Serosurvey of anti-treponema pallidum (syphilis), anti-hepatitis C virus and anti-HIV antibodies in homeless persons of São Paulo city, southeastern Brazil
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.bjid.2021.101602 http://hdl.handle.net/11449/222213 |
Resumo: | Homeless persons have been considered as one of the most susceptible populations to sexually transmitted infections. In Brazil, these population experienced an increase of 140% from 2012 to 2020. Accordingly, the present study aimed to assess the seroprevalence of anti-Treponema pallidum, anti-HCV, anti-HIV antibodies, and the risk factors associated with homeless persons in a daytime attendance shelter of São Paulo city during the syphilis epidemic in Brazil. Blood samples of 116 volunteers and epidemiological data were conveniently collected in the shelter from June through August 2018. Detection of syphilis, HCV, and HIV antibodies was performed by chemiluminescent microparticle immunoassay (CMIA). CMIA-reagent samples for anti-T. pallidum antibodies were confirmed by Venereal Disease Research Laboratory (VDRL) non-treponemal test. VDRL non-reagent samples were confirmed by treponemal rapid immunochromatographic test. A rapid immunoblot assay confirmed seropositivity to HIV. Overall, anti-T. pallidum antibodies were observed in 29/116 (25.0%), anti-HCV antibodies in 4/116 (3.4%), and anti-HIV antibodies in 2/116 (1.7%) individuals, both co-infected with anti-T. pallidum antibodies. Associated risk factors for syphilis in homeless persons were being born or previously living in another city (p = 0.043) and becoming homeless due to family conflicts (p = 0.035). Besides homeless vulnerability, worldwide shortage of benzathine penicillin supply and increasing of syphilis testing access through rapid testing in primary health care services may have also impacted disease spreading at the time. The prevalence of syphilis found herein is the highest worldwide to date in this population. |
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Serosurvey of anti-treponema pallidum (syphilis), anti-hepatitis C virus and anti-HIV antibodies in homeless persons of São Paulo city, southeastern BrazilHCVHIVHomelessSyphilisVulnerabilityHomeless persons have been considered as one of the most susceptible populations to sexually transmitted infections. In Brazil, these population experienced an increase of 140% from 2012 to 2020. Accordingly, the present study aimed to assess the seroprevalence of anti-Treponema pallidum, anti-HCV, anti-HIV antibodies, and the risk factors associated with homeless persons in a daytime attendance shelter of São Paulo city during the syphilis epidemic in Brazil. Blood samples of 116 volunteers and epidemiological data were conveniently collected in the shelter from June through August 2018. Detection of syphilis, HCV, and HIV antibodies was performed by chemiluminescent microparticle immunoassay (CMIA). CMIA-reagent samples for anti-T. pallidum antibodies were confirmed by Venereal Disease Research Laboratory (VDRL) non-treponemal test. VDRL non-reagent samples were confirmed by treponemal rapid immunochromatographic test. A rapid immunoblot assay confirmed seropositivity to HIV. Overall, anti-T. pallidum antibodies were observed in 29/116 (25.0%), anti-HCV antibodies in 4/116 (3.4%), and anti-HIV antibodies in 2/116 (1.7%) individuals, both co-infected with anti-T. pallidum antibodies. Associated risk factors for syphilis in homeless persons were being born or previously living in another city (p = 0.043) and becoming homeless due to family conflicts (p = 0.035). Besides homeless vulnerability, worldwide shortage of benzathine penicillin supply and increasing of syphilis testing access through rapid testing in primary health care services may have also impacted disease spreading at the time. The prevalence of syphilis found herein is the highest worldwide to date in this population.Universidade Federal do ParanáInstitute of Biotechnology and Bioengineering, Isfahan University of TechnologyPurdue UniversityFederal University of Paraná Department of Veterinary Medicine College of Veterinary ScienceFederal University of Paraná Clinics Hospital Clinical Analysis Laboratory UnitFederal University of Paraná Department of Cellular and Molecular Biology College of Cellular and Molecular BiologyState University of Ponta Grossa Department of Nursing and Public HealthSão Paulo State University Institute of Biotechnology, BotucatuUniversity of São Paulo Department of Medical MicrobiologyPurdue University Department of Comparative PathobiologyFederal University of Paraná Department of Veterinary Medicine BrazilSão Paulo State University Institute of Biotechnology, BotucatuCollege of Veterinary ScienceClinical Analysis Laboratory UnitCollege of Cellular and Molecular BiologyState University of Ponta GrossaUniversidade Estadual Paulista (UNESP)Universidade de São Paulo (USP)Purdue UniversityBrazilFelipetto, Laís GiulianiTeider-Junior, Pedro Irineuda Silva, Felipe Fortino VerdanCouto, Anahi Chechia doKmetiuk, Louise BachMartins, Camila MarinelliUllmann, Leila Sabrina [UNESP]Timenetsky, JorgeSantos, Andrea Pires dosBiondo, Alexander Welker2022-04-28T19:43:26Z2022-04-28T19:43:26Z2021-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.bjid.2021.101602Brazilian Journal of Infectious Diseases, v. 25, n. 4, 2021.1678-43911413-8670http://hdl.handle.net/11449/22221310.1016/j.bjid.2021.1016022-s2.0-85112531940Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal of Infectious Diseasesinfo:eu-repo/semantics/openAccess2022-04-28T19:43:26Zoai:repositorio.unesp.br:11449/222213Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-28T19:43:26Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Serosurvey of anti-treponema pallidum (syphilis), anti-hepatitis C virus and anti-HIV antibodies in homeless persons of São Paulo city, southeastern Brazil |
title |
Serosurvey of anti-treponema pallidum (syphilis), anti-hepatitis C virus and anti-HIV antibodies in homeless persons of São Paulo city, southeastern Brazil |
spellingShingle |
Serosurvey of anti-treponema pallidum (syphilis), anti-hepatitis C virus and anti-HIV antibodies in homeless persons of São Paulo city, southeastern Brazil Felipetto, Laís Giuliani HCV HIV Homeless Syphilis Vulnerability |
title_short |
Serosurvey of anti-treponema pallidum (syphilis), anti-hepatitis C virus and anti-HIV antibodies in homeless persons of São Paulo city, southeastern Brazil |
title_full |
Serosurvey of anti-treponema pallidum (syphilis), anti-hepatitis C virus and anti-HIV antibodies in homeless persons of São Paulo city, southeastern Brazil |
title_fullStr |
Serosurvey of anti-treponema pallidum (syphilis), anti-hepatitis C virus and anti-HIV antibodies in homeless persons of São Paulo city, southeastern Brazil |
title_full_unstemmed |
Serosurvey of anti-treponema pallidum (syphilis), anti-hepatitis C virus and anti-HIV antibodies in homeless persons of São Paulo city, southeastern Brazil |
title_sort |
Serosurvey of anti-treponema pallidum (syphilis), anti-hepatitis C virus and anti-HIV antibodies in homeless persons of São Paulo city, southeastern Brazil |
author |
Felipetto, Laís Giuliani |
author_facet |
Felipetto, Laís Giuliani Teider-Junior, Pedro Irineu da Silva, Felipe Fortino Verdan Couto, Anahi Chechia do Kmetiuk, Louise Bach Martins, Camila Marinelli Ullmann, Leila Sabrina [UNESP] Timenetsky, Jorge Santos, Andrea Pires dos Biondo, Alexander Welker |
author_role |
author |
author2 |
Teider-Junior, Pedro Irineu da Silva, Felipe Fortino Verdan Couto, Anahi Chechia do Kmetiuk, Louise Bach Martins, Camila Marinelli Ullmann, Leila Sabrina [UNESP] Timenetsky, Jorge Santos, Andrea Pires dos Biondo, Alexander Welker |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
College of Veterinary Science Clinical Analysis Laboratory Unit College of Cellular and Molecular Biology State University of Ponta Grossa Universidade Estadual Paulista (UNESP) Universidade de São Paulo (USP) Purdue University Brazil |
dc.contributor.author.fl_str_mv |
Felipetto, Laís Giuliani Teider-Junior, Pedro Irineu da Silva, Felipe Fortino Verdan Couto, Anahi Chechia do Kmetiuk, Louise Bach Martins, Camila Marinelli Ullmann, Leila Sabrina [UNESP] Timenetsky, Jorge Santos, Andrea Pires dos Biondo, Alexander Welker |
dc.subject.por.fl_str_mv |
HCV HIV Homeless Syphilis Vulnerability |
topic |
HCV HIV Homeless Syphilis Vulnerability |
description |
Homeless persons have been considered as one of the most susceptible populations to sexually transmitted infections. In Brazil, these population experienced an increase of 140% from 2012 to 2020. Accordingly, the present study aimed to assess the seroprevalence of anti-Treponema pallidum, anti-HCV, anti-HIV antibodies, and the risk factors associated with homeless persons in a daytime attendance shelter of São Paulo city during the syphilis epidemic in Brazil. Blood samples of 116 volunteers and epidemiological data were conveniently collected in the shelter from June through August 2018. Detection of syphilis, HCV, and HIV antibodies was performed by chemiluminescent microparticle immunoassay (CMIA). CMIA-reagent samples for anti-T. pallidum antibodies were confirmed by Venereal Disease Research Laboratory (VDRL) non-treponemal test. VDRL non-reagent samples were confirmed by treponemal rapid immunochromatographic test. A rapid immunoblot assay confirmed seropositivity to HIV. Overall, anti-T. pallidum antibodies were observed in 29/116 (25.0%), anti-HCV antibodies in 4/116 (3.4%), and anti-HIV antibodies in 2/116 (1.7%) individuals, both co-infected with anti-T. pallidum antibodies. Associated risk factors for syphilis in homeless persons were being born or previously living in another city (p = 0.043) and becoming homeless due to family conflicts (p = 0.035). Besides homeless vulnerability, worldwide shortage of benzathine penicillin supply and increasing of syphilis testing access through rapid testing in primary health care services may have also impacted disease spreading at the time. The prevalence of syphilis found herein is the highest worldwide to date in this population. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-07-01 2022-04-28T19:43:26Z 2022-04-28T19:43:26Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.bjid.2021.101602 Brazilian Journal of Infectious Diseases, v. 25, n. 4, 2021. 1678-4391 1413-8670 http://hdl.handle.net/11449/222213 10.1016/j.bjid.2021.101602 2-s2.0-85112531940 |
url |
http://dx.doi.org/10.1016/j.bjid.2021.101602 http://hdl.handle.net/11449/222213 |
identifier_str_mv |
Brazilian Journal of Infectious Diseases, v. 25, n. 4, 2021. 1678-4391 1413-8670 10.1016/j.bjid.2021.101602 2-s2.0-85112531940 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal of Infectious Diseases |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1797789580931366912 |