Antioxidant Action of Mangrove Polyphenols against Gastric Damage Induced by Absolute Ethanol and Ischemia-Reperfusion in the Rat
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1100/2012/327071 http://hdl.handle.net/11449/42643 |
Resumo: | Rhizophora mangle, the red mangrove, has long been known as a traditional medicine. Its bark has been used as astringent, antiseptic, hemostatic, with antifungic and antiulcerogenic properties. In this paper, we aimed to evaluate the antioxidant properties of a buthanolic fraction of the R. mangle bark extract (RM) against experimental gastric ulcer in rats. Unib-Wh rats received pretreatment of R. mangle after the induction of gastric injury with absolute ethanol and ischemia-reperfusion. Gastric tissues from both methods were prepared to the enzymatic assays, the levels of sulfhydril compounds (GSH), lipid peroxides (LPO), and the activities of glutathione reductase (GR), glutathione peroxidase (GPx), superoxide dismutase (SOD) and myeloperoxidase (MPO) were measured. The RM protected the gastric mucosa in both methods used, ethanol-induced gastric ulcer and ischemia-reperfusion, probably, by modulating the activities of the enzymes SOD, GPx, and GR and increasing or maintaining the levels of GSH; in adittion, LPO levels were reduced. The results suggest that the RM antioxidant activity leads to tissue protection; thus one of the antiulcer mechanisms present on the pharmacological effects of R. mangle is the antioxidant property. |
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Antioxidant Action of Mangrove Polyphenols against Gastric Damage Induced by Absolute Ethanol and Ischemia-Reperfusion in the RatRhizophora mangle, the red mangrove, has long been known as a traditional medicine. Its bark has been used as astringent, antiseptic, hemostatic, with antifungic and antiulcerogenic properties. In this paper, we aimed to evaluate the antioxidant properties of a buthanolic fraction of the R. mangle bark extract (RM) against experimental gastric ulcer in rats. Unib-Wh rats received pretreatment of R. mangle after the induction of gastric injury with absolute ethanol and ischemia-reperfusion. Gastric tissues from both methods were prepared to the enzymatic assays, the levels of sulfhydril compounds (GSH), lipid peroxides (LPO), and the activities of glutathione reductase (GR), glutathione peroxidase (GPx), superoxide dismutase (SOD) and myeloperoxidase (MPO) were measured. The RM protected the gastric mucosa in both methods used, ethanol-induced gastric ulcer and ischemia-reperfusion, probably, by modulating the activities of the enzymes SOD, GPx, and GR and increasing or maintaining the levels of GSH; in adittion, LPO levels were reduced. The results suggest that the RM antioxidant activity leads to tissue protection; thus one of the antiulcer mechanisms present on the pharmacological effects of R. mangle is the antioxidant property.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Estadual Campinas, Fac Ciencias Med, Dept Farmacol, BR-13083970 Campinas, SP, BrazilUniv Estadual Campinas, Inst Biol, Dept Fisiol & Biofis, BR-13083970 Campinas, SP, BrazilUNESP, Inst Quim, Dept Quim Organ, Araraquara, SP, BrazilUniv Estadual Campinas, Inst Biol, Dept Biol Vegetal, BR-13083970 Campinas, SP, BrazilUniv Estadual Campinas, Inst Quim, Dept Quim Organ, BR-13083970 Campinas, SP, BrazilUniv Santa Cecilia, UNISANTA, Fac Farm, Santos, SP, BrazilUNESP, Inst Quim, Dept Quim Organ, Araraquara, SP, BrazilHindawi Publishing CorporationUniversidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (Unesp)Univ Santa Ceciliade-Faria, Felipe MeiraAlves Almeida, Ana CristinaLuiz-Ferreira, AndersonTakayama, ChristianeDunder, Ricardo Joseda Silva, Marcelo Aparecido [UNESP]Salvador, Marcos JoseAbdelnur, Patricia VerardiEberlin, Marcos NogueiraVilegas, Wagner [UNESP]Toma, WalberMonteiro Souza-Brito, Alba Regina2014-05-20T15:34:46Z2014-05-20T15:34:46Z2012-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article9application/pdfhttp://dx.doi.org/10.1100/2012/327071Scientific World Journal. New York: Hindawi Publishing Corporation, p. 9, 2012.1537-744Xhttp://hdl.handle.net/11449/4264310.1100/2012/327071WOS:000304778600001WOS000304778600001.pdf0000-0003-3032-2556Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengScientific World Journalinfo:eu-repo/semantics/openAccess2023-10-14T06:02:53Zoai:repositorio.unesp.br:11449/42643Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-10-14T06:02:53Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Antioxidant Action of Mangrove Polyphenols against Gastric Damage Induced by Absolute Ethanol and Ischemia-Reperfusion in the Rat |
title |
Antioxidant Action of Mangrove Polyphenols against Gastric Damage Induced by Absolute Ethanol and Ischemia-Reperfusion in the Rat |
spellingShingle |
Antioxidant Action of Mangrove Polyphenols against Gastric Damage Induced by Absolute Ethanol and Ischemia-Reperfusion in the Rat de-Faria, Felipe Meira |
title_short |
Antioxidant Action of Mangrove Polyphenols against Gastric Damage Induced by Absolute Ethanol and Ischemia-Reperfusion in the Rat |
title_full |
Antioxidant Action of Mangrove Polyphenols against Gastric Damage Induced by Absolute Ethanol and Ischemia-Reperfusion in the Rat |
title_fullStr |
Antioxidant Action of Mangrove Polyphenols against Gastric Damage Induced by Absolute Ethanol and Ischemia-Reperfusion in the Rat |
title_full_unstemmed |
Antioxidant Action of Mangrove Polyphenols against Gastric Damage Induced by Absolute Ethanol and Ischemia-Reperfusion in the Rat |
title_sort |
Antioxidant Action of Mangrove Polyphenols against Gastric Damage Induced by Absolute Ethanol and Ischemia-Reperfusion in the Rat |
author |
de-Faria, Felipe Meira |
author_facet |
de-Faria, Felipe Meira Alves Almeida, Ana Cristina Luiz-Ferreira, Anderson Takayama, Christiane Dunder, Ricardo Jose da Silva, Marcelo Aparecido [UNESP] Salvador, Marcos Jose Abdelnur, Patricia Verardi Eberlin, Marcos Nogueira Vilegas, Wagner [UNESP] Toma, Walber Monteiro Souza-Brito, Alba Regina |
author_role |
author |
author2 |
Alves Almeida, Ana Cristina Luiz-Ferreira, Anderson Takayama, Christiane Dunder, Ricardo Jose da Silva, Marcelo Aparecido [UNESP] Salvador, Marcos Jose Abdelnur, Patricia Verardi Eberlin, Marcos Nogueira Vilegas, Wagner [UNESP] Toma, Walber Monteiro Souza-Brito, Alba Regina |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual de Campinas (UNICAMP) Universidade Estadual Paulista (Unesp) Univ Santa Cecilia |
dc.contributor.author.fl_str_mv |
de-Faria, Felipe Meira Alves Almeida, Ana Cristina Luiz-Ferreira, Anderson Takayama, Christiane Dunder, Ricardo Jose da Silva, Marcelo Aparecido [UNESP] Salvador, Marcos Jose Abdelnur, Patricia Verardi Eberlin, Marcos Nogueira Vilegas, Wagner [UNESP] Toma, Walber Monteiro Souza-Brito, Alba Regina |
description |
Rhizophora mangle, the red mangrove, has long been known as a traditional medicine. Its bark has been used as astringent, antiseptic, hemostatic, with antifungic and antiulcerogenic properties. In this paper, we aimed to evaluate the antioxidant properties of a buthanolic fraction of the R. mangle bark extract (RM) against experimental gastric ulcer in rats. Unib-Wh rats received pretreatment of R. mangle after the induction of gastric injury with absolute ethanol and ischemia-reperfusion. Gastric tissues from both methods were prepared to the enzymatic assays, the levels of sulfhydril compounds (GSH), lipid peroxides (LPO), and the activities of glutathione reductase (GR), glutathione peroxidase (GPx), superoxide dismutase (SOD) and myeloperoxidase (MPO) were measured. The RM protected the gastric mucosa in both methods used, ethanol-induced gastric ulcer and ischemia-reperfusion, probably, by modulating the activities of the enzymes SOD, GPx, and GR and increasing or maintaining the levels of GSH; in adittion, LPO levels were reduced. The results suggest that the RM antioxidant activity leads to tissue protection; thus one of the antiulcer mechanisms present on the pharmacological effects of R. mangle is the antioxidant property. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-01-01 2014-05-20T15:34:46Z 2014-05-20T15:34:46Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1100/2012/327071 Scientific World Journal. New York: Hindawi Publishing Corporation, p. 9, 2012. 1537-744X http://hdl.handle.net/11449/42643 10.1100/2012/327071 WOS:000304778600001 WOS000304778600001.pdf 0000-0003-3032-2556 |
url |
http://dx.doi.org/10.1100/2012/327071 http://hdl.handle.net/11449/42643 |
identifier_str_mv |
Scientific World Journal. New York: Hindawi Publishing Corporation, p. 9, 2012. 1537-744X 10.1100/2012/327071 WOS:000304778600001 WOS000304778600001.pdf 0000-0003-3032-2556 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Scientific World Journal |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
9 application/pdf |
dc.publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1799964552587116544 |