Effect of acupuncture on TNF-alpha, IL-1b and IL-10 concentrations in the peritoneal exudates of carrageenan-induced peritonitis in rats

Detalhes bibliográficos
Autor(a) principal: Scognamillo-szabó, Márcia Valéria Rizzo [UNESP]
Data de Publicação: 2005
Outros Autores: Bechara, Gervásio Henrique [UNESP], Cunha, Fernando De Queiroz
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S0103-84782005000100016
http://hdl.handle.net/11449/212790
Resumo: Acupuncture is an ancient and empirical therapeutic procedure known by its efficacy in the treatment of pain. However, the influence of acupuncture on inflammatory process is still poorly understood and additional research is needed. In this work, we investigated the mechanism of action of manual acupuncture on the inhibition of neutrophil migration to the peritoneal cavity induced by the inflammatory stimulus carrageenan in Wistar rats. Previous results from our laboratory showed that this anti-inflammatory effect is not due to endogenous corticoid release. Furthermore, the concentration of IL-1b, but not of TNF-alpha or IL-10 in the carrageenan-induced exudates was reduced in the acupuncture group. Further research will be needed to elucidate the mechanisms involved in the anti-inflammatory action of acupuncture as described here.
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spelling Effect of acupuncture on TNF-alpha, IL-1b and IL-10 concentrations in the peritoneal exudates of carrageenan-induced peritonitis in ratsEfeito da acupuntura sobre a concentração de TNF-alfa, IL-1b e IL-10 no exsudato peritoneal de ratos com peritonite induzida por carrageninaacupunctureinflammationcytokinesneutrophilsratscarrageenanacupunturainflamaçãocitocinasneutrófilosratoscarrageninaAcupuncture is an ancient and empirical therapeutic procedure known by its efficacy in the treatment of pain. However, the influence of acupuncture on inflammatory process is still poorly understood and additional research is needed. In this work, we investigated the mechanism of action of manual acupuncture on the inhibition of neutrophil migration to the peritoneal cavity induced by the inflammatory stimulus carrageenan in Wistar rats. Previous results from our laboratory showed that this anti-inflammatory effect is not due to endogenous corticoid release. Furthermore, the concentration of IL-1b, but not of TNF-alpha or IL-10 in the carrageenan-induced exudates was reduced in the acupuncture group. Further research will be needed to elucidate the mechanisms involved in the anti-inflammatory action of acupuncture as described here.A acupuntura é método terapêutico milenar reconhecido por sua eficácia no tratamento da dor, porém seu efeito sobre processos inflamatórios é ainda pouco conhecido e maiores estudos são necessários. Neste trabalho, é investigado o mecanismo de ação da acupuntura manual sobre a inibição na migração de neutrófilos para a cavidade peritoneal induzida por carragenina em ratos Wistar. Resultados prévios indicam que esse efeito antiinflamatório não depende de hormônios corticóides. Entretanto, as concentrações de IL-1b no exsudato induzido por carragenina foram reduzidas pelo tratamento com acupuntura. Por outro lado os níveis de TNF-alfa e IL-10 não foram afetados pelo tratamento. Mais pesquisas poderão elucidar os mecanismos envolvidos na ação antiinflamatória da acupuntura.Universidade de São Paulo, Faculty of Medicine of Ribeirão PretoUniversidade Estadual Paulista, Faculty of Agricultural and Veterinary SciencesUniversidade Estadual Paulista, Faculty of Agricultural and Veterinary SciencesUniversidade Federal de Santa MariaUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Scognamillo-szabó, Márcia Valéria Rizzo [UNESP]Bechara, Gervásio Henrique [UNESP]Cunha, Fernando De Queiroz2021-07-14T10:45:12Z2021-07-14T10:45:12Z2005-02info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article103-108application/pdfhttp://dx.doi.org/10.1590/S0103-84782005000100016Ciência Rural. Santa Maria, RS, Brazil: Universidade Federal de Santa Maria, v. 35, n. 1, p. 103-108, 2005.0103-84781678-4596http://hdl.handle.net/11449/21279010.1590/S0103-84782005000100016S0103-84782005000100016S0103-84782005000100016.pdfSciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCiência Ruralinfo:eu-repo/semantics/openAccess2023-10-22T06:12:36Zoai:repositorio.unesp.br:11449/212790Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-10-22T06:12:36Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Effect of acupuncture on TNF-alpha, IL-1b and IL-10 concentrations in the peritoneal exudates of carrageenan-induced peritonitis in rats
Efeito da acupuntura sobre a concentração de TNF-alfa, IL-1b e IL-10 no exsudato peritoneal de ratos com peritonite induzida por carragenina
title Effect of acupuncture on TNF-alpha, IL-1b and IL-10 concentrations in the peritoneal exudates of carrageenan-induced peritonitis in rats
spellingShingle Effect of acupuncture on TNF-alpha, IL-1b and IL-10 concentrations in the peritoneal exudates of carrageenan-induced peritonitis in rats
Scognamillo-szabó, Márcia Valéria Rizzo [UNESP]
acupuncture
inflammation
cytokines
neutrophils
rats
carrageenan
acupuntura
inflamação
citocinas
neutrófilos
ratos
carragenina
title_short Effect of acupuncture on TNF-alpha, IL-1b and IL-10 concentrations in the peritoneal exudates of carrageenan-induced peritonitis in rats
title_full Effect of acupuncture on TNF-alpha, IL-1b and IL-10 concentrations in the peritoneal exudates of carrageenan-induced peritonitis in rats
title_fullStr Effect of acupuncture on TNF-alpha, IL-1b and IL-10 concentrations in the peritoneal exudates of carrageenan-induced peritonitis in rats
title_full_unstemmed Effect of acupuncture on TNF-alpha, IL-1b and IL-10 concentrations in the peritoneal exudates of carrageenan-induced peritonitis in rats
title_sort Effect of acupuncture on TNF-alpha, IL-1b and IL-10 concentrations in the peritoneal exudates of carrageenan-induced peritonitis in rats
author Scognamillo-szabó, Márcia Valéria Rizzo [UNESP]
author_facet Scognamillo-szabó, Márcia Valéria Rizzo [UNESP]
Bechara, Gervásio Henrique [UNESP]
Cunha, Fernando De Queiroz
author_role author
author2 Bechara, Gervásio Henrique [UNESP]
Cunha, Fernando De Queiroz
author2_role author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Scognamillo-szabó, Márcia Valéria Rizzo [UNESP]
Bechara, Gervásio Henrique [UNESP]
Cunha, Fernando De Queiroz
dc.subject.por.fl_str_mv acupuncture
inflammation
cytokines
neutrophils
rats
carrageenan
acupuntura
inflamação
citocinas
neutrófilos
ratos
carragenina
topic acupuncture
inflammation
cytokines
neutrophils
rats
carrageenan
acupuntura
inflamação
citocinas
neutrófilos
ratos
carragenina
description Acupuncture is an ancient and empirical therapeutic procedure known by its efficacy in the treatment of pain. However, the influence of acupuncture on inflammatory process is still poorly understood and additional research is needed. In this work, we investigated the mechanism of action of manual acupuncture on the inhibition of neutrophil migration to the peritoneal cavity induced by the inflammatory stimulus carrageenan in Wistar rats. Previous results from our laboratory showed that this anti-inflammatory effect is not due to endogenous corticoid release. Furthermore, the concentration of IL-1b, but not of TNF-alpha or IL-10 in the carrageenan-induced exudates was reduced in the acupuncture group. Further research will be needed to elucidate the mechanisms involved in the anti-inflammatory action of acupuncture as described here.
publishDate 2005
dc.date.none.fl_str_mv 2005-02
2021-07-14T10:45:12Z
2021-07-14T10:45:12Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0103-84782005000100016
Ciência Rural. Santa Maria, RS, Brazil: Universidade Federal de Santa Maria, v. 35, n. 1, p. 103-108, 2005.
0103-8478
1678-4596
http://hdl.handle.net/11449/212790
10.1590/S0103-84782005000100016
S0103-84782005000100016
S0103-84782005000100016.pdf
url http://dx.doi.org/10.1590/S0103-84782005000100016
http://hdl.handle.net/11449/212790
identifier_str_mv Ciência Rural. Santa Maria, RS, Brazil: Universidade Federal de Santa Maria, v. 35, n. 1, p. 103-108, 2005.
0103-8478
1678-4596
10.1590/S0103-84782005000100016
S0103-84782005000100016
S0103-84782005000100016.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Ciência Rural
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 103-108
application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Santa Maria
publisher.none.fl_str_mv Universidade Federal de Santa Maria
dc.source.none.fl_str_mv SciELO
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1797789479169163264

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