NAMPT levels are inversely related to nitric oxide formation and positively related to soluble fms-like tyrosine kinase-1 levels in preeclampsia

• Main Author: Pereira, Daniela A.
• Publication Date: 2019
• Other Authors: Sandrim, Valéria C. [UNESP], Palei, Ana C.T., Tanus-Santos, Jose E., Belo, Vanessa A., Cavalli, Ricardo C., Luizon, Marcelo R.
• Format: Article
• Language: eng
• Source: Repositório Institucional da UNESP
• Download full: http://dx.doi.org/10.1016/j.preghy.2019.09.022; http://hdl.handle.net/11449/201075
• topic: Nicotinamide phosphorybosil transferase (NAMPT); Nitric oxide formation; Nitrite levels; Preeclampsia; Soluble fms-like tyrosine kinase-1 (sFLT-1); Visfatin/NAMPT

NAMPT is a biomarker for endothelial dysfunction, but its relationship with nitrite (marker of NO formation) and soluble fms-like tyrosine kinase-1 (sFLT-1) has not been previously evaluated in preeclampsia. Therefore, we measured plasma NAMPT and sFLT-1 levels using enzyme immunoassays and plasma nitrite concentrations using an ozone-based chemiluminescence assay. NAMPT was positively correlated to nitrite (r = 0.217; P = 0.034) and inversely related to sFLT-1 (r = −0.340; P = 0.029) in healthy pregnant women, but inversely related to nitrite (r = −0.259; P = 0.035) and positively correlated to sFLT-1 (r = 0.326; P = 0.007) in preeclamptic patients, suggesting that NAMPT inhibits NO formation and interacts with the antiangiogenic factor sFLT-1 in preeclampsia.