Evaluation of the microvascular density in astrocytomas in adults correlated using SPECT-MIBI
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3892/etm_00000045 http://hdl.handle.net/11449/41732 |
Resumo: | Microvascular density (MVD) may be an additional prognostic marker for astrocytomas, but the heterogeneity of these tumors limits its use. Thus, imaging examinations such as SPECT-MIBI (2-methoxyisobutyl isonitrile) may take on an indirect role in astrocytoma evaluation. The aim of this study was to evaluate MVD in astrocytomas using immunohistochemistry with anti-CD34 monoclonal antibodies. The relationship between the immunohistochemical data and the parameters obtained from SPECT-MIBI was evaluated. This cross-sectional study evaluated 48 patients with brain tumors including low-grade astrocytomas (LGAs), anaplastic astrocytomas (AAs) and glioblastoma multiformes (GBMs). Patients had been admitted to the Hospital de Cancer de Barretos - Fundação Pio XII, and underwent brain SPECT-MIBI prior to any treatment. MVD was determined under an optical microscope by counting microvessels on slides from each case. SPECT-MIBI images were analyzed visually and semiquantitatively. GBMs, AAs and LGAs represented 50, 16.7 and 33.3% of the total sample, respectively. There were 13 normal and 35 abnormal SPECT-MIBI images. Significant differences in MVD were found between AA and LGA cases (p=0.040), but not between normal and abnormal SPECT-MIBI. The mean counts from SPECT-MIBI were not correlated with MVD. Among the GBM cases, there were no significant findings, except for an increased likelihood of abnormal histological test results. MVD was related to histological grade (in AA and LGA cases) but was not correlated with SPECT-MIBI. |
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Repositório Institucional da UNESP |
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2946 |
spelling |
Evaluation of the microvascular density in astrocytomas in adults correlated using SPECT-MIBImicrovascular densitySPECT-MIBIastrocytomasMicrovascular density (MVD) may be an additional prognostic marker for astrocytomas, but the heterogeneity of these tumors limits its use. Thus, imaging examinations such as SPECT-MIBI (2-methoxyisobutyl isonitrile) may take on an indirect role in astrocytoma evaluation. The aim of this study was to evaluate MVD in astrocytomas using immunohistochemistry with anti-CD34 monoclonal antibodies. The relationship between the immunohistochemical data and the parameters obtained from SPECT-MIBI was evaluated. This cross-sectional study evaluated 48 patients with brain tumors including low-grade astrocytomas (LGAs), anaplastic astrocytomas (AAs) and glioblastoma multiformes (GBMs). Patients had been admitted to the Hospital de Cancer de Barretos - Fundação Pio XII, and underwent brain SPECT-MIBI prior to any treatment. MVD was determined under an optical microscope by counting microvessels on slides from each case. SPECT-MIBI images were analyzed visually and semiquantitatively. GBMs, AAs and LGAs represented 50, 16.7 and 33.3% of the total sample, respectively. There were 13 normal and 35 abnormal SPECT-MIBI images. Significant differences in MVD were found between AA and LGA cases (p=0.040), but not between normal and abnormal SPECT-MIBI. The mean counts from SPECT-MIBI were not correlated with MVD. Among the GBM cases, there were no significant findings, except for an increased likelihood of abnormal histological test results. MVD was related to histological grade (in AA and LGA cases) but was not correlated with SPECT-MIBI.Hosp Canc Fundação Pio XII, Dept Surg, Neurooncol Div, BR-14784400 Barretos, BrazilHosp Canc Fundação Pio XII, Dept Pathol, BR-14784400 Barretos, BrazilHosp Canc Fundação Pio XII, Res Support Grp, BR-14784400 Barretos, BrazilSão Paulo State Univ UNESP, Sch Med, Ctr Blood Transfus, BR-18618000 São Paulo, BrazilSão Paulo State Univ UNESP, Sch Med, Ctr Blood Transfus, BR-18618000 São Paulo, BrazilSpandidos Publ LtdHosp Canc Fundação Pio XIIUniversidade Estadual Paulista (Unesp)Cavalcante, Sandro Pantoja [UNESP]Walther de Almeida, Jose ReynaldoClara, Carlos AfonsoScapulatempo Neto, CristovamPeres, Stela VerzinhaseMoriguchi, Sônia Marta [UNESP]Dos Santos, Marcelo JoseDa Rocha, Euclides Timoteo [UNESP]2014-05-20T15:32:58Z2014-05-20T15:32:58Z2010-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article293-299http://dx.doi.org/10.3892/etm_00000045Experimental and Therapeutic Medicine. Athens: Spandidos Publ Ltd, v. 1, n. 2, p. 293-299, 2010.1792-0981http://hdl.handle.net/11449/4173210.3892/etm_00000045WOS:000284811700010Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengExperimental and Therapeutic Medicine1.4100,510info:eu-repo/semantics/openAccess2021-10-23T11:02:52Zoai:repositorio.unesp.br:11449/41732Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T11:02:52Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Evaluation of the microvascular density in astrocytomas in adults correlated using SPECT-MIBI |
title |
Evaluation of the microvascular density in astrocytomas in adults correlated using SPECT-MIBI |
spellingShingle |
Evaluation of the microvascular density in astrocytomas in adults correlated using SPECT-MIBI Cavalcante, Sandro Pantoja [UNESP] microvascular density SPECT-MIBI astrocytomas |
title_short |
Evaluation of the microvascular density in astrocytomas in adults correlated using SPECT-MIBI |
title_full |
Evaluation of the microvascular density in astrocytomas in adults correlated using SPECT-MIBI |
title_fullStr |
Evaluation of the microvascular density in astrocytomas in adults correlated using SPECT-MIBI |
title_full_unstemmed |
Evaluation of the microvascular density in astrocytomas in adults correlated using SPECT-MIBI |
title_sort |
Evaluation of the microvascular density in astrocytomas in adults correlated using SPECT-MIBI |
author |
Cavalcante, Sandro Pantoja [UNESP] |
author_facet |
Cavalcante, Sandro Pantoja [UNESP] Walther de Almeida, Jose Reynaldo Clara, Carlos Afonso Scapulatempo Neto, Cristovam Peres, Stela Verzinhase Moriguchi, Sônia Marta [UNESP] Dos Santos, Marcelo Jose Da Rocha, Euclides Timoteo [UNESP] |
author_role |
author |
author2 |
Walther de Almeida, Jose Reynaldo Clara, Carlos Afonso Scapulatempo Neto, Cristovam Peres, Stela Verzinhase Moriguchi, Sônia Marta [UNESP] Dos Santos, Marcelo Jose Da Rocha, Euclides Timoteo [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Hosp Canc Fundação Pio XII Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Cavalcante, Sandro Pantoja [UNESP] Walther de Almeida, Jose Reynaldo Clara, Carlos Afonso Scapulatempo Neto, Cristovam Peres, Stela Verzinhase Moriguchi, Sônia Marta [UNESP] Dos Santos, Marcelo Jose Da Rocha, Euclides Timoteo [UNESP] |
dc.subject.por.fl_str_mv |
microvascular density SPECT-MIBI astrocytomas |
topic |
microvascular density SPECT-MIBI astrocytomas |
description |
Microvascular density (MVD) may be an additional prognostic marker for astrocytomas, but the heterogeneity of these tumors limits its use. Thus, imaging examinations such as SPECT-MIBI (2-methoxyisobutyl isonitrile) may take on an indirect role in astrocytoma evaluation. The aim of this study was to evaluate MVD in astrocytomas using immunohistochemistry with anti-CD34 monoclonal antibodies. The relationship between the immunohistochemical data and the parameters obtained from SPECT-MIBI was evaluated. This cross-sectional study evaluated 48 patients with brain tumors including low-grade astrocytomas (LGAs), anaplastic astrocytomas (AAs) and glioblastoma multiformes (GBMs). Patients had been admitted to the Hospital de Cancer de Barretos - Fundação Pio XII, and underwent brain SPECT-MIBI prior to any treatment. MVD was determined under an optical microscope by counting microvessels on slides from each case. SPECT-MIBI images were analyzed visually and semiquantitatively. GBMs, AAs and LGAs represented 50, 16.7 and 33.3% of the total sample, respectively. There were 13 normal and 35 abnormal SPECT-MIBI images. Significant differences in MVD were found between AA and LGA cases (p=0.040), but not between normal and abnormal SPECT-MIBI. The mean counts from SPECT-MIBI were not correlated with MVD. Among the GBM cases, there were no significant findings, except for an increased likelihood of abnormal histological test results. MVD was related to histological grade (in AA and LGA cases) but was not correlated with SPECT-MIBI. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-03-01 2014-05-20T15:32:58Z 2014-05-20T15:32:58Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3892/etm_00000045 Experimental and Therapeutic Medicine. Athens: Spandidos Publ Ltd, v. 1, n. 2, p. 293-299, 2010. 1792-0981 http://hdl.handle.net/11449/41732 10.3892/etm_00000045 WOS:000284811700010 |
url |
http://dx.doi.org/10.3892/etm_00000045 http://hdl.handle.net/11449/41732 |
identifier_str_mv |
Experimental and Therapeutic Medicine. Athens: Spandidos Publ Ltd, v. 1, n. 2, p. 293-299, 2010. 1792-0981 10.3892/etm_00000045 WOS:000284811700010 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Experimental and Therapeutic Medicine 1.410 0,510 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
293-299 |
dc.publisher.none.fl_str_mv |
Spandidos Publ Ltd |
publisher.none.fl_str_mv |
Spandidos Publ Ltd |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965592649728000 |