Spongiotic hyperplasia of the oral mucosa: case series and immunohistochemical analysis
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s10006-021-00996-2 http://hdl.handle.net/11449/229330 |
Resumo: | The localized juvenile spongiotic gingival hyperplasia (LJSGH) mainly affects the maxillary vestibular attached gingiva of juvenile patients, without sex predilection. Similar lesions involving extragingival sites have not been reported to date. Here, we report 2 cases of extragingival soft tissue lesions with similar clinicopathological features to those reported in LJSGH and 12 cases of intraoral reactive soft tissue lesions microscopically showing LJSGH-like focal areas. The 2 cases were adult patients, affecting the maxillary alveolar ridge (55-year-old female) and hard palate (78-year-old male), which were diagnosed as “spongiotic hyperplasia of the oral mucosa.” The 12 intraoral reactive soft tissue lesions (6 men and 6 women; mean age, 49.5 years) were diagnosed as inflammatory fibrous hyperplasia (n = 6), peripheral ossifying fibroma (n = 3), and pyogenic granuloma (n = 3), each of them presenting LJSGH-like focal areas. By immunohistochemistry, the spongiotic hyperplasia areas showed positivity for CK19, CK14, CK34βE12, and CAM5.2 (weak/focal), while CK4 was negative. Considering the anatomical locations (extragingival) of these 2 cases, the term “spongiotic hyperplasia of the oral mucosa” is suggested. Moreover, LJSGH-like focal areas can be detected when microscopically assessing common intraoral reactive soft tissue lesions. |
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Spongiotic hyperplasia of the oral mucosa: case series and immunohistochemical analysisImmunohistochemistryLocalized juvenile spongiotic gingival hyperplasiaOral mucosaReactive soft tissue lesionsThe localized juvenile spongiotic gingival hyperplasia (LJSGH) mainly affects the maxillary vestibular attached gingiva of juvenile patients, without sex predilection. Similar lesions involving extragingival sites have not been reported to date. Here, we report 2 cases of extragingival soft tissue lesions with similar clinicopathological features to those reported in LJSGH and 12 cases of intraoral reactive soft tissue lesions microscopically showing LJSGH-like focal areas. The 2 cases were adult patients, affecting the maxillary alveolar ridge (55-year-old female) and hard palate (78-year-old male), which were diagnosed as “spongiotic hyperplasia of the oral mucosa.” The 12 intraoral reactive soft tissue lesions (6 men and 6 women; mean age, 49.5 years) were diagnosed as inflammatory fibrous hyperplasia (n = 6), peripheral ossifying fibroma (n = 3), and pyogenic granuloma (n = 3), each of them presenting LJSGH-like focal areas. By immunohistochemistry, the spongiotic hyperplasia areas showed positivity for CK19, CK14, CK34βE12, and CAM5.2 (weak/focal), while CK4 was negative. Considering the anatomical locations (extragingival) of these 2 cases, the term “spongiotic hyperplasia of the oral mucosa” is suggested. Moreover, LJSGH-like focal areas can be detected when microscopically assessing common intraoral reactive soft tissue lesions.Department of Diagnosis and Surgery Araraquara Dental School São Paulo State University (UNESP)Oral Pathology Department of Stomatology Public Oral Health and Forensic Dentistry Ribeirão Preto Dental School (FORP/USP) University of São PauloSchool of Dentistry National Autonomous University of MexicoUniversidade Vale Do Rio Verde (UninCor)Department of Pathology and Forensic Medicine Ribeirão Preto Medical School (FMRP/USP) University of São PauloDepartment of Diagnosis and Surgery Univ Estadual Paulista (UNESP), Rua Humaitá, 1680Department of Diagnosis and Surgery Araraquara Dental School São Paulo State University (UNESP)Department of Diagnosis and Surgery Univ Estadual Paulista (UNESP), Rua Humaitá, 1680Universidade Estadual Paulista (UNESP)Universidade de São Paulo (USP)National Autonomous University of MexicoUniversidade Vale Do Rio Verde (UninCor)Silveira, Heitor Albergoni [UNESP]Toral-Rizo, Victor HugoLara-Carrillo, EdithDominguete, Matheus Henrique LopesSilva, Evânio Vilela [UNESP]Ribeiro-Silva, AlfredoBufalino, Andreia [UNESP]Almeida, Luciana Yamamoto [UNESP]León, Jorge Esquiche2022-04-29T08:31:59Z2022-04-29T08:31:59Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1007/s10006-021-00996-2Oral and Maxillofacial Surgery.1865-15691865-1550http://hdl.handle.net/11449/22933010.1007/s10006-021-00996-22-s2.0-85112562171Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengOral and Maxillofacial Surgeryinfo:eu-repo/semantics/openAccess2022-04-29T08:31:59Zoai:repositorio.unesp.br:11449/229330Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-29T08:31:59Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Spongiotic hyperplasia of the oral mucosa: case series and immunohistochemical analysis |
title |
Spongiotic hyperplasia of the oral mucosa: case series and immunohistochemical analysis |
spellingShingle |
Spongiotic hyperplasia of the oral mucosa: case series and immunohistochemical analysis Silveira, Heitor Albergoni [UNESP] Immunohistochemistry Localized juvenile spongiotic gingival hyperplasia Oral mucosa Reactive soft tissue lesions |
title_short |
Spongiotic hyperplasia of the oral mucosa: case series and immunohistochemical analysis |
title_full |
Spongiotic hyperplasia of the oral mucosa: case series and immunohistochemical analysis |
title_fullStr |
Spongiotic hyperplasia of the oral mucosa: case series and immunohistochemical analysis |
title_full_unstemmed |
Spongiotic hyperplasia of the oral mucosa: case series and immunohistochemical analysis |
title_sort |
Spongiotic hyperplasia of the oral mucosa: case series and immunohistochemical analysis |
author |
Silveira, Heitor Albergoni [UNESP] |
author_facet |
Silveira, Heitor Albergoni [UNESP] Toral-Rizo, Victor Hugo Lara-Carrillo, Edith Dominguete, Matheus Henrique Lopes Silva, Evânio Vilela [UNESP] Ribeiro-Silva, Alfredo Bufalino, Andreia [UNESP] Almeida, Luciana Yamamoto [UNESP] León, Jorge Esquiche |
author_role |
author |
author2 |
Toral-Rizo, Victor Hugo Lara-Carrillo, Edith Dominguete, Matheus Henrique Lopes Silva, Evânio Vilela [UNESP] Ribeiro-Silva, Alfredo Bufalino, Andreia [UNESP] Almeida, Luciana Yamamoto [UNESP] León, Jorge Esquiche |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Universidade de São Paulo (USP) National Autonomous University of Mexico Universidade Vale Do Rio Verde (UninCor) |
dc.contributor.author.fl_str_mv |
Silveira, Heitor Albergoni [UNESP] Toral-Rizo, Victor Hugo Lara-Carrillo, Edith Dominguete, Matheus Henrique Lopes Silva, Evânio Vilela [UNESP] Ribeiro-Silva, Alfredo Bufalino, Andreia [UNESP] Almeida, Luciana Yamamoto [UNESP] León, Jorge Esquiche |
dc.subject.por.fl_str_mv |
Immunohistochemistry Localized juvenile spongiotic gingival hyperplasia Oral mucosa Reactive soft tissue lesions |
topic |
Immunohistochemistry Localized juvenile spongiotic gingival hyperplasia Oral mucosa Reactive soft tissue lesions |
description |
The localized juvenile spongiotic gingival hyperplasia (LJSGH) mainly affects the maxillary vestibular attached gingiva of juvenile patients, without sex predilection. Similar lesions involving extragingival sites have not been reported to date. Here, we report 2 cases of extragingival soft tissue lesions with similar clinicopathological features to those reported in LJSGH and 12 cases of intraoral reactive soft tissue lesions microscopically showing LJSGH-like focal areas. The 2 cases were adult patients, affecting the maxillary alveolar ridge (55-year-old female) and hard palate (78-year-old male), which were diagnosed as “spongiotic hyperplasia of the oral mucosa.” The 12 intraoral reactive soft tissue lesions (6 men and 6 women; mean age, 49.5 years) were diagnosed as inflammatory fibrous hyperplasia (n = 6), peripheral ossifying fibroma (n = 3), and pyogenic granuloma (n = 3), each of them presenting LJSGH-like focal areas. By immunohistochemistry, the spongiotic hyperplasia areas showed positivity for CK19, CK14, CK34βE12, and CAM5.2 (weak/focal), while CK4 was negative. Considering the anatomical locations (extragingival) of these 2 cases, the term “spongiotic hyperplasia of the oral mucosa” is suggested. Moreover, LJSGH-like focal areas can be detected when microscopically assessing common intraoral reactive soft tissue lesions. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 2022-04-29T08:31:59Z 2022-04-29T08:31:59Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s10006-021-00996-2 Oral and Maxillofacial Surgery. 1865-1569 1865-1550 http://hdl.handle.net/11449/229330 10.1007/s10006-021-00996-2 2-s2.0-85112562171 |
url |
http://dx.doi.org/10.1007/s10006-021-00996-2 http://hdl.handle.net/11449/229330 |
identifier_str_mv |
Oral and Maxillofacial Surgery. 1865-1569 1865-1550 10.1007/s10006-021-00996-2 2-s2.0-85112562171 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Oral and Maxillofacial Surgery |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965161205792768 |