Cardiovascular Complications following Chronic Treatment with Cocaine and Testosterone in Adolescent Rats
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1371/journal.pone.0105172 http://hdl.handle.net/11449/117399 |
Resumo: | Concomitant use of anabolic androgenic steroids and cocaine has increased in the last years. However, the effects of chronic exposure to these substances during adolescence on cardiovascular function are unknown. Here, we investigated the effects of treatment for 10 consecutive days with testosterone and cocaine alone or in combination on basal cardiovascular parameters, baroreflex activity, hemodynamic responses to vasoactive agents, and cardiac morphology in adolescent rats. Administration of testosterone alone increased arterial pressure, reduced heart rate (HR), and exacerbated the tachycardiac baroreflex response. Cocaine-treated animals showed resting bradycardia without changes in arterial pressure and baroreflex activity. Combined treatment with testosterone and cocaine did not affect baseline arterial pressure and HR, but reduced baroreflex-mediated tachycardia. None of the treatments affected arterial pressure response to either vasoconstrictor or vasodilator agents. Also, heart to body ratio and left and right ventricular wall thickness were not modified by drug treatments. However, histological analysis of left ventricular sections of animals subjected to treatment with testosterone and cocaine alone and combined showed a greater spacing between cardiac muscle fibers, dilated blood vessels, and fibrosis. These data show important cardiovascular changes following treatment with testosterone in adolescent rats. However, the results suggest that exposure to cocaine alone or combined with testosterone during adolescence minimally affect cardiovascular function. |
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Cardiovascular Complications following Chronic Treatment with Cocaine and Testosterone in Adolescent RatsConcomitant use of anabolic androgenic steroids and cocaine has increased in the last years. However, the effects of chronic exposure to these substances during adolescence on cardiovascular function are unknown. Here, we investigated the effects of treatment for 10 consecutive days with testosterone and cocaine alone or in combination on basal cardiovascular parameters, baroreflex activity, hemodynamic responses to vasoactive agents, and cardiac morphology in adolescent rats. Administration of testosterone alone increased arterial pressure, reduced heart rate (HR), and exacerbated the tachycardiac baroreflex response. Cocaine-treated animals showed resting bradycardia without changes in arterial pressure and baroreflex activity. Combined treatment with testosterone and cocaine did not affect baseline arterial pressure and HR, but reduced baroreflex-mediated tachycardia. None of the treatments affected arterial pressure response to either vasoconstrictor or vasodilator agents. Also, heart to body ratio and left and right ventricular wall thickness were not modified by drug treatments. However, histological analysis of left ventricular sections of animals subjected to treatment with testosterone and cocaine alone and combined showed a greater spacing between cardiac muscle fibers, dilated blood vessels, and fibrosis. These data show important cardiovascular changes following treatment with testosterone in adolescent rats. However, the results suggest that exposure to cocaine alone or combined with testosterone during adolescence minimally affect cardiovascular function.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)PADC-School of Pharmaceutical Sciences-Sao Paulo State UniversityUNESP, Sch Pharmaceut Sci, Dept Nat Act Principles & Toxicol, Pharmacol Lab, Araraquara, SP, BrazilUNESP, Grad Program Physiol Sci, Joint UFSCar, Sao Carlos, SP, BrazilNIDA, Behav Neurosci Branch, Intramural Res Program, US NIH,Dept Hlth & Human Serv, Baltimore, MD USAUNESP, Sch Dent Araraquara, Dept Physiol & Pathol, Araraquara, SP, BrazilUNESP, Sch Pharmaceut Sci, Dept Nat Act Principles & Toxicol, Pharmacol Lab, Araraquara, SP, BrazilUNESP, Grad Program Physiol Sci, Joint UFSCar, Sao Carlos, SP, BrazilUNESP, Sch Dent Araraquara, Dept Physiol & Pathol, Araraquara, SP, BrazilFAPESP: 10/16192-8FAPESP: 12/14376-0FAPESP: 12/50549-6Public Library ScienceUniversidade Estadual Paulista (Unesp)NIDAEngi, Sheila A. [UNESP]Cruz, Fabio C.Leao, Rodrigo M.Spolidório, Luis Carlos [UNESP]Planeta, Cleopatra da Silva [UNESP]Crestani, Carlos Cesar [UNESP]2015-03-18T15:56:02Z2015-03-18T15:56:02Z2014-08-14info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article11application/pdfhttp://dx.doi.org/10.1371/journal.pone.0105172Plos One. San Francisco: Public Library Science, v. 9, n. 8, 11 p., 2014.1932-6203http://hdl.handle.net/11449/11739910.1371/journal.pone.0105172WOS:000341017000102WOS000341017000102.pdf264092929180841525147625452809420000-0002-1378-6327Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPlos One2.7661,164info:eu-repo/semantics/openAccess2024-01-02T06:20:36Zoai:repositorio.unesp.br:11449/117399Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-01-02T06:20:36Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Cardiovascular Complications following Chronic Treatment with Cocaine and Testosterone in Adolescent Rats |
title |
Cardiovascular Complications following Chronic Treatment with Cocaine and Testosterone in Adolescent Rats |
spellingShingle |
Cardiovascular Complications following Chronic Treatment with Cocaine and Testosterone in Adolescent Rats Engi, Sheila A. [UNESP] |
title_short |
Cardiovascular Complications following Chronic Treatment with Cocaine and Testosterone in Adolescent Rats |
title_full |
Cardiovascular Complications following Chronic Treatment with Cocaine and Testosterone in Adolescent Rats |
title_fullStr |
Cardiovascular Complications following Chronic Treatment with Cocaine and Testosterone in Adolescent Rats |
title_full_unstemmed |
Cardiovascular Complications following Chronic Treatment with Cocaine and Testosterone in Adolescent Rats |
title_sort |
Cardiovascular Complications following Chronic Treatment with Cocaine and Testosterone in Adolescent Rats |
author |
Engi, Sheila A. [UNESP] |
author_facet |
Engi, Sheila A. [UNESP] Cruz, Fabio C. Leao, Rodrigo M. Spolidório, Luis Carlos [UNESP] Planeta, Cleopatra da Silva [UNESP] Crestani, Carlos Cesar [UNESP] |
author_role |
author |
author2 |
Cruz, Fabio C. Leao, Rodrigo M. Spolidório, Luis Carlos [UNESP] Planeta, Cleopatra da Silva [UNESP] Crestani, Carlos Cesar [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) NIDA |
dc.contributor.author.fl_str_mv |
Engi, Sheila A. [UNESP] Cruz, Fabio C. Leao, Rodrigo M. Spolidório, Luis Carlos [UNESP] Planeta, Cleopatra da Silva [UNESP] Crestani, Carlos Cesar [UNESP] |
description |
Concomitant use of anabolic androgenic steroids and cocaine has increased in the last years. However, the effects of chronic exposure to these substances during adolescence on cardiovascular function are unknown. Here, we investigated the effects of treatment for 10 consecutive days with testosterone and cocaine alone or in combination on basal cardiovascular parameters, baroreflex activity, hemodynamic responses to vasoactive agents, and cardiac morphology in adolescent rats. Administration of testosterone alone increased arterial pressure, reduced heart rate (HR), and exacerbated the tachycardiac baroreflex response. Cocaine-treated animals showed resting bradycardia without changes in arterial pressure and baroreflex activity. Combined treatment with testosterone and cocaine did not affect baseline arterial pressure and HR, but reduced baroreflex-mediated tachycardia. None of the treatments affected arterial pressure response to either vasoconstrictor or vasodilator agents. Also, heart to body ratio and left and right ventricular wall thickness were not modified by drug treatments. However, histological analysis of left ventricular sections of animals subjected to treatment with testosterone and cocaine alone and combined showed a greater spacing between cardiac muscle fibers, dilated blood vessels, and fibrosis. These data show important cardiovascular changes following treatment with testosterone in adolescent rats. However, the results suggest that exposure to cocaine alone or combined with testosterone during adolescence minimally affect cardiovascular function. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-08-14 2015-03-18T15:56:02Z 2015-03-18T15:56:02Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1371/journal.pone.0105172 Plos One. San Francisco: Public Library Science, v. 9, n. 8, 11 p., 2014. 1932-6203 http://hdl.handle.net/11449/117399 10.1371/journal.pone.0105172 WOS:000341017000102 WOS000341017000102.pdf 2640929291808415 2514762545280942 0000-0002-1378-6327 |
url |
http://dx.doi.org/10.1371/journal.pone.0105172 http://hdl.handle.net/11449/117399 |
identifier_str_mv |
Plos One. San Francisco: Public Library Science, v. 9, n. 8, 11 p., 2014. 1932-6203 10.1371/journal.pone.0105172 WOS:000341017000102 WOS000341017000102.pdf 2640929291808415 2514762545280942 0000-0002-1378-6327 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Plos One 2.766 1,164 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
11 application/pdf |
dc.publisher.none.fl_str_mv |
Public Library Science |
publisher.none.fl_str_mv |
Public Library Science |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1799965489859919872 |