Brazilian propolis promotes immunomodulation on human cells from American Tegumentar Leishmaniasis patients and healthy donors infected with L. braziliensis
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.cellimm.2016.09.014 http://hdl.handle.net/11449/173858 |
Resumo: | American Tegumentar Leishmaniasis (ATL) is an infectious disease caused by Leishmania parasites with ineffective treatment. The properties of propolis have been studied in different experimental studies, however, few works have investigated the effects of propolis on human-derived peripheral blood mononuclear cells (PBMC) in leishmaniasis models. Thus, we investigate the immunomodulatory effects of propolis treatment on PBMC from ATL patients and on PBMC from healthy donors infected with Leishmania braziliensis. Our data demonstrate that propolis pretreatment shows immunomodulatory effects on both healthy donors and ATL patients adherent cells, increasing IL-4 and IL-17 and decreasing IL-10, in either the presence or absence of the L. braziliensis infection, demonstrating that propolis contributes with the decrease of the inflammation and could also contribute with parasite control. |
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Brazilian propolis promotes immunomodulation on human cells from American Tegumentar Leishmaniasis patients and healthy donors infected with L. braziliensisHuman PBMCIL-10IL-4IL-6In vitroTh17American Tegumentar Leishmaniasis (ATL) is an infectious disease caused by Leishmania parasites with ineffective treatment. The properties of propolis have been studied in different experimental studies, however, few works have investigated the effects of propolis on human-derived peripheral blood mononuclear cells (PBMC) in leishmaniasis models. Thus, we investigate the immunomodulatory effects of propolis treatment on PBMC from ATL patients and on PBMC from healthy donors infected with Leishmania braziliensis. Our data demonstrate that propolis pretreatment shows immunomodulatory effects on both healthy donors and ATL patients adherent cells, increasing IL-4 and IL-17 and decreasing IL-10, in either the presence or absence of the L. braziliensis infection, demonstrating that propolis contributes with the decrease of the inflammation and could also contribute with parasite control.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação AraucáriaDepartamento de Ciências Patológicas Centro de Ciências Biológicas Universidade Estadual de LondrinaLaboratório de Mediadores Inflamatórios Universidade do Oeste do Paraná UNIOESTEAmbulatório de Especialidades do Hospital Universitário de LondrinaLaboratório de Virologia Molecular Instituto Carlos Chagas/Fundação Oswaldo CruzDepartamento de Microbiologia e Imunologia Instituto de Biociência Universidade Estadual Paulista UNESPDepartamento de Microbiologia e Imunologia Instituto de Biociência Universidade Estadual Paulista UNESPUniversidade Estadual de Londrina (UEL)UNIOESTEAmbulatório de Especialidades do Hospital Universitário de LondrinaInstituto Carlos Chagas/Fundação Oswaldo CruzUniversidade Estadual Paulista (Unesp)dos Santos Thomazelli, Ana Paula FortesTomiotto-Pellissier, Fernandada Silva, Suelen SantosPanis, CarolinaOrsini, Tatiane MarcussoCataneo, Allan Henrique DepieriMiranda-Sapla, Milena MenegazzoCustódio, Luiz AntonioTatakihara, Vera Lúcia HidekoBordignon, JulianoSilveira, Guilherme FerreiraSforcin, José Maurício [UNESP]Pavanelli, Wander RogérioConchon-Costa, Ivete2018-12-11T17:08:04Z2018-12-11T17:08:04Z2017-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article22-27application/pdfhttp://dx.doi.org/10.1016/j.cellimm.2016.09.014Cellular Immunology, v. 311, p. 22-27.1090-21630008-8749http://hdl.handle.net/11449/17385810.1016/j.cellimm.2016.09.0142-s2.0-850003991842-s2.0-85000399184.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCellular Immunology1,3551,355info:eu-repo/semantics/openAccess2023-11-28T06:16:34Zoai:repositorio.unesp.br:11449/173858Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-28T06:16:34Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Brazilian propolis promotes immunomodulation on human cells from American Tegumentar Leishmaniasis patients and healthy donors infected with L. braziliensis |
title |
Brazilian propolis promotes immunomodulation on human cells from American Tegumentar Leishmaniasis patients and healthy donors infected with L. braziliensis |
spellingShingle |
Brazilian propolis promotes immunomodulation on human cells from American Tegumentar Leishmaniasis patients and healthy donors infected with L. braziliensis dos Santos Thomazelli, Ana Paula Fortes Human PBMC IL-10 IL-4 IL-6 In vitro Th17 |
title_short |
Brazilian propolis promotes immunomodulation on human cells from American Tegumentar Leishmaniasis patients and healthy donors infected with L. braziliensis |
title_full |
Brazilian propolis promotes immunomodulation on human cells from American Tegumentar Leishmaniasis patients and healthy donors infected with L. braziliensis |
title_fullStr |
Brazilian propolis promotes immunomodulation on human cells from American Tegumentar Leishmaniasis patients and healthy donors infected with L. braziliensis |
title_full_unstemmed |
Brazilian propolis promotes immunomodulation on human cells from American Tegumentar Leishmaniasis patients and healthy donors infected with L. braziliensis |
title_sort |
Brazilian propolis promotes immunomodulation on human cells from American Tegumentar Leishmaniasis patients and healthy donors infected with L. braziliensis |
author |
dos Santos Thomazelli, Ana Paula Fortes |
author_facet |
dos Santos Thomazelli, Ana Paula Fortes Tomiotto-Pellissier, Fernanda da Silva, Suelen Santos Panis, Carolina Orsini, Tatiane Marcusso Cataneo, Allan Henrique Depieri Miranda-Sapla, Milena Menegazzo Custódio, Luiz Antonio Tatakihara, Vera Lúcia Hideko Bordignon, Juliano Silveira, Guilherme Ferreira Sforcin, José Maurício [UNESP] Pavanelli, Wander Rogério Conchon-Costa, Ivete |
author_role |
author |
author2 |
Tomiotto-Pellissier, Fernanda da Silva, Suelen Santos Panis, Carolina Orsini, Tatiane Marcusso Cataneo, Allan Henrique Depieri Miranda-Sapla, Milena Menegazzo Custódio, Luiz Antonio Tatakihara, Vera Lúcia Hideko Bordignon, Juliano Silveira, Guilherme Ferreira Sforcin, José Maurício [UNESP] Pavanelli, Wander Rogério Conchon-Costa, Ivete |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual de Londrina (UEL) UNIOESTE Ambulatório de Especialidades do Hospital Universitário de Londrina Instituto Carlos Chagas/Fundação Oswaldo Cruz Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
dos Santos Thomazelli, Ana Paula Fortes Tomiotto-Pellissier, Fernanda da Silva, Suelen Santos Panis, Carolina Orsini, Tatiane Marcusso Cataneo, Allan Henrique Depieri Miranda-Sapla, Milena Menegazzo Custódio, Luiz Antonio Tatakihara, Vera Lúcia Hideko Bordignon, Juliano Silveira, Guilherme Ferreira Sforcin, José Maurício [UNESP] Pavanelli, Wander Rogério Conchon-Costa, Ivete |
dc.subject.por.fl_str_mv |
Human PBMC IL-10 IL-4 IL-6 In vitro Th17 |
topic |
Human PBMC IL-10 IL-4 IL-6 In vitro Th17 |
description |
American Tegumentar Leishmaniasis (ATL) is an infectious disease caused by Leishmania parasites with ineffective treatment. The properties of propolis have been studied in different experimental studies, however, few works have investigated the effects of propolis on human-derived peripheral blood mononuclear cells (PBMC) in leishmaniasis models. Thus, we investigate the immunomodulatory effects of propolis treatment on PBMC from ATL patients and on PBMC from healthy donors infected with Leishmania braziliensis. Our data demonstrate that propolis pretreatment shows immunomodulatory effects on both healthy donors and ATL patients adherent cells, increasing IL-4 and IL-17 and decreasing IL-10, in either the presence or absence of the L. braziliensis infection, demonstrating that propolis contributes with the decrease of the inflammation and could also contribute with parasite control. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-01-01 2018-12-11T17:08:04Z 2018-12-11T17:08:04Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.cellimm.2016.09.014 Cellular Immunology, v. 311, p. 22-27. 1090-2163 0008-8749 http://hdl.handle.net/11449/173858 10.1016/j.cellimm.2016.09.014 2-s2.0-85000399184 2-s2.0-85000399184.pdf |
url |
http://dx.doi.org/10.1016/j.cellimm.2016.09.014 http://hdl.handle.net/11449/173858 |
identifier_str_mv |
Cellular Immunology, v. 311, p. 22-27. 1090-2163 0008-8749 10.1016/j.cellimm.2016.09.014 2-s2.0-85000399184 2-s2.0-85000399184.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Cellular Immunology 1,355 1,355 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
22-27 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965100771115008 |