Immunohistochemical evaluation of Langerhans cells in oral lichen planus and oral lichenoid lesions
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.archoralbio.2020.105027 http://hdl.handle.net/11449/208373 |
Resumo: | Objective: the aim of this study was to evaluate the density of Langerhans cells in oral lichen planus (OLP) and oral lichenoid lesions (OLL). Design: 14 cases of OLP, 15 cases of OLL and 14 cases of oral inflammatory fibrous hyperplasia (OIFH), were selected for immunohistochemical analysis of CD1a, CD207 and S100 expression. The OIFH group was subdivided according to the presence (OIFHL n = 14) or absence (OIFHNL n = 14) of lichenoid inflammatory infiltrate. Positive cells were counted in intraepithelial and subepithelial areas. Results were analyzed by multivariate comparative analysis, correlation analysis, linear regression models and Student's T-test. Results: A significantly higher amount of CD207+ cells in OLL vs OLP was observed (p = 0.015). The prevailing reticular pattern observed was CD207high for OLP (p = 0.0329). A statistically significant difference in the expression of CD1a and CD207 was observed for intraepithelial vs subepithelial areas (p = 0.024 and p=0.015, for CD1a and CD207, respectively). Significant correlations were also observed between the expression of CD1a + and CD207+ cells in the pathogenesis of OLP and OLL. Conclusion: High levels of CD207+cells in OLP compared with OLL may help explain the differences in the immunopathogenesis of both diseases. Additionally, CD1a + and CD207+ cells appear to be more essential to immunopathogenesis of OLL than to the pathogenesis of OLP. |
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Immunohistochemical evaluation of Langerhans cells in oral lichen planus and oral lichenoid lesionsDendritic cellsImmunohistochemistryLangerhans cellsMultivariate analysesOral lichen planusRegression modelObjective: the aim of this study was to evaluate the density of Langerhans cells in oral lichen planus (OLP) and oral lichenoid lesions (OLL). Design: 14 cases of OLP, 15 cases of OLL and 14 cases of oral inflammatory fibrous hyperplasia (OIFH), were selected for immunohistochemical analysis of CD1a, CD207 and S100 expression. The OIFH group was subdivided according to the presence (OIFHL n = 14) or absence (OIFHNL n = 14) of lichenoid inflammatory infiltrate. Positive cells were counted in intraepithelial and subepithelial areas. Results were analyzed by multivariate comparative analysis, correlation analysis, linear regression models and Student's T-test. Results: A significantly higher amount of CD207+ cells in OLL vs OLP was observed (p = 0.015). The prevailing reticular pattern observed was CD207high for OLP (p = 0.0329). A statistically significant difference in the expression of CD1a and CD207 was observed for intraepithelial vs subepithelial areas (p = 0.024 and p=0.015, for CD1a and CD207, respectively). Significant correlations were also observed between the expression of CD1a + and CD207+ cells in the pathogenesis of OLP and OLL. Conclusion: High levels of CD207+cells in OLP compared with OLL may help explain the differences in the immunopathogenesis of both diseases. Additionally, CD1a + and CD207+ cells appear to be more essential to immunopathogenesis of OLL than to the pathogenesis of OLP.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Oral Medicine Department of Diagnosis and Surgery São Paulo State University (UNESP) School of DentistryDepartment of Orthodontics and Pediatric Dentistry São Paulo State University (UNESP) School of DentistryDepartment of Pathology and Forensic Medicine Ribeirão Preto Medical Scholl (FMRP/USP) University of São PauloOral Pathology Department of Stomatology Public Oral Health and Forensic Dentistry Ribeirão Preto Dental School (FORP/USP) University of São Paulo, Avenida do Café, S/NOral Medicine Department of Diagnosis and Surgery São Paulo State University (UNESP) School of DentistryDepartment of Orthodontics and Pediatric Dentistry São Paulo State University (UNESP) School of DentistryFAPESP: 2016/11419-0FAPESP: 2017/01438-0Universidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Ferrisse, Túlio Morandin [UNESP]de Oliveira, Analú Barros [UNESP]Palaçon, Mariana Paravani [UNESP]da Silveira, Heitor Albergoni [UNESP]Massucato, Elaine Maria Sgavioli [UNESP]de Almeida, Luciana YamamotoLéon, Jorge EsquicheBufalino, Andreia [UNESP]2021-06-25T11:11:05Z2021-06-25T11:11:05Z2021-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.archoralbio.2020.105027Archives of Oral Biology, v. 124.1879-15060003-9969http://hdl.handle.net/11449/20837310.1016/j.archoralbio.2020.1050272-s2.0-85100383969Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArchives of Oral Biologyinfo:eu-repo/semantics/openAccess2021-10-23T19:02:09Zoai:repositorio.unesp.br:11449/208373Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T19:02:09Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Immunohistochemical evaluation of Langerhans cells in oral lichen planus and oral lichenoid lesions |
title |
Immunohistochemical evaluation of Langerhans cells in oral lichen planus and oral lichenoid lesions |
spellingShingle |
Immunohistochemical evaluation of Langerhans cells in oral lichen planus and oral lichenoid lesions Ferrisse, Túlio Morandin [UNESP] Dendritic cells Immunohistochemistry Langerhans cells Multivariate analyses Oral lichen planus Regression model |
title_short |
Immunohistochemical evaluation of Langerhans cells in oral lichen planus and oral lichenoid lesions |
title_full |
Immunohistochemical evaluation of Langerhans cells in oral lichen planus and oral lichenoid lesions |
title_fullStr |
Immunohistochemical evaluation of Langerhans cells in oral lichen planus and oral lichenoid lesions |
title_full_unstemmed |
Immunohistochemical evaluation of Langerhans cells in oral lichen planus and oral lichenoid lesions |
title_sort |
Immunohistochemical evaluation of Langerhans cells in oral lichen planus and oral lichenoid lesions |
author |
Ferrisse, Túlio Morandin [UNESP] |
author_facet |
Ferrisse, Túlio Morandin [UNESP] de Oliveira, Analú Barros [UNESP] Palaçon, Mariana Paravani [UNESP] da Silveira, Heitor Albergoni [UNESP] Massucato, Elaine Maria Sgavioli [UNESP] de Almeida, Luciana Yamamoto Léon, Jorge Esquiche Bufalino, Andreia [UNESP] |
author_role |
author |
author2 |
de Oliveira, Analú Barros [UNESP] Palaçon, Mariana Paravani [UNESP] da Silveira, Heitor Albergoni [UNESP] Massucato, Elaine Maria Sgavioli [UNESP] de Almeida, Luciana Yamamoto Léon, Jorge Esquiche Bufalino, Andreia [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Ferrisse, Túlio Morandin [UNESP] de Oliveira, Analú Barros [UNESP] Palaçon, Mariana Paravani [UNESP] da Silveira, Heitor Albergoni [UNESP] Massucato, Elaine Maria Sgavioli [UNESP] de Almeida, Luciana Yamamoto Léon, Jorge Esquiche Bufalino, Andreia [UNESP] |
dc.subject.por.fl_str_mv |
Dendritic cells Immunohistochemistry Langerhans cells Multivariate analyses Oral lichen planus Regression model |
topic |
Dendritic cells Immunohistochemistry Langerhans cells Multivariate analyses Oral lichen planus Regression model |
description |
Objective: the aim of this study was to evaluate the density of Langerhans cells in oral lichen planus (OLP) and oral lichenoid lesions (OLL). Design: 14 cases of OLP, 15 cases of OLL and 14 cases of oral inflammatory fibrous hyperplasia (OIFH), were selected for immunohistochemical analysis of CD1a, CD207 and S100 expression. The OIFH group was subdivided according to the presence (OIFHL n = 14) or absence (OIFHNL n = 14) of lichenoid inflammatory infiltrate. Positive cells were counted in intraepithelial and subepithelial areas. Results were analyzed by multivariate comparative analysis, correlation analysis, linear regression models and Student's T-test. Results: A significantly higher amount of CD207+ cells in OLL vs OLP was observed (p = 0.015). The prevailing reticular pattern observed was CD207high for OLP (p = 0.0329). A statistically significant difference in the expression of CD1a and CD207 was observed for intraepithelial vs subepithelial areas (p = 0.024 and p=0.015, for CD1a and CD207, respectively). Significant correlations were also observed between the expression of CD1a + and CD207+ cells in the pathogenesis of OLP and OLL. Conclusion: High levels of CD207+cells in OLP compared with OLL may help explain the differences in the immunopathogenesis of both diseases. Additionally, CD1a + and CD207+ cells appear to be more essential to immunopathogenesis of OLL than to the pathogenesis of OLP. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T11:11:05Z 2021-06-25T11:11:05Z 2021-04-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.archoralbio.2020.105027 Archives of Oral Biology, v. 124. 1879-1506 0003-9969 http://hdl.handle.net/11449/208373 10.1016/j.archoralbio.2020.105027 2-s2.0-85100383969 |
url |
http://dx.doi.org/10.1016/j.archoralbio.2020.105027 http://hdl.handle.net/11449/208373 |
identifier_str_mv |
Archives of Oral Biology, v. 124. 1879-1506 0003-9969 10.1016/j.archoralbio.2020.105027 2-s2.0-85100383969 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Archives of Oral Biology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1799965249315536896 |