Biocompatible anti-aging face mask prepared with curcumin and natural rubber with antioxidant properties
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.ijbiomac.2023.124778 http://hdl.handle.net/11449/248812 |
Resumo: | Natural rubber latex (NRL) is a biopolymer widely used in biomedical applications. In this work, we propose an innovative cosmetic face mask, combining the NRL's biological properties with curcumin (CURC), which has a high level of antioxidant activity (AA) to provide anti-aging benefits. Chemical, mechanical and morphological characterizations were performed. The CURC released by the NRL was evaluated by permeation in Franz cells. Cytotoxicity and hemolytic activity assays were performed to assess safety. The findings showed that the biological properties of CURC were preserved after loading in the NRL. About 44.2 % of CURC was released within the first six hours, and in vitro permeation showed that 9.36 % ± 0.65 was permeated over 24 h. CURC–NRL was associated with a metabolic activity higher than 70 % in 3 T3 fibroblasts, cell viability ≥95 % in human dermal fibroblasts, and a hemolytic rate ≤ 2.24 % after 24 h. Furthermore, CURC-NRL maintained the mechanical characteristics (range suitable) for human skin application. We observed that CURC-NRL preserved ~20 % antioxidant activity from curcumin-free after loading in the NRL. Our results suggest that CURC–NRL has the potential to be used in the cosmetics industry, and the experimental methodology utilized in this study can be applied to different kinds of face masks. |
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Biocompatible anti-aging face mask prepared with curcumin and natural rubber with antioxidant propertiesCurcuminFacial maskNatural rubber latexNatural rubber latex (NRL) is a biopolymer widely used in biomedical applications. In this work, we propose an innovative cosmetic face mask, combining the NRL's biological properties with curcumin (CURC), which has a high level of antioxidant activity (AA) to provide anti-aging benefits. Chemical, mechanical and morphological characterizations were performed. The CURC released by the NRL was evaluated by permeation in Franz cells. Cytotoxicity and hemolytic activity assays were performed to assess safety. The findings showed that the biological properties of CURC were preserved after loading in the NRL. About 44.2 % of CURC was released within the first six hours, and in vitro permeation showed that 9.36 % ± 0.65 was permeated over 24 h. CURC–NRL was associated with a metabolic activity higher than 70 % in 3 T3 fibroblasts, cell viability ≥95 % in human dermal fibroblasts, and a hemolytic rate ≤ 2.24 % after 24 h. Furthermore, CURC-NRL maintained the mechanical characteristics (range suitable) for human skin application. We observed that CURC-NRL preserved ~20 % antioxidant activity from curcumin-free after loading in the NRL. Our results suggest that CURC–NRL has the potential to be used in the cosmetics industry, and the experimental methodology utilized in this study can be applied to different kinds of face masks.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Bioengineering & Biomaterials Group São Paulo State University (UNESP) School of Pharmaceutical Sciences, Km 01 Araraquara-Jaú Road, São PauloDepartment of Clinical Analysis São Paulo State University (UNESP) School of Pharmaceutical Sciences, Km 01 Araraquara-Jaú Road, São PauloBionanomaterials and Bioengineering Group Department of Biotechnology and Bioprocesses Engineering São Paulo State University (UNESP) Faculty of Pharmaceutical Sciences, São PauloEscuela de Agronomía Facultad de Ciencias Agronómicas y de los Alimentos Pontificia Universidad Católica de ValparaísoScience Faculty São Paulo State University (UNESP), São PauloSão Paulo State University (UNESP) Botucatu Medical School, São PauloNational Heart and Lung Institute Imperial College LondonDepartment of Biochemistry Pharmacology and Physiology Federal University of Triangulo Mineiro (UFTM), Minas GeraisUniversity Center of Hermínio Ometto Foundation (FHO), São PauloDivision of Dermatology Department of Internal Medicine São Paulo University (USP) Ribeirão Preto Medical School, SPTerasaki Institute for Biomedical Innovation (TIBI), 11507 West Olympic BlvdAutonomy Research Center for STEAHM (ARCS) California State UniversitySão Paulo State University (UNESP) School of Sciences and Languages of Assis Department of Biotechnology, São PauloSão Carlos Institute of Physics University of São Paulo, PO Box 369, SPBioengineering & Biomaterials Group São Paulo State University (UNESP) School of Pharmaceutical Sciences, Km 01 Araraquara-Jaú Road, São PauloDepartment of Clinical Analysis São Paulo State University (UNESP) School of Pharmaceutical Sciences, Km 01 Araraquara-Jaú Road, São PauloBionanomaterials and Bioengineering Group Department of Biotechnology and Bioprocesses Engineering São Paulo State University (UNESP) Faculty of Pharmaceutical Sciences, São PauloScience Faculty São Paulo State University (UNESP), São PauloSão Paulo State University (UNESP) Botucatu Medical School, São PauloSão Paulo State University (UNESP) School of Sciences and Languages of Assis Department of Biotechnology, São PauloFAPESP: 2017/19603-8FAPESP: 2018/07342-8FAPESP: 2021/09207-3CNPq: 317203/2021-5CNPq: 401285/2022-7CNPq: 470261/2012-9Universidade Estadual Paulista (UNESP)Pontificia Universidad Católica de ValparaísoImperial College LondonFederal University of Triangulo Mineiro (UFTM)University Center of Hermínio Ometto Foundation (FHO)Universidade de São Paulo (USP)Terasaki Institute for Biomedical Innovation (TIBI)California State Universityde Souza Silva, Flávio Kunert [UNESP]Costa-Orlandi, Caroline Barcelos [UNESP]Fernandes, Mariza Aires [UNESP]Pegorin Brasil, Giovana Sant'Ana [UNESP]Mussagy, Cassamo UssemaneScontri, Mateus [UNESP]Sasaki, Josana Carla da Silva [UNESP]de Sousa Abreu, Ana Paula [UNESP]Guerra, Nayrim Brizuela [UNESP]Floriano, Juliana Ferreira [UNESP]de Mendonça, Ricardo JoséCaetano, Guilherme FerreiraFarhadi, NedaGómez, AlejandroHuang, ShuyiFarias, Andressa Machado [UNESP]Primo, Fernando Lucas [UNESP]Li, BingbingFusco-Almeida, Ana Marisa [UNESP]Dokmeci, Mehmet RemziJucaud, VadimMendes-Giannini, Maria José Soares [UNESP]Cardoso, Marcos RobertoHerculano, Rondinelli Donizetti [UNESP]2023-07-29T13:54:22Z2023-07-29T13:54:22Z2023-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.ijbiomac.2023.124778International Journal of Biological Macromolecules, v. 242.1879-00030141-8130http://hdl.handle.net/11449/24881210.1016/j.ijbiomac.2023.1247782-s2.0-85159071052Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Journal of Biological Macromoleculesinfo:eu-repo/semantics/openAccess2023-07-29T13:54:22Zoai:repositorio.unesp.br:11449/248812Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-07-29T13:54:22Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Biocompatible anti-aging face mask prepared with curcumin and natural rubber with antioxidant properties |
title |
Biocompatible anti-aging face mask prepared with curcumin and natural rubber with antioxidant properties |
spellingShingle |
Biocompatible anti-aging face mask prepared with curcumin and natural rubber with antioxidant properties de Souza Silva, Flávio Kunert [UNESP] Curcumin Facial mask Natural rubber latex |
title_short |
Biocompatible anti-aging face mask prepared with curcumin and natural rubber with antioxidant properties |
title_full |
Biocompatible anti-aging face mask prepared with curcumin and natural rubber with antioxidant properties |
title_fullStr |
Biocompatible anti-aging face mask prepared with curcumin and natural rubber with antioxidant properties |
title_full_unstemmed |
Biocompatible anti-aging face mask prepared with curcumin and natural rubber with antioxidant properties |
title_sort |
Biocompatible anti-aging face mask prepared with curcumin and natural rubber with antioxidant properties |
author |
de Souza Silva, Flávio Kunert [UNESP] |
author_facet |
de Souza Silva, Flávio Kunert [UNESP] Costa-Orlandi, Caroline Barcelos [UNESP] Fernandes, Mariza Aires [UNESP] Pegorin Brasil, Giovana Sant'Ana [UNESP] Mussagy, Cassamo Ussemane Scontri, Mateus [UNESP] Sasaki, Josana Carla da Silva [UNESP] de Sousa Abreu, Ana Paula [UNESP] Guerra, Nayrim Brizuela [UNESP] Floriano, Juliana Ferreira [UNESP] de Mendonça, Ricardo José Caetano, Guilherme Ferreira Farhadi, Neda Gómez, Alejandro Huang, Shuyi Farias, Andressa Machado [UNESP] Primo, Fernando Lucas [UNESP] Li, Bingbing Fusco-Almeida, Ana Marisa [UNESP] Dokmeci, Mehmet Remzi Jucaud, Vadim Mendes-Giannini, Maria José Soares [UNESP] Cardoso, Marcos Roberto Herculano, Rondinelli Donizetti [UNESP] |
author_role |
author |
author2 |
Costa-Orlandi, Caroline Barcelos [UNESP] Fernandes, Mariza Aires [UNESP] Pegorin Brasil, Giovana Sant'Ana [UNESP] Mussagy, Cassamo Ussemane Scontri, Mateus [UNESP] Sasaki, Josana Carla da Silva [UNESP] de Sousa Abreu, Ana Paula [UNESP] Guerra, Nayrim Brizuela [UNESP] Floriano, Juliana Ferreira [UNESP] de Mendonça, Ricardo José Caetano, Guilherme Ferreira Farhadi, Neda Gómez, Alejandro Huang, Shuyi Farias, Andressa Machado [UNESP] Primo, Fernando Lucas [UNESP] Li, Bingbing Fusco-Almeida, Ana Marisa [UNESP] Dokmeci, Mehmet Remzi Jucaud, Vadim Mendes-Giannini, Maria José Soares [UNESP] Cardoso, Marcos Roberto Herculano, Rondinelli Donizetti [UNESP] |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Pontificia Universidad Católica de Valparaíso Imperial College London Federal University of Triangulo Mineiro (UFTM) University Center of Hermínio Ometto Foundation (FHO) Universidade de São Paulo (USP) Terasaki Institute for Biomedical Innovation (TIBI) California State University |
dc.contributor.author.fl_str_mv |
de Souza Silva, Flávio Kunert [UNESP] Costa-Orlandi, Caroline Barcelos [UNESP] Fernandes, Mariza Aires [UNESP] Pegorin Brasil, Giovana Sant'Ana [UNESP] Mussagy, Cassamo Ussemane Scontri, Mateus [UNESP] Sasaki, Josana Carla da Silva [UNESP] de Sousa Abreu, Ana Paula [UNESP] Guerra, Nayrim Brizuela [UNESP] Floriano, Juliana Ferreira [UNESP] de Mendonça, Ricardo José Caetano, Guilherme Ferreira Farhadi, Neda Gómez, Alejandro Huang, Shuyi Farias, Andressa Machado [UNESP] Primo, Fernando Lucas [UNESP] Li, Bingbing Fusco-Almeida, Ana Marisa [UNESP] Dokmeci, Mehmet Remzi Jucaud, Vadim Mendes-Giannini, Maria José Soares [UNESP] Cardoso, Marcos Roberto Herculano, Rondinelli Donizetti [UNESP] |
dc.subject.por.fl_str_mv |
Curcumin Facial mask Natural rubber latex |
topic |
Curcumin Facial mask Natural rubber latex |
description |
Natural rubber latex (NRL) is a biopolymer widely used in biomedical applications. In this work, we propose an innovative cosmetic face mask, combining the NRL's biological properties with curcumin (CURC), which has a high level of antioxidant activity (AA) to provide anti-aging benefits. Chemical, mechanical and morphological characterizations were performed. The CURC released by the NRL was evaluated by permeation in Franz cells. Cytotoxicity and hemolytic activity assays were performed to assess safety. The findings showed that the biological properties of CURC were preserved after loading in the NRL. About 44.2 % of CURC was released within the first six hours, and in vitro permeation showed that 9.36 % ± 0.65 was permeated over 24 h. CURC–NRL was associated with a metabolic activity higher than 70 % in 3 T3 fibroblasts, cell viability ≥95 % in human dermal fibroblasts, and a hemolytic rate ≤ 2.24 % after 24 h. Furthermore, CURC-NRL maintained the mechanical characteristics (range suitable) for human skin application. We observed that CURC-NRL preserved ~20 % antioxidant activity from curcumin-free after loading in the NRL. Our results suggest that CURC–NRL has the potential to be used in the cosmetics industry, and the experimental methodology utilized in this study can be applied to different kinds of face masks. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07-29T13:54:22Z 2023-07-29T13:54:22Z 2023-07-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.ijbiomac.2023.124778 International Journal of Biological Macromolecules, v. 242. 1879-0003 0141-8130 http://hdl.handle.net/11449/248812 10.1016/j.ijbiomac.2023.124778 2-s2.0-85159071052 |
url |
http://dx.doi.org/10.1016/j.ijbiomac.2023.124778 http://hdl.handle.net/11449/248812 |
identifier_str_mv |
International Journal of Biological Macromolecules, v. 242. 1879-0003 0141-8130 10.1016/j.ijbiomac.2023.124778 2-s2.0-85159071052 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
International Journal of Biological Macromolecules |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964973324042240 |