In Vitro Evaluation Of Antifungal Activity Of Calcium Hydroxide Paste Mixed To Different Drugs, Against Candida Albicans
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.14436/2358-2545.9.1.043-047.oar http://hdl.handle.net/11449/223027 |
Resumo: | Introduction: the frequency of invasive mycoses caused by opportunistic fungal pathogens has increased significantly in the last decades. Among the main etiological agents of opportunistic mycoses is Candida albicans. This yeast has several important virulence factors for producing disease. Some studies have demonstrated that C. albicans colonized root canals and dentinal tubules. The spectrum of antimicrobial activity of calcium hydroxide dressing should include this yeast. Objectives: the aim of the present study was to determine the in vitro susceptibility of four C. albicans strains collected from the oral cavity and a standard strain ATCC 10231 to calcium hydroxide paste associated with antifungal, antibiotic and anti-inflammatory drugs. The efficiency of the Ca(OH)2 paste associated with the drugs on the yeasts was analyzed by the radial diffusion method and also by the direct contact method. Data were analyzed by Kruskal Wallis test and the Dunn post-test were used to indicate the differences between the groups with a significance level of 5%. Results: all antifungal drugs increased the action of the calcium hydroxide pastes against Candida albicans. Conclusions: the association of antifungals with Ca(OH)2 may be considered for use as intracanal medicaments |
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In Vitro Evaluation Of Antifungal Activity Of Calcium Hydroxide Paste Mixed To Different Drugs, Against Candida AlbicansAnti Inflammatory AgentsCalcium HydroxideCandida albicansEndodonticsIntroduction: the frequency of invasive mycoses caused by opportunistic fungal pathogens has increased significantly in the last decades. Among the main etiological agents of opportunistic mycoses is Candida albicans. This yeast has several important virulence factors for producing disease. Some studies have demonstrated that C. albicans colonized root canals and dentinal tubules. The spectrum of antimicrobial activity of calcium hydroxide dressing should include this yeast. Objectives: the aim of the present study was to determine the in vitro susceptibility of four C. albicans strains collected from the oral cavity and a standard strain ATCC 10231 to calcium hydroxide paste associated with antifungal, antibiotic and anti-inflammatory drugs. The efficiency of the Ca(OH)2 paste associated with the drugs on the yeasts was analyzed by the radial diffusion method and also by the direct contact method. Data were analyzed by Kruskal Wallis test and the Dunn post-test were used to indicate the differences between the groups with a significance level of 5%. Results: all antifungal drugs increased the action of the calcium hydroxide pastes against Candida albicans. Conclusions: the association of antifungals with Ca(OH)2 may be considered for use as intracanal medicamentsUniversidade do Sagrado Coracao Centro de Ciencias da SaudeUniversidade do Sagrado Coracao Pro Reitoria de Pesquisa e Pos GraduacaoMaster’s degree in Oral Biology Universidade do Sagrado CoracaoDoctorate degree in Applied Dental Sciences Endodontics area Universidade de Sao Paulo Faculdade de Odontologia de BauruInstituto Lauro de Souza Lima Pesquisador Cientifico da Secretaria da Saude do Estado de Sao PauloSpecialist in Clinical Analysis Universidade do Sagrado CoracaoDoctorate degree in Dentistry Universidade Estadual Paulista Faculdade de Odontologia de AraraquaraDoctorate degree in Tropical Diseases Universidade Estadual PaulistaDoctorate degree in Dentistry Universidade Estadual Paulista Faculdade de Odontologia de AraraquaraDoctorate degree in Tropical Diseases Universidade Estadual PaulistaCentro de Ciencias da SaudePro Reitoria de Pesquisa e Pos GraduacaoUniversidade do Sagrado CoracaoUniversidade de São Paulo (USP)Pesquisador Cientifico da Secretaria da Saude do Estado de Sao PauloUniversidade Estadual Paulista (UNESP)Forcin, Leticia Vendramettode Freitas, Rafaela PignattiMidena, Raquel ZaninWeckwerth, Ana Carolina Villas Bôasda Silva, Guilherme Ferreira [UNESP]Weckwerth, Paulo Henrique [UNESP]2022-04-28T19:48:14Z2022-04-28T19:48:14Z2019-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article43-47http://dx.doi.org/10.14436/2358-2545.9.1.043-047.oarDental Press Endodontics, v. 9, n. 1, p. 43-47, 2019.2178-3713http://hdl.handle.net/11449/22302710.14436/2358-2545.9.1.043-047.oar2-s2.0-85120994326Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengDental Press Endodonticsinfo:eu-repo/semantics/openAccess2022-04-28T19:48:14Zoai:repositorio.unesp.br:11449/223027Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-28T19:48:14Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
In Vitro Evaluation Of Antifungal Activity Of Calcium Hydroxide Paste Mixed To Different Drugs, Against Candida Albicans |
title |
In Vitro Evaluation Of Antifungal Activity Of Calcium Hydroxide Paste Mixed To Different Drugs, Against Candida Albicans |
spellingShingle |
In Vitro Evaluation Of Antifungal Activity Of Calcium Hydroxide Paste Mixed To Different Drugs, Against Candida Albicans Forcin, Leticia Vendrametto Anti Inflammatory Agents Calcium Hydroxide Candida albicans Endodontics |
title_short |
In Vitro Evaluation Of Antifungal Activity Of Calcium Hydroxide Paste Mixed To Different Drugs, Against Candida Albicans |
title_full |
In Vitro Evaluation Of Antifungal Activity Of Calcium Hydroxide Paste Mixed To Different Drugs, Against Candida Albicans |
title_fullStr |
In Vitro Evaluation Of Antifungal Activity Of Calcium Hydroxide Paste Mixed To Different Drugs, Against Candida Albicans |
title_full_unstemmed |
In Vitro Evaluation Of Antifungal Activity Of Calcium Hydroxide Paste Mixed To Different Drugs, Against Candida Albicans |
title_sort |
In Vitro Evaluation Of Antifungal Activity Of Calcium Hydroxide Paste Mixed To Different Drugs, Against Candida Albicans |
author |
Forcin, Leticia Vendrametto |
author_facet |
Forcin, Leticia Vendrametto de Freitas, Rafaela Pignatti Midena, Raquel Zanin Weckwerth, Ana Carolina Villas Bôas da Silva, Guilherme Ferreira [UNESP] Weckwerth, Paulo Henrique [UNESP] |
author_role |
author |
author2 |
de Freitas, Rafaela Pignatti Midena, Raquel Zanin Weckwerth, Ana Carolina Villas Bôas da Silva, Guilherme Ferreira [UNESP] Weckwerth, Paulo Henrique [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Centro de Ciencias da Saude Pro Reitoria de Pesquisa e Pos Graduacao Universidade do Sagrado Coracao Universidade de São Paulo (USP) Pesquisador Cientifico da Secretaria da Saude do Estado de Sao Paulo Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Forcin, Leticia Vendrametto de Freitas, Rafaela Pignatti Midena, Raquel Zanin Weckwerth, Ana Carolina Villas Bôas da Silva, Guilherme Ferreira [UNESP] Weckwerth, Paulo Henrique [UNESP] |
dc.subject.por.fl_str_mv |
Anti Inflammatory Agents Calcium Hydroxide Candida albicans Endodontics |
topic |
Anti Inflammatory Agents Calcium Hydroxide Candida albicans Endodontics |
description |
Introduction: the frequency of invasive mycoses caused by opportunistic fungal pathogens has increased significantly in the last decades. Among the main etiological agents of opportunistic mycoses is Candida albicans. This yeast has several important virulence factors for producing disease. Some studies have demonstrated that C. albicans colonized root canals and dentinal tubules. The spectrum of antimicrobial activity of calcium hydroxide dressing should include this yeast. Objectives: the aim of the present study was to determine the in vitro susceptibility of four C. albicans strains collected from the oral cavity and a standard strain ATCC 10231 to calcium hydroxide paste associated with antifungal, antibiotic and anti-inflammatory drugs. The efficiency of the Ca(OH)2 paste associated with the drugs on the yeasts was analyzed by the radial diffusion method and also by the direct contact method. Data were analyzed by Kruskal Wallis test and the Dunn post-test were used to indicate the differences between the groups with a significance level of 5%. Results: all antifungal drugs increased the action of the calcium hydroxide pastes against Candida albicans. Conclusions: the association of antifungals with Ca(OH)2 may be considered for use as intracanal medicaments |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-01-01 2022-04-28T19:48:14Z 2022-04-28T19:48:14Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.14436/2358-2545.9.1.043-047.oar Dental Press Endodontics, v. 9, n. 1, p. 43-47, 2019. 2178-3713 http://hdl.handle.net/11449/223027 10.14436/2358-2545.9.1.043-047.oar 2-s2.0-85120994326 |
url |
http://dx.doi.org/10.14436/2358-2545.9.1.043-047.oar http://hdl.handle.net/11449/223027 |
identifier_str_mv |
Dental Press Endodontics, v. 9, n. 1, p. 43-47, 2019. 2178-3713 10.14436/2358-2545.9.1.043-047.oar 2-s2.0-85120994326 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Dental Press Endodontics |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
43-47 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964497207623680 |