post-COVID group compared to baseline (p = 0.02) and 3-6 months (p = 0.04). At 6-12 months, there was a time increase in TMT-A in the COVID-19 group compared to that in the controls (p = 0.04). Some correlations were found between EEG data and cognitive test in both groups. In conclusion, there was a reduction in brain activity at rest in the Fz-F4 areas and during high cognitive demands in the F3-F7 areas. A reduction in signal complexity in F3-F7 at rest was found in the COVID-19 group at 6-12 months after acute infection. Furthermore, individuals with COVID-19 experience long-term changes in cognitive function.Department of Applied Physical Therapy Federal University of Triângulo Mineiro, Minas GeraisDepartment of Sport Science Federal University of Triângulo Mineiro, Minas GeraisDepartment of Neurology Psychology and Psychiatry Botucatu Medical School, São PauloCentre for Innovation and Technology Assessment in Health Faculty of Electrical Engineering Federal University of Uberlândia, MGDepartment of Neurology Psychology and Psychiatry Botucatu Medical School, São PauloFederal University of Triângulo MineiroUniversidade Estadual Paulista (UNESP)Universidade Federal de Uberlândia (UFU)Andrei Appelt, PabloTaciana Sisconetto, AngélicaBaldo Sucupira, Kelly Savana MinaréNeto, Eduardo de MouraChagas, Tatiane de JesusBazan, Rodrigo [UNESP]Moura Cabral, ArianaAndrade, Adriano de Oliveirade Souza, Luciane Aparecida Pascucci SandeJosé Luvizutto, Gustavo2023-03-01T20:47:36Z2023-03-01T20:47:36Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1177/15500594221103834Clinical EEG and Neuroscience.2169-52021550-0594http://hdl.handle.net/11449/24110910.1177/155005942211038342-s2.0-85131374695Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengClinical EEG and Neuroscienceinfo:eu-repo/semantics/openAccess2023-03-01T20:47:37Zoai:repositorio.unesp.br:11449/241109Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-03-01T20:47:37Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Changes in Electrical Brain Activity and Cognitive Functions Following Mild to Moderate COVID-19: A one-Year Prospective Study After Acute Infection |
title |
Changes in Electrical Brain Activity and Cognitive Functions Following Mild to Moderate COVID-19: A one-Year Prospective Study After Acute Infection |
spellingShingle |
Changes in Electrical Brain Activity and Cognitive Functions Following Mild to Moderate COVID-19: A one-Year Prospective Study After Acute Infection Andrei Appelt, Pablo cognition COVID-19 electroencephalography SARS-CoV-2 |
title_short |
Changes in Electrical Brain Activity and Cognitive Functions Following Mild to Moderate COVID-19: A one-Year Prospective Study After Acute Infection |
title_full |
Changes in Electrical Brain Activity and Cognitive Functions Following Mild to Moderate COVID-19: A one-Year Prospective Study After Acute Infection |
title_fullStr |
Changes in Electrical Brain Activity and Cognitive Functions Following Mild to Moderate COVID-19: A one-Year Prospective Study After Acute Infection |
title_full_unstemmed |
Changes in Electrical Brain Activity and Cognitive Functions Following Mild to Moderate COVID-19: A one-Year Prospective Study After Acute Infection |
title_sort |
Changes in Electrical Brain Activity and Cognitive Functions Following Mild to Moderate COVID-19: A one-Year Prospective Study After Acute Infection |
author |
Andrei Appelt, Pablo |
author_facet |
Andrei Appelt, Pablo Taciana Sisconetto, Angélica Baldo Sucupira, Kelly Savana Minaré Neto, Eduardo de Moura Chagas, Tatiane de Jesus Bazan, Rodrigo [UNESP] Moura Cabral, Ariana Andrade, Adriano de Oliveira de Souza, Luciane Aparecida Pascucci Sande José Luvizutto, Gustavo |
author_role |
author |
author2 |
Taciana Sisconetto, Angélica Baldo Sucupira, Kelly Savana Minaré Neto, Eduardo de Moura Chagas, Tatiane de Jesus Bazan, Rodrigo [UNESP] Moura Cabral, Ariana Andrade, Adriano de Oliveira de Souza, Luciane Aparecida Pascucci Sande José Luvizutto, Gustavo |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Federal University of Triângulo Mineiro Universidade Estadual Paulista (UNESP) Universidade Federal de Uberlândia (UFU) |
dc.contributor.author.fl_str_mv |
Andrei Appelt, Pablo Taciana Sisconetto, Angélica Baldo Sucupira, Kelly Savana Minaré Neto, Eduardo de Moura Chagas, Tatiane de Jesus Bazan, Rodrigo [UNESP] Moura Cabral, Ariana Andrade, Adriano de Oliveira de Souza, Luciane Aparecida Pascucci Sande José Luvizutto, Gustavo |
dc.subject.por.fl_str_mv |
cognition COVID-19 electroencephalography SARS-CoV-2 |
topic |
cognition COVID-19 electroencephalography SARS-CoV-2 |
description |
The coronavirus disease 2019 (COVID-19) can disrupt various brain functions. Over a one-year period, we aimed to assess brain activity and cognitive function in 53 COVID-19 patients and 30 individuals without COVID-19 (or asymptomatic). The Montreal Cognitive Assessment, Trail Making Test Parts A and B (TMT-A and B), and Digit Span Test were used to assess cognitive function. Cognitive variables and electroencephalography (EEG) data (activity, mobility, and complexity) were compared between the groups at rest and during cognitive demand (F3-F7, Fz-F3, Fz-F4, and F4-F8). There was a reduction in F3-F7 activity during the TMT-B in the COVID-19 group at 6-12 months compared to the controls (p = 0.01) at baseline (p = 0.03), a reduction in signal complexity at F3-F7 at rest in the COVID-19 group at baseline and 6-12 months compared to the controls (p < 0.001), and a reduction in Fz-F4 activity at rest from 6-12 months in the post-COVID group compared to baseline (p = 0.02) and 3-6 months (p = 0.04). At 6-12 months, there was a time increase in TMT-A in the COVID-19 group compared to that in the controls (p = 0.04). Some correlations were found between EEG data and cognitive test in both groups. In conclusion, there was a reduction in brain activity at rest in the Fz-F4 areas and during high cognitive demands in the F3-F7 areas. A reduction in signal complexity in F3-F7 at rest was found in the COVID-19 group at 6-12 months after acute infection. Furthermore, individuals with COVID-19 experience long-term changes in cognitive function. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 2023-03-01T20:47:36Z 2023-03-01T20:47:36Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1177/15500594221103834 Clinical EEG and Neuroscience. 2169-5202 1550-0594 http://hdl.handle.net/11449/241109 10.1177/15500594221103834 2-s2.0-85131374695 |
url |
http://dx.doi.org/10.1177/15500594221103834 http://hdl.handle.net/11449/241109 |
identifier_str_mv |
Clinical EEG and Neuroscience. 2169-5202 1550-0594 10.1177/15500594221103834 2-s2.0-85131374695 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Clinical EEG and Neuroscience |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1797789835746869248 |