Burden of Influenza and Respiratory Syncytial Viruses in Suspected COVID-19 Patients: A Cross-Sectional and Meta-Analysis Study
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3390/v15030665 http://hdl.handle.net/11449/248595 |
Resumo: | Non-SARS-CoV-2 respiratory viral infections, such as influenza virus (FluV) and human respiratory syncytial virus (RSV), have contributed considerably to the burden of infectious diseases in the non-COVID-19 era. While the rates of co-infection in SARS-CoV-2-positive group (SCPG) patients have been determined, the burden of other respiratory viruses in the SARS-CoV-2-negative group (SCNG) remains unclear. Here, we conducted a cross-sectional study (São José do Rio Preto county, Brazil), and we collected our data using a meta-analysis to evaluate the pooled prevalence of FluV and RSV among SCNG patients. Out of the 901 patients suspected of COVID-19, our molecular results showed positivity of FluV and RSV in the SCNG was 2% (15/733) and 0.27% (2/733), respectively. Co-infection with SARS-CoV-2 and FluV, or RSV, was identified in 1.7% of the patients (3/168). Following our meta-analysis, 28 studies were selected (n = 114,318 suspected COVID-19 patients), with a pooled prevalence of 4% (95% CI: 3–6) for FluV and 2% (95% CI: 1–3) for RSV among SCNG patients were observed. Interestingly, FluV positivity in the SCNG was four times higher (OR = 4, 95% CI: 3.6–5.4, p < 0.01) than in the SCPG. Similarly, RSV positivity was significantly associated with SCNG patients (OR = 2.9, 95% CI: 2–4, p < 0.01). For subgroup analysis, cold-like symptoms, including fever, cough, sore throat, headache, myalgia, diarrhea, and nausea/vomiting, were positively associated (p < 0.05) with the SCPG. In conclusion, these results show that the pooled prevalence of FluV and RSV were significantly higher in the SCNG than in the SCPG during the early phase of the COVID-19 pandemic. |
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Burden of Influenza and Respiratory Syncytial Viruses in Suspected COVID-19 Patients: A Cross-Sectional and Meta-Analysis Studya systematic reviewinfluenza virusnon-COVID-19respiratory syncytial virusSARS-CoV-2-negativeNon-SARS-CoV-2 respiratory viral infections, such as influenza virus (FluV) and human respiratory syncytial virus (RSV), have contributed considerably to the burden of infectious diseases in the non-COVID-19 era. While the rates of co-infection in SARS-CoV-2-positive group (SCPG) patients have been determined, the burden of other respiratory viruses in the SARS-CoV-2-negative group (SCNG) remains unclear. Here, we conducted a cross-sectional study (São José do Rio Preto county, Brazil), and we collected our data using a meta-analysis to evaluate the pooled prevalence of FluV and RSV among SCNG patients. Out of the 901 patients suspected of COVID-19, our molecular results showed positivity of FluV and RSV in the SCNG was 2% (15/733) and 0.27% (2/733), respectively. Co-infection with SARS-CoV-2 and FluV, or RSV, was identified in 1.7% of the patients (3/168). Following our meta-analysis, 28 studies were selected (n = 114,318 suspected COVID-19 patients), with a pooled prevalence of 4% (95% CI: 3–6) for FluV and 2% (95% CI: 1–3) for RSV among SCNG patients were observed. Interestingly, FluV positivity in the SCNG was four times higher (OR = 4, 95% CI: 3.6–5.4, p < 0.01) than in the SCPG. Similarly, RSV positivity was significantly associated with SCNG patients (OR = 2.9, 95% CI: 2–4, p < 0.01). For subgroup analysis, cold-like symptoms, including fever, cough, sore throat, headache, myalgia, diarrhea, and nausea/vomiting, were positively associated (p < 0.05) with the SCPG. In conclusion, these results show that the pooled prevalence of FluV and RSV were significantly higher in the SCNG than in the SCPG during the early phase of the COVID-19 pandemic.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Laboratório de Estudos Genômicos Departamento de Biologia Instituto de Biociências Letras e Ciências Exatas Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), SPLaboratório de Pesquisas em Virologia (LPV) Departamento de Doenças Dermatológicas Infecciosas e Parasitárias Faculdade de Medicina de São José do Rio Preto (FAMERP), SPLaboratório de Virologia Molecular Departamento de Ciências Biológicas Faculdade de Ciências Farmacêuticas (UNESP), SPDepartamento de Análises Clínicas Faculdade de Ciências Farmacêuticas (UNESP), SPInstituto de Biotecnologia Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), SPLaboratório de Microbiologia Molecular Instituto de Ciências da Saúde Universidade Feevale, RSLaboratório de Estudos Genômicos Departamento de Biologia Instituto de Biociências Letras e Ciências Exatas Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), SPLaboratório de Virologia Molecular Departamento de Ciências Biológicas Faculdade de Ciências Farmacêuticas (UNESP), SPDepartamento de Análises Clínicas Faculdade de Ciências Farmacêuticas (UNESP), SPInstituto de Biotecnologia Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), SPFAPESP: 2019/18581-6FAPESP: 2020/07419-0FAPESP: 2021/00603-3Universidade Estadual Paulista (UNESP)Faculdade de Medicina de São José do Rio Preto (FAMERP)Universidade FeevaleCosta, Vivaldo Gomes da [UNESP]Gomes, Ana Júlia Chaves [UNESP]Bittar, Cíntia [UNESP]Geraldini, Dayla Bott [UNESP]Previdelli da Conceição, Pâmela Jóyce [UNESP]Cabral, Ágata Silva [UNESP]Carvalho, Tamara [UNESP]Biselli, Joice Matos [UNESP]Provazzi, Paola Jocelan Scarin [UNESP]Campos, Guilherme Rodrigues FernandesSanches, Paulo Ricardo da Silva [UNESP]Costa, Paulo Inácio [UNESP]Nogueira, Maurício LacerdaAraujo, João Pessoa [UNESP]Spilki, Fernando RosadoCalmon, Marília Freitas [UNESP]Rahal, Paula [UNESP]2023-07-29T13:48:23Z2023-07-29T13:48:23Z2023-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/v15030665Viruses, v. 15, n. 3, 2023.1999-4915http://hdl.handle.net/11449/24859510.3390/v150306652-s2.0-85151189656Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengVirusesinfo:eu-repo/semantics/openAccess2023-07-29T13:48:23Zoai:repositorio.unesp.br:11449/248595Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-07-29T13:48:23Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Burden of Influenza and Respiratory Syncytial Viruses in Suspected COVID-19 Patients: A Cross-Sectional and Meta-Analysis Study |
title |
Burden of Influenza and Respiratory Syncytial Viruses in Suspected COVID-19 Patients: A Cross-Sectional and Meta-Analysis Study |
spellingShingle |
Burden of Influenza and Respiratory Syncytial Viruses in Suspected COVID-19 Patients: A Cross-Sectional and Meta-Analysis Study Costa, Vivaldo Gomes da [UNESP] a systematic review influenza virus non-COVID-19 respiratory syncytial virus SARS-CoV-2-negative |
title_short |
Burden of Influenza and Respiratory Syncytial Viruses in Suspected COVID-19 Patients: A Cross-Sectional and Meta-Analysis Study |
title_full |
Burden of Influenza and Respiratory Syncytial Viruses in Suspected COVID-19 Patients: A Cross-Sectional and Meta-Analysis Study |
title_fullStr |
Burden of Influenza and Respiratory Syncytial Viruses in Suspected COVID-19 Patients: A Cross-Sectional and Meta-Analysis Study |
title_full_unstemmed |
Burden of Influenza and Respiratory Syncytial Viruses in Suspected COVID-19 Patients: A Cross-Sectional and Meta-Analysis Study |
title_sort |
Burden of Influenza and Respiratory Syncytial Viruses in Suspected COVID-19 Patients: A Cross-Sectional and Meta-Analysis Study |
author |
Costa, Vivaldo Gomes da [UNESP] |
author_facet |
Costa, Vivaldo Gomes da [UNESP] Gomes, Ana Júlia Chaves [UNESP] Bittar, Cíntia [UNESP] Geraldini, Dayla Bott [UNESP] Previdelli da Conceição, Pâmela Jóyce [UNESP] Cabral, Ágata Silva [UNESP] Carvalho, Tamara [UNESP] Biselli, Joice Matos [UNESP] Provazzi, Paola Jocelan Scarin [UNESP] Campos, Guilherme Rodrigues Fernandes Sanches, Paulo Ricardo da Silva [UNESP] Costa, Paulo Inácio [UNESP] Nogueira, Maurício Lacerda Araujo, João Pessoa [UNESP] Spilki, Fernando Rosado Calmon, Marília Freitas [UNESP] Rahal, Paula [UNESP] |
author_role |
author |
author2 |
Gomes, Ana Júlia Chaves [UNESP] Bittar, Cíntia [UNESP] Geraldini, Dayla Bott [UNESP] Previdelli da Conceição, Pâmela Jóyce [UNESP] Cabral, Ágata Silva [UNESP] Carvalho, Tamara [UNESP] Biselli, Joice Matos [UNESP] Provazzi, Paola Jocelan Scarin [UNESP] Campos, Guilherme Rodrigues Fernandes Sanches, Paulo Ricardo da Silva [UNESP] Costa, Paulo Inácio [UNESP] Nogueira, Maurício Lacerda Araujo, João Pessoa [UNESP] Spilki, Fernando Rosado Calmon, Marília Freitas [UNESP] Rahal, Paula [UNESP] |
author2_role |
author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Faculdade de Medicina de São José do Rio Preto (FAMERP) Universidade Feevale |
dc.contributor.author.fl_str_mv |
Costa, Vivaldo Gomes da [UNESP] Gomes, Ana Júlia Chaves [UNESP] Bittar, Cíntia [UNESP] Geraldini, Dayla Bott [UNESP] Previdelli da Conceição, Pâmela Jóyce [UNESP] Cabral, Ágata Silva [UNESP] Carvalho, Tamara [UNESP] Biselli, Joice Matos [UNESP] Provazzi, Paola Jocelan Scarin [UNESP] Campos, Guilherme Rodrigues Fernandes Sanches, Paulo Ricardo da Silva [UNESP] Costa, Paulo Inácio [UNESP] Nogueira, Maurício Lacerda Araujo, João Pessoa [UNESP] Spilki, Fernando Rosado Calmon, Marília Freitas [UNESP] Rahal, Paula [UNESP] |
dc.subject.por.fl_str_mv |
a systematic review influenza virus non-COVID-19 respiratory syncytial virus SARS-CoV-2-negative |
topic |
a systematic review influenza virus non-COVID-19 respiratory syncytial virus SARS-CoV-2-negative |
description |
Non-SARS-CoV-2 respiratory viral infections, such as influenza virus (FluV) and human respiratory syncytial virus (RSV), have contributed considerably to the burden of infectious diseases in the non-COVID-19 era. While the rates of co-infection in SARS-CoV-2-positive group (SCPG) patients have been determined, the burden of other respiratory viruses in the SARS-CoV-2-negative group (SCNG) remains unclear. Here, we conducted a cross-sectional study (São José do Rio Preto county, Brazil), and we collected our data using a meta-analysis to evaluate the pooled prevalence of FluV and RSV among SCNG patients. Out of the 901 patients suspected of COVID-19, our molecular results showed positivity of FluV and RSV in the SCNG was 2% (15/733) and 0.27% (2/733), respectively. Co-infection with SARS-CoV-2 and FluV, or RSV, was identified in 1.7% of the patients (3/168). Following our meta-analysis, 28 studies were selected (n = 114,318 suspected COVID-19 patients), with a pooled prevalence of 4% (95% CI: 3–6) for FluV and 2% (95% CI: 1–3) for RSV among SCNG patients were observed. Interestingly, FluV positivity in the SCNG was four times higher (OR = 4, 95% CI: 3.6–5.4, p < 0.01) than in the SCPG. Similarly, RSV positivity was significantly associated with SCNG patients (OR = 2.9, 95% CI: 2–4, p < 0.01). For subgroup analysis, cold-like symptoms, including fever, cough, sore throat, headache, myalgia, diarrhea, and nausea/vomiting, were positively associated (p < 0.05) with the SCPG. In conclusion, these results show that the pooled prevalence of FluV and RSV were significantly higher in the SCNG than in the SCPG during the early phase of the COVID-19 pandemic. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07-29T13:48:23Z 2023-07-29T13:48:23Z 2023-03-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3390/v15030665 Viruses, v. 15, n. 3, 2023. 1999-4915 http://hdl.handle.net/11449/248595 10.3390/v15030665 2-s2.0-85151189656 |
url |
http://dx.doi.org/10.3390/v15030665 http://hdl.handle.net/11449/248595 |
identifier_str_mv |
Viruses, v. 15, n. 3, 2023. 1999-4915 10.3390/v15030665 2-s2.0-85151189656 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Viruses |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1797789827402301440 |