Evaluating the acute contributions of dopaminergic replacement to gait with obstacles in parkinson's disease
Autor(a) principal: | |
---|---|
Data de Publicação: | 2013 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1080/00222895.2013.810139 http://hdl.handle.net/11449/219976 |
Resumo: | The influence of dopaminergic replacement (DR) on gait in people with Parkinson's disease (PD) is well documented. However, little is known about the acute effects of dopamine on more complex locomotor tasks that require visual guidance to avoid obstacles during gait. The authors investigated the influence of DR on locomotor behavior in a task where movement planning and control might be challenged by the height of the obstacle. The PD group included patients diagnosed with idiopathic PD (n = 12), as well as healthy controls (n = 12). Patients walked and stepped over obstacles of different heights before (OFF) and after (ON) levodopa intake. Spatial adjustments were not modulated by DR, but the step time to perform these anticipatory gait adjustments was longer only in PD-OFF (compared with healthy controls) when approaching the highest obstacle, but not PD-ON. During the crossing phase, trail limb toe clearance of PD patients was shorter than healthy controls only during the OFF state. ON-OFF comparisons were significantly different only for the time to reach the lead foot clearance over the highest obstacle. In summary, DR partially improved movement slowness but did not directly affect movement amplitude of lower limb regulation in this gait task. Copyright © 2013 Taylor & Francis Group. |
id |
UNSP_4d8ae5c09c2d6dedaf563d3a10284fdb |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/219976 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Evaluating the acute contributions of dopaminergic replacement to gait with obstacles in parkinson's diseaseAdaptive gaitDopaminergic replacementLocomotionObstacle crossingObstacle heightsParkinson's diseaseThe influence of dopaminergic replacement (DR) on gait in people with Parkinson's disease (PD) is well documented. However, little is known about the acute effects of dopamine on more complex locomotor tasks that require visual guidance to avoid obstacles during gait. The authors investigated the influence of DR on locomotor behavior in a task where movement planning and control might be challenged by the height of the obstacle. The PD group included patients diagnosed with idiopathic PD (n = 12), as well as healthy controls (n = 12). Patients walked and stepped over obstacles of different heights before (OFF) and after (ON) levodopa intake. Spatial adjustments were not modulated by DR, but the step time to perform these anticipatory gait adjustments was longer only in PD-OFF (compared with healthy controls) when approaching the highest obstacle, but not PD-ON. During the crossing phase, trail limb toe clearance of PD patients was shorter than healthy controls only during the OFF state. ON-OFF comparisons were significantly different only for the time to reach the lead foot clearance over the highest obstacle. In summary, DR partially improved movement slowness but did not directly affect movement amplitude of lower limb regulation in this gait task. Copyright © 2013 Taylor & Francis Group.Physical Education Department Posture and Gait Studies Lab University of Sao Paulo StateSun Life Financial Movement Disorders Research and Rehabilitation Centre Wilfrid Laurier University, 66 Hickory Street West, Waterloo, ON N2L 3C5Faculty of Medical Sciences Campinas State University, CampinasKinesiology Department University of Waterloo, ONUniversidade de São Paulo (USP)Wilfrid Laurier UniversityUniversidade Estadual de Campinas (UNICAMP)University of WaterlooPieruccini-Faria, F.Vitório, R.Almeida, Q. J.Silveira, C. R.A.Caetano, M. J.D.Stella, F.Gobbi, S.Gobbi, L. T.B.2022-04-28T18:58:52Z2022-04-28T18:58:52Z2013-11-25info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article369-380http://dx.doi.org/10.1080/00222895.2013.810139Journal of Motor Behavior, v. 45, n. 5, p. 369-380, 2013.0022-28951940-1027http://hdl.handle.net/11449/21997610.1080/00222895.2013.8101392-s2.0-84887970256Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Motor Behaviorinfo:eu-repo/semantics/openAccess2022-04-28T18:58:52Zoai:repositorio.unesp.br:11449/219976Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-28T18:58:52Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Evaluating the acute contributions of dopaminergic replacement to gait with obstacles in parkinson's disease |
title |
Evaluating the acute contributions of dopaminergic replacement to gait with obstacles in parkinson's disease |
spellingShingle |
Evaluating the acute contributions of dopaminergic replacement to gait with obstacles in parkinson's disease Pieruccini-Faria, F. Adaptive gait Dopaminergic replacement Locomotion Obstacle crossing Obstacle heights Parkinson's disease |
title_short |
Evaluating the acute contributions of dopaminergic replacement to gait with obstacles in parkinson's disease |
title_full |
Evaluating the acute contributions of dopaminergic replacement to gait with obstacles in parkinson's disease |
title_fullStr |
Evaluating the acute contributions of dopaminergic replacement to gait with obstacles in parkinson's disease |
title_full_unstemmed |
Evaluating the acute contributions of dopaminergic replacement to gait with obstacles in parkinson's disease |
title_sort |
Evaluating the acute contributions of dopaminergic replacement to gait with obstacles in parkinson's disease |
author |
Pieruccini-Faria, F. |
author_facet |
Pieruccini-Faria, F. Vitório, R. Almeida, Q. J. Silveira, C. R.A. Caetano, M. J.D. Stella, F. Gobbi, S. Gobbi, L. T.B. |
author_role |
author |
author2 |
Vitório, R. Almeida, Q. J. Silveira, C. R.A. Caetano, M. J.D. Stella, F. Gobbi, S. Gobbi, L. T.B. |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Wilfrid Laurier University Universidade Estadual de Campinas (UNICAMP) University of Waterloo |
dc.contributor.author.fl_str_mv |
Pieruccini-Faria, F. Vitório, R. Almeida, Q. J. Silveira, C. R.A. Caetano, M. J.D. Stella, F. Gobbi, S. Gobbi, L. T.B. |
dc.subject.por.fl_str_mv |
Adaptive gait Dopaminergic replacement Locomotion Obstacle crossing Obstacle heights Parkinson's disease |
topic |
Adaptive gait Dopaminergic replacement Locomotion Obstacle crossing Obstacle heights Parkinson's disease |
description |
The influence of dopaminergic replacement (DR) on gait in people with Parkinson's disease (PD) is well documented. However, little is known about the acute effects of dopamine on more complex locomotor tasks that require visual guidance to avoid obstacles during gait. The authors investigated the influence of DR on locomotor behavior in a task where movement planning and control might be challenged by the height of the obstacle. The PD group included patients diagnosed with idiopathic PD (n = 12), as well as healthy controls (n = 12). Patients walked and stepped over obstacles of different heights before (OFF) and after (ON) levodopa intake. Spatial adjustments were not modulated by DR, but the step time to perform these anticipatory gait adjustments was longer only in PD-OFF (compared with healthy controls) when approaching the highest obstacle, but not PD-ON. During the crossing phase, trail limb toe clearance of PD patients was shorter than healthy controls only during the OFF state. ON-OFF comparisons were significantly different only for the time to reach the lead foot clearance over the highest obstacle. In summary, DR partially improved movement slowness but did not directly affect movement amplitude of lower limb regulation in this gait task. Copyright © 2013 Taylor & Francis Group. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-11-25 2022-04-28T18:58:52Z 2022-04-28T18:58:52Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1080/00222895.2013.810139 Journal of Motor Behavior, v. 45, n. 5, p. 369-380, 2013. 0022-2895 1940-1027 http://hdl.handle.net/11449/219976 10.1080/00222895.2013.810139 2-s2.0-84887970256 |
url |
http://dx.doi.org/10.1080/00222895.2013.810139 http://hdl.handle.net/11449/219976 |
identifier_str_mv |
Journal of Motor Behavior, v. 45, n. 5, p. 369-380, 2013. 0022-2895 1940-1027 10.1080/00222895.2013.810139 2-s2.0-84887970256 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Motor Behavior |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
369-380 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965219507666944 |