In vitro antiglycation and antioxidant properties of Eugenia pyriformis leaves and fruits
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1080/14786419.2021.2005049 http://hdl.handle.net/11449/229933 |
Resumo: | Eight phenolic compounds were isolated from Eugenia pyriformis leaves fraction by semi-preparative HPLC and characterized by Nuclear Magnetic Resonance (NMR) and mass spectrometry (ESI-MS). Five compounds were isolated and identified for the first time in E. pyriformis species, while this is the first report of the accumulation of isoquercitrin, quercitrin, and the aglycone quercetin in its leaves. E. pyriformis leaves and fruits extracts, as well as the compounds isolated from the leaves most active fraction, were evaluated for their antiglycation and antioxidant activities. The mixture of myricetin-3-O-(2″-O-galloyl)-α-L-rhamnoside and myricetin-3-O-(4″-O-galloyl)-α-L-rhamnoside showed the highest antiglycation activity. These results suggest that this species is a promising source of bioactive compounds. Further studies to investigate the inhibition of the glycation process in vivo are necessary to evaluate its use in the treatment and/or prevention of advanced glycation end-products (AGEs)-associated diseases. |
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In vitro antiglycation and antioxidant properties of Eugenia pyriformis leaves and fruitsantiglycation activityantioxidantEugenia pyriformisflavonoidsphenolic compoundsuvaiaEight phenolic compounds were isolated from Eugenia pyriformis leaves fraction by semi-preparative HPLC and characterized by Nuclear Magnetic Resonance (NMR) and mass spectrometry (ESI-MS). Five compounds were isolated and identified for the first time in E. pyriformis species, while this is the first report of the accumulation of isoquercitrin, quercitrin, and the aglycone quercetin in its leaves. E. pyriformis leaves and fruits extracts, as well as the compounds isolated from the leaves most active fraction, were evaluated for their antiglycation and antioxidant activities. The mixture of myricetin-3-O-(2″-O-galloyl)-α-L-rhamnoside and myricetin-3-O-(4″-O-galloyl)-α-L-rhamnoside showed the highest antiglycation activity. These results suggest that this species is a promising source of bioactive compounds. Further studies to investigate the inhibition of the glycation process in vivo are necessary to evaluate its use in the treatment and/or prevention of advanced glycation end-products (AGEs)-associated diseases.Laboratory of Phytochemistry and Biomolecules (LabFitoBio) Department of Chemistry State University of Londrina (UEL)Nuclei of Bioassays Biosynthesis and Ecophysiology of Natural Products (NuBBE) Department of Biochemistry and Organic Chemistry Institute of Chemistry São Paulo State University (UNESP)BioSmart Nanotechnology LTDA MeNuclei of Bioassays Biosynthesis and Ecophysiology of Natural Products (NuBBE) Department of Biochemistry and Organic Chemistry Institute of Chemistry São Paulo State University (UNESP)Universidade Estadual de Londrina (UEL)Universidade Estadual Paulista (UNESP)BioSmart Nanotechnology LTDA Meda Silva, Giselle LopesCampideli, Mariana Bordin [UNESP]Ferrari, Anna Beatriz SabinoMannochio-Russo, Helena [UNESP]Fraige, Karina [UNESP]Dametto, Alessandra CristinaBolzani, Vanderlan da Silva [UNESP]Zeraik, Maria Luiza2022-04-29T08:36:43Z2022-04-29T08:36:43Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1080/14786419.2021.2005049Natural Product Research.1478-64271478-6419http://hdl.handle.net/11449/22993310.1080/14786419.2021.20050492-s2.0-85119661032Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengNatural Product Researchinfo:eu-repo/semantics/openAccess2022-04-29T08:36:43Zoai:repositorio.unesp.br:11449/229933Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-29T08:36:43Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
In vitro antiglycation and antioxidant properties of Eugenia pyriformis leaves and fruits |
title |
In vitro antiglycation and antioxidant properties of Eugenia pyriformis leaves and fruits |
spellingShingle |
In vitro antiglycation and antioxidant properties of Eugenia pyriformis leaves and fruits da Silva, Giselle Lopes antiglycation activity antioxidant Eugenia pyriformis flavonoids phenolic compounds uvaia |
title_short |
In vitro antiglycation and antioxidant properties of Eugenia pyriformis leaves and fruits |
title_full |
In vitro antiglycation and antioxidant properties of Eugenia pyriformis leaves and fruits |
title_fullStr |
In vitro antiglycation and antioxidant properties of Eugenia pyriformis leaves and fruits |
title_full_unstemmed |
In vitro antiglycation and antioxidant properties of Eugenia pyriformis leaves and fruits |
title_sort |
In vitro antiglycation and antioxidant properties of Eugenia pyriformis leaves and fruits |
author |
da Silva, Giselle Lopes |
author_facet |
da Silva, Giselle Lopes Campideli, Mariana Bordin [UNESP] Ferrari, Anna Beatriz Sabino Mannochio-Russo, Helena [UNESP] Fraige, Karina [UNESP] Dametto, Alessandra Cristina Bolzani, Vanderlan da Silva [UNESP] Zeraik, Maria Luiza |
author_role |
author |
author2 |
Campideli, Mariana Bordin [UNESP] Ferrari, Anna Beatriz Sabino Mannochio-Russo, Helena [UNESP] Fraige, Karina [UNESP] Dametto, Alessandra Cristina Bolzani, Vanderlan da Silva [UNESP] Zeraik, Maria Luiza |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual de Londrina (UEL) Universidade Estadual Paulista (UNESP) BioSmart Nanotechnology LTDA Me |
dc.contributor.author.fl_str_mv |
da Silva, Giselle Lopes Campideli, Mariana Bordin [UNESP] Ferrari, Anna Beatriz Sabino Mannochio-Russo, Helena [UNESP] Fraige, Karina [UNESP] Dametto, Alessandra Cristina Bolzani, Vanderlan da Silva [UNESP] Zeraik, Maria Luiza |
dc.subject.por.fl_str_mv |
antiglycation activity antioxidant Eugenia pyriformis flavonoids phenolic compounds uvaia |
topic |
antiglycation activity antioxidant Eugenia pyriformis flavonoids phenolic compounds uvaia |
description |
Eight phenolic compounds were isolated from Eugenia pyriformis leaves fraction by semi-preparative HPLC and characterized by Nuclear Magnetic Resonance (NMR) and mass spectrometry (ESI-MS). Five compounds were isolated and identified for the first time in E. pyriformis species, while this is the first report of the accumulation of isoquercitrin, quercitrin, and the aglycone quercetin in its leaves. E. pyriformis leaves and fruits extracts, as well as the compounds isolated from the leaves most active fraction, were evaluated for their antiglycation and antioxidant activities. The mixture of myricetin-3-O-(2″-O-galloyl)-α-L-rhamnoside and myricetin-3-O-(4″-O-galloyl)-α-L-rhamnoside showed the highest antiglycation activity. These results suggest that this species is a promising source of bioactive compounds. Further studies to investigate the inhibition of the glycation process in vivo are necessary to evaluate its use in the treatment and/or prevention of advanced glycation end-products (AGEs)-associated diseases. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 2022-04-29T08:36:43Z 2022-04-29T08:36:43Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1080/14786419.2021.2005049 Natural Product Research. 1478-6427 1478-6419 http://hdl.handle.net/11449/229933 10.1080/14786419.2021.2005049 2-s2.0-85119661032 |
url |
http://dx.doi.org/10.1080/14786419.2021.2005049 http://hdl.handle.net/11449/229933 |
identifier_str_mv |
Natural Product Research. 1478-6427 1478-6419 10.1080/14786419.2021.2005049 2-s2.0-85119661032 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Natural Product Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965144794529792 |