Determination of elemental impurities in acyclovir ointment and raw materials using microwave acid digestion (MW-AD) and ICP-MS
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.5935/0103-5053.20160151 http://hdl.handle.net/11449/169210 |
Resumo: | Inorganic elements present in pharmaceutical products were determined by inductively coupled plasma-mass spectrometer (ICP-MS), employing microwave acid digestion as a sample preparation method. The most abundant isotopes, 75As+, 65Cu+, 52Cr+, 58Ni+, 208Pb+, and 51V+, were determined in acyclovir ointment and its constituents. Elemental impurities in the pharmaceutical samples were determined using an inductively coupled plasma-universal cell technology-mass spectrometer (ICP-UCT-MS) operated in kinetic energy discrimination (KED) and standard mode. The accuracy of the method was assessed by means of addition and recovery experiments. Except for Cr, spiked recoveries of the elements added to the samples before microwave acid digestion (MW-AD) step were between 95.1 and 126%, and after MW-AD step ranged from 85.6 to 132%. Limits of detection (LOD) obtained by proposed method is in agreement to those required by the U.S. Pharmacopeia Convention (USP), showing that the ICP-MS technique is well suited for quantification of these elements. The LOD's (ng L-1) for 51V+, 52Cr+, 58Ni+, 65Cu+, 75As+ and 208Pb+ in 1% v v-1 HNO3 medium were: 2.2, 81.3, 91.9, 6.9, 0.2 and 3.1, respectively. The concentration of the analytes in these samples presented a wide range, varying from 2.3 ± 0.8 μg kg-1 for As to 3446 ± 47 μg kg-1 for Cr. |
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Determination of elemental impurities in acyclovir ointment and raw materials using microwave acid digestion (MW-AD) and ICP-MSAcyclovirElemental impurityICP-MSMicrowave acid digestion (MW-AD)Pharmaceutical productInorganic elements present in pharmaceutical products were determined by inductively coupled plasma-mass spectrometer (ICP-MS), employing microwave acid digestion as a sample preparation method. The most abundant isotopes, 75As+, 65Cu+, 52Cr+, 58Ni+, 208Pb+, and 51V+, were determined in acyclovir ointment and its constituents. Elemental impurities in the pharmaceutical samples were determined using an inductively coupled plasma-universal cell technology-mass spectrometer (ICP-UCT-MS) operated in kinetic energy discrimination (KED) and standard mode. The accuracy of the method was assessed by means of addition and recovery experiments. Except for Cr, spiked recoveries of the elements added to the samples before microwave acid digestion (MW-AD) step were between 95.1 and 126%, and after MW-AD step ranged from 85.6 to 132%. Limits of detection (LOD) obtained by proposed method is in agreement to those required by the U.S. Pharmacopeia Convention (USP), showing that the ICP-MS technique is well suited for quantification of these elements. The LOD's (ng L-1) for 51V+, 52Cr+, 58Ni+, 65Cu+, 75As+ and 208Pb+ in 1% v v-1 HNO3 medium were: 2.2, 81.3, 91.9, 6.9, 0.2 and 3.1, respectively. The concentration of the analytes in these samples presented a wide range, varying from 2.3 ± 0.8 μg kg-1 for As to 3446 ± 47 μg kg-1 for Cr.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Departamento de Química e Ciências Ambientais Universidade Estadual Paulista UNESP CP 136Embrapa Pecuária SudesteGrupo de Análise Instrumental Aplicada Departamento de Química Universidade Federal de São CarlosEmbrapa SolosDepartamento de Química Universidade Federal do ParanáDepartamento de Química e Ciências Ambientais Universidade Estadual Paulista UNESP CP 136CAPES: 15/2104FAPESP: 2015/08873-9Universidade Estadual Paulista (Unesp)Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA)Universidade Federal de São Carlos (UFSCar)Universidade Federal do Paraná (UFPR)Gonzalez, Mario H. [UNESP]Da Silva, Caroline S.Amaral, Clarice D. B.Bianchi, Silmara R.De Oliveira, Luciano H. B. [UNESP]Coelho, Jéssica S. [UNESP]Oliveira, AndreaNogueira, Ana Rita A.2018-12-11T16:44:55Z2018-12-11T16:44:55Z2017-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article98-105application/pdfhttp://dx.doi.org/10.5935/0103-5053.20160151Journal of the Brazilian Chemical Society, v. 28, n. 1, p. 98-105, 2017.1678-47900103-5053http://hdl.handle.net/11449/16921010.5935/0103-5053.20160151S0103-505320170001000982-s2.0-85003845098S0103-50532017000100098.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of the Brazilian Chemical Society0,3570,357info:eu-repo/semantics/openAccess2023-11-16T06:14:54Zoai:repositorio.unesp.br:11449/169210Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-16T06:14:54Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Determination of elemental impurities in acyclovir ointment and raw materials using microwave acid digestion (MW-AD) and ICP-MS |
title |
Determination of elemental impurities in acyclovir ointment and raw materials using microwave acid digestion (MW-AD) and ICP-MS |
spellingShingle |
Determination of elemental impurities in acyclovir ointment and raw materials using microwave acid digestion (MW-AD) and ICP-MS Gonzalez, Mario H. [UNESP] Acyclovir Elemental impurity ICP-MS Microwave acid digestion (MW-AD) Pharmaceutical product |
title_short |
Determination of elemental impurities in acyclovir ointment and raw materials using microwave acid digestion (MW-AD) and ICP-MS |
title_full |
Determination of elemental impurities in acyclovir ointment and raw materials using microwave acid digestion (MW-AD) and ICP-MS |
title_fullStr |
Determination of elemental impurities in acyclovir ointment and raw materials using microwave acid digestion (MW-AD) and ICP-MS |
title_full_unstemmed |
Determination of elemental impurities in acyclovir ointment and raw materials using microwave acid digestion (MW-AD) and ICP-MS |
title_sort |
Determination of elemental impurities in acyclovir ointment and raw materials using microwave acid digestion (MW-AD) and ICP-MS |
author |
Gonzalez, Mario H. [UNESP] |
author_facet |
Gonzalez, Mario H. [UNESP] Da Silva, Caroline S. Amaral, Clarice D. B. Bianchi, Silmara R. De Oliveira, Luciano H. B. [UNESP] Coelho, Jéssica S. [UNESP] Oliveira, Andrea Nogueira, Ana Rita A. |
author_role |
author |
author2 |
Da Silva, Caroline S. Amaral, Clarice D. B. Bianchi, Silmara R. De Oliveira, Luciano H. B. [UNESP] Coelho, Jéssica S. [UNESP] Oliveira, Andrea Nogueira, Ana Rita A. |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA) Universidade Federal de São Carlos (UFSCar) Universidade Federal do Paraná (UFPR) |
dc.contributor.author.fl_str_mv |
Gonzalez, Mario H. [UNESP] Da Silva, Caroline S. Amaral, Clarice D. B. Bianchi, Silmara R. De Oliveira, Luciano H. B. [UNESP] Coelho, Jéssica S. [UNESP] Oliveira, Andrea Nogueira, Ana Rita A. |
dc.subject.por.fl_str_mv |
Acyclovir Elemental impurity ICP-MS Microwave acid digestion (MW-AD) Pharmaceutical product |
topic |
Acyclovir Elemental impurity ICP-MS Microwave acid digestion (MW-AD) Pharmaceutical product |
description |
Inorganic elements present in pharmaceutical products were determined by inductively coupled plasma-mass spectrometer (ICP-MS), employing microwave acid digestion as a sample preparation method. The most abundant isotopes, 75As+, 65Cu+, 52Cr+, 58Ni+, 208Pb+, and 51V+, were determined in acyclovir ointment and its constituents. Elemental impurities in the pharmaceutical samples were determined using an inductively coupled plasma-universal cell technology-mass spectrometer (ICP-UCT-MS) operated in kinetic energy discrimination (KED) and standard mode. The accuracy of the method was assessed by means of addition and recovery experiments. Except for Cr, spiked recoveries of the elements added to the samples before microwave acid digestion (MW-AD) step were between 95.1 and 126%, and after MW-AD step ranged from 85.6 to 132%. Limits of detection (LOD) obtained by proposed method is in agreement to those required by the U.S. Pharmacopeia Convention (USP), showing that the ICP-MS technique is well suited for quantification of these elements. The LOD's (ng L-1) for 51V+, 52Cr+, 58Ni+, 65Cu+, 75As+ and 208Pb+ in 1% v v-1 HNO3 medium were: 2.2, 81.3, 91.9, 6.9, 0.2 and 3.1, respectively. The concentration of the analytes in these samples presented a wide range, varying from 2.3 ± 0.8 μg kg-1 for As to 3446 ± 47 μg kg-1 for Cr. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-01-01 2018-12-11T16:44:55Z 2018-12-11T16:44:55Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.5935/0103-5053.20160151 Journal of the Brazilian Chemical Society, v. 28, n. 1, p. 98-105, 2017. 1678-4790 0103-5053 http://hdl.handle.net/11449/169210 10.5935/0103-5053.20160151 S0103-50532017000100098 2-s2.0-85003845098 S0103-50532017000100098.pdf |
url |
http://dx.doi.org/10.5935/0103-5053.20160151 http://hdl.handle.net/11449/169210 |
identifier_str_mv |
Journal of the Brazilian Chemical Society, v. 28, n. 1, p. 98-105, 2017. 1678-4790 0103-5053 10.5935/0103-5053.20160151 S0103-50532017000100098 2-s2.0-85003845098 S0103-50532017000100098.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of the Brazilian Chemical Society 0,357 0,357 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
98-105 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964961215086592 |