Water Dilutes and Alcohol Concentrates Urinary Arsenic Species When Food is the Dominant Source of Exposure
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s12403-019-00329-5 http://hdl.handle.net/11449/199650 |
Resumo: | Exposure to certain arsenic (As) species has been associated with increased cancer risk and a wide range of other health concerns, even at low levels. Here we used urine as a biomarker of As internal dose in a well-characterized cohort to relate diet, demographics and geography to exposure. As speciation in spot urine samples was determined for 89 participants aged ≥ 50 years from the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA), stratified to cover the country. Principal component analysis showed that all As species clustered together, suggesting that arsenobetaine, inorganic As (iAs) and the methylated species monomethylarsonic acid and dimethylarsinic acid forms have a common source. Seafood and alcohol consumption were positively correlated with As species, while dairy products (i.e. milk) and tap water were negatively correlated. Multiple regression analysis showed that diet explained approximately 30% of the variability in urinary iAs concentrations. Geography was not found to be a predictor of As exposure. Dairy consumption was negatively correlated and the best predictor of iAs in urine, explaining 15.9% of the variability. The majority of the variation in As biomarkers was not explained, suggesting the contribution of other sources and other non-predicted variables on As metabolism and elimination. |
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Water Dilutes and Alcohol Concentrates Urinary Arsenic Species When Food is the Dominant Source of ExposureArsenicDietMetabolismSpeciationUrineExposure to certain arsenic (As) species has been associated with increased cancer risk and a wide range of other health concerns, even at low levels. Here we used urine as a biomarker of As internal dose in a well-characterized cohort to relate diet, demographics and geography to exposure. As speciation in spot urine samples was determined for 89 participants aged ≥ 50 years from the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA), stratified to cover the country. Principal component analysis showed that all As species clustered together, suggesting that arsenobetaine, inorganic As (iAs) and the methylated species monomethylarsonic acid and dimethylarsinic acid forms have a common source. Seafood and alcohol consumption were positively correlated with As species, while dairy products (i.e. milk) and tap water were negatively correlated. Multiple regression analysis showed that diet explained approximately 30% of the variability in urinary iAs concentrations. Geography was not found to be a predictor of As exposure. Dairy consumption was negatively correlated and the best predictor of iAs in urine, explaining 15.9% of the variability. The majority of the variation in As biomarkers was not explained, suggesting the contribution of other sources and other non-predicted variables on As metabolism and elimination.Institute for Global Food Security Queen’s University Belfast, 19 Chlorine GardensCentre for Public Health Queen’s University BelfastDepartment of Natural Products and Toxicology School of Pharmaceutical Sciences São Paulo State University (UNESP), Rodovia Araraquara-Jaú, km 01Department of Natural Products and Toxicology School of Pharmaceutical Sciences São Paulo State University (UNESP), Rodovia Araraquara-Jaú, km 01Queen’s University BelfastUniversidade Estadual Paulista (Unesp)de Moraes, Natalia V. [UNESP]Carey, ManusNeville, Charlotte E.Cruise, SharonMcGuinness, BernadetteKee, FrankYoung, Ian S.Woodside, Jayne V.Meharg, Andrew A.2020-12-12T01:45:39Z2020-12-12T01:45:39Z2019-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1007/s12403-019-00329-5Exposure and Health.2451-96852451-9766http://hdl.handle.net/11449/19965010.1007/s12403-019-00329-52-s2.0-85074936059Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengExposure and Healthinfo:eu-repo/semantics/openAccess2021-10-22T22:17:22Zoai:repositorio.unesp.br:11449/199650Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-22T22:17:22Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Water Dilutes and Alcohol Concentrates Urinary Arsenic Species When Food is the Dominant Source of Exposure |
title |
Water Dilutes and Alcohol Concentrates Urinary Arsenic Species When Food is the Dominant Source of Exposure |
spellingShingle |
Water Dilutes and Alcohol Concentrates Urinary Arsenic Species When Food is the Dominant Source of Exposure de Moraes, Natalia V. [UNESP] Arsenic Diet Metabolism Speciation Urine |
title_short |
Water Dilutes and Alcohol Concentrates Urinary Arsenic Species When Food is the Dominant Source of Exposure |
title_full |
Water Dilutes and Alcohol Concentrates Urinary Arsenic Species When Food is the Dominant Source of Exposure |
title_fullStr |
Water Dilutes and Alcohol Concentrates Urinary Arsenic Species When Food is the Dominant Source of Exposure |
title_full_unstemmed |
Water Dilutes and Alcohol Concentrates Urinary Arsenic Species When Food is the Dominant Source of Exposure |
title_sort |
Water Dilutes and Alcohol Concentrates Urinary Arsenic Species When Food is the Dominant Source of Exposure |
author |
de Moraes, Natalia V. [UNESP] |
author_facet |
de Moraes, Natalia V. [UNESP] Carey, Manus Neville, Charlotte E. Cruise, Sharon McGuinness, Bernadette Kee, Frank Young, Ian S. Woodside, Jayne V. Meharg, Andrew A. |
author_role |
author |
author2 |
Carey, Manus Neville, Charlotte E. Cruise, Sharon McGuinness, Bernadette Kee, Frank Young, Ian S. Woodside, Jayne V. Meharg, Andrew A. |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Queen’s University Belfast Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
de Moraes, Natalia V. [UNESP] Carey, Manus Neville, Charlotte E. Cruise, Sharon McGuinness, Bernadette Kee, Frank Young, Ian S. Woodside, Jayne V. Meharg, Andrew A. |
dc.subject.por.fl_str_mv |
Arsenic Diet Metabolism Speciation Urine |
topic |
Arsenic Diet Metabolism Speciation Urine |
description |
Exposure to certain arsenic (As) species has been associated with increased cancer risk and a wide range of other health concerns, even at low levels. Here we used urine as a biomarker of As internal dose in a well-characterized cohort to relate diet, demographics and geography to exposure. As speciation in spot urine samples was determined for 89 participants aged ≥ 50 years from the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA), stratified to cover the country. Principal component analysis showed that all As species clustered together, suggesting that arsenobetaine, inorganic As (iAs) and the methylated species monomethylarsonic acid and dimethylarsinic acid forms have a common source. Seafood and alcohol consumption were positively correlated with As species, while dairy products (i.e. milk) and tap water were negatively correlated. Multiple regression analysis showed that diet explained approximately 30% of the variability in urinary iAs concentrations. Geography was not found to be a predictor of As exposure. Dairy consumption was negatively correlated and the best predictor of iAs in urine, explaining 15.9% of the variability. The majority of the variation in As biomarkers was not explained, suggesting the contribution of other sources and other non-predicted variables on As metabolism and elimination. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-01-01 2020-12-12T01:45:39Z 2020-12-12T01:45:39Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s12403-019-00329-5 Exposure and Health. 2451-9685 2451-9766 http://hdl.handle.net/11449/199650 10.1007/s12403-019-00329-5 2-s2.0-85074936059 |
url |
http://dx.doi.org/10.1007/s12403-019-00329-5 http://hdl.handle.net/11449/199650 |
identifier_str_mv |
Exposure and Health. 2451-9685 2451-9766 10.1007/s12403-019-00329-5 2-s2.0-85074936059 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Exposure and Health |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964756221624320 |