Isolation and evaluation of the antioxidant activity of phenolic constituents of the Garcinia brasiliensis epicarp

Detalhes bibliográficos
Autor(a) principal: Gontijo, Vanessa Silva
Data de Publicação: 2012
Outros Autores: de Souza, Thiago Correa, Rosa, Isael Aparecido, Soares, Marisi Gomes, da Silva, Marcelo Aparecido, Vilegas, Wagner [UNESP], Viegas Junior, Claudio, dos Santos, Marcelo Henrique
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.foodchem.2011.10.110
http://hdl.handle.net/11449/42633
Resumo: A new glycosylated biflavonone, morelloflavone-4 '''-O-beta-D-glycosyl, and the known compounds 1,3,6,7-tetrahydroxyxanthone, morelloflavone (fukugetin) and morelloflavone-7 ''-O-beta-D-glycosyl (fukugeside) were isolated from the epicarp of Garcinia brasiliensis collected in Brazil. The structures of these compounds were established using H-1 and C-13 NMR, COSY, gHMQC and gHMBC spectroscopy. The compounds exhibited antioxidant activity. The greatest potency was displayed by morelloflavone (2), with IC50 = 49.5 mM against DPPH and absorbance of 0.583 at 400 mu g/mL for the reduction of Fe3+. The weakest potency was displayed by 1,3,6,7-tetrahydroxyxanthone (1), with IC50 = 148 mM against DPPH and absorbance of 0.194 at 400 mu g/mL for the reduction of Fe3+. (C) 2011 Elsevier Ltd. All rights reserved.
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spelling Isolation and evaluation of the antioxidant activity of phenolic constituents of the Garcinia brasiliensis epicarpGarcinia brasiliensisBiflavonoidsNatural productsAntioxidantsA new glycosylated biflavonone, morelloflavone-4 '''-O-beta-D-glycosyl, and the known compounds 1,3,6,7-tetrahydroxyxanthone, morelloflavone (fukugetin) and morelloflavone-7 ''-O-beta-D-glycosyl (fukugeside) were isolated from the epicarp of Garcinia brasiliensis collected in Brazil. The structures of these compounds were established using H-1 and C-13 NMR, COSY, gHMQC and gHMBC spectroscopy. The compounds exhibited antioxidant activity. The greatest potency was displayed by morelloflavone (2), with IC50 = 49.5 mM against DPPH and absorbance of 0.583 at 400 mu g/mL for the reduction of Fe3+. The weakest potency was displayed by 1,3,6,7-tetrahydroxyxanthone (1), with IC50 = 148 mM against DPPH and absorbance of 0.194 at 400 mu g/mL for the reduction of Fe3+. (C) 2011 Elsevier Ltd. All rights reserved.Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Financiadora de Estudos e Projetos (FINEP)Univ Fed Alfenas, Lab Fitoquim & Quim Med, Inst Quim Exatas, UNIFAL MG, Alfenas, MG, BrazilUniv Fed Alfenas, Lab Plantas Med & Fitoterapicos, Fac Ciencias Farmaceut, UNIFAL MG, Alfenas, MG, BrazilUNESP, Dept Quim Organ, Inst Quim Araraquara, Araraquara, BrazilUNESP, Dept Quim Organ, Inst Quim Araraquara, Araraquara, BrazilElsevier B.V.Universidade Federal de Alfenas (UNIFAL)Universidade Estadual Paulista (Unesp)Gontijo, Vanessa Silvade Souza, Thiago CorreaRosa, Isael AparecidoSoares, Marisi Gomesda Silva, Marcelo AparecidoVilegas, Wagner [UNESP]Viegas Junior, Claudiodos Santos, Marcelo Henrique2014-05-20T15:34:43Z2014-05-20T15:34:43Z2012-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1230-1235application/pdfhttp://dx.doi.org/10.1016/j.foodchem.2011.10.110Food Chemistry. Oxford: Elsevier B.V., v. 132, n. 3, p. 1230-1235, 2012.0308-8146http://hdl.handle.net/11449/4263310.1016/j.foodchem.2011.10.110WOS:000301022400016WOS000301022400016.pdf0000-0003-3032-2556Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengFood Chemistry4.9461,793info:eu-repo/semantics/openAccess2024-01-06T06:23:49Zoai:repositorio.unesp.br:11449/42633Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-01-06T06:23:49Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Isolation and evaluation of the antioxidant activity of phenolic constituents of the Garcinia brasiliensis epicarp
title Isolation and evaluation of the antioxidant activity of phenolic constituents of the Garcinia brasiliensis epicarp
spellingShingle Isolation and evaluation of the antioxidant activity of phenolic constituents of the Garcinia brasiliensis epicarp
Gontijo, Vanessa Silva
Garcinia brasiliensis
Biflavonoids
Natural products
Antioxidants
title_short Isolation and evaluation of the antioxidant activity of phenolic constituents of the Garcinia brasiliensis epicarp
title_full Isolation and evaluation of the antioxidant activity of phenolic constituents of the Garcinia brasiliensis epicarp
title_fullStr Isolation and evaluation of the antioxidant activity of phenolic constituents of the Garcinia brasiliensis epicarp
title_full_unstemmed Isolation and evaluation of the antioxidant activity of phenolic constituents of the Garcinia brasiliensis epicarp
title_sort Isolation and evaluation of the antioxidant activity of phenolic constituents of the Garcinia brasiliensis epicarp
author Gontijo, Vanessa Silva
author_facet Gontijo, Vanessa Silva
de Souza, Thiago Correa
Rosa, Isael Aparecido
Soares, Marisi Gomes
da Silva, Marcelo Aparecido
Vilegas, Wagner [UNESP]
Viegas Junior, Claudio
dos Santos, Marcelo Henrique
author_role author
author2 de Souza, Thiago Correa
Rosa, Isael Aparecido
Soares, Marisi Gomes
da Silva, Marcelo Aparecido
Vilegas, Wagner [UNESP]
Viegas Junior, Claudio
dos Santos, Marcelo Henrique
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de Alfenas (UNIFAL)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Gontijo, Vanessa Silva
de Souza, Thiago Correa
Rosa, Isael Aparecido
Soares, Marisi Gomes
da Silva, Marcelo Aparecido
Vilegas, Wagner [UNESP]
Viegas Junior, Claudio
dos Santos, Marcelo Henrique
dc.subject.por.fl_str_mv Garcinia brasiliensis
Biflavonoids
Natural products
Antioxidants
topic Garcinia brasiliensis
Biflavonoids
Natural products
Antioxidants
description A new glycosylated biflavonone, morelloflavone-4 '''-O-beta-D-glycosyl, and the known compounds 1,3,6,7-tetrahydroxyxanthone, morelloflavone (fukugetin) and morelloflavone-7 ''-O-beta-D-glycosyl (fukugeside) were isolated from the epicarp of Garcinia brasiliensis collected in Brazil. The structures of these compounds were established using H-1 and C-13 NMR, COSY, gHMQC and gHMBC spectroscopy. The compounds exhibited antioxidant activity. The greatest potency was displayed by morelloflavone (2), with IC50 = 49.5 mM against DPPH and absorbance of 0.583 at 400 mu g/mL for the reduction of Fe3+. The weakest potency was displayed by 1,3,6,7-tetrahydroxyxanthone (1), with IC50 = 148 mM against DPPH and absorbance of 0.194 at 400 mu g/mL for the reduction of Fe3+. (C) 2011 Elsevier Ltd. All rights reserved.
publishDate 2012
dc.date.none.fl_str_mv 2012-06-01
2014-05-20T15:34:43Z
2014-05-20T15:34:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.foodchem.2011.10.110
Food Chemistry. Oxford: Elsevier B.V., v. 132, n. 3, p. 1230-1235, 2012.
0308-8146
http://hdl.handle.net/11449/42633
10.1016/j.foodchem.2011.10.110
WOS:000301022400016
WOS000301022400016.pdf
0000-0003-3032-2556
url http://dx.doi.org/10.1016/j.foodchem.2011.10.110
http://hdl.handle.net/11449/42633
identifier_str_mv Food Chemistry. Oxford: Elsevier B.V., v. 132, n. 3, p. 1230-1235, 2012.
0308-8146
10.1016/j.foodchem.2011.10.110
WOS:000301022400016
WOS000301022400016.pdf
0000-0003-3032-2556
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Food Chemistry
4.946
1,793
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1230-1235
application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1797790215335575552

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