Magnetic molecularly imprinted polymers obtained by photopolymerization for selective recognition of penicillin G
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1002/app.48496 http://hdl.handle.net/11449/199532 |
Resumo: | Some of the most important life-saving medications are β-lactam antibiotics (such as Penicillin G). However, these medicines have not adequately been discharged into the environment; penicillin residues offer health risks and enhance the development of resistances. Thus, its selective separation from complex matrices is a challenge worth tackling. A novel strategy of synthesis, by photopolymerization, was applied to develop magnetic molecular imprinted polymers (mag-MIPs) aiming the recognition of penicillin G (also known as benzylpenicillin). Photopolymerization, when compared with the more common thermopolymerization, has the advantage of occurring at lower temperatures, which prevents analyte degradation. The Mag-MIP presented higher surface area than the conventional MIP and good adsorption capacity of the analyte while maintaining its selectivity. The synthesized material was characterized by X-ray diffraction, showing that the magnetite nanoparticles were formed and the MIP polymerization on their surface was performed, once the material was amorphous. Furthermore, the pore formation was evaluated by BET, indicating a high surface area (832 m2 g−1) and large pore volume (0.80 cm3 g−1) in the mag-MIP compared to the magnetic non-imprinted polymer (mag-NIP: 147 m2 g−1 and 0.33 cm3 g−1). © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48496. |
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Magnetic molecularly imprinted polymers obtained by photopolymerization for selective recognition of penicillin Gbiomimetic materialsextractionmolecular imprinting and recognitionphotopolymerizationsample preparationseparation scienceSome of the most important life-saving medications are β-lactam antibiotics (such as Penicillin G). However, these medicines have not adequately been discharged into the environment; penicillin residues offer health risks and enhance the development of resistances. Thus, its selective separation from complex matrices is a challenge worth tackling. A novel strategy of synthesis, by photopolymerization, was applied to develop magnetic molecular imprinted polymers (mag-MIPs) aiming the recognition of penicillin G (also known as benzylpenicillin). Photopolymerization, when compared with the more common thermopolymerization, has the advantage of occurring at lower temperatures, which prevents analyte degradation. The Mag-MIP presented higher surface area than the conventional MIP and good adsorption capacity of the analyte while maintaining its selectivity. The synthesized material was characterized by X-ray diffraction, showing that the magnetite nanoparticles were formed and the MIP polymerization on their surface was performed, once the material was amorphous. Furthermore, the pore formation was evaluated by BET, indicating a high surface area (832 m2 g−1) and large pore volume (0.80 cm3 g−1) in the mag-MIP compared to the magnetic non-imprinted polymer (mag-NIP: 147 m2 g−1 and 0.33 cm3 g−1). © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48496.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Department of Analytical Chemistry Institute of Chemistry UNESP – Univ Estadual PaulistaUNESP National Institute for Alternative Technologies of Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM) Institute of ChemistryDepartment of Chemistry University of Central FloridaDepartamento de Química Fundamental Instituto de Química Universidade de São Paulo (USP)Department of Analytical Chemistry Institute of Chemistry UNESP – Univ Estadual PaulistaUNESP National Institute for Alternative Technologies of Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM) Institute of ChemistryFAPESP: 2012/14181-4FAPESP: 2016/06926-0FAPESP: 2018/14425-7CNPq: 400459/2012-4Universidade Estadual Paulista (Unesp)University of Central FloridaUniversidade de São Paulo (USP)Pupin, Rafael Rovatti [UNESP]Foguel, Marcos Vinicius [UNESP]Gonçalves, Luís MoreiraSotomayor, Maria del Pilar T. [UNESP]2020-12-12T01:42:28Z2020-12-12T01:42:28Z2020-04-05info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1002/app.48496Journal of Applied Polymer Science, v. 137, n. 13, 2020.1097-46280021-8995http://hdl.handle.net/11449/19953210.1002/app.484962-s2.0-85073788211Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Applied Polymer Scienceinfo:eu-repo/semantics/openAccess2021-10-23T07:59:03Zoai:repositorio.unesp.br:11449/199532Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T07:59:03Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Magnetic molecularly imprinted polymers obtained by photopolymerization for selective recognition of penicillin G |
title |
Magnetic molecularly imprinted polymers obtained by photopolymerization for selective recognition of penicillin G |
spellingShingle |
Magnetic molecularly imprinted polymers obtained by photopolymerization for selective recognition of penicillin G Pupin, Rafael Rovatti [UNESP] biomimetic materials extraction molecular imprinting and recognition photopolymerization sample preparation separation science |
title_short |
Magnetic molecularly imprinted polymers obtained by photopolymerization for selective recognition of penicillin G |
title_full |
Magnetic molecularly imprinted polymers obtained by photopolymerization for selective recognition of penicillin G |
title_fullStr |
Magnetic molecularly imprinted polymers obtained by photopolymerization for selective recognition of penicillin G |
title_full_unstemmed |
Magnetic molecularly imprinted polymers obtained by photopolymerization for selective recognition of penicillin G |
title_sort |
Magnetic molecularly imprinted polymers obtained by photopolymerization for selective recognition of penicillin G |
author |
Pupin, Rafael Rovatti [UNESP] |
author_facet |
Pupin, Rafael Rovatti [UNESP] Foguel, Marcos Vinicius [UNESP] Gonçalves, Luís Moreira Sotomayor, Maria del Pilar T. [UNESP] |
author_role |
author |
author2 |
Foguel, Marcos Vinicius [UNESP] Gonçalves, Luís Moreira Sotomayor, Maria del Pilar T. [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) University of Central Florida Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Pupin, Rafael Rovatti [UNESP] Foguel, Marcos Vinicius [UNESP] Gonçalves, Luís Moreira Sotomayor, Maria del Pilar T. [UNESP] |
dc.subject.por.fl_str_mv |
biomimetic materials extraction molecular imprinting and recognition photopolymerization sample preparation separation science |
topic |
biomimetic materials extraction molecular imprinting and recognition photopolymerization sample preparation separation science |
description |
Some of the most important life-saving medications are β-lactam antibiotics (such as Penicillin G). However, these medicines have not adequately been discharged into the environment; penicillin residues offer health risks and enhance the development of resistances. Thus, its selective separation from complex matrices is a challenge worth tackling. A novel strategy of synthesis, by photopolymerization, was applied to develop magnetic molecular imprinted polymers (mag-MIPs) aiming the recognition of penicillin G (also known as benzylpenicillin). Photopolymerization, when compared with the more common thermopolymerization, has the advantage of occurring at lower temperatures, which prevents analyte degradation. The Mag-MIP presented higher surface area than the conventional MIP and good adsorption capacity of the analyte while maintaining its selectivity. The synthesized material was characterized by X-ray diffraction, showing that the magnetite nanoparticles were formed and the MIP polymerization on their surface was performed, once the material was amorphous. Furthermore, the pore formation was evaluated by BET, indicating a high surface area (832 m2 g−1) and large pore volume (0.80 cm3 g−1) in the mag-MIP compared to the magnetic non-imprinted polymer (mag-NIP: 147 m2 g−1 and 0.33 cm3 g−1). © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48496. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T01:42:28Z 2020-12-12T01:42:28Z 2020-04-05 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1002/app.48496 Journal of Applied Polymer Science, v. 137, n. 13, 2020. 1097-4628 0021-8995 http://hdl.handle.net/11449/199532 10.1002/app.48496 2-s2.0-85073788211 |
url |
http://dx.doi.org/10.1002/app.48496 http://hdl.handle.net/11449/199532 |
identifier_str_mv |
Journal of Applied Polymer Science, v. 137, n. 13, 2020. 1097-4628 0021-8995 10.1002/app.48496 2-s2.0-85073788211 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Applied Polymer Science |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1792961734656393216 |