Repeated administration of caffeine induces either sensitization or tolerance of locomotor stimulation depending on the environmental context
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.if-pan.krakow.pl/pjp/pdf/2012/1_70.pdf http://hdl.handle.net/11449/8113 |
Resumo: | Caffeine is the psychostimulant substance consumed in greatest quantities in the world. The repeated administration of psychostimulants can either decrease or increase the drug effect, inducing tolerance or sensitization, respectively, depending on administration procedure. Not only the dose and regimen, but also the environment where drug is administered, seem to modulate the changes in locomotor activity following repeated psychostimulant administration. The purpose of the present study was to examine the influence of the environmental context on caffeine-induced psychomotor stimulation following repeated administration of this drug. Our results showed that repeated caffeine induced psychomotor sensitization when drug injections were paired with the environment in which the animals were subsequently tested, whereas tolerance occurred when the animals received repeated caffeine in an environment different from that where the tests were performed. In conclusion, the present results demonstrated that the environmental context where caffeine is administered is a key factor modulating the adaptations of the organism to drug effects. |
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Repositório Institucional da UNESP |
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Repeated administration of caffeine induces either sensitization or tolerance of locomotor stimulation depending on the environmental contextcaffeinesensitizationtoleranceenvironmental contextpsychostimulantsCaffeine is the psychostimulant substance consumed in greatest quantities in the world. The repeated administration of psychostimulants can either decrease or increase the drug effect, inducing tolerance or sensitization, respectively, depending on administration procedure. Not only the dose and regimen, but also the environment where drug is administered, seem to modulate the changes in locomotor activity following repeated psychostimulant administration. The purpose of the present study was to examine the influence of the environmental context on caffeine-induced psychomotor stimulation following repeated administration of this drug. Our results showed that repeated caffeine induced psychomotor sensitization when drug injections were paired with the environment in which the animals were subsequently tested, whereas tolerance occurred when the animals received repeated caffeine in an environment different from that where the tests were performed. In conclusion, the present results demonstrated that the environmental context where caffeine is administered is a key factor modulating the adaptations of the organism to drug effects.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Estadual Paulista UNESP, Sch Pharmaceut Sci, Pharmacol Lab, BR-14801902 Araraquara, SP, BrazilUFSCar UNESP, Interinst Grad Program Physiol Sci, BR-13565905 São Carlos, SP, BrazilFed Univ Uberlandia UFU, Inst Biomed Sci, BR-38400902 Uberlandia, MG, BrazilUniv Estadual Paulista UNESP, Sch Pharmaceut Sci, Pharmacol Lab, BR-14801902 Araraquara, SP, BrazilUFSCar UNESP, Interinst Grad Program Physiol Sci, BR-13565905 São Carlos, SP, BrazilFAPESP: 07/57542-9FAPESP: 07/57541-2FAPESP: 08/10892FAPESP: 08/01744-5Polish Acad Sciences Inst PharmacologyUniversidade Estadual Paulista (Unesp)Universidade Federal de Uberlândia (UFU)Zancheta, Roberta [UNESP]Possi, Ana P. M. [UNESP]Planeta, Cleopatra da Silva [UNESP]Marin, Marcelo Tadeu [UNESP]2014-05-20T13:25:34Z2014-05-20T13:25:34Z2012-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article70-77http://www.if-pan.krakow.pl/pjp/pdf/2012/1_70.pdfPharmacological Reports. Krakow: Polish Acad Sciences Inst Pharmacology, v. 64, n. 1, p. 70-77, 2012.1734-1140http://hdl.handle.net/11449/8113WOS:000304224900008251476254528094279204388025397270000-0002-1378-6327Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPharmacological Reports2.7870,773info:eu-repo/semantics/openAccess2022-02-10T00:29:19Zoai:repositorio.unesp.br:11449/8113Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-02-10T00:29:19Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Repeated administration of caffeine induces either sensitization or tolerance of locomotor stimulation depending on the environmental context |
title |
Repeated administration of caffeine induces either sensitization or tolerance of locomotor stimulation depending on the environmental context |
spellingShingle |
Repeated administration of caffeine induces either sensitization or tolerance of locomotor stimulation depending on the environmental context Zancheta, Roberta [UNESP] caffeine sensitization tolerance environmental context psychostimulants |
title_short |
Repeated administration of caffeine induces either sensitization or tolerance of locomotor stimulation depending on the environmental context |
title_full |
Repeated administration of caffeine induces either sensitization or tolerance of locomotor stimulation depending on the environmental context |
title_fullStr |
Repeated administration of caffeine induces either sensitization or tolerance of locomotor stimulation depending on the environmental context |
title_full_unstemmed |
Repeated administration of caffeine induces either sensitization or tolerance of locomotor stimulation depending on the environmental context |
title_sort |
Repeated administration of caffeine induces either sensitization or tolerance of locomotor stimulation depending on the environmental context |
author |
Zancheta, Roberta [UNESP] |
author_facet |
Zancheta, Roberta [UNESP] Possi, Ana P. M. [UNESP] Planeta, Cleopatra da Silva [UNESP] Marin, Marcelo Tadeu [UNESP] |
author_role |
author |
author2 |
Possi, Ana P. M. [UNESP] Planeta, Cleopatra da Silva [UNESP] Marin, Marcelo Tadeu [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Federal de Uberlândia (UFU) |
dc.contributor.author.fl_str_mv |
Zancheta, Roberta [UNESP] Possi, Ana P. M. [UNESP] Planeta, Cleopatra da Silva [UNESP] Marin, Marcelo Tadeu [UNESP] |
dc.subject.por.fl_str_mv |
caffeine sensitization tolerance environmental context psychostimulants |
topic |
caffeine sensitization tolerance environmental context psychostimulants |
description |
Caffeine is the psychostimulant substance consumed in greatest quantities in the world. The repeated administration of psychostimulants can either decrease or increase the drug effect, inducing tolerance or sensitization, respectively, depending on administration procedure. Not only the dose and regimen, but also the environment where drug is administered, seem to modulate the changes in locomotor activity following repeated psychostimulant administration. The purpose of the present study was to examine the influence of the environmental context on caffeine-induced psychomotor stimulation following repeated administration of this drug. Our results showed that repeated caffeine induced psychomotor sensitization when drug injections were paired with the environment in which the animals were subsequently tested, whereas tolerance occurred when the animals received repeated caffeine in an environment different from that where the tests were performed. In conclusion, the present results demonstrated that the environmental context where caffeine is administered is a key factor modulating the adaptations of the organism to drug effects. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-01-01 2014-05-20T13:25:34Z 2014-05-20T13:25:34Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.if-pan.krakow.pl/pjp/pdf/2012/1_70.pdf Pharmacological Reports. Krakow: Polish Acad Sciences Inst Pharmacology, v. 64, n. 1, p. 70-77, 2012. 1734-1140 http://hdl.handle.net/11449/8113 WOS:000304224900008 2514762545280942 7920438802539727 0000-0002-1378-6327 |
url |
http://www.if-pan.krakow.pl/pjp/pdf/2012/1_70.pdf http://hdl.handle.net/11449/8113 |
identifier_str_mv |
Pharmacological Reports. Krakow: Polish Acad Sciences Inst Pharmacology, v. 64, n. 1, p. 70-77, 2012. 1734-1140 WOS:000304224900008 2514762545280942 7920438802539727 0000-0002-1378-6327 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pharmacological Reports 2.787 0,773 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
70-77 |
dc.publisher.none.fl_str_mv |
Polish Acad Sciences Inst Pharmacology |
publisher.none.fl_str_mv |
Polish Acad Sciences Inst Pharmacology |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964454192939008 |