Palladium(II)/N,N-disubstituted-N′-acylthioureas complexes as anti-Mycobacterium tuberculosis and anti-Trypanosoma cruzi agents
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.poly.2017.05.003 http://hdl.handle.net/11449/178874 |
Resumo: | The new complexes of Pd(II) with N,N-disubstituted-N′-acylthioureas:[(1) [Pd(dppf)(N,N-dimethyl-N′-benzoylthioureato-k2O,S)]PF6, (2) [Pd(dppf)(N,N-diethyl-N′-benzoylthioureato-k2O,S)]PF6, (3) [Pd(dppf)(N,N-dibuthyl-N′-benzoylthioureato-k2O,S)]PF6, (4) [Pd(dppf)(N,N-diphenyl-N′-benzoylthioureato-k2O,S)]PF6, (5) [Pd(dppf)(N,N-diethyl-N′-furoylthioureato-k2O,S)]PF6, (6) [Pd(dppf)(N,N-diphenyl-N′-furoylthioureato-k2O,S)]PF6, (7) [Pd(dppf)(N,N-dimethyl-N′- thiophenylthioureato-k2O,S)]PF6, and (8) [Pd(dppf)(N,N-diphenyl-N′-thiophenylthioureato-k2O,S)]PF6, were prepared and characterized by elemental analysis, and spectroscopic techniques. The structures of complexes (2), (3), (5), (6) and (8) had their structures determined by X-ray crystallography, confirming the coordination of the ligands with the metal through sulfur and oxygen atoms, forming distorted square-planar geometries. These complexes have shown antibacterial activity against anti-Mycobacterium tuberculosis H37Rv ATCC 27294. The complexes exhibited antiparasitic activity against Trypanosoma cruzi, while the metal-free thioureas did not. The results demonstrated that the compounds described here can be considered as promising anti-Mycobacterium tuberculosis and anti-T. cruzi agents, since in both cases their in vitro activity were better than reference drugs available for the treatment of both diseases. |
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Palladium(II)/N,N-disubstituted-N′-acylthioureas complexes as anti-Mycobacterium tuberculosis and anti-Trypanosoma cruzi agentsMetal complexesPalladiumThioureasTrypanosoma cruziTuberculosisThe new complexes of Pd(II) with N,N-disubstituted-N′-acylthioureas:[(1) [Pd(dppf)(N,N-dimethyl-N′-benzoylthioureato-k2O,S)]PF6, (2) [Pd(dppf)(N,N-diethyl-N′-benzoylthioureato-k2O,S)]PF6, (3) [Pd(dppf)(N,N-dibuthyl-N′-benzoylthioureato-k2O,S)]PF6, (4) [Pd(dppf)(N,N-diphenyl-N′-benzoylthioureato-k2O,S)]PF6, (5) [Pd(dppf)(N,N-diethyl-N′-furoylthioureato-k2O,S)]PF6, (6) [Pd(dppf)(N,N-diphenyl-N′-furoylthioureato-k2O,S)]PF6, (7) [Pd(dppf)(N,N-dimethyl-N′- thiophenylthioureato-k2O,S)]PF6, and (8) [Pd(dppf)(N,N-diphenyl-N′-thiophenylthioureato-k2O,S)]PF6, were prepared and characterized by elemental analysis, and spectroscopic techniques. The structures of complexes (2), (3), (5), (6) and (8) had their structures determined by X-ray crystallography, confirming the coordination of the ligands with the metal through sulfur and oxygen atoms, forming distorted square-planar geometries. These complexes have shown antibacterial activity against anti-Mycobacterium tuberculosis H37Rv ATCC 27294. The complexes exhibited antiparasitic activity against Trypanosoma cruzi, while the metal-free thioureas did not. The results demonstrated that the compounds described here can be considered as promising anti-Mycobacterium tuberculosis and anti-T. cruzi agents, since in both cases their in vitro activity were better than reference drugs available for the treatment of both diseases.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Laboratorio de Síntesis Orgánica Facultad de Química Universidad de La HabanaInstituto de Física de São Carlos Universidade de São PauloDepartamento de Química Universidade Federal de São CarlosFaculdade de Ciências Farmacêuticas UNESPInstituto Gonçalo Moniz Fundação Oswaldo CruzCentro de Biotecnologia e Terapia Celular Hospital São RafaelFaculdade de Ciências Farmacêuticas UNESPUniversidad de La HabanaUniversidade de São Paulo (USP)Universidade Federal de São Carlos (UFSCar)Universidade Estadual Paulista (Unesp)Fundação Oswaldo CruzHospital São RafaelPlutín, Ana M.Alvarez, AnislayMocelo, RaúlRamos, RaúlCastellano, Eduardo E.da Silva, Monize M.Villarreal, WilmerPavan, Fernando R. [UNESP]Meira, Cássio SantanaFilho, José Simão RodriguesMoreira, Diogo Rodrigo M.Soares, Milena Botelho P.Batista, Alzir A.2018-12-11T17:32:29Z2018-12-11T17:32:29Z2017-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article70-77application/pdfhttp://dx.doi.org/10.1016/j.poly.2017.05.003Polyhedron, v. 132, p. 70-77.0277-5387http://hdl.handle.net/11449/17887410.1016/j.poly.2017.05.0032-s2.0-850193904062-s2.0-85019390406.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPolyhedron0,472info:eu-repo/semantics/openAccess2024-06-24T13:08:14Zoai:repositorio.unesp.br:11449/178874Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:02:51.709481Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Palladium(II)/N,N-disubstituted-N′-acylthioureas complexes as anti-Mycobacterium tuberculosis and anti-Trypanosoma cruzi agents |
title |
Palladium(II)/N,N-disubstituted-N′-acylthioureas complexes as anti-Mycobacterium tuberculosis and anti-Trypanosoma cruzi agents |
spellingShingle |
Palladium(II)/N,N-disubstituted-N′-acylthioureas complexes as anti-Mycobacterium tuberculosis and anti-Trypanosoma cruzi agents Plutín, Ana M. Metal complexes Palladium Thioureas Trypanosoma cruzi Tuberculosis |
title_short |
Palladium(II)/N,N-disubstituted-N′-acylthioureas complexes as anti-Mycobacterium tuberculosis and anti-Trypanosoma cruzi agents |
title_full |
Palladium(II)/N,N-disubstituted-N′-acylthioureas complexes as anti-Mycobacterium tuberculosis and anti-Trypanosoma cruzi agents |
title_fullStr |
Palladium(II)/N,N-disubstituted-N′-acylthioureas complexes as anti-Mycobacterium tuberculosis and anti-Trypanosoma cruzi agents |
title_full_unstemmed |
Palladium(II)/N,N-disubstituted-N′-acylthioureas complexes as anti-Mycobacterium tuberculosis and anti-Trypanosoma cruzi agents |
title_sort |
Palladium(II)/N,N-disubstituted-N′-acylthioureas complexes as anti-Mycobacterium tuberculosis and anti-Trypanosoma cruzi agents |
author |
Plutín, Ana M. |
author_facet |
Plutín, Ana M. Alvarez, Anislay Mocelo, Raúl Ramos, Raúl Castellano, Eduardo E. da Silva, Monize M. Villarreal, Wilmer Pavan, Fernando R. [UNESP] Meira, Cássio Santana Filho, José Simão Rodrigues Moreira, Diogo Rodrigo M. Soares, Milena Botelho P. Batista, Alzir A. |
author_role |
author |
author2 |
Alvarez, Anislay Mocelo, Raúl Ramos, Raúl Castellano, Eduardo E. da Silva, Monize M. Villarreal, Wilmer Pavan, Fernando R. [UNESP] Meira, Cássio Santana Filho, José Simão Rodrigues Moreira, Diogo Rodrigo M. Soares, Milena Botelho P. Batista, Alzir A. |
author2_role |
author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidad de La Habana Universidade de São Paulo (USP) Universidade Federal de São Carlos (UFSCar) Universidade Estadual Paulista (Unesp) Fundação Oswaldo Cruz Hospital São Rafael |
dc.contributor.author.fl_str_mv |
Plutín, Ana M. Alvarez, Anislay Mocelo, Raúl Ramos, Raúl Castellano, Eduardo E. da Silva, Monize M. Villarreal, Wilmer Pavan, Fernando R. [UNESP] Meira, Cássio Santana Filho, José Simão Rodrigues Moreira, Diogo Rodrigo M. Soares, Milena Botelho P. Batista, Alzir A. |
dc.subject.por.fl_str_mv |
Metal complexes Palladium Thioureas Trypanosoma cruzi Tuberculosis |
topic |
Metal complexes Palladium Thioureas Trypanosoma cruzi Tuberculosis |
description |
The new complexes of Pd(II) with N,N-disubstituted-N′-acylthioureas:[(1) [Pd(dppf)(N,N-dimethyl-N′-benzoylthioureato-k2O,S)]PF6, (2) [Pd(dppf)(N,N-diethyl-N′-benzoylthioureato-k2O,S)]PF6, (3) [Pd(dppf)(N,N-dibuthyl-N′-benzoylthioureato-k2O,S)]PF6, (4) [Pd(dppf)(N,N-diphenyl-N′-benzoylthioureato-k2O,S)]PF6, (5) [Pd(dppf)(N,N-diethyl-N′-furoylthioureato-k2O,S)]PF6, (6) [Pd(dppf)(N,N-diphenyl-N′-furoylthioureato-k2O,S)]PF6, (7) [Pd(dppf)(N,N-dimethyl-N′- thiophenylthioureato-k2O,S)]PF6, and (8) [Pd(dppf)(N,N-diphenyl-N′-thiophenylthioureato-k2O,S)]PF6, were prepared and characterized by elemental analysis, and spectroscopic techniques. The structures of complexes (2), (3), (5), (6) and (8) had their structures determined by X-ray crystallography, confirming the coordination of the ligands with the metal through sulfur and oxygen atoms, forming distorted square-planar geometries. These complexes have shown antibacterial activity against anti-Mycobacterium tuberculosis H37Rv ATCC 27294. The complexes exhibited antiparasitic activity against Trypanosoma cruzi, while the metal-free thioureas did not. The results demonstrated that the compounds described here can be considered as promising anti-Mycobacterium tuberculosis and anti-T. cruzi agents, since in both cases their in vitro activity were better than reference drugs available for the treatment of both diseases. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-01-01 2018-12-11T17:32:29Z 2018-12-11T17:32:29Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.poly.2017.05.003 Polyhedron, v. 132, p. 70-77. 0277-5387 http://hdl.handle.net/11449/178874 10.1016/j.poly.2017.05.003 2-s2.0-85019390406 2-s2.0-85019390406.pdf |
url |
http://dx.doi.org/10.1016/j.poly.2017.05.003 http://hdl.handle.net/11449/178874 |
identifier_str_mv |
Polyhedron, v. 132, p. 70-77. 0277-5387 10.1016/j.poly.2017.05.003 2-s2.0-85019390406 2-s2.0-85019390406.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Polyhedron 0,472 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
70-77 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808129387074158592 |