Topical cyclosporine A 0.05% before and after surgery to prevent pterygium recurrence
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.5935/0004-2749.20190075 http://hdl.handle.net/11449/186161 |
Resumo: | Purpose: We evaluated the role of the conjunctival flap rotation technique using 5-fluorouracil and adjuvant therapy with topical cyclosporine A at 0.05% during short pre- and postoperative periods for the prevention of primary pterygium recurrence. Methods: In this prospective study, 76 patients with primary pterygium (76 eyes) were categorized into two groups: the control group with 31 patients who did not receive cyclosporine treatment, and the cyclosporine group with 45 patients who received topical cyclosporine A (0.05%) twice a day, for 10 days before and 10 days after the pterygium excision operations. Patients were examined for disease recurrence, side effects, and complications at 10 and 21 days, and at 2 and 6 months after the operation. Data on demography, systemic diseases, and ophthalmologic histories were obtained from all patients, and these data were analyzed using descriptive statistics involving the absolute and relative percentages of frequency distribution. Goodman test was used for contrasts among multinomial populations to study the association between cyclosporine A and recurrence. Results: Most patients were between 30 and 60 years of age, and 67.1% were women. We confirmed a higher recurrence in patients with occupational sunlight exposure. The cyclosporine A used topically 10 days before and 10 days after the pterygium removal did not significantly reduce the recurrence of the pterygium. Conclusion: Topical 0.05% cyclosporine A when used for 10 days before and 10 days after the pterygium removal does not prevent or reduce the recurrence of primary pterygium. |
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Topical cyclosporine A 0.05% before and after surgery to prevent pterygium recurrenceCyclosporine/administration and dosagePterygium/prevention and controlRecurrencePurpose: We evaluated the role of the conjunctival flap rotation technique using 5-fluorouracil and adjuvant therapy with topical cyclosporine A at 0.05% during short pre- and postoperative periods for the prevention of primary pterygium recurrence. Methods: In this prospective study, 76 patients with primary pterygium (76 eyes) were categorized into two groups: the control group with 31 patients who did not receive cyclosporine treatment, and the cyclosporine group with 45 patients who received topical cyclosporine A (0.05%) twice a day, for 10 days before and 10 days after the pterygium excision operations. Patients were examined for disease recurrence, side effects, and complications at 10 and 21 days, and at 2 and 6 months after the operation. Data on demography, systemic diseases, and ophthalmologic histories were obtained from all patients, and these data were analyzed using descriptive statistics involving the absolute and relative percentages of frequency distribution. Goodman test was used for contrasts among multinomial populations to study the association between cyclosporine A and recurrence. Results: Most patients were between 30 and 60 years of age, and 67.1% were women. We confirmed a higher recurrence in patients with occupational sunlight exposure. The cyclosporine A used topically 10 days before and 10 days after the pterygium removal did not significantly reduce the recurrence of the pterygium. Conclusion: Topical 0.05% cyclosporine A when used for 10 days before and 10 days after the pterygium removal does not prevent or reduce the recurrence of primary pterygium.Univ Estadual Paulista, Botucatu Med Sch, Dept Ophthalmol, Botucatu, SP, BrazilUniv Estadual Paulista, Biosci Inst, Dept Biostat, Botucatu, SP, BrazilUniv Estadual Paulista, Botucatu Med Sch, Dept Ophthalmol, Botucatu, SP, BrazilUniv Estadual Paulista, Biosci Inst, Dept Biostat, Botucatu, SP, BrazilConsel Brasil OftalmologiaUniversidade Estadual Paulista (Unesp)Fernandes de Sousa Meneghim, Roberta Lilian [UNESP]Satto, Larissa Horikawa [UNESP]Natsuaki, Kryscia Leiko [UNESP]Oliveira, Alessandro Carvalho de [UNESP]Padovani, Carlos Roberto [UNESP]Hata Viveiros, Magda Massae [UNESP]Schellini, Silvana Artioli [UNESP]2019-10-04T12:42:20Z2019-10-04T12:42:20Z2019-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article372-376application/pdfhttp://dx.doi.org/10.5935/0004-2749.20190075Arquivos Brasileiros De Oftalmologia. Sao Paulo: Consel Brasil Oftalmologia, v. 82, n. 5, p. 372-376, 2019.0004-2749http://hdl.handle.net/11449/18616110.5935/0004-2749.20190075S0004-27492019000500372WOS:000484856400003S0004-27492019000500372.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArquivos Brasileiros De Oftalmologiainfo:eu-repo/semantics/openAccess2023-10-26T06:11:04Zoai:repositorio.unesp.br:11449/186161Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-10-26T06:11:04Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Topical cyclosporine A 0.05% before and after surgery to prevent pterygium recurrence |
title |
Topical cyclosporine A 0.05% before and after surgery to prevent pterygium recurrence |
spellingShingle |
Topical cyclosporine A 0.05% before and after surgery to prevent pterygium recurrence Fernandes de Sousa Meneghim, Roberta Lilian [UNESP] Cyclosporine/administration and dosage Pterygium/prevention and control Recurrence |
title_short |
Topical cyclosporine A 0.05% before and after surgery to prevent pterygium recurrence |
title_full |
Topical cyclosporine A 0.05% before and after surgery to prevent pterygium recurrence |
title_fullStr |
Topical cyclosporine A 0.05% before and after surgery to prevent pterygium recurrence |
title_full_unstemmed |
Topical cyclosporine A 0.05% before and after surgery to prevent pterygium recurrence |
title_sort |
Topical cyclosporine A 0.05% before and after surgery to prevent pterygium recurrence |
author |
Fernandes de Sousa Meneghim, Roberta Lilian [UNESP] |
author_facet |
Fernandes de Sousa Meneghim, Roberta Lilian [UNESP] Satto, Larissa Horikawa [UNESP] Natsuaki, Kryscia Leiko [UNESP] Oliveira, Alessandro Carvalho de [UNESP] Padovani, Carlos Roberto [UNESP] Hata Viveiros, Magda Massae [UNESP] Schellini, Silvana Artioli [UNESP] |
author_role |
author |
author2 |
Satto, Larissa Horikawa [UNESP] Natsuaki, Kryscia Leiko [UNESP] Oliveira, Alessandro Carvalho de [UNESP] Padovani, Carlos Roberto [UNESP] Hata Viveiros, Magda Massae [UNESP] Schellini, Silvana Artioli [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Fernandes de Sousa Meneghim, Roberta Lilian [UNESP] Satto, Larissa Horikawa [UNESP] Natsuaki, Kryscia Leiko [UNESP] Oliveira, Alessandro Carvalho de [UNESP] Padovani, Carlos Roberto [UNESP] Hata Viveiros, Magda Massae [UNESP] Schellini, Silvana Artioli [UNESP] |
dc.subject.por.fl_str_mv |
Cyclosporine/administration and dosage Pterygium/prevention and control Recurrence |
topic |
Cyclosporine/administration and dosage Pterygium/prevention and control Recurrence |
description |
Purpose: We evaluated the role of the conjunctival flap rotation technique using 5-fluorouracil and adjuvant therapy with topical cyclosporine A at 0.05% during short pre- and postoperative periods for the prevention of primary pterygium recurrence. Methods: In this prospective study, 76 patients with primary pterygium (76 eyes) were categorized into two groups: the control group with 31 patients who did not receive cyclosporine treatment, and the cyclosporine group with 45 patients who received topical cyclosporine A (0.05%) twice a day, for 10 days before and 10 days after the pterygium excision operations. Patients were examined for disease recurrence, side effects, and complications at 10 and 21 days, and at 2 and 6 months after the operation. Data on demography, systemic diseases, and ophthalmologic histories were obtained from all patients, and these data were analyzed using descriptive statistics involving the absolute and relative percentages of frequency distribution. Goodman test was used for contrasts among multinomial populations to study the association between cyclosporine A and recurrence. Results: Most patients were between 30 and 60 years of age, and 67.1% were women. We confirmed a higher recurrence in patients with occupational sunlight exposure. The cyclosporine A used topically 10 days before and 10 days after the pterygium removal did not significantly reduce the recurrence of the pterygium. Conclusion: Topical 0.05% cyclosporine A when used for 10 days before and 10 days after the pterygium removal does not prevent or reduce the recurrence of primary pterygium. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-04T12:42:20Z 2019-10-04T12:42:20Z 2019-09-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.5935/0004-2749.20190075 Arquivos Brasileiros De Oftalmologia. Sao Paulo: Consel Brasil Oftalmologia, v. 82, n. 5, p. 372-376, 2019. 0004-2749 http://hdl.handle.net/11449/186161 10.5935/0004-2749.20190075 S0004-27492019000500372 WOS:000484856400003 S0004-27492019000500372.pdf |
url |
http://dx.doi.org/10.5935/0004-2749.20190075 http://hdl.handle.net/11449/186161 |
identifier_str_mv |
Arquivos Brasileiros De Oftalmologia. Sao Paulo: Consel Brasil Oftalmologia, v. 82, n. 5, p. 372-376, 2019. 0004-2749 10.5935/0004-2749.20190075 S0004-27492019000500372 WOS:000484856400003 S0004-27492019000500372.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Arquivos Brasileiros De Oftalmologia |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
372-376 application/pdf |
dc.publisher.none.fl_str_mv |
Consel Brasil Oftalmologia |
publisher.none.fl_str_mv |
Consel Brasil Oftalmologia |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1799964709586206720 |