Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer
Main Author: | |
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Publication Date: | 2016 |
Other Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Format: | Article |
Language: | eng |
Source: | Repositório Institucional da UNESP |
Download full: | http://dx.doi.org/10.7554/eLife.14552 http://hdl.handle.net/11449/158902 |
Summary: | Canine transmissible venereal tumour (CTVT) is a clonally transmissible cancer that originated approximately 11,000 years ago and affects dogs worldwide. Despite the clonal origin of the CTVT nuclear genome, CTVT mitochondrial genomes (mtDNAs) have been acquired by periodic capture from transient hosts. We sequenced 449 complete mtDNAs from a global population of CTVTs, and show that mtDNA horizontal transfer has occurred at least five times, delineating five tumour clades whose distributions track two millennia of dog global migration. Negative selection has operated to prevent accumulation of deleterious mutations in captured mtDNA, and recombination has caused occasional mtDNA re-assortment. These findings implicate functional mtDNA as a driver of CTVT global metastatic spread, further highlighting the important role of mtDNA in cancer evolution. |
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Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancerCanine transmissible venereal tumour (CTVT) is a clonally transmissible cancer that originated approximately 11,000 years ago and affects dogs worldwide. Despite the clonal origin of the CTVT nuclear genome, CTVT mitochondrial genomes (mtDNAs) have been acquired by periodic capture from transient hosts. We sequenced 449 complete mtDNAs from a global population of CTVTs, and show that mtDNA horizontal transfer has occurred at least five times, delineating five tumour clades whose distributions track two millennia of dog global migration. Negative selection has operated to prevent accumulation of deleterious mutations in captured mtDNA, and recombination has caused occasional mtDNA re-assortment. These findings implicate functional mtDNA as a driver of CTVT global metastatic spread, further highlighting the important role of mtDNA in cancer evolution.Wellcome TrustLeverhulme TrustRoyal SocietyUniv Cambridge, Dept Vet Med, Cambridge, EnglandChinese Acad Sci, Kunming Inst Zool, Yunnan Lab Mol Biol Domest Anim, State Key Lab Genet Resources & Evolut, Kunming, Peoples R ChinaInt Training Ctr, Worldwide Vet Serv, Aruvankadu, IndiaAnim Management Rural & Remote Indigenous Commun, Darwin, NT, AustraliaWorld Vets, Fargo, ND USAStichting Dierenbescherming Suriname, Paramaribo, SurinamUniv Panama, Corozal Vet Hosp, Panama City, PanamaSao Paulo State Univ, Dept Clin & Vet Surg, Sao Paulo, BrazilSt Georges Univ, True Blue, GrenadaNakuru Dist Vet Scheme Ltd, Nakuru, KenyaAnim Med Ctr, Belize City, BelizeVet Clin Sr Dogs, Guadalajara, MexicoNatl Inst Vet Res, Vom, NigeriaInt Fund Anim Welf, Quintana Roo, MexicoIntermunicipal Stray Anim Care Ctr, Perama, GreeceAnim Protect Soc Samoa, Apia, SamoaUniv Zulia, Fac Vet Sci, Maracaibo, VenezuelaVet Clin BIOCONTROL, Moscow, RussiaVet Clin El Roble, Santiago, ChileCtr Vet Berna, OnevetGrp, Lisbon, PortugalVet Clin Zoovetservis, Kiev, UkraineBryanston Vet Hosp, Bryanston, South AfricaVet Clin Lopez Quintana, Maldonado, UruguayClin Vet Grand Fond, St Gilles Les Bains, FranceUniv Messina, Dept Vet Sci, Messina, ItalyWellcome Trust Sanger Inst, Hinxton, EnglandUniv Autonoma Estado Mexico, Fac Med Vet & Zootecnia, Toluca, MexicoAmer Univ, Sch Vet Med, Quito, EcuadorTouray & Meyer Vet Clin, Serrekunda, GambiaKampala Vet Surg, Kampala, UgandaVets Borders, The Rocks, AustraliaAniworld Vet Clin, Kisumu, KenyaAutonomous Univ Yucatan, Fac Vet Med, Merida, MexicoUniv Lisbon, Fac Vet Med, Interdisciplinary Ctr Res Anim Hlth, P-1699 Lisbon, PortugalHelp Suffering, Jaipur, Rajasthan, IndiaVet Clin Dr Jose Rojas, Los Andes, ChileUniv Vet & Anim Sci, Lahore, PakistanCorozal Vet Clin, Corozal Town, BelizeVet Clin Vetmaster, Ramenskoye, RussiaLilongwe Soc Protect & Care Anim, Lilongwe, MalawiState Hosp Vet Med, Dniprodzerzhynsk, UkraineKenya Soc Protect & Care Anim, Nairobi, KenyaFac Vet Med, Dept Clin Sci, Bucharest, RomaniaLadybrand Anim Clin, Ladybrand, South AfricaVet Oncol Referral Ctr Ottenhorst, Terneuzen, NetherlandsNatl Univ Asunc, Fac Vet Sci, San Lorenzo, ParaguayAnim Anti Cruelty League, Port Elizabeth, South AfricaSao Paulo State Univ, Dept Clin & Vet Surg, Sao Paulo, BrazilWellcome Trust: 102942/Z/13/ARoyal Society: RG130615Elife Sciences Publications LtdUniv CambridgeChinese Acad SciInt Training CtrAnim Management Rural & Remote Indigenous CommunWorld VetsStichting Dierenbescherming SurinameUniv PanamaUniversidade Estadual Paulista (Unesp)St Georges UnivNakuru Dist Vet Scheme LtdAnim Med CtrVet Clin Sr DogsNatl Inst Vet ResInt Fund Anim WelfIntermunicipal Stray Anim Care CtrAnim Protect Soc SamoaUniv ZuliaVet Clin BIOCONTROLVet Clin El RobleCtr Vet BernaVet Clin ZoovetservisBryanston Vet HospVet Clin Lopez QuintanaClin Vet Grand FondUniv MessinaWellcome Trust Sanger InstUniv Autonoma Estado MexicoAmer UnivTouray & Meyer Vet ClinKampala Vet SurgVets BordersAniworld Vet ClinAutonomous Univ YucatanUniv LisbonHelp SufferingVet Clin Dr Jose RojasUniv Vet & Anim SciCorozal Vet ClinVet Clin VetmasterLilongwe Soc Protect & Care AnimState Hosp Vet MedKenya Soc Protect & Care AnimFac Vet MedLadybrand Anim ClinVet Oncol Referral Ctr OttenhorstNatl Univ AsuncAnim Anti Cruelty LeagueStrakova, AndreaLeathlobhair, Maire NiWang, Guo-DongYin, Ting-TingAirikkala-Otter, IlonaAllen, Janice L.Allum, Karen M.Bansse-Issa, LeontineBisson, Jocelyn L.Domracheva, Artemio CastilloCastro, Karina F. de [UNESP]Corrigan, Anne M.Cran, Hugh R.Crawford, Jane T.Cutter, Stephen M.Keenan, Laura DelgadilloDonelan, Edward M.Faramade, Ibikunle A.Reynoso, Erika FloresFotopoulou, EleniFruean, Skye N.Gallardo-Arrieta, FannyGlebova, OlgaHaefelin Manrique, Rodrigo F.Henriques, Joaquim J. G. P.Ignatenko, NataliaKoenig, DebbieLanza-Perea, MartaLobetti, RemoLopez Quintana, Adriana M.Losfelt, ThibaultMarino, GabrieleMartincorena, InigoCastaneda, Simon MartinezMartinez-Lopez, Mayra F.Meyer, MichaelNakanwagi, BerneDe Nardi, Andrigo B. [UNESP]Neunzie, WinifredNixon, Sally J.Onsare, Marsden M.Ortega-Pacheco, AntonioPeleteiro, Maria C.Pye, Ruth J.Reece, John F.Gutierrez, Jose RojasSadia, HaleemaSchmeling, Sheila K.Shamanova, OlgaSsuna, Richard K.Steenland-Smith, Audrey E.Svitich, AllaNgoka, Ismail ThoyaVitalaru, Bogdan A.Vos, Anna P. deVos, Johan P. deWalkinton, OliverWedge, David C.Wehrle-Martinez, Alvaro S.van der Wel, Mirjam G.Widdowson, Sophie A. E.Murchison, Elizabeth P.2018-11-26T15:29:55Z2018-11-26T15:29:55Z2016-05-17info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article25application/pdfhttp://dx.doi.org/10.7554/eLife.14552Elife. Cambridge: Elife Sciences Publications Ltd, v. 5, 25 p., 2016.2050-084Xhttp://hdl.handle.net/11449/15890210.7554/eLife.14552WOS:000376922000001WOS000376922000001.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengElifeinfo:eu-repo/semantics/openAccess2023-11-19T06:12:37Zoai:repositorio.unesp.br:11449/158902Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-19T06:12:37Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer |
title |
Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer |
spellingShingle |
Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer Strakova, Andrea |
title_short |
Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer |
title_full |
Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer |
title_fullStr |
Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer |
title_full_unstemmed |
Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer |
title_sort |
Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer |
author |
Strakova, Andrea |
author_facet |
Strakova, Andrea Leathlobhair, Maire Ni Wang, Guo-Dong Yin, Ting-Ting Airikkala-Otter, Ilona Allen, Janice L. Allum, Karen M. Bansse-Issa, Leontine Bisson, Jocelyn L. Domracheva, Artemio Castillo Castro, Karina F. de [UNESP] Corrigan, Anne M. Cran, Hugh R. Crawford, Jane T. Cutter, Stephen M. Keenan, Laura Delgadillo Donelan, Edward M. Faramade, Ibikunle A. Reynoso, Erika Flores Fotopoulou, Eleni Fruean, Skye N. Gallardo-Arrieta, Fanny Glebova, Olga Haefelin Manrique, Rodrigo F. Henriques, Joaquim J. G. P. Ignatenko, Natalia Koenig, Debbie Lanza-Perea, Marta Lobetti, Remo Lopez Quintana, Adriana M. Losfelt, Thibault Marino, Gabriele Martincorena, Inigo Castaneda, Simon Martinez Martinez-Lopez, Mayra F. Meyer, Michael Nakanwagi, Berne De Nardi, Andrigo B. [UNESP] Neunzie, Winifred Nixon, Sally J. Onsare, Marsden M. Ortega-Pacheco, Antonio Peleteiro, Maria C. Pye, Ruth J. Reece, John F. Gutierrez, Jose Rojas Sadia, Haleema Schmeling, Sheila K. Shamanova, Olga Ssuna, Richard K. Steenland-Smith, Audrey E. Svitich, Alla Ngoka, Ismail Thoya Vitalaru, Bogdan A. Vos, Anna P. de Vos, Johan P. de Walkinton, Oliver Wedge, David C. Wehrle-Martinez, Alvaro S. van der Wel, Mirjam G. Widdowson, Sophie A. E. Murchison, Elizabeth P. |
author_role |
author |
author2 |
Leathlobhair, Maire Ni Wang, Guo-Dong Yin, Ting-Ting Airikkala-Otter, Ilona Allen, Janice L. Allum, Karen M. Bansse-Issa, Leontine Bisson, Jocelyn L. Domracheva, Artemio Castillo Castro, Karina F. de [UNESP] Corrigan, Anne M. Cran, Hugh R. Crawford, Jane T. Cutter, Stephen M. Keenan, Laura Delgadillo Donelan, Edward M. Faramade, Ibikunle A. Reynoso, Erika Flores Fotopoulou, Eleni Fruean, Skye N. Gallardo-Arrieta, Fanny Glebova, Olga Haefelin Manrique, Rodrigo F. Henriques, Joaquim J. G. P. Ignatenko, Natalia Koenig, Debbie Lanza-Perea, Marta Lobetti, Remo Lopez Quintana, Adriana M. Losfelt, Thibault Marino, Gabriele Martincorena, Inigo Castaneda, Simon Martinez Martinez-Lopez, Mayra F. Meyer, Michael Nakanwagi, Berne De Nardi, Andrigo B. [UNESP] Neunzie, Winifred Nixon, Sally J. Onsare, Marsden M. Ortega-Pacheco, Antonio Peleteiro, Maria C. Pye, Ruth J. Reece, John F. Gutierrez, Jose Rojas Sadia, Haleema Schmeling, Sheila K. Shamanova, Olga Ssuna, Richard K. Steenland-Smith, Audrey E. Svitich, Alla Ngoka, Ismail Thoya Vitalaru, Bogdan A. Vos, Anna P. de Vos, Johan P. de Walkinton, Oliver Wedge, David C. Wehrle-Martinez, Alvaro S. van der Wel, Mirjam G. Widdowson, Sophie A. E. Murchison, Elizabeth P. |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Univ Cambridge Chinese Acad Sci Int Training Ctr Anim Management Rural & Remote Indigenous Commun World Vets Stichting Dierenbescherming Suriname Univ Panama Universidade Estadual Paulista (Unesp) St Georges Univ Nakuru Dist Vet Scheme Ltd Anim Med Ctr Vet Clin Sr Dogs Natl Inst Vet Res Int Fund Anim Welf Intermunicipal Stray Anim Care Ctr Anim Protect Soc Samoa Univ Zulia Vet Clin BIOCONTROL Vet Clin El Roble Ctr Vet Berna Vet Clin Zoovetservis Bryanston Vet Hosp Vet Clin Lopez Quintana Clin Vet Grand Fond Univ Messina Wellcome Trust Sanger Inst Univ Autonoma Estado Mexico Amer Univ Touray & Meyer Vet Clin Kampala Vet Surg Vets Borders Aniworld Vet Clin Autonomous Univ Yucatan Univ Lisbon Help Suffering Vet Clin Dr Jose Rojas Univ Vet & Anim Sci Corozal Vet Clin Vet Clin Vetmaster Lilongwe Soc Protect & Care Anim State Hosp Vet Med Kenya Soc Protect & Care Anim Fac Vet Med Ladybrand Anim Clin Vet Oncol Referral Ctr Ottenhorst Natl Univ Asunc Anim Anti Cruelty League |
dc.contributor.author.fl_str_mv |
Strakova, Andrea Leathlobhair, Maire Ni Wang, Guo-Dong Yin, Ting-Ting Airikkala-Otter, Ilona Allen, Janice L. Allum, Karen M. Bansse-Issa, Leontine Bisson, Jocelyn L. Domracheva, Artemio Castillo Castro, Karina F. de [UNESP] Corrigan, Anne M. Cran, Hugh R. Crawford, Jane T. Cutter, Stephen M. Keenan, Laura Delgadillo Donelan, Edward M. Faramade, Ibikunle A. Reynoso, Erika Flores Fotopoulou, Eleni Fruean, Skye N. Gallardo-Arrieta, Fanny Glebova, Olga Haefelin Manrique, Rodrigo F. Henriques, Joaquim J. G. P. Ignatenko, Natalia Koenig, Debbie Lanza-Perea, Marta Lobetti, Remo Lopez Quintana, Adriana M. Losfelt, Thibault Marino, Gabriele Martincorena, Inigo Castaneda, Simon Martinez Martinez-Lopez, Mayra F. Meyer, Michael Nakanwagi, Berne De Nardi, Andrigo B. [UNESP] Neunzie, Winifred Nixon, Sally J. Onsare, Marsden M. Ortega-Pacheco, Antonio Peleteiro, Maria C. Pye, Ruth J. Reece, John F. Gutierrez, Jose Rojas Sadia, Haleema Schmeling, Sheila K. Shamanova, Olga Ssuna, Richard K. Steenland-Smith, Audrey E. Svitich, Alla Ngoka, Ismail Thoya Vitalaru, Bogdan A. Vos, Anna P. de Vos, Johan P. de Walkinton, Oliver Wedge, David C. Wehrle-Martinez, Alvaro S. van der Wel, Mirjam G. Widdowson, Sophie A. E. Murchison, Elizabeth P. |
description |
Canine transmissible venereal tumour (CTVT) is a clonally transmissible cancer that originated approximately 11,000 years ago and affects dogs worldwide. Despite the clonal origin of the CTVT nuclear genome, CTVT mitochondrial genomes (mtDNAs) have been acquired by periodic capture from transient hosts. We sequenced 449 complete mtDNAs from a global population of CTVTs, and show that mtDNA horizontal transfer has occurred at least five times, delineating five tumour clades whose distributions track two millennia of dog global migration. Negative selection has operated to prevent accumulation of deleterious mutations in captured mtDNA, and recombination has caused occasional mtDNA re-assortment. These findings implicate functional mtDNA as a driver of CTVT global metastatic spread, further highlighting the important role of mtDNA in cancer evolution. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-05-17 2018-11-26T15:29:55Z 2018-11-26T15:29:55Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.7554/eLife.14552 Elife. Cambridge: Elife Sciences Publications Ltd, v. 5, 25 p., 2016. 2050-084X http://hdl.handle.net/11449/158902 10.7554/eLife.14552 WOS:000376922000001 WOS000376922000001.pdf |
url |
http://dx.doi.org/10.7554/eLife.14552 http://hdl.handle.net/11449/158902 |
identifier_str_mv |
Elife. Cambridge: Elife Sciences Publications Ltd, v. 5, 25 p., 2016. 2050-084X 10.7554/eLife.14552 WOS:000376922000001 WOS000376922000001.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Elife |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
25 application/pdf |
dc.publisher.none.fl_str_mv |
Elife Sciences Publications Ltd |
publisher.none.fl_str_mv |
Elife Sciences Publications Ltd |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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