Impact of early-onset preeclampsia on feeding tolerance and growth of very low birth weight infants during hospitalization
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/1984-0462/2023/41/2021203 http://hdl.handle.net/11449/249214 |
Resumo: | Objective: The provision of adequate enteral nutrition to preterm infants is a great challenge, and preeclampsia (PE) may have a detrimental effect on the safety of nutrition supply. This study aims to investigate the influence of early-onset PE on preterm infants’ enteral feeding tolerance and growth during hospitalization. Methods: This is a prospective study with 55 preterm infants <34 weeks born to PE mothers matched by gestational age with 55 preterm infants born to normotensive mothers from 2013 to 2016. We evaluated maternal, gestational, and neonatal clinical data. The outcomes were feeding intolerance and growth during hospitalization. Comparison between groups was performed by Student’s t-test or Mann-Whitney U test, chi-square test, or Fisher’s exact test. Multiple logistic regression was used to investigate whether PE was an independent risk factor for feeding intolerance. Results: The mean gestational age was 30 weeks. Preterm infants of mothers with PE had lower birth weight and were smaller at discharge. Feeding intolerance was frequent, but necrotizing enterocolitis was rare in this sample (PE=4% vs. control=2%) with no difference between groups. Preterm infants of mothers with PE had worse growth outcomes; however, PE was not an independent risk factor for feeding intolerance. The increase in gestational age was a protective factor, and being born small for gestational age (SGA) increased the risk of feeding intolerance by six times. Conclusions: Preterm infants of mothers with early-onset PE were more likely to be born SGA and had a worse growth trajectory during hospitalization. In adjusted analyses, however, low gestational age and SGA were independent predictors of feeding intolerance. |
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Impact of early-onset preeclampsia on feeding tolerance and growth of very low birth weight infants during hospitalizationEfeito da pré-eclâmpsia precoce na tolerância alimentar e no crescimento de recém-nascidos de muito baixo peso durante a hospitalizaçãoEnteral feedingGastrointestinal tractInfant, prematurePreeclampsiaObjective: The provision of adequate enteral nutrition to preterm infants is a great challenge, and preeclampsia (PE) may have a detrimental effect on the safety of nutrition supply. This study aims to investigate the influence of early-onset PE on preterm infants’ enteral feeding tolerance and growth during hospitalization. Methods: This is a prospective study with 55 preterm infants <34 weeks born to PE mothers matched by gestational age with 55 preterm infants born to normotensive mothers from 2013 to 2016. We evaluated maternal, gestational, and neonatal clinical data. The outcomes were feeding intolerance and growth during hospitalization. Comparison between groups was performed by Student’s t-test or Mann-Whitney U test, chi-square test, or Fisher’s exact test. Multiple logistic regression was used to investigate whether PE was an independent risk factor for feeding intolerance. Results: The mean gestational age was 30 weeks. Preterm infants of mothers with PE had lower birth weight and were smaller at discharge. Feeding intolerance was frequent, but necrotizing enterocolitis was rare in this sample (PE=4% vs. control=2%) with no difference between groups. Preterm infants of mothers with PE had worse growth outcomes; however, PE was not an independent risk factor for feeding intolerance. The increase in gestational age was a protective factor, and being born small for gestational age (SGA) increased the risk of feeding intolerance by six times. Conclusions: Preterm infants of mothers with early-onset PE were more likely to be born SGA and had a worse growth trajectory during hospitalization. In adjusted analyses, however, low gestational age and SGA were independent predictors of feeding intolerance.Universidade Estadual Paulista Faculdade de Medicina de Botucatu, SPUniversidade Estadual Paulista Faculdade de Medicina de Botucatu, SPUniversidade Estadual Paulista (UNESP)de Carvalho Pelícia, Simone Manso [UNESP]Fekete, Saskia Maria Wiegerinck [UNESP]Corrente, Jose Eduardo [UNESP]de Souza Rugolo, Ligia Maria Suppo [UNESP]2023-07-29T14:13:28Z2023-07-29T14:13:28Z2023-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1590/1984-0462/2023/41/2021203Revista Paulista de Pediatria, v. 41.1984-04620103-0582http://hdl.handle.net/11449/24921410.1590/1984-0462/2023/41/20212032-s2.0-85139008055Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista Paulista de Pediatriainfo:eu-repo/semantics/openAccess2023-07-29T14:13:28Zoai:repositorio.unesp.br:11449/249214Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-07-29T14:13:28Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Impact of early-onset preeclampsia on feeding tolerance and growth of very low birth weight infants during hospitalization Efeito da pré-eclâmpsia precoce na tolerância alimentar e no crescimento de recém-nascidos de muito baixo peso durante a hospitalização |
title |
Impact of early-onset preeclampsia on feeding tolerance and growth of very low birth weight infants during hospitalization |
spellingShingle |
Impact of early-onset preeclampsia on feeding tolerance and growth of very low birth weight infants during hospitalization de Carvalho Pelícia, Simone Manso [UNESP] Enteral feeding Gastrointestinal tract Infant, premature Preeclampsia |
title_short |
Impact of early-onset preeclampsia on feeding tolerance and growth of very low birth weight infants during hospitalization |
title_full |
Impact of early-onset preeclampsia on feeding tolerance and growth of very low birth weight infants during hospitalization |
title_fullStr |
Impact of early-onset preeclampsia on feeding tolerance and growth of very low birth weight infants during hospitalization |
title_full_unstemmed |
Impact of early-onset preeclampsia on feeding tolerance and growth of very low birth weight infants during hospitalization |
title_sort |
Impact of early-onset preeclampsia on feeding tolerance and growth of very low birth weight infants during hospitalization |
author |
de Carvalho Pelícia, Simone Manso [UNESP] |
author_facet |
de Carvalho Pelícia, Simone Manso [UNESP] Fekete, Saskia Maria Wiegerinck [UNESP] Corrente, Jose Eduardo [UNESP] de Souza Rugolo, Ligia Maria Suppo [UNESP] |
author_role |
author |
author2 |
Fekete, Saskia Maria Wiegerinck [UNESP] Corrente, Jose Eduardo [UNESP] de Souza Rugolo, Ligia Maria Suppo [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
de Carvalho Pelícia, Simone Manso [UNESP] Fekete, Saskia Maria Wiegerinck [UNESP] Corrente, Jose Eduardo [UNESP] de Souza Rugolo, Ligia Maria Suppo [UNESP] |
dc.subject.por.fl_str_mv |
Enteral feeding Gastrointestinal tract Infant, premature Preeclampsia |
topic |
Enteral feeding Gastrointestinal tract Infant, premature Preeclampsia |
description |
Objective: The provision of adequate enteral nutrition to preterm infants is a great challenge, and preeclampsia (PE) may have a detrimental effect on the safety of nutrition supply. This study aims to investigate the influence of early-onset PE on preterm infants’ enteral feeding tolerance and growth during hospitalization. Methods: This is a prospective study with 55 preterm infants <34 weeks born to PE mothers matched by gestational age with 55 preterm infants born to normotensive mothers from 2013 to 2016. We evaluated maternal, gestational, and neonatal clinical data. The outcomes were feeding intolerance and growth during hospitalization. Comparison between groups was performed by Student’s t-test or Mann-Whitney U test, chi-square test, or Fisher’s exact test. Multiple logistic regression was used to investigate whether PE was an independent risk factor for feeding intolerance. Results: The mean gestational age was 30 weeks. Preterm infants of mothers with PE had lower birth weight and were smaller at discharge. Feeding intolerance was frequent, but necrotizing enterocolitis was rare in this sample (PE=4% vs. control=2%) with no difference between groups. Preterm infants of mothers with PE had worse growth outcomes; however, PE was not an independent risk factor for feeding intolerance. The increase in gestational age was a protective factor, and being born small for gestational age (SGA) increased the risk of feeding intolerance by six times. Conclusions: Preterm infants of mothers with early-onset PE were more likely to be born SGA and had a worse growth trajectory during hospitalization. In adjusted analyses, however, low gestational age and SGA were independent predictors of feeding intolerance. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07-29T14:13:28Z 2023-07-29T14:13:28Z 2023-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/1984-0462/2023/41/2021203 Revista Paulista de Pediatria, v. 41. 1984-0462 0103-0582 http://hdl.handle.net/11449/249214 10.1590/1984-0462/2023/41/2021203 2-s2.0-85139008055 |
url |
http://dx.doi.org/10.1590/1984-0462/2023/41/2021203 http://hdl.handle.net/11449/249214 |
identifier_str_mv |
Revista Paulista de Pediatria, v. 41. 1984-0462 0103-0582 10.1590/1984-0462/2023/41/2021203 2-s2.0-85139008055 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Revista Paulista de Pediatria |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965418875518976 |