Gender, body mass index and rheumatoid arthritis disease activity: Results from the QUEST-RA study
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/219633 |
Resumo: | Objective: To investigate whether body mass index (BMI), as a proxy for body fat, influences rheumatoid arthritis (RA) disease activity in a gender-specific manner. Methods: Consecutive patients with RA were enrolled from 25 countries into the QUEST-RA program between 2005 and 2008. Clinical and demographic data were collected by treating rheumatologists and by patient self-report. Distributions of Disease Activity Scores (DAS28), BMI, age, and disease duration were assessed for each country and for the entire dataset; mean values between genders were compared using Student's t-tests. An association between BMI and DAS28 was investigated using linear regression, adjusting for age, disease duration and country. Results: A total of 5,161 RA patients (4,082 women and 1,079 men) were included in the analyses. Overall, women were younger, had longer disease duration, and higher DAS28 scores than men, but BMI was similar between genders. The mean DAS28 scores increased with increasing BMI from normal to overweight and obese, among women, whereas the opposite trend was observed among men. Regression results showed BMI (continuous or categorical) to be associated with DAS28. Compared to the normal BMI range, being obese was associated with a larger difference in mean DAS28 (0.23, 95% CI: 0.11, 0.34) than being overweight (0.12, 95% CI: 0.03, 0.21); being underweight was not associated with disease activity. These associations were more pronounced among women, and were not explained by any single component of the DAS28. Conclusion: BMI appears to be associated with RA disease activity in women, but not in men. © Copyright Clinical and Experimental Rheumatology 2010. |
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spelling |
Gender, body mass index and rheumatoid arthritis disease activity: Results from the QUEST-RA studyBmiDisease activityGenderRheumatoid arthritisObjective: To investigate whether body mass index (BMI), as a proxy for body fat, influences rheumatoid arthritis (RA) disease activity in a gender-specific manner. Methods: Consecutive patients with RA were enrolled from 25 countries into the QUEST-RA program between 2005 and 2008. Clinical and demographic data were collected by treating rheumatologists and by patient self-report. Distributions of Disease Activity Scores (DAS28), BMI, age, and disease duration were assessed for each country and for the entire dataset; mean values between genders were compared using Student's t-tests. An association between BMI and DAS28 was investigated using linear regression, adjusting for age, disease duration and country. Results: A total of 5,161 RA patients (4,082 women and 1,079 men) were included in the analyses. Overall, women were younger, had longer disease duration, and higher DAS28 scores than men, but BMI was similar between genders. The mean DAS28 scores increased with increasing BMI from normal to overweight and obese, among women, whereas the opposite trend was observed among men. Regression results showed BMI (continuous or categorical) to be associated with DAS28. Compared to the normal BMI range, being obese was associated with a larger difference in mean DAS28 (0.23, 95% CI: 0.11, 0.34) than being overweight (0.12, 95% CI: 0.03, 0.21); being underweight was not associated with disease activity. These associations were more pronounced among women, and were not explained by any single component of the DAS28. Conclusion: BMI appears to be associated with RA disease activity in women, but not in men. © Copyright Clinical and Experimental Rheumatology 2010.University of California Los Angeles, Los Angeles, CAUniversity of California Berkeley, Berkeley, CANorth Karelia Central Hospital, JoensuuPontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto AlegreUniversidade Federal do Ceará, FortalezaUniversidade Estadual de São Paulo, São PauloHospital Universitário de Brasília, BrasiliaUniversity of Ioannina IoanninaWaterford Regional Hospital, WaterfordConnolly Hospital, DublinUniversity of Genova, GenovaRheumatology Department, PristineInstitute of Experimental and Clinical Medicine Vilnius University, VilniusUniversity Medical Centre Utrecht, UtrechtJyväskylä Central Hospital, JyväskyläMedcare Oy, ÄänekoskiHospital Oakland Research Institute, Oakland, CAHospital San Juan Bautista, CatamarcaHospital of Cordoba, CordobaUniversidade do Estado do Rio de Janeiro, Rio de JaneiroRiverside Professional Centre, Sydney, NSCopenhagen University Hospital at Hvidovre, HvidovreKing Christian the Xth Hospital, GråstenCopenhagen University Hospital at Herlev, HerlevAl-Azhar University, CairoAssiut University Hospital, AssiutAbo Sohage University Hospital, SohageTartu University Hospital, TartuEast-Tallinn Central Hospital, TallinnCentre for Clinical and Basic Research, TallinnSatakunta Central Hospital, RaumaUniversity René Descartes Hôpital Cochin, ParisDijon University Hospital University of Burgundy INSERM U887, DijonHôpital Lapeyronie, MontpellierHôpital Hautepierre, StrasbourgSchool of Medicine National University of Athens, AthensEuroclinic Hospital, AthensEvangelisches Fachkrankenhaus, RatingenSchlosspark-Klinik, BerlinUniversity Medicine Berlin, BerlinSemmelweis University of Medical Sciences, BudapestIlona Újfalussy Polyclinic of the Hospitaller Brothers of St. John of God in Budapest, BudapestSt. Vincent University Hospital, DublinOur Lady's Hospice, DublinDepartment of Immunology, LucknowVedanta Institiute of Medical Sciences, AhmedabadDepartment of Immunology Jaipur HospitalSanta Chiara Hospital, PisaCatholic University of Sacred Heart, RomeUniversity of Ancona, AnconaInstitute of Rheumatology Tokyo Women's Medical University, TokyoDepartment of Rheumatology Kyoto First Red Cross Hospital, KyotoShono Rheumatism Clinic, FukuokaKenyatta Hospital, NairobiPauls Stradina Clinical University Hospital, RigaKaunas University Hospital, KaunasEl Ayachi Hospital Mohamed Vth Souissi University, RabatSint Franciscus Gasthuis Hospital, RotterdamMedisch Spectrum Twente, EnschedeSørlandet Hospital, KristiansandMedical University in Bialystok, BialystokMedical University of Lublin, LublinPoznan Rheumatology Centre in Srem, SremMilitary Institute of Medicine, WarsawSilesian Hospital for Rheumatology and Rehabilitation in Ustron Slaski, Ustroñ SlaskiSzpital Wojewodzki im. Jana Biziela, BydgoszczWojewodzki Zespol Reumatologiczny im. dr Jadwigi Titz-Kosko, SopotSpitalul Clinic Sf Maria, BucharestInstitute of Rheumatology of Russian Academy of Medical Sciences, MoscowMoscow Medical Academy, MoscowRussian Medical Academy of Postgraduate Education, MoscowRheumatology Institut, Niska BanjaHospital de Gran Canaria Dr. Negrin, Las PalmasHospital Sierrallana Ganzo, TorrelavegaHospital General de Castellón, CastellónUppsala University Hospital, UppsalaCentrallasarettet, VästeråsHudiksvall Medical Clinic, HudiksvallGazi University Medical Faculty, AnkaraMeram Medical Faculty, KonyaCerrahpasa Medic Faculty, IstanbulDubai Bone and Joint Centre, DubaiAmerican Hospital Dubai, DubaiCharing Cross Hospital, LondonRoyal Cornwall Hospital, TruroKings College Hospital, LondonVanderbilt University, Nashville, TNNYU Hospital for Joint Diseases, New York, NYTaylor Hospital, Ridley Park, PACentra Care Clinic, St. Cloud, MNUniversity of Arkansas for Medical Sciences, Little Rock, ARNew York University Hospital for Joint Diseases, New York, NYUniversidade Estadual de São Paulo, São PauloUniversity of California Los AngelesUniversity of California BerkeleyNorth Karelia Central HospitalPontifícia Universidade Católica do Rio Grande do Sul (PUCRS)Universidade Federal do CearáUniversidade Estadual Paulista (UNESP)Hospital Universitário de BrasíliaUniversity of Ioannina IoanninaWaterford Regional HospitalConnolly HospitalUniversity of GenovaRheumatology DepartmentVilnius UniversityUniversity Medical Centre UtrechtJyväskylä Central HospitalMedcare OyHospital Oakland Research InstituteHospital San Juan BautistaHospital of CordobaUniversidade do Estado do Rio de Janeiro (UERJ)Riverside Professional CentreCopenhagen University Hospital at HvidovreKing Christian the Xth HospitalCopenhagen University Hospital at HerlevAl-Azhar UniversityAssiut University HospitalAbo Sohage University HospitalTartu University HospitalEast-Tallinn Central HospitalCentre for Clinical and Basic ResearchSatakunta Central HospitalHôpital CochinINSERM U887Hôpital LapeyronieHôpital HautepierreNational University of AthensEuroclinic HospitalEvangelisches FachkrankenhausSchlosspark-KlinikUniversity Medicine BerlinSemmelweis University of Medical SciencesPolyclinic of the Hospitaller Brothers of St. John of God in BudapestSt. Vincent University HospitalOur Lady's HospiceVedanta Institiute of Medical SciencesJaipur HospitalSanta Chiara HospitalCatholic University of Sacred HeartUniversity of AnconaTokyo Women's Medical UniversityKyoto First Red Cross HospitalShono Rheumatism ClinicKenyatta HospitalPauls Stradina Clinical University HospitalKaunas University HospitalEl Ayachi Hospital Mohamed Vth Souissi UniversitySint Franciscus Gasthuis HospitalMedisch Spectrum TwenteSørlandet HospitalMedical University in BialystokMedical University of LublinPoznan Rheumatology Centre in SremMilitary Institute of MedicineSilesian Hospital for Rheumatology and Rehabilitation in Ustron SlaskiSzpital Wojewodzki im. Jana BizielaWojewodzki Zespol Reumatologiczny im. dr Jadwigi Titz-KoskoSpitalul Clinic Sf MariaInstitute of Rheumatology of Russian Academy of Medical SciencesMoscow Medical AcademyRussian Medical Academy of Postgraduate EducationRheumatology InstitutHospital de Gran Canaria Dr. NegrinHospital Sierrallana GanzoHospital General de CastellónUppsala University HospitalCentrallasarettetHudiksvall Medical ClinicGazi University Medical FacultyMeram Medical FacultyCerrahpasa Medic FacultyDubai Bone and Joint CentreAmerican Hospital DubaiCharing Cross HospitalRoyal Cornwall HospitalKings College HospitalVanderbilt UniversityNYU Hospital for Joint DiseasesTaylor HospitalCentra Care ClinicUniversity of Arkansas for Medical SciencesNew York University Hospital for Joint DiseasesJawaheer, DaminiOlsen, JørnLahiff, MaureenForsberg, SinikkaLähteenmäki, Jukkada Silveira, Ines GuimaraesRocha, Francisco AirtonLaurindo, Ieda Maria Magalhães [UNESP]da Mota, Licia Maria HenriqueDrosos, Alexandros A.Murphy, EithneSheehy, ClaireQuirke, EdelCutolo, MaurizioRexhepi, SylejmanDadoniene, JolantaVerstappen, Suzan M.M.Sokka, TuulikkiToloza, SergioAguero, SantiagoBarrera, Sergio OrellanaRetamozo, SoledadAlba, PaulaLascano, CruzBabini, AlejandraAlbiero, EduardoPinheiro, Geraldo da Rocha CastelarLazovskis, JurisHetland, Merete LundØrnbjerg, LykkeHørslev-Petersen, KimHansen, Troels MørkKnudsen, Lene SurlandHamoud, HishamSobhy, MohamadFahmy, AhmadMagdy, MohamadAly, HanySaeid, HatemNagm, AhmadFathi, Nihal A.Abda, EsamEbraheam, ZahraMüller, RailiKuuse, ReetTammaru, MarikaKallikorm, RiinaPeets, TonyOtsa, KatiLaas, KarinValter, IvoMäkinen, HeidiImmonen, KaiLuukkainen, ReijoGossec, LaureDougados, MaximeMaillefert, Jean FrancisCombe, BernardSibilia, JeanExarchou, SofiaMoutsopoulos, H. M.Tsirogianni, AfroditeSkopouli, Fotini N.Mavrommati, MariaHerborn, GertraudRau, RolfAlten, RiekePohl, ChristofBurmester, Gerd R.Marsmann, BettinaGéher, PálRojkovich, BernadetteBresnihan, BarryMinnock, PatriciaDevlin, JoeAlraqi, ShafeeqAggarwal, AmitaPandya, SapanSharma, BanwariCazzato, MassimilianoBombardieri, StefanoFerraccioli, GianfrancoMorelli, AlessiaSalaffi, FaustoStancati, AndreaYamanaka, HisashiNakajima, AyakoFukuda, WataruShono, EisukeOyoo, OmondiRexhepi, MjellmaAndersone, DainaStropuviene, SigitaBaranauskaite, AstaHajjaj-Hassouni, NaijaBenbouazza, KarimaAllali, FadouaBahiri, RachidAmine, BouchraJacobs, Johannes W.G.Huisman, MargrietHoekstra, MoniqueHaugeberg, GlennGjelberg, HildeSierakowski, StanislawMajdan, MariaRomanowski, WojciechTlustochowicz, WitoldKapolka, DanutaSadkiewicz, StefanZarowny-Wierzbinska, DanutaIonescu, RuxandraPredeteanu, DenisaKarateev, DmitryLuchikhina, ElenaChichasova, NataliaBadokin, VladimirSkakic, VladoDimic, AleksanderNedovic, JovanStankovic, AleksandraNaranjo, AntonioRodríguez-Lozano, CarlosCalvo-Alen, JaimeBelmonte, MiguelBaecklund, EvaHenrohn, DanOding, RolfLiveborn, MargarethHolmqvist, Ann-CarinGogus, FerideTunc, RecepCelic, SeldaBadsha, HumeiraMofti, AymanTaylor, PeterMcClinton, CatherineWoolf, AnthonyChorghade, GinnyChoy, ErnestKelly, StephenPincus, TheodoreYazici, YusufBergman, MartinCraig-Muller, JurgenKautiainen, HannuSwearingen, Christopher2022-04-28T18:56:40Z2022-04-28T18:56:40Z2010-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article454-461Clinical and Experimental Rheumatology, v. 28, n. 4, p. 454-461, 2010.0392-856X1593-098Xhttp://hdl.handle.net/11449/2196332-s2.0-79952056556Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengClinical and Experimental Rheumatologyinfo:eu-repo/semantics/openAccess2022-04-28T18:56:43Zoai:repositorio.unesp.br:11449/219633Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-28T18:56:43Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Gender, body mass index and rheumatoid arthritis disease activity: Results from the QUEST-RA study |
title |
Gender, body mass index and rheumatoid arthritis disease activity: Results from the QUEST-RA study |
spellingShingle |
Gender, body mass index and rheumatoid arthritis disease activity: Results from the QUEST-RA study Jawaheer, Damini Bmi Disease activity Gender Rheumatoid arthritis |
title_short |
Gender, body mass index and rheumatoid arthritis disease activity: Results from the QUEST-RA study |
title_full |
Gender, body mass index and rheumatoid arthritis disease activity: Results from the QUEST-RA study |
title_fullStr |
Gender, body mass index and rheumatoid arthritis disease activity: Results from the QUEST-RA study |
title_full_unstemmed |
Gender, body mass index and rheumatoid arthritis disease activity: Results from the QUEST-RA study |
title_sort |
Gender, body mass index and rheumatoid arthritis disease activity: Results from the QUEST-RA study |
author |
Jawaheer, Damini |
author_facet |
Jawaheer, Damini Olsen, Jørn Lahiff, Maureen Forsberg, Sinikka Lähteenmäki, Jukka da Silveira, Ines Guimaraes Rocha, Francisco Airton Laurindo, Ieda Maria Magalhães [UNESP] da Mota, Licia Maria Henrique Drosos, Alexandros A. Murphy, Eithne Sheehy, Claire Quirke, Edel Cutolo, Maurizio Rexhepi, Sylejman Dadoniene, Jolanta Verstappen, Suzan M.M. Sokka, Tuulikki Toloza, Sergio Aguero, Santiago Barrera, Sergio Orellana Retamozo, Soledad Alba, Paula Lascano, Cruz Babini, Alejandra Albiero, Eduardo Pinheiro, Geraldo da Rocha Castelar Lazovskis, Juris Hetland, Merete Lund Ørnbjerg, Lykke Hørslev-Petersen, Kim Hansen, Troels Mørk Knudsen, Lene Surland Hamoud, Hisham Sobhy, Mohamad Fahmy, Ahmad Magdy, Mohamad Aly, Hany Saeid, Hatem Nagm, Ahmad Fathi, Nihal A. Abda, Esam Ebraheam, Zahra Müller, Raili Kuuse, Reet Tammaru, Marika Kallikorm, Riina Peets, Tony Otsa, Kati Laas, Karin Valter, Ivo Mäkinen, Heidi Immonen, Kai Luukkainen, Reijo Gossec, Laure Dougados, Maxime Maillefert, Jean Francis Combe, Bernard Sibilia, Jean Exarchou, Sofia Moutsopoulos, H. M. Tsirogianni, Afrodite Skopouli, Fotini N. Mavrommati, Maria Herborn, Gertraud Rau, Rolf Alten, Rieke Pohl, Christof Burmester, Gerd R. Marsmann, Bettina Géher, Pál Rojkovich, Bernadette Bresnihan, Barry Minnock, Patricia Devlin, Joe Alraqi, Shafeeq Aggarwal, Amita Pandya, Sapan Sharma, Banwari Cazzato, Massimiliano Bombardieri, Stefano Ferraccioli, Gianfranco Morelli, Alessia Salaffi, Fausto Stancati, Andrea Yamanaka, Hisashi Nakajima, Ayako Fukuda, Wataru Shono, Eisuke Oyoo, Omondi Rexhepi, Mjellma Andersone, Daina Stropuviene, Sigita Baranauskaite, Asta Hajjaj-Hassouni, Naija Benbouazza, Karima Allali, Fadoua Bahiri, Rachid Amine, Bouchra Jacobs, Johannes W.G. Huisman, Margriet Hoekstra, Monique Haugeberg, Glenn Gjelberg, Hilde Sierakowski, Stanislaw Majdan, Maria Romanowski, Wojciech Tlustochowicz, Witold Kapolka, Danuta Sadkiewicz, Stefan Zarowny-Wierzbinska, Danuta Ionescu, Ruxandra Predeteanu, Denisa Karateev, Dmitry Luchikhina, Elena Chichasova, Natalia Badokin, Vladimir Skakic, Vlado Dimic, Aleksander Nedovic, Jovan Stankovic, Aleksandra Naranjo, Antonio Rodríguez-Lozano, Carlos Calvo-Alen, Jaime Belmonte, Miguel Baecklund, Eva Henrohn, Dan Oding, Rolf Liveborn, Margareth Holmqvist, Ann-Carin Gogus, Feride Tunc, Recep Celic, Selda Badsha, Humeira Mofti, Ayman Taylor, Peter McClinton, Catherine Woolf, Anthony Chorghade, Ginny Choy, Ernest Kelly, Stephen Pincus, Theodore Yazici, Yusuf Bergman, Martin Craig-Muller, Jurgen Kautiainen, Hannu Swearingen, Christopher |
author_role |
author |
author2 |
Olsen, Jørn Lahiff, Maureen Forsberg, Sinikka Lähteenmäki, Jukka da Silveira, Ines Guimaraes Rocha, Francisco Airton Laurindo, Ieda Maria Magalhães [UNESP] da Mota, Licia Maria Henrique Drosos, Alexandros A. Murphy, Eithne Sheehy, Claire Quirke, Edel Cutolo, Maurizio Rexhepi, Sylejman Dadoniene, Jolanta Verstappen, Suzan M.M. Sokka, Tuulikki Toloza, Sergio Aguero, Santiago Barrera, Sergio Orellana Retamozo, Soledad Alba, Paula Lascano, Cruz Babini, Alejandra Albiero, Eduardo Pinheiro, Geraldo da Rocha Castelar Lazovskis, Juris Hetland, Merete Lund Ørnbjerg, Lykke Hørslev-Petersen, Kim Hansen, Troels Mørk Knudsen, Lene Surland Hamoud, Hisham Sobhy, Mohamad Fahmy, Ahmad Magdy, Mohamad Aly, Hany Saeid, Hatem Nagm, Ahmad Fathi, Nihal A. Abda, Esam Ebraheam, Zahra Müller, Raili Kuuse, Reet Tammaru, Marika Kallikorm, Riina Peets, Tony Otsa, Kati Laas, Karin Valter, Ivo Mäkinen, Heidi Immonen, Kai Luukkainen, Reijo Gossec, Laure Dougados, Maxime Maillefert, Jean Francis Combe, Bernard Sibilia, Jean Exarchou, Sofia Moutsopoulos, H. M. Tsirogianni, Afrodite Skopouli, Fotini N. Mavrommati, Maria Herborn, Gertraud Rau, Rolf Alten, Rieke Pohl, Christof Burmester, Gerd R. Marsmann, Bettina Géher, Pál Rojkovich, Bernadette Bresnihan, Barry Minnock, Patricia Devlin, Joe Alraqi, Shafeeq Aggarwal, Amita Pandya, Sapan Sharma, Banwari Cazzato, Massimiliano Bombardieri, Stefano Ferraccioli, Gianfranco Morelli, Alessia Salaffi, Fausto Stancati, Andrea Yamanaka, Hisashi Nakajima, Ayako Fukuda, Wataru Shono, Eisuke Oyoo, Omondi Rexhepi, Mjellma Andersone, Daina Stropuviene, Sigita Baranauskaite, Asta Hajjaj-Hassouni, Naija Benbouazza, Karima Allali, Fadoua Bahiri, Rachid Amine, Bouchra Jacobs, Johannes W.G. Huisman, Margriet Hoekstra, Monique Haugeberg, Glenn Gjelberg, Hilde Sierakowski, Stanislaw Majdan, Maria Romanowski, Wojciech Tlustochowicz, Witold Kapolka, Danuta Sadkiewicz, Stefan Zarowny-Wierzbinska, Danuta Ionescu, Ruxandra Predeteanu, Denisa Karateev, Dmitry Luchikhina, Elena Chichasova, Natalia Badokin, Vladimir Skakic, Vlado Dimic, Aleksander Nedovic, Jovan Stankovic, Aleksandra Naranjo, Antonio Rodríguez-Lozano, Carlos Calvo-Alen, Jaime Belmonte, Miguel Baecklund, Eva Henrohn, Dan Oding, Rolf Liveborn, Margareth Holmqvist, Ann-Carin Gogus, Feride Tunc, Recep Celic, Selda Badsha, Humeira Mofti, Ayman Taylor, Peter McClinton, Catherine Woolf, Anthony Chorghade, Ginny Choy, Ernest Kelly, Stephen Pincus, Theodore Yazici, Yusuf Bergman, Martin Craig-Muller, Jurgen Kautiainen, Hannu Swearingen, Christopher |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
University of California Los Angeles University of California Berkeley North Karelia Central Hospital Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) Universidade Federal do Ceará Universidade Estadual Paulista (UNESP) Hospital Universitário de Brasília University of Ioannina Ioannina Waterford Regional Hospital Connolly Hospital University of Genova Rheumatology Department Vilnius University University Medical Centre Utrecht Jyväskylä Central Hospital Medcare Oy Hospital Oakland Research Institute Hospital San Juan Bautista Hospital of Cordoba Universidade do Estado do Rio de Janeiro (UERJ) Riverside Professional Centre Copenhagen University Hospital at Hvidovre King Christian the Xth Hospital Copenhagen University Hospital at Herlev Al-Azhar University Assiut University Hospital Abo Sohage University Hospital Tartu University Hospital East-Tallinn Central Hospital Centre for Clinical and Basic Research Satakunta Central Hospital Hôpital Cochin INSERM U887 Hôpital Lapeyronie Hôpital Hautepierre National University of Athens Euroclinic Hospital Evangelisches Fachkrankenhaus Schlosspark-Klinik University Medicine Berlin Semmelweis University of Medical Sciences Polyclinic of the Hospitaller Brothers of St. John of God in Budapest St. Vincent University Hospital Our Lady's Hospice Vedanta Institiute of Medical Sciences Jaipur Hospital Santa Chiara Hospital Catholic University of Sacred Heart University of Ancona Tokyo Women's Medical University Kyoto First Red Cross Hospital Shono Rheumatism Clinic Kenyatta Hospital Pauls Stradina Clinical University Hospital Kaunas University Hospital El Ayachi Hospital Mohamed Vth Souissi University Sint Franciscus Gasthuis Hospital Medisch Spectrum Twente Sørlandet Hospital Medical University in Bialystok Medical University of Lublin Poznan Rheumatology Centre in Srem Military Institute of Medicine Silesian Hospital for Rheumatology and Rehabilitation in Ustron Slaski Szpital Wojewodzki im. Jana Biziela Wojewodzki Zespol Reumatologiczny im. dr Jadwigi Titz-Kosko Spitalul Clinic Sf Maria Institute of Rheumatology of Russian Academy of Medical Sciences Moscow Medical Academy Russian Medical Academy of Postgraduate Education Rheumatology Institut Hospital de Gran Canaria Dr. Negrin Hospital Sierrallana Ganzo Hospital General de Castellón Uppsala University Hospital Centrallasarettet Hudiksvall Medical Clinic Gazi University Medical Faculty Meram Medical Faculty Cerrahpasa Medic Faculty Dubai Bone and Joint Centre American Hospital Dubai Charing Cross Hospital Royal Cornwall Hospital Kings College Hospital Vanderbilt University NYU Hospital for Joint Diseases Taylor Hospital Centra Care Clinic University of Arkansas for Medical Sciences New York University Hospital for Joint Diseases |
dc.contributor.author.fl_str_mv |
Jawaheer, Damini Olsen, Jørn Lahiff, Maureen Forsberg, Sinikka Lähteenmäki, Jukka da Silveira, Ines Guimaraes Rocha, Francisco Airton Laurindo, Ieda Maria Magalhães [UNESP] da Mota, Licia Maria Henrique Drosos, Alexandros A. Murphy, Eithne Sheehy, Claire Quirke, Edel Cutolo, Maurizio Rexhepi, Sylejman Dadoniene, Jolanta Verstappen, Suzan M.M. Sokka, Tuulikki Toloza, Sergio Aguero, Santiago Barrera, Sergio Orellana Retamozo, Soledad Alba, Paula Lascano, Cruz Babini, Alejandra Albiero, Eduardo Pinheiro, Geraldo da Rocha Castelar Lazovskis, Juris Hetland, Merete Lund Ørnbjerg, Lykke Hørslev-Petersen, Kim Hansen, Troels Mørk Knudsen, Lene Surland Hamoud, Hisham Sobhy, Mohamad Fahmy, Ahmad Magdy, Mohamad Aly, Hany Saeid, Hatem Nagm, Ahmad Fathi, Nihal A. Abda, Esam Ebraheam, Zahra Müller, Raili Kuuse, Reet Tammaru, Marika Kallikorm, Riina Peets, Tony Otsa, Kati Laas, Karin Valter, Ivo Mäkinen, Heidi Immonen, Kai Luukkainen, Reijo Gossec, Laure Dougados, Maxime Maillefert, Jean Francis Combe, Bernard Sibilia, Jean Exarchou, Sofia Moutsopoulos, H. M. Tsirogianni, Afrodite Skopouli, Fotini N. Mavrommati, Maria Herborn, Gertraud Rau, Rolf Alten, Rieke Pohl, Christof Burmester, Gerd R. Marsmann, Bettina Géher, Pál Rojkovich, Bernadette Bresnihan, Barry Minnock, Patricia Devlin, Joe Alraqi, Shafeeq Aggarwal, Amita Pandya, Sapan Sharma, Banwari Cazzato, Massimiliano Bombardieri, Stefano Ferraccioli, Gianfranco Morelli, Alessia Salaffi, Fausto Stancati, Andrea Yamanaka, Hisashi Nakajima, Ayako Fukuda, Wataru Shono, Eisuke Oyoo, Omondi Rexhepi, Mjellma Andersone, Daina Stropuviene, Sigita Baranauskaite, Asta Hajjaj-Hassouni, Naija Benbouazza, Karima Allali, Fadoua Bahiri, Rachid Amine, Bouchra Jacobs, Johannes W.G. Huisman, Margriet Hoekstra, Monique Haugeberg, Glenn Gjelberg, Hilde Sierakowski, Stanislaw Majdan, Maria Romanowski, Wojciech Tlustochowicz, Witold Kapolka, Danuta Sadkiewicz, Stefan Zarowny-Wierzbinska, Danuta Ionescu, Ruxandra Predeteanu, Denisa Karateev, Dmitry Luchikhina, Elena Chichasova, Natalia Badokin, Vladimir Skakic, Vlado Dimic, Aleksander Nedovic, Jovan Stankovic, Aleksandra Naranjo, Antonio Rodríguez-Lozano, Carlos Calvo-Alen, Jaime Belmonte, Miguel Baecklund, Eva Henrohn, Dan Oding, Rolf Liveborn, Margareth Holmqvist, Ann-Carin Gogus, Feride Tunc, Recep Celic, Selda Badsha, Humeira Mofti, Ayman Taylor, Peter McClinton, Catherine Woolf, Anthony Chorghade, Ginny Choy, Ernest Kelly, Stephen Pincus, Theodore Yazici, Yusuf Bergman, Martin Craig-Muller, Jurgen Kautiainen, Hannu Swearingen, Christopher |
dc.subject.por.fl_str_mv |
Bmi Disease activity Gender Rheumatoid arthritis |
topic |
Bmi Disease activity Gender Rheumatoid arthritis |
description |
Objective: To investigate whether body mass index (BMI), as a proxy for body fat, influences rheumatoid arthritis (RA) disease activity in a gender-specific manner. Methods: Consecutive patients with RA were enrolled from 25 countries into the QUEST-RA program between 2005 and 2008. Clinical and demographic data were collected by treating rheumatologists and by patient self-report. Distributions of Disease Activity Scores (DAS28), BMI, age, and disease duration were assessed for each country and for the entire dataset; mean values between genders were compared using Student's t-tests. An association between BMI and DAS28 was investigated using linear regression, adjusting for age, disease duration and country. Results: A total of 5,161 RA patients (4,082 women and 1,079 men) were included in the analyses. Overall, women were younger, had longer disease duration, and higher DAS28 scores than men, but BMI was similar between genders. The mean DAS28 scores increased with increasing BMI from normal to overweight and obese, among women, whereas the opposite trend was observed among men. Regression results showed BMI (continuous or categorical) to be associated with DAS28. Compared to the normal BMI range, being obese was associated with a larger difference in mean DAS28 (0.23, 95% CI: 0.11, 0.34) than being overweight (0.12, 95% CI: 0.03, 0.21); being underweight was not associated with disease activity. These associations were more pronounced among women, and were not explained by any single component of the DAS28. Conclusion: BMI appears to be associated with RA disease activity in women, but not in men. © Copyright Clinical and Experimental Rheumatology 2010. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-12-01 2022-04-28T18:56:40Z 2022-04-28T18:56:40Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Clinical and Experimental Rheumatology, v. 28, n. 4, p. 454-461, 2010. 0392-856X 1593-098X http://hdl.handle.net/11449/219633 2-s2.0-79952056556 |
identifier_str_mv |
Clinical and Experimental Rheumatology, v. 28, n. 4, p. 454-461, 2010. 0392-856X 1593-098X 2-s2.0-79952056556 |
url |
http://hdl.handle.net/11449/219633 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Clinical and Experimental Rheumatology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
454-461 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1797789871286255616 |