Subcutaneous tissue reaction to castor oil bean and calcium hydroxide in rats
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S1678-77572010000300014 http://hdl.handle.net/11449/226074 |
Resumo: | Castor oil bean cement (COB) is a new material that has been used as an endodontic sealer, and is a candidate material for direct pulp capping. Objective: The purpose of this study was to evaluate the biocompatibility of a new formulation of COB compared to calcium hydroxide cement (CH) and a control group without any material, in the subcutaneous tissue of rats. Material and methods: The materials were prepared, packed into polyethylene tubes, and implanted in the rat dorsal subcutaneous tissue. Animals were sacrificed at the 7th and 50th days after implantation. A quantitative analysis of inflammatory cells was performed and data were subjected to ANOVA and Tukey's tests at 5% significance level. Results: Comparing the mean number of inflammatory cells between the two experimental groups (COB and CH) and the control group, statistically significant difference (p=0.0001) was observed at 7 and 50 days. There were no significant differences (p=0.111) between tissue reaction to CH (382 inflammatory cells) and COB (330 inflammatory cells) after 7 days. After 50 days, significantly more inflammatory cells (p=0.02) were observed in the CH group (404 inflammatory cells) than in the COB group (177 inflammatory cells). Conclusions: These results demonstrate that the COB cement induces less inflammatory response within long periods. |
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Repositório Institucional da UNESP |
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Subcutaneous tissue reaction to castor oil bean and calcium hydroxide in ratsCalcium hydroxideCastor oilPulp cappingRatsCastor oil bean cement (COB) is a new material that has been used as an endodontic sealer, and is a candidate material for direct pulp capping. Objective: The purpose of this study was to evaluate the biocompatibility of a new formulation of COB compared to calcium hydroxide cement (CH) and a control group without any material, in the subcutaneous tissue of rats. Material and methods: The materials were prepared, packed into polyethylene tubes, and implanted in the rat dorsal subcutaneous tissue. Animals were sacrificed at the 7th and 50th days after implantation. A quantitative analysis of inflammatory cells was performed and data were subjected to ANOVA and Tukey's tests at 5% significance level. Results: Comparing the mean number of inflammatory cells between the two experimental groups (COB and CH) and the control group, statistically significant difference (p=0.0001) was observed at 7 and 50 days. There were no significant differences (p=0.111) between tissue reaction to CH (382 inflammatory cells) and COB (330 inflammatory cells) after 7 days. After 50 days, significantly more inflammatory cells (p=0.02) were observed in the CH group (404 inflammatory cells) than in the COB group (177 inflammatory cells). Conclusions: These results demonstrate that the COB cement induces less inflammatory response within long periods.Department of Bioscience and Oral Diagnosis São José dos Campos Dental School São Paulo State University (UNESP), São José dos Campos, SPDepartment of Dental Materials and Prosthodontics São José dos Campos Dental School São Paulo State University (UNESP), São José dos Campos, SPDepartment of Physiotherapy Superior School of Cruzeiro, Cruzeiro, SPDepartment of Restorative Dentistry São José dos Campos Dental School São Paulo State University (UNESP), São José dos Campos, SPDepartment of Bioscience and Oral Diagnosis São José dos Campos Dental School São Paulo State University (UNESP), São José dos Campos, SPDepartment of Dental Materials and Prosthodontics São José dos Campos Dental School São Paulo State University (UNESP), São José dos Campos, SPDepartment of Restorative Dentistry São José dos Campos Dental School São Paulo State University (UNESP), São José dos Campos, SPUniversidade Estadual Paulista (UNESP)Superior School of CruzeiroCamargo, Samira Esteves Afonso [UNESP]Rode, Sigmar de Mello [UNESP]do Prado, Renata FalcheteCarvalho, Yasmin Rodarte [UNESP]Camargo, Carlos Henrique Ribeiro [UNESP]2022-04-28T21:25:11Z2022-04-28T21:25:11Z2010-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article273-278http://dx.doi.org/10.1590/S1678-77572010000300014Journal of Applied Oral Science, v. 18, n. 3, p. 273-278, 2010.1678-77651678-7757http://hdl.handle.net/11449/22607410.1590/S1678-775720100003000142-s2.0-77957726584Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Applied Oral Scienceinfo:eu-repo/semantics/openAccess2022-04-28T21:25:11Zoai:repositorio.unesp.br:11449/226074Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-28T21:25:11Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Subcutaneous tissue reaction to castor oil bean and calcium hydroxide in rats |
title |
Subcutaneous tissue reaction to castor oil bean and calcium hydroxide in rats |
spellingShingle |
Subcutaneous tissue reaction to castor oil bean and calcium hydroxide in rats Camargo, Samira Esteves Afonso [UNESP] Calcium hydroxide Castor oil Pulp capping Rats |
title_short |
Subcutaneous tissue reaction to castor oil bean and calcium hydroxide in rats |
title_full |
Subcutaneous tissue reaction to castor oil bean and calcium hydroxide in rats |
title_fullStr |
Subcutaneous tissue reaction to castor oil bean and calcium hydroxide in rats |
title_full_unstemmed |
Subcutaneous tissue reaction to castor oil bean and calcium hydroxide in rats |
title_sort |
Subcutaneous tissue reaction to castor oil bean and calcium hydroxide in rats |
author |
Camargo, Samira Esteves Afonso [UNESP] |
author_facet |
Camargo, Samira Esteves Afonso [UNESP] Rode, Sigmar de Mello [UNESP] do Prado, Renata Falchete Carvalho, Yasmin Rodarte [UNESP] Camargo, Carlos Henrique Ribeiro [UNESP] |
author_role |
author |
author2 |
Rode, Sigmar de Mello [UNESP] do Prado, Renata Falchete Carvalho, Yasmin Rodarte [UNESP] Camargo, Carlos Henrique Ribeiro [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Superior School of Cruzeiro |
dc.contributor.author.fl_str_mv |
Camargo, Samira Esteves Afonso [UNESP] Rode, Sigmar de Mello [UNESP] do Prado, Renata Falchete Carvalho, Yasmin Rodarte [UNESP] Camargo, Carlos Henrique Ribeiro [UNESP] |
dc.subject.por.fl_str_mv |
Calcium hydroxide Castor oil Pulp capping Rats |
topic |
Calcium hydroxide Castor oil Pulp capping Rats |
description |
Castor oil bean cement (COB) is a new material that has been used as an endodontic sealer, and is a candidate material for direct pulp capping. Objective: The purpose of this study was to evaluate the biocompatibility of a new formulation of COB compared to calcium hydroxide cement (CH) and a control group without any material, in the subcutaneous tissue of rats. Material and methods: The materials were prepared, packed into polyethylene tubes, and implanted in the rat dorsal subcutaneous tissue. Animals were sacrificed at the 7th and 50th days after implantation. A quantitative analysis of inflammatory cells was performed and data were subjected to ANOVA and Tukey's tests at 5% significance level. Results: Comparing the mean number of inflammatory cells between the two experimental groups (COB and CH) and the control group, statistically significant difference (p=0.0001) was observed at 7 and 50 days. There were no significant differences (p=0.111) between tissue reaction to CH (382 inflammatory cells) and COB (330 inflammatory cells) after 7 days. After 50 days, significantly more inflammatory cells (p=0.02) were observed in the CH group (404 inflammatory cells) than in the COB group (177 inflammatory cells). Conclusions: These results demonstrate that the COB cement induces less inflammatory response within long periods. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-01-01 2022-04-28T21:25:11Z 2022-04-28T21:25:11Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1678-77572010000300014 Journal of Applied Oral Science, v. 18, n. 3, p. 273-278, 2010. 1678-7765 1678-7757 http://hdl.handle.net/11449/226074 10.1590/S1678-77572010000300014 2-s2.0-77957726584 |
url |
http://dx.doi.org/10.1590/S1678-77572010000300014 http://hdl.handle.net/11449/226074 |
identifier_str_mv |
Journal of Applied Oral Science, v. 18, n. 3, p. 273-278, 2010. 1678-7765 1678-7757 10.1590/S1678-77572010000300014 2-s2.0-77957726584 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Applied Oral Science |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
273-278 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1797789247746342912 |