Can atrazine loaded nanocapsules reduce the toxic effects of this herbicide on the fish Prochilodus lineatus? A multibiomarker approach
Autor(a) principal: | |
---|---|
Data de Publicação: | 2019 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/183130 |
Resumo: | Atrazine (ATZ) is a widely used herbicide that has the potential to contaminate the environment and cause deleterious effects on non-target organisms. Release systems for ATZ have been developed to minimize this contamination, such as nanocapsules prepared with poly (ε-caprolactone) (PCL). The objective of this work was to investigate the effects of nanoencapsulated ATZ compared to ATZ on biomarkers of the freshwater teleost Prochilodus lineatus. The fish were exposed for 24 and 96 h to nanoencapsulated ATZ (nATZ) and atrazine (ATZ) at concentrations of 2 and 20 μg L-1, just to the PCL nanocapsules without the herbicide (NANO) in the corresponding amounts or only to dechlorinated water (CTR). The results showed that nATZ was less toxic compared to ATZ, as it did not promote an increase in glycemia, alterations in antioxidants, nor in carbonic anhydrase enzyme activity, and no increase in the frequency of micronuclei and other nuclear erythrocyte abnormalities either. However, exposure to nATZ, as well as to ATZ and PCL nanocapsules, resulted in a reduction in hemoglobin content, increase in erythrocyte DNA damage, as well as changes in Ca2+-ATPase activity, leading to a decrease in plasma Ca+2. The Integrated Biomarker Response Index (IBR) depicted that exposure to ATZ promoted changes in a greater number of biomarkers compared to nATZ, indicating that the nanoencapsulation of the herbicide protected the animal from the effects of ATZ |
id |
UNSP_43d6338b960884f889929a810b11b204 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/183130 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Can atrazine loaded nanocapsules reduce the toxic effects of this herbicide on the fish Prochilodus lineatus? A multibiomarker approachNanotechnologyOxidative stressGenotoxicityOsmoregulationNanopesticideAtrazine (ATZ) is a widely used herbicide that has the potential to contaminate the environment and cause deleterious effects on non-target organisms. Release systems for ATZ have been developed to minimize this contamination, such as nanocapsules prepared with poly (ε-caprolactone) (PCL). The objective of this work was to investigate the effects of nanoencapsulated ATZ compared to ATZ on biomarkers of the freshwater teleost Prochilodus lineatus. The fish were exposed for 24 and 96 h to nanoencapsulated ATZ (nATZ) and atrazine (ATZ) at concentrations of 2 and 20 μg L-1, just to the PCL nanocapsules without the herbicide (NANO) in the corresponding amounts or only to dechlorinated water (CTR). The results showed that nATZ was less toxic compared to ATZ, as it did not promote an increase in glycemia, alterations in antioxidants, nor in carbonic anhydrase enzyme activity, and no increase in the frequency of micronuclei and other nuclear erythrocyte abnormalities either. However, exposure to nATZ, as well as to ATZ and PCL nanocapsules, resulted in a reduction in hemoglobin content, increase in erythrocyte DNA damage, as well as changes in Ca2+-ATPase activity, leading to a decrease in plasma Ca+2. The Integrated Biomarker Response Index (IBR) depicted that exposure to ATZ promoted changes in a greater number of biomarkers compared to nATZ, indicating that the nanoencapsulation of the herbicide protected the animal from the effects of ATZFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)PreprintDepartment of Physiological Sciences, State University of Londrina (UEL)Institute of Science and Technology, São Paulo State University (UNESP)FAPESP: 2017/21004-5ElsevierUniversidade Estadual Paulista (Unesp)Andrade, Laura Lui dePereira, Anderson Espirito Santo [UNESP]Fraceto, Leonardo Fernandes [UNESP]Martinez, Claudia Bueno dos Reis2019-08-05T17:13:25Z2019-08-05T17:13:25Z2019-01-29info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article548-559application/pdfScience of the Total Environment, v. 663, p. 548-5590048-9697http://hdl.handle.net/11449/18313010.1016/j.scitotenv.2019.01.38047414805388833950000-0002-2827-2038engScience of The Total Environmentinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESP2023-10-17T06:07:32Zoai:repositorio.unesp.br:11449/183130Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-10-17T06:07:32Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Can atrazine loaded nanocapsules reduce the toxic effects of this herbicide on the fish Prochilodus lineatus? A multibiomarker approach |
title |
Can atrazine loaded nanocapsules reduce the toxic effects of this herbicide on the fish Prochilodus lineatus? A multibiomarker approach |
spellingShingle |
Can atrazine loaded nanocapsules reduce the toxic effects of this herbicide on the fish Prochilodus lineatus? A multibiomarker approach Andrade, Laura Lui de Nanotechnology Oxidative stress Genotoxicity Osmoregulation Nanopesticide |
title_short |
Can atrazine loaded nanocapsules reduce the toxic effects of this herbicide on the fish Prochilodus lineatus? A multibiomarker approach |
title_full |
Can atrazine loaded nanocapsules reduce the toxic effects of this herbicide on the fish Prochilodus lineatus? A multibiomarker approach |
title_fullStr |
Can atrazine loaded nanocapsules reduce the toxic effects of this herbicide on the fish Prochilodus lineatus? A multibiomarker approach |
title_full_unstemmed |
Can atrazine loaded nanocapsules reduce the toxic effects of this herbicide on the fish Prochilodus lineatus? A multibiomarker approach |
title_sort |
Can atrazine loaded nanocapsules reduce the toxic effects of this herbicide on the fish Prochilodus lineatus? A multibiomarker approach |
author |
Andrade, Laura Lui de |
author_facet |
Andrade, Laura Lui de Pereira, Anderson Espirito Santo [UNESP] Fraceto, Leonardo Fernandes [UNESP] Martinez, Claudia Bueno dos Reis |
author_role |
author |
author2 |
Pereira, Anderson Espirito Santo [UNESP] Fraceto, Leonardo Fernandes [UNESP] Martinez, Claudia Bueno dos Reis |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Andrade, Laura Lui de Pereira, Anderson Espirito Santo [UNESP] Fraceto, Leonardo Fernandes [UNESP] Martinez, Claudia Bueno dos Reis |
dc.subject.por.fl_str_mv |
Nanotechnology Oxidative stress Genotoxicity Osmoregulation Nanopesticide |
topic |
Nanotechnology Oxidative stress Genotoxicity Osmoregulation Nanopesticide |
description |
Atrazine (ATZ) is a widely used herbicide that has the potential to contaminate the environment and cause deleterious effects on non-target organisms. Release systems for ATZ have been developed to minimize this contamination, such as nanocapsules prepared with poly (ε-caprolactone) (PCL). The objective of this work was to investigate the effects of nanoencapsulated ATZ compared to ATZ on biomarkers of the freshwater teleost Prochilodus lineatus. The fish were exposed for 24 and 96 h to nanoencapsulated ATZ (nATZ) and atrazine (ATZ) at concentrations of 2 and 20 μg L-1, just to the PCL nanocapsules without the herbicide (NANO) in the corresponding amounts or only to dechlorinated water (CTR). The results showed that nATZ was less toxic compared to ATZ, as it did not promote an increase in glycemia, alterations in antioxidants, nor in carbonic anhydrase enzyme activity, and no increase in the frequency of micronuclei and other nuclear erythrocyte abnormalities either. However, exposure to nATZ, as well as to ATZ and PCL nanocapsules, resulted in a reduction in hemoglobin content, increase in erythrocyte DNA damage, as well as changes in Ca2+-ATPase activity, leading to a decrease in plasma Ca+2. The Integrated Biomarker Response Index (IBR) depicted that exposure to ATZ promoted changes in a greater number of biomarkers compared to nATZ, indicating that the nanoencapsulation of the herbicide protected the animal from the effects of ATZ |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-08-05T17:13:25Z 2019-08-05T17:13:25Z 2019-01-29 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Science of the Total Environment, v. 663, p. 548-559 0048-9697 http://hdl.handle.net/11449/183130 10.1016/j.scitotenv.2019.01.380 4741480538883395 0000-0002-2827-2038 |
identifier_str_mv |
Science of the Total Environment, v. 663, p. 548-559 0048-9697 10.1016/j.scitotenv.2019.01.380 4741480538883395 0000-0002-2827-2038 |
url |
http://hdl.handle.net/11449/183130 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Science of The Total Environment |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
548-559 application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964597028913152 |