Palladium(II)/N,N-disubstituted-N′-acylthioureas complexes as anti-Mycobacterium tuberculosis and anti-Trypanosoma cruzi agents

Detalhes bibliográficos
Autor(a) principal: Plutín, Ana M.
Data de Publicação: 2017
Outros Autores: Alvarez, Anislay, Mocelo, Raúl, Ramos, Raúl, Castellano, Eduardo E., da Silva, Monize M., Villarreal, Wilmer, Pavan, Fernando R. [UNESP], Meira, Cássio Santana, Filho, José Simão Rodrigues, Moreira, Diogo Rodrigo M., Soares, Milena Botelho P., Batista, Alzir A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.poly.2017.05.003
http://hdl.handle.net/11449/178874
Resumo: The new complexes of Pd(II) with N,N-disubstituted-N′-acylthioureas:[(1) [Pd(dppf)(N,N-dimethyl-N′-benzoylthioureato-k2O,S)]PF6, (2) [Pd(dppf)(N,N-diethyl-N′-benzoylthioureato-k2O,S)]PF6, (3) [Pd(dppf)(N,N-dibuthyl-N′-benzoylthioureato-k2O,S)]PF6, (4) [Pd(dppf)(N,N-diphenyl-N′-benzoylthioureato-k2O,S)]PF6, (5) [Pd(dppf)(N,N-diethyl-N′-furoylthioureato-k2O,S)]PF6, (6) [Pd(dppf)(N,N-diphenyl-N′-furoylthioureato-k2O,S)]PF6, (7) [Pd(dppf)(N,N-dimethyl-N′- thiophenylthioureato-k2O,S)]PF6, and (8) [Pd(dppf)(N,N-diphenyl-N′-thiophenylthioureato-k2O,S)]PF6, were prepared and characterized by elemental analysis, and spectroscopic techniques. The structures of complexes (2), (3), (5), (6) and (8) had their structures determined by X-ray crystallography, confirming the coordination of the ligands with the metal through sulfur and oxygen atoms, forming distorted square-planar geometries. These complexes have shown antibacterial activity against anti-Mycobacterium tuberculosis H37Rv ATCC 27294. The complexes exhibited antiparasitic activity against Trypanosoma cruzi, while the metal-free thioureas did not. The results demonstrated that the compounds described here can be considered as promising anti-Mycobacterium tuberculosis and anti-T. cruzi agents, since in both cases their in vitro activity were better than reference drugs available for the treatment of both diseases.
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spelling Palladium(II)/N,N-disubstituted-N′-acylthioureas complexes as anti-Mycobacterium tuberculosis and anti-Trypanosoma cruzi agentsMetal complexesPalladiumThioureasTrypanosoma cruziTuberculosisThe new complexes of Pd(II) with N,N-disubstituted-N′-acylthioureas:[(1) [Pd(dppf)(N,N-dimethyl-N′-benzoylthioureato-k2O,S)]PF6, (2) [Pd(dppf)(N,N-diethyl-N′-benzoylthioureato-k2O,S)]PF6, (3) [Pd(dppf)(N,N-dibuthyl-N′-benzoylthioureato-k2O,S)]PF6, (4) [Pd(dppf)(N,N-diphenyl-N′-benzoylthioureato-k2O,S)]PF6, (5) [Pd(dppf)(N,N-diethyl-N′-furoylthioureato-k2O,S)]PF6, (6) [Pd(dppf)(N,N-diphenyl-N′-furoylthioureato-k2O,S)]PF6, (7) [Pd(dppf)(N,N-dimethyl-N′- thiophenylthioureato-k2O,S)]PF6, and (8) [Pd(dppf)(N,N-diphenyl-N′-thiophenylthioureato-k2O,S)]PF6, were prepared and characterized by elemental analysis, and spectroscopic techniques. The structures of complexes (2), (3), (5), (6) and (8) had their structures determined by X-ray crystallography, confirming the coordination of the ligands with the metal through sulfur and oxygen atoms, forming distorted square-planar geometries. These complexes have shown antibacterial activity against anti-Mycobacterium tuberculosis H37Rv ATCC 27294. The complexes exhibited antiparasitic activity against Trypanosoma cruzi, while the metal-free thioureas did not. The results demonstrated that the compounds described here can be considered as promising anti-Mycobacterium tuberculosis and anti-T. cruzi agents, since in both cases their in vitro activity were better than reference drugs available for the treatment of both diseases.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Laboratorio de Síntesis Orgánica Facultad de Química Universidad de La HabanaInstituto de Física de São Carlos Universidade de São PauloDepartamento de Química Universidade Federal de São CarlosFaculdade de Ciências Farmacêuticas UNESPInstituto Gonçalo Moniz Fundação Oswaldo CruzCentro de Biotecnologia e Terapia Celular Hospital São RafaelFaculdade de Ciências Farmacêuticas UNESPUniversidad de La HabanaUniversidade de São Paulo (USP)Universidade Federal de São Carlos (UFSCar)Universidade Estadual Paulista (Unesp)Fundação Oswaldo CruzHospital São RafaelPlutín, Ana M.Alvarez, AnislayMocelo, RaúlRamos, RaúlCastellano, Eduardo E.da Silva, Monize M.Villarreal, WilmerPavan, Fernando R. [UNESP]Meira, Cássio SantanaFilho, José Simão RodriguesMoreira, Diogo Rodrigo M.Soares, Milena Botelho P.Batista, Alzir A.2018-12-11T17:32:29Z2018-12-11T17:32:29Z2017-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article70-77application/pdfhttp://dx.doi.org/10.1016/j.poly.2017.05.003Polyhedron, v. 132, p. 70-77.0277-5387http://hdl.handle.net/11449/17887410.1016/j.poly.2017.05.0032-s2.0-850193904062-s2.0-85019390406.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPolyhedron0,472info:eu-repo/semantics/openAccess2024-06-24T13:08:14Zoai:repositorio.unesp.br:11449/178874Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:02:51.709481Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Palladium(II)/N,N-disubstituted-N′-acylthioureas complexes as anti-Mycobacterium tuberculosis and anti-Trypanosoma cruzi agents
title Palladium(II)/N,N-disubstituted-N′-acylthioureas complexes as anti-Mycobacterium tuberculosis and anti-Trypanosoma cruzi agents
spellingShingle Palladium(II)/N,N-disubstituted-N′-acylthioureas complexes as anti-Mycobacterium tuberculosis and anti-Trypanosoma cruzi agents
Plutín, Ana M.
Metal complexes
Palladium
Thioureas
Trypanosoma cruzi
Tuberculosis
title_short Palladium(II)/N,N-disubstituted-N′-acylthioureas complexes as anti-Mycobacterium tuberculosis and anti-Trypanosoma cruzi agents
title_full Palladium(II)/N,N-disubstituted-N′-acylthioureas complexes as anti-Mycobacterium tuberculosis and anti-Trypanosoma cruzi agents
title_fullStr Palladium(II)/N,N-disubstituted-N′-acylthioureas complexes as anti-Mycobacterium tuberculosis and anti-Trypanosoma cruzi agents
title_full_unstemmed Palladium(II)/N,N-disubstituted-N′-acylthioureas complexes as anti-Mycobacterium tuberculosis and anti-Trypanosoma cruzi agents
title_sort Palladium(II)/N,N-disubstituted-N′-acylthioureas complexes as anti-Mycobacterium tuberculosis and anti-Trypanosoma cruzi agents
author Plutín, Ana M.
author_facet Plutín, Ana M.
Alvarez, Anislay
Mocelo, Raúl
Ramos, Raúl
Castellano, Eduardo E.
da Silva, Monize M.
Villarreal, Wilmer
Pavan, Fernando R. [UNESP]
Meira, Cássio Santana
Filho, José Simão Rodrigues
Moreira, Diogo Rodrigo M.
Soares, Milena Botelho P.
Batista, Alzir A.
author_role author
author2 Alvarez, Anislay
Mocelo, Raúl
Ramos, Raúl
Castellano, Eduardo E.
da Silva, Monize M.
Villarreal, Wilmer
Pavan, Fernando R. [UNESP]
Meira, Cássio Santana
Filho, José Simão Rodrigues
Moreira, Diogo Rodrigo M.
Soares, Milena Botelho P.
Batista, Alzir A.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad de La Habana
Universidade de São Paulo (USP)
Universidade Federal de São Carlos (UFSCar)
Universidade Estadual Paulista (Unesp)
Fundação Oswaldo Cruz
Hospital São Rafael
dc.contributor.author.fl_str_mv Plutín, Ana M.
Alvarez, Anislay
Mocelo, Raúl
Ramos, Raúl
Castellano, Eduardo E.
da Silva, Monize M.
Villarreal, Wilmer
Pavan, Fernando R. [UNESP]
Meira, Cássio Santana
Filho, José Simão Rodrigues
Moreira, Diogo Rodrigo M.
Soares, Milena Botelho P.
Batista, Alzir A.
dc.subject.por.fl_str_mv Metal complexes
Palladium
Thioureas
Trypanosoma cruzi
Tuberculosis
topic Metal complexes
Palladium
Thioureas
Trypanosoma cruzi
Tuberculosis
description The new complexes of Pd(II) with N,N-disubstituted-N′-acylthioureas:[(1) [Pd(dppf)(N,N-dimethyl-N′-benzoylthioureato-k2O,S)]PF6, (2) [Pd(dppf)(N,N-diethyl-N′-benzoylthioureato-k2O,S)]PF6, (3) [Pd(dppf)(N,N-dibuthyl-N′-benzoylthioureato-k2O,S)]PF6, (4) [Pd(dppf)(N,N-diphenyl-N′-benzoylthioureato-k2O,S)]PF6, (5) [Pd(dppf)(N,N-diethyl-N′-furoylthioureato-k2O,S)]PF6, (6) [Pd(dppf)(N,N-diphenyl-N′-furoylthioureato-k2O,S)]PF6, (7) [Pd(dppf)(N,N-dimethyl-N′- thiophenylthioureato-k2O,S)]PF6, and (8) [Pd(dppf)(N,N-diphenyl-N′-thiophenylthioureato-k2O,S)]PF6, were prepared and characterized by elemental analysis, and spectroscopic techniques. The structures of complexes (2), (3), (5), (6) and (8) had their structures determined by X-ray crystallography, confirming the coordination of the ligands with the metal through sulfur and oxygen atoms, forming distorted square-planar geometries. These complexes have shown antibacterial activity against anti-Mycobacterium tuberculosis H37Rv ATCC 27294. The complexes exhibited antiparasitic activity against Trypanosoma cruzi, while the metal-free thioureas did not. The results demonstrated that the compounds described here can be considered as promising anti-Mycobacterium tuberculosis and anti-T. cruzi agents, since in both cases their in vitro activity were better than reference drugs available for the treatment of both diseases.
publishDate 2017
dc.date.none.fl_str_mv 2017-01-01
2018-12-11T17:32:29Z
2018-12-11T17:32:29Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.poly.2017.05.003
Polyhedron, v. 132, p. 70-77.
0277-5387
http://hdl.handle.net/11449/178874
10.1016/j.poly.2017.05.003
2-s2.0-85019390406
2-s2.0-85019390406.pdf
url http://dx.doi.org/10.1016/j.poly.2017.05.003
http://hdl.handle.net/11449/178874
identifier_str_mv Polyhedron, v. 132, p. 70-77.
0277-5387
10.1016/j.poly.2017.05.003
2-s2.0-85019390406
2-s2.0-85019390406.pdf
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language eng
dc.relation.none.fl_str_mv Polyhedron
0,472
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eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 70-77
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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