New Palladium(II) Complexes Containing Methyl Gallate and Octyl Gallate: Effect against Mycobacterium tuberculosis and Campylobacter jejuni

• Autor(a) principal: Silva, Raphael Tristão Cruvinel
• Data de Publicação: 2023
• Outros Autores: Guidotti-Takeuchi, Micaela, Peixoto, Jéssica Laura Miranda, Demarqui, Fernanda Manaia [UNESP], Mori, Ananda Paula, Dumont, Carolyne Ferreira, Ferreira, Gabriella Rayane Aparecida, Pereira, Gabriele de Menezes, Rossi, Daise Aparecida, Corbi, Pedro Paulo, Pavan, Fernando Rogério [UNESP], Rezende Júnior, Celso de Oliveira, Melo, Roberta Torres de, Guerra, Wendell
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.3390/molecules28093887; http://hdl.handle.net/11449/249955
• topic: anti-infective drugs; antibacterial activity; Campylobacter jejuni; Mycobacterium tuberculosis; palladium(II) complexes

This work describes the preparation, characterization and antimicrobial activity of four palladium(II) complexes, namely, [Pd(meg)(1,10-phen)] 1, [Pd(meg)(PPh3)2] 2, [Pd(og)(1,10-phen)] 3 and [Pd(og)(PPh3)2] 4, where meg = methyl gallate, og = octyl gallate, 1,10-phen = 1,10-phenanthroline and PPh3 = triphenylphosphine. As to the chemical structures, spectral and physicochemical studies of 1–4 indicated that methyl or octyl gallate coordinates a palladium(II) ion through two oxygen atoms upon deprotonation. A chelating bidentate phenanthroline or two triphenylphosphine molecules complete the coordination sphere of palladium(II) ion, depending on the complex. The metal complexes were tested against the Mycobacterium tuberculosis H37Rv strain and 2 exhibited high activity (MIC = 3.28 μg/mL). As to the tests with Campylobacter jejuni, complex 1 showed a significant effect in reducing bacterial population (greater than 7 log CFU) in planktonic forms, as well as in the biomass intensity (IBF: 0.87) when compared to peracetic acid (IBF: 1.11) at a concentration of 400 μg/mL. The effect provided by these complexes has specificity according to the target microorganism and represent a promising alternative for the control of microorganisms of public health importance.