Potential of the association of dodecyl gallate with nanostructured lipid system as a treatment for paracoccidioidomycosis: In vitro and in vivo efficacy and toxicity
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.ijpharm.2018.06.013 http://hdl.handle.net/11449/179967 |
Resumo: | Paracoccidioidomycosis (PCM) is a systemic mycosis endemic in Latin America, caused by Paracoccidioides spp. A limited number of antifungal agents are available and the search for new compounds has increased. Additionally, nanostructured lipid system (NLS) has emmerged as an interesting strategy to carrier compounds for the treatment of mycosis. In this work, the antifungal efficacy and toxicity of dodecyl gallate (DOD) associated with a NLS was evaluated through in vitro and in vivo tests. DOD showed good in vitro antifungal activity and low toxicity in lung fibroblasts and zebrafish embryos, but no antifungal efficacy in infected mice, which may have been a result of low bioavailability. On the other hand, the association of DOD + NLS was beneficial and resulted in lower toxicity in lung fibroblasts and zebrafish embryos. In addition, NLS + DOD promoted a significant reduction in the fungal burden of mice lungs and could be a potential therapeutic option against PCM. |
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Potential of the association of dodecyl gallate with nanostructured lipid system as a treatment for paracoccidioidomycosis: In vitro and in vivo efficacy and toxicityAntifungal compoundIn vivo modelsLipid nanoparticlesParacoccidioides sp.Systemic mycosisParacoccidioidomycosis (PCM) is a systemic mycosis endemic in Latin America, caused by Paracoccidioides spp. A limited number of antifungal agents are available and the search for new compounds has increased. Additionally, nanostructured lipid system (NLS) has emmerged as an interesting strategy to carrier compounds for the treatment of mycosis. In this work, the antifungal efficacy and toxicity of dodecyl gallate (DOD) associated with a NLS was evaluated through in vitro and in vivo tests. DOD showed good in vitro antifungal activity and low toxicity in lung fibroblasts and zebrafish embryos, but no antifungal efficacy in infected mice, which may have been a result of low bioavailability. On the other hand, the association of DOD + NLS was beneficial and resulted in lower toxicity in lung fibroblasts and zebrafish embryos. In addition, NLS + DOD promoted a significant reduction in the fungal burden of mice lungs and could be a potential therapeutic option against PCM.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)São Paulo State University (UNESP) School of Pharmaceutical SciencesSão Paulo State University (UNESP) Institute of Biosciences Letters and Exact Sciences, São José do Rio PretoSão Paulo State University (UNESP) School of Pharmaceutical SciencesSão Paulo State University (UNESP) Institute of Biosciences Letters and Exact Sciences, São José do Rio PretoFAPESP: 2013/10917-9FAPESP: 2014/10446-9FAPESP: 2015/03700-9Universidade Estadual Paulista (Unesp)Singulani, Junya de Lacorte [UNESP]Scorzoni, Liliana [UNESP]Lourencetti, Natália Manuela Strohmayer [UNESP]Oliveira, Luana Rossi [UNESP]Conçolaro, Rosana Silva [UNESP]da Silva, Patricia Bento [UNESP]Nazaré, Ana Carolina [UNESP]Polaquini, Carlos Roberto [UNESP]Victorelli, Francesca Damiani [UNESP]Chorilli, Marlus [UNESP]Regasini, Luis Octávio [UNESP]Fusco Almeida, Ana Marisa [UNESP]Mendes Giannini, Maria José Soares [UNESP]2018-12-11T17:37:29Z2018-12-11T17:37:29Z2018-08-25info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article630-636application/pdfhttp://dx.doi.org/10.1016/j.ijpharm.2018.06.013International Journal of Pharmaceutics, v. 547, n. 1-2, p. 630-636, 2018.1873-34760378-5173http://hdl.handle.net/11449/17996710.1016/j.ijpharm.2018.06.0132-s2.0-850487558432-s2.0-85048755843.pdf09927364527645501427125996716282Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Journal of Pharmaceutics1,172info:eu-repo/semantics/openAccess2023-12-12T06:19:49Zoai:repositorio.unesp.br:11449/179967Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-12T06:19:49Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Potential of the association of dodecyl gallate with nanostructured lipid system as a treatment for paracoccidioidomycosis: In vitro and in vivo efficacy and toxicity |
title |
Potential of the association of dodecyl gallate with nanostructured lipid system as a treatment for paracoccidioidomycosis: In vitro and in vivo efficacy and toxicity |
spellingShingle |
Potential of the association of dodecyl gallate with nanostructured lipid system as a treatment for paracoccidioidomycosis: In vitro and in vivo efficacy and toxicity Singulani, Junya de Lacorte [UNESP] Antifungal compound In vivo models Lipid nanoparticles Paracoccidioides sp. Systemic mycosis |
title_short |
Potential of the association of dodecyl gallate with nanostructured lipid system as a treatment for paracoccidioidomycosis: In vitro and in vivo efficacy and toxicity |
title_full |
Potential of the association of dodecyl gallate with nanostructured lipid system as a treatment for paracoccidioidomycosis: In vitro and in vivo efficacy and toxicity |
title_fullStr |
Potential of the association of dodecyl gallate with nanostructured lipid system as a treatment for paracoccidioidomycosis: In vitro and in vivo efficacy and toxicity |
title_full_unstemmed |
Potential of the association of dodecyl gallate with nanostructured lipid system as a treatment for paracoccidioidomycosis: In vitro and in vivo efficacy and toxicity |
title_sort |
Potential of the association of dodecyl gallate with nanostructured lipid system as a treatment for paracoccidioidomycosis: In vitro and in vivo efficacy and toxicity |
author |
Singulani, Junya de Lacorte [UNESP] |
author_facet |
Singulani, Junya de Lacorte [UNESP] Scorzoni, Liliana [UNESP] Lourencetti, Natália Manuela Strohmayer [UNESP] Oliveira, Luana Rossi [UNESP] Conçolaro, Rosana Silva [UNESP] da Silva, Patricia Bento [UNESP] Nazaré, Ana Carolina [UNESP] Polaquini, Carlos Roberto [UNESP] Victorelli, Francesca Damiani [UNESP] Chorilli, Marlus [UNESP] Regasini, Luis Octávio [UNESP] Fusco Almeida, Ana Marisa [UNESP] Mendes Giannini, Maria José Soares [UNESP] |
author_role |
author |
author2 |
Scorzoni, Liliana [UNESP] Lourencetti, Natália Manuela Strohmayer [UNESP] Oliveira, Luana Rossi [UNESP] Conçolaro, Rosana Silva [UNESP] da Silva, Patricia Bento [UNESP] Nazaré, Ana Carolina [UNESP] Polaquini, Carlos Roberto [UNESP] Victorelli, Francesca Damiani [UNESP] Chorilli, Marlus [UNESP] Regasini, Luis Octávio [UNESP] Fusco Almeida, Ana Marisa [UNESP] Mendes Giannini, Maria José Soares [UNESP] |
author2_role |
author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Singulani, Junya de Lacorte [UNESP] Scorzoni, Liliana [UNESP] Lourencetti, Natália Manuela Strohmayer [UNESP] Oliveira, Luana Rossi [UNESP] Conçolaro, Rosana Silva [UNESP] da Silva, Patricia Bento [UNESP] Nazaré, Ana Carolina [UNESP] Polaquini, Carlos Roberto [UNESP] Victorelli, Francesca Damiani [UNESP] Chorilli, Marlus [UNESP] Regasini, Luis Octávio [UNESP] Fusco Almeida, Ana Marisa [UNESP] Mendes Giannini, Maria José Soares [UNESP] |
dc.subject.por.fl_str_mv |
Antifungal compound In vivo models Lipid nanoparticles Paracoccidioides sp. Systemic mycosis |
topic |
Antifungal compound In vivo models Lipid nanoparticles Paracoccidioides sp. Systemic mycosis |
description |
Paracoccidioidomycosis (PCM) is a systemic mycosis endemic in Latin America, caused by Paracoccidioides spp. A limited number of antifungal agents are available and the search for new compounds has increased. Additionally, nanostructured lipid system (NLS) has emmerged as an interesting strategy to carrier compounds for the treatment of mycosis. In this work, the antifungal efficacy and toxicity of dodecyl gallate (DOD) associated with a NLS was evaluated through in vitro and in vivo tests. DOD showed good in vitro antifungal activity and low toxicity in lung fibroblasts and zebrafish embryos, but no antifungal efficacy in infected mice, which may have been a result of low bioavailability. On the other hand, the association of DOD + NLS was beneficial and resulted in lower toxicity in lung fibroblasts and zebrafish embryos. In addition, NLS + DOD promoted a significant reduction in the fungal burden of mice lungs and could be a potential therapeutic option against PCM. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-11T17:37:29Z 2018-12-11T17:37:29Z 2018-08-25 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.ijpharm.2018.06.013 International Journal of Pharmaceutics, v. 547, n. 1-2, p. 630-636, 2018. 1873-3476 0378-5173 http://hdl.handle.net/11449/179967 10.1016/j.ijpharm.2018.06.013 2-s2.0-85048755843 2-s2.0-85048755843.pdf 0992736452764550 1427125996716282 |
url |
http://dx.doi.org/10.1016/j.ijpharm.2018.06.013 http://hdl.handle.net/11449/179967 |
identifier_str_mv |
International Journal of Pharmaceutics, v. 547, n. 1-2, p. 630-636, 2018. 1873-3476 0378-5173 10.1016/j.ijpharm.2018.06.013 2-s2.0-85048755843 2-s2.0-85048755843.pdf 0992736452764550 1427125996716282 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
International Journal of Pharmaceutics 1,172 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
630-636 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965259481481216 |