Flunixin Meglumine Is Superior to Meloxicam for Providing Analgesia after Surgical Castration in 2-Month-Old Goats
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3390/ani12233437 http://hdl.handle.net/11449/246442 |
Resumo: | Farm animals are exposed to various painful procedures during their productive lives, making it necessary to implement anesthetic and analgesic protocols. However, there are few studies evaluating the effectiveness of these drugs. Our objective was to compare the analgesic effects of two nonsteroidal anti-inflammatory drugs (NSAIDs): meloxicam (MEL) and flunixin meglumine (FLU), in goat kids subjected to surgical castration under local anesthesia. Anglo-Nubian goat kids (60 days old) were allocated into two groups: MEL (n = 9), and FLU (n = 8), each administered 5 min before starting castration. All had been previously subjected to local anesthesia with lidocaine, injected bilaterally into the testes, plus subcutaneous in the scrotal raphe. Pain sensitivity was evaluated using the von Frey monofilaments test. Reactions were recorded before castration (M0), immediately after castration (M1), and once-daily for three consecutive days post-castration (M2, M3, and M4, respectively). Pain assessments were conducted in three body regions: at four points of the scrotum (dorsal and ventral; left and right lateral; R1); medial region of the pelvic limb, gracilis muscle (R2); and hypogastric region of the abdomen (R3). MEL goats had considerably greater pain reaction in R1 and R2 over time, mainly in M2; therefore, FLU was a more effective analgesic than MEL, resulting in less pain reaction. |
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Flunixin Meglumine Is Superior to Meloxicam for Providing Analgesia after Surgical Castration in 2-Month-Old GoatsAnglo-Nubian goat kidsanimal welfarenon-steroidal anti-inflammatory drugspainvon Frey monofilament testFarm animals are exposed to various painful procedures during their productive lives, making it necessary to implement anesthetic and analgesic protocols. However, there are few studies evaluating the effectiveness of these drugs. Our objective was to compare the analgesic effects of two nonsteroidal anti-inflammatory drugs (NSAIDs): meloxicam (MEL) and flunixin meglumine (FLU), in goat kids subjected to surgical castration under local anesthesia. Anglo-Nubian goat kids (60 days old) were allocated into two groups: MEL (n = 9), and FLU (n = 8), each administered 5 min before starting castration. All had been previously subjected to local anesthesia with lidocaine, injected bilaterally into the testes, plus subcutaneous in the scrotal raphe. Pain sensitivity was evaluated using the von Frey monofilaments test. Reactions were recorded before castration (M0), immediately after castration (M1), and once-daily for three consecutive days post-castration (M2, M3, and M4, respectively). Pain assessments were conducted in three body regions: at four points of the scrotum (dorsal and ventral; left and right lateral; R1); medial region of the pelvic limb, gracilis muscle (R2); and hypogastric region of the abdomen (R3). MEL goats had considerably greater pain reaction in R1 and R2 over time, mainly in M2; therefore, FLU was a more effective analgesic than MEL, resulting in less pain reaction.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Faculty of Veterinary Medicine University of CalgaryUNESP Faculty of Agricultural and Veterinary Sciences Ethology and Animal Ecology Research Group (ETCO), SPUNESP Faculty of Veterinary Medicine and Animal Science Graduate Program in Animal Biotechnology São Paulo State University, SPUNESP Faculty of Agricultural and Veterinary Sciences Department of Animal Science, SPCNPq—National Council for Scientific and Technological Development, DFUNESP Faculty of Agricultural and Veterinary Sciences Ethology and Animal Ecology Research Group (ETCO), SPUNESP Faculty of Veterinary Medicine and Animal Science Graduate Program in Animal Biotechnology São Paulo State University, SPUNESP Faculty of Agricultural and Veterinary Sciences Department of Animal Science, SPUniversity of CalgaryUniversidade Estadual Paulista (UNESP)CNPq—National Council for Scientific and Technological DevelopmentBrusin, Victor [UNESP]Ceballos, Maria CamilaTrindade, Pedro Henrique Esteves [UNESP]Rocha Góis, Karen CamilleConde, Gabriel [UNESP]Tessarine Barbosa, Virginia [UNESP]Rosa, Gustavo dos Santos [UNESP]Paranhos da Costa, Mateus Jose Rodrigues [UNESP]2023-07-29T12:41:00Z2023-07-29T12:41:00Z2022-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/ani12233437Animals, v. 12, n. 23, 2022.2076-2615http://hdl.handle.net/11449/24644210.3390/ani122334372-s2.0-85143619886Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAnimalsinfo:eu-repo/semantics/openAccess2023-07-29T12:41:00Zoai:repositorio.unesp.br:11449/246442Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-07-29T12:41Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Flunixin Meglumine Is Superior to Meloxicam for Providing Analgesia after Surgical Castration in 2-Month-Old Goats |
title |
Flunixin Meglumine Is Superior to Meloxicam for Providing Analgesia after Surgical Castration in 2-Month-Old Goats |
spellingShingle |
Flunixin Meglumine Is Superior to Meloxicam for Providing Analgesia after Surgical Castration in 2-Month-Old Goats Brusin, Victor [UNESP] Anglo-Nubian goat kids animal welfare non-steroidal anti-inflammatory drugs pain von Frey monofilament test |
title_short |
Flunixin Meglumine Is Superior to Meloxicam for Providing Analgesia after Surgical Castration in 2-Month-Old Goats |
title_full |
Flunixin Meglumine Is Superior to Meloxicam for Providing Analgesia after Surgical Castration in 2-Month-Old Goats |
title_fullStr |
Flunixin Meglumine Is Superior to Meloxicam for Providing Analgesia after Surgical Castration in 2-Month-Old Goats |
title_full_unstemmed |
Flunixin Meglumine Is Superior to Meloxicam for Providing Analgesia after Surgical Castration in 2-Month-Old Goats |
title_sort |
Flunixin Meglumine Is Superior to Meloxicam for Providing Analgesia after Surgical Castration in 2-Month-Old Goats |
author |
Brusin, Victor [UNESP] |
author_facet |
Brusin, Victor [UNESP] Ceballos, Maria Camila Trindade, Pedro Henrique Esteves [UNESP] Rocha Góis, Karen Camille Conde, Gabriel [UNESP] Tessarine Barbosa, Virginia [UNESP] Rosa, Gustavo dos Santos [UNESP] Paranhos da Costa, Mateus Jose Rodrigues [UNESP] |
author_role |
author |
author2 |
Ceballos, Maria Camila Trindade, Pedro Henrique Esteves [UNESP] Rocha Góis, Karen Camille Conde, Gabriel [UNESP] Tessarine Barbosa, Virginia [UNESP] Rosa, Gustavo dos Santos [UNESP] Paranhos da Costa, Mateus Jose Rodrigues [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
University of Calgary Universidade Estadual Paulista (UNESP) CNPq—National Council for Scientific and Technological Development |
dc.contributor.author.fl_str_mv |
Brusin, Victor [UNESP] Ceballos, Maria Camila Trindade, Pedro Henrique Esteves [UNESP] Rocha Góis, Karen Camille Conde, Gabriel [UNESP] Tessarine Barbosa, Virginia [UNESP] Rosa, Gustavo dos Santos [UNESP] Paranhos da Costa, Mateus Jose Rodrigues [UNESP] |
dc.subject.por.fl_str_mv |
Anglo-Nubian goat kids animal welfare non-steroidal anti-inflammatory drugs pain von Frey monofilament test |
topic |
Anglo-Nubian goat kids animal welfare non-steroidal anti-inflammatory drugs pain von Frey monofilament test |
description |
Farm animals are exposed to various painful procedures during their productive lives, making it necessary to implement anesthetic and analgesic protocols. However, there are few studies evaluating the effectiveness of these drugs. Our objective was to compare the analgesic effects of two nonsteroidal anti-inflammatory drugs (NSAIDs): meloxicam (MEL) and flunixin meglumine (FLU), in goat kids subjected to surgical castration under local anesthesia. Anglo-Nubian goat kids (60 days old) were allocated into two groups: MEL (n = 9), and FLU (n = 8), each administered 5 min before starting castration. All had been previously subjected to local anesthesia with lidocaine, injected bilaterally into the testes, plus subcutaneous in the scrotal raphe. Pain sensitivity was evaluated using the von Frey monofilaments test. Reactions were recorded before castration (M0), immediately after castration (M1), and once-daily for three consecutive days post-castration (M2, M3, and M4, respectively). Pain assessments were conducted in three body regions: at four points of the scrotum (dorsal and ventral; left and right lateral; R1); medial region of the pelvic limb, gracilis muscle (R2); and hypogastric region of the abdomen (R3). MEL goats had considerably greater pain reaction in R1 and R2 over time, mainly in M2; therefore, FLU was a more effective analgesic than MEL, resulting in less pain reaction. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-12-01 2023-07-29T12:41:00Z 2023-07-29T12:41:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3390/ani12233437 Animals, v. 12, n. 23, 2022. 2076-2615 http://hdl.handle.net/11449/246442 10.3390/ani12233437 2-s2.0-85143619886 |
url |
http://dx.doi.org/10.3390/ani12233437 http://hdl.handle.net/11449/246442 |
identifier_str_mv |
Animals, v. 12, n. 23, 2022. 2076-2615 10.3390/ani12233437 2-s2.0-85143619886 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Animals |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965581277921280 |