(A)symmetry during gait initiation in people with Parkinson’s disease: A motor and cortical activity exploratory study
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3389/fnagi.2023.1142540 http://hdl.handle.net/11449/249944 |
Resumo: | Background: Gait asymmetry and deficits in gait initiation (GI) are among the most disabling symptoms in people with Parkinson’s disease (PwPD). Understanding if PwPD with reduced asymmetry during GI have higher asymmetry in cortical activity may provide support for an adaptive mechanism to improve GI, particularly in the presence of an obstacle. Objective: This study quantified the asymmetry of anticipatory postural adjustments (APAs), stepping parameters and cortical activity during GI, and tested if the presence of an obstacle regulates asymmetry in PwPD. Methods: Sixteen PwPD and 16 control group (CG) performed 20-trials in two conditions: unobstructed and obstructed GI with right and left limbs. We measured, through symmetry index, (i) motor parameters: APAs and stepping, and (ii) cortical activity: the PSD of the frontal, sensorimotor and occipital areas during APA, STEP-I (moment of heel-off of the leading foot in the GI until the heel contact of the same foot); and STEP-II (moment of the heel-off of the trailing foot in the GI until the heel contact of the same foot) phases. Results: Parkinson’s disease showed higher asymmetry in cortical activity during APA, STEP-I and STEP-II phases and step velocity (STEP-II phase) during unobstructed GI than CG. However, unexpectedly, PwPD reduced the level of asymmetry of anterior–posterior displacement (p < 0.01) and medial-lateral velocity (p < 0.05) of the APAs. Also, when an obstacle was in place, PwPD showed higher APAs asymmetry (medial-lateral velocity: p < 0.002), with reduced and increased asymmetry of the cortical activity during APA and STEP-I phases, respectively. Conclusion: Parkinson’s disease were not motor asymmetric during GI, indicating that higher cortical activity asymmetry can be interpreted as an adaptive behavior to reduce motor asymmetry. In addition, the presence of obstacle did not regulate motor asymmetry during GI in PwPD. |
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Repositório Institucional da UNESP |
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(A)symmetry during gait initiation in people with Parkinson’s disease: A motor and cortical activity exploratory studyasymmetrycortical activitygait initiationobstacle avoidanceParkinson’s diseaseBackground: Gait asymmetry and deficits in gait initiation (GI) are among the most disabling symptoms in people with Parkinson’s disease (PwPD). Understanding if PwPD with reduced asymmetry during GI have higher asymmetry in cortical activity may provide support for an adaptive mechanism to improve GI, particularly in the presence of an obstacle. Objective: This study quantified the asymmetry of anticipatory postural adjustments (APAs), stepping parameters and cortical activity during GI, and tested if the presence of an obstacle regulates asymmetry in PwPD. Methods: Sixteen PwPD and 16 control group (CG) performed 20-trials in two conditions: unobstructed and obstructed GI with right and left limbs. We measured, through symmetry index, (i) motor parameters: APAs and stepping, and (ii) cortical activity: the PSD of the frontal, sensorimotor and occipital areas during APA, STEP-I (moment of heel-off of the leading foot in the GI until the heel contact of the same foot); and STEP-II (moment of the heel-off of the trailing foot in the GI until the heel contact of the same foot) phases. Results: Parkinson’s disease showed higher asymmetry in cortical activity during APA, STEP-I and STEP-II phases and step velocity (STEP-II phase) during unobstructed GI than CG. However, unexpectedly, PwPD reduced the level of asymmetry of anterior–posterior displacement (p < 0.01) and medial-lateral velocity (p < 0.05) of the APAs. Also, when an obstacle was in place, PwPD showed higher APAs asymmetry (medial-lateral velocity: p < 0.002), with reduced and increased asymmetry of the cortical activity during APA and STEP-I phases, respectively. Conclusion: Parkinson’s disease were not motor asymmetric during GI, indicating that higher cortical activity asymmetry can be interpreted as an adaptive behavior to reduce motor asymmetry. In addition, the presence of obstacle did not regulate motor asymmetry during GI in PwPD.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Human Movement Research Laboratory (MOVI-LAB) School of Sciences Department of Physical Education São Paulo State University (Unesp), São PauloDepartment of Health and Kinesiology Purdue UniversityREVAL Rehabilitation Research Center Faculty of Rehabilitation Sciences Hasselt UniversityHuman Movement Research Laboratory (MOVI-LAB) School of Sciences Department of Physical Education São Paulo State University (Unesp), São PauloFAPESP: #2016/14950–6FAPESP: #2018/21870–7FAPESP: #2019/24752–8Universidade Estadual Paulista (UNESP)Purdue UniversityHasselt UniversityFaria, Murilo Henrique [UNESP]Simieli, Lucas [UNESP]Rietdyk, ShirleyPenedo, Tiago [UNESP]Santinelli, Felipe Balistieri [UNESP]Barbieri, Fabio Augusto [UNESP]2023-07-29T16:13:32Z2023-07-29T16:13:32Z2023-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3389/fnagi.2023.1142540Frontiers in Aging Neuroscience, v. 15.1663-4365http://hdl.handle.net/11449/24994410.3389/fnagi.2023.11425402-s2.0-85159003673Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengFrontiers in Aging Neuroscienceinfo:eu-repo/semantics/openAccess2024-04-24T18:53:43Zoai:repositorio.unesp.br:11449/249944Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-04-24T18:53:43Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
(A)symmetry during gait initiation in people with Parkinson’s disease: A motor and cortical activity exploratory study |
title |
(A)symmetry during gait initiation in people with Parkinson’s disease: A motor and cortical activity exploratory study |
spellingShingle |
(A)symmetry during gait initiation in people with Parkinson’s disease: A motor and cortical activity exploratory study Faria, Murilo Henrique [UNESP] asymmetry cortical activity gait initiation obstacle avoidance Parkinson’s disease |
title_short |
(A)symmetry during gait initiation in people with Parkinson’s disease: A motor and cortical activity exploratory study |
title_full |
(A)symmetry during gait initiation in people with Parkinson’s disease: A motor and cortical activity exploratory study |
title_fullStr |
(A)symmetry during gait initiation in people with Parkinson’s disease: A motor and cortical activity exploratory study |
title_full_unstemmed |
(A)symmetry during gait initiation in people with Parkinson’s disease: A motor and cortical activity exploratory study |
title_sort |
(A)symmetry during gait initiation in people with Parkinson’s disease: A motor and cortical activity exploratory study |
author |
Faria, Murilo Henrique [UNESP] |
author_facet |
Faria, Murilo Henrique [UNESP] Simieli, Lucas [UNESP] Rietdyk, Shirley Penedo, Tiago [UNESP] Santinelli, Felipe Balistieri [UNESP] Barbieri, Fabio Augusto [UNESP] |
author_role |
author |
author2 |
Simieli, Lucas [UNESP] Rietdyk, Shirley Penedo, Tiago [UNESP] Santinelli, Felipe Balistieri [UNESP] Barbieri, Fabio Augusto [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Purdue University Hasselt University |
dc.contributor.author.fl_str_mv |
Faria, Murilo Henrique [UNESP] Simieli, Lucas [UNESP] Rietdyk, Shirley Penedo, Tiago [UNESP] Santinelli, Felipe Balistieri [UNESP] Barbieri, Fabio Augusto [UNESP] |
dc.subject.por.fl_str_mv |
asymmetry cortical activity gait initiation obstacle avoidance Parkinson’s disease |
topic |
asymmetry cortical activity gait initiation obstacle avoidance Parkinson’s disease |
description |
Background: Gait asymmetry and deficits in gait initiation (GI) are among the most disabling symptoms in people with Parkinson’s disease (PwPD). Understanding if PwPD with reduced asymmetry during GI have higher asymmetry in cortical activity may provide support for an adaptive mechanism to improve GI, particularly in the presence of an obstacle. Objective: This study quantified the asymmetry of anticipatory postural adjustments (APAs), stepping parameters and cortical activity during GI, and tested if the presence of an obstacle regulates asymmetry in PwPD. Methods: Sixteen PwPD and 16 control group (CG) performed 20-trials in two conditions: unobstructed and obstructed GI with right and left limbs. We measured, through symmetry index, (i) motor parameters: APAs and stepping, and (ii) cortical activity: the PSD of the frontal, sensorimotor and occipital areas during APA, STEP-I (moment of heel-off of the leading foot in the GI until the heel contact of the same foot); and STEP-II (moment of the heel-off of the trailing foot in the GI until the heel contact of the same foot) phases. Results: Parkinson’s disease showed higher asymmetry in cortical activity during APA, STEP-I and STEP-II phases and step velocity (STEP-II phase) during unobstructed GI than CG. However, unexpectedly, PwPD reduced the level of asymmetry of anterior–posterior displacement (p < 0.01) and medial-lateral velocity (p < 0.05) of the APAs. Also, when an obstacle was in place, PwPD showed higher APAs asymmetry (medial-lateral velocity: p < 0.002), with reduced and increased asymmetry of the cortical activity during APA and STEP-I phases, respectively. Conclusion: Parkinson’s disease were not motor asymmetric during GI, indicating that higher cortical activity asymmetry can be interpreted as an adaptive behavior to reduce motor asymmetry. In addition, the presence of obstacle did not regulate motor asymmetry during GI in PwPD. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07-29T16:13:32Z 2023-07-29T16:13:32Z 2023-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3389/fnagi.2023.1142540 Frontiers in Aging Neuroscience, v. 15. 1663-4365 http://hdl.handle.net/11449/249944 10.3389/fnagi.2023.1142540 2-s2.0-85159003673 |
url |
http://dx.doi.org/10.3389/fnagi.2023.1142540 http://hdl.handle.net/11449/249944 |
identifier_str_mv |
Frontiers in Aging Neuroscience, v. 15. 1663-4365 10.3389/fnagi.2023.1142540 2-s2.0-85159003673 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Frontiers in Aging Neuroscience |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965755377188864 |