Preemptive Analgesia with Acupuncture Monitored by c-Fos Expression in Rats
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.jams.2015.08.002 http://hdl.handle.net/11449/172530 |
Resumo: | Pain behavior and awareness are characterized by heightened alertness and anxiety, which begin to disappear as soon as the curative process starts. The present study aimed to quantify c-fos expression in rat spinal cords and brains after a surgical stimulus and with preoperative or postoperative acupuncture. Animals were randomly divided into preoperative and postoperative groups and were then further divided into control, manual acupuncture (MA), or electroacupuncture (EA) groups. Expression of c-fos was quantified using immunohistochemistry. The collected data were analyzed using the t test at a 5% probability level. Presurgery and postsurgery spinal cord c-fos expressions were similar in all of the treatment groups. In the control rats, c-fos expression was higher before surgery than after surgery, contradicting the expected outcome of acupuncture and preemptive analgesia. After treatment, the expression of c-fos in the brains of the rats in the MA and the EA groups was reduced compared with that of the rats in the control group. These findings suggest that acupuncture used as preemptive analgesia in rats is a useful model for studying its application in human treatment. |
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Preemptive Analgesia with Acupuncture Monitored by c-Fos Expression in RatsAcupunctureAnalgesiaC-fos proteinPainPain behavior and awareness are characterized by heightened alertness and anxiety, which begin to disappear as soon as the curative process starts. The present study aimed to quantify c-fos expression in rat spinal cords and brains after a surgical stimulus and with preoperative or postoperative acupuncture. Animals were randomly divided into preoperative and postoperative groups and were then further divided into control, manual acupuncture (MA), or electroacupuncture (EA) groups. Expression of c-fos was quantified using immunohistochemistry. The collected data were analyzed using the t test at a 5% probability level. Presurgery and postsurgery spinal cord c-fos expressions were similar in all of the treatment groups. In the control rats, c-fos expression was higher before surgery than after surgery, contradicting the expected outcome of acupuncture and preemptive analgesia. After treatment, the expression of c-fos in the brains of the rats in the MA and the EA groups was reduced compared with that of the rats in the control group. These findings suggest that acupuncture used as preemptive analgesia in rats is a useful model for studying its application in human treatment.Department of Morphology Universidade Estadual Paulista Júlio de Mesquita Filho UNESP-BotucatuDepartment of Anesthesiology Universidade Estadual Paulista Júlio de Mesquita Filho UNESP-BotucatuDepartment of Pathology Universidade Estadual Paulista Júlio de Mesquita Filho UNESP-BotucatuDepartment of Biological Sciences Universidade Estadual Paulista Júlio de Mesquita Filho UNESP-BotucatuClinic of Acupuncture and Homeopathy Universidade Estadual Paulista Júlio de Mesquita Filho UNESP-BotucatuDepartment of Morphology Universidade Estadual Paulista Júlio de Mesquita Filho UNESP-BotucatuDepartment of Anesthesiology Universidade Estadual Paulista Júlio de Mesquita Filho UNESP-BotucatuDepartment of Pathology Universidade Estadual Paulista Júlio de Mesquita Filho UNESP-BotucatuDepartment of Biological Sciences Universidade Estadual Paulista Júlio de Mesquita Filho UNESP-BotucatuClinic of Acupuncture and Homeopathy Universidade Estadual Paulista Júlio de Mesquita Filho UNESP-BotucatuUniversidade Estadual Paulista (Unesp)Gonçalves de Freitas, André T.A. [UNESP]Lemonica, Lino [UNESP]De Faveri, Julio [UNESP]Pereira, Sergio [UNESP]Bedoya Henao, Maria D. [UNESP]2018-12-11T17:00:49Z2018-12-11T17:00:49Z2016-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article16-21application/pdfhttp://dx.doi.org/10.1016/j.jams.2015.08.002JAMS Journal of Acupuncture and Meridian Studies, v. 9, n. 1, p. 16-21, 2016.2093-81522005-2901http://hdl.handle.net/11449/17253010.1016/j.jams.2015.08.0022-s2.0-849581065292-s2.0-84958106529.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJAMS Journal of Acupuncture and Meridian Studies0,347info:eu-repo/semantics/openAccess2023-10-19T06:04:57Zoai:repositorio.unesp.br:11449/172530Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-10-19T06:04:57Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Preemptive Analgesia with Acupuncture Monitored by c-Fos Expression in Rats |
title |
Preemptive Analgesia with Acupuncture Monitored by c-Fos Expression in Rats |
spellingShingle |
Preemptive Analgesia with Acupuncture Monitored by c-Fos Expression in Rats Gonçalves de Freitas, André T.A. [UNESP] Acupuncture Analgesia C-fos protein Pain |
title_short |
Preemptive Analgesia with Acupuncture Monitored by c-Fos Expression in Rats |
title_full |
Preemptive Analgesia with Acupuncture Monitored by c-Fos Expression in Rats |
title_fullStr |
Preemptive Analgesia with Acupuncture Monitored by c-Fos Expression in Rats |
title_full_unstemmed |
Preemptive Analgesia with Acupuncture Monitored by c-Fos Expression in Rats |
title_sort |
Preemptive Analgesia with Acupuncture Monitored by c-Fos Expression in Rats |
author |
Gonçalves de Freitas, André T.A. [UNESP] |
author_facet |
Gonçalves de Freitas, André T.A. [UNESP] Lemonica, Lino [UNESP] De Faveri, Julio [UNESP] Pereira, Sergio [UNESP] Bedoya Henao, Maria D. [UNESP] |
author_role |
author |
author2 |
Lemonica, Lino [UNESP] De Faveri, Julio [UNESP] Pereira, Sergio [UNESP] Bedoya Henao, Maria D. [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Gonçalves de Freitas, André T.A. [UNESP] Lemonica, Lino [UNESP] De Faveri, Julio [UNESP] Pereira, Sergio [UNESP] Bedoya Henao, Maria D. [UNESP] |
dc.subject.por.fl_str_mv |
Acupuncture Analgesia C-fos protein Pain |
topic |
Acupuncture Analgesia C-fos protein Pain |
description |
Pain behavior and awareness are characterized by heightened alertness and anxiety, which begin to disappear as soon as the curative process starts. The present study aimed to quantify c-fos expression in rat spinal cords and brains after a surgical stimulus and with preoperative or postoperative acupuncture. Animals were randomly divided into preoperative and postoperative groups and were then further divided into control, manual acupuncture (MA), or electroacupuncture (EA) groups. Expression of c-fos was quantified using immunohistochemistry. The collected data were analyzed using the t test at a 5% probability level. Presurgery and postsurgery spinal cord c-fos expressions were similar in all of the treatment groups. In the control rats, c-fos expression was higher before surgery than after surgery, contradicting the expected outcome of acupuncture and preemptive analgesia. After treatment, the expression of c-fos in the brains of the rats in the MA and the EA groups was reduced compared with that of the rats in the control group. These findings suggest that acupuncture used as preemptive analgesia in rats is a useful model for studying its application in human treatment. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-02-01 2018-12-11T17:00:49Z 2018-12-11T17:00:49Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.jams.2015.08.002 JAMS Journal of Acupuncture and Meridian Studies, v. 9, n. 1, p. 16-21, 2016. 2093-8152 2005-2901 http://hdl.handle.net/11449/172530 10.1016/j.jams.2015.08.002 2-s2.0-84958106529 2-s2.0-84958106529.pdf |
url |
http://dx.doi.org/10.1016/j.jams.2015.08.002 http://hdl.handle.net/11449/172530 |
identifier_str_mv |
JAMS Journal of Acupuncture and Meridian Studies, v. 9, n. 1, p. 16-21, 2016. 2093-8152 2005-2901 10.1016/j.jams.2015.08.002 2-s2.0-84958106529 2-s2.0-84958106529.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
JAMS Journal of Acupuncture and Meridian Studies 0,347 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
16-21 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964616987508736 |