Effects of tissucol™ and epsilon aminocaproic acid in the healing process following dental extraction in dehydrated rats
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S1806-83242006000100007 http://hdl.handle.net/11449/68902 |
Resumo: | A histological study was conducted of the alveolar bone healing process following tooth extraction of dehydrated rats after the implantation of fibrin adhesive (TISSUCOL™) associated to previous irrigation of the wound with a 5% epsilon aminocaproic acid solution (EACA). Seventy two rats were used, divided into three groups receiving different treatments after the surgical procedure. In group I, the gingival mucosa was sutured after extraction of the right upper incisor. In groups II and III, chronic dehydration was produced by water deprivation for 9 days (3 days in the preoperative period and 6 days in the postoperative period). In the animals of Group II, after tooth extraction, the gingival mucosa was sutured in the same way as performed in group I. In group III, after extraction, the dental socket was irrigated with 5% EACA, followed by implantation of the fibrin adhesive (TISSUCOL™). The mucosa was sutured in the same way as performed in the other groups. At 3, 7, 15 and 21 postoperative days, the animals were sacrificed in number of 6 for each group. Specimens containing the dental socket were removed and fixed in 10% formalin and decalcified in an equal part formic acid and sodium citrate solution. After routine processing, the specimens were embedded in paraffin for microtomy. We obtained 6 μm semi-serial slices that were stained with hematoxylin and eosin for histological evaluation. The results showed that the water deprivation in the pre- and postoperative periods caused a delay in the alveolar bone healing process. The use of the fibrin adhesive (TISSUCOL™) produced an improvement in the fibrinolytic picture caused by dehydration. |
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Effects of tissucol™ and epsilon aminocaproic acid in the healing process following dental extraction in dehydrated ratsDehydrationFibrin tissue adhesiveTooth socketA histological study was conducted of the alveolar bone healing process following tooth extraction of dehydrated rats after the implantation of fibrin adhesive (TISSUCOL™) associated to previous irrigation of the wound with a 5% epsilon aminocaproic acid solution (EACA). Seventy two rats were used, divided into three groups receiving different treatments after the surgical procedure. In group I, the gingival mucosa was sutured after extraction of the right upper incisor. In groups II and III, chronic dehydration was produced by water deprivation for 9 days (3 days in the preoperative period and 6 days in the postoperative period). In the animals of Group II, after tooth extraction, the gingival mucosa was sutured in the same way as performed in group I. In group III, after extraction, the dental socket was irrigated with 5% EACA, followed by implantation of the fibrin adhesive (TISSUCOL™). The mucosa was sutured in the same way as performed in the other groups. At 3, 7, 15 and 21 postoperative days, the animals were sacrificed in number of 6 for each group. Specimens containing the dental socket were removed and fixed in 10% formalin and decalcified in an equal part formic acid and sodium citrate solution. After routine processing, the specimens were embedded in paraffin for microtomy. We obtained 6 μm semi-serial slices that were stained with hematoxylin and eosin for histological evaluation. The results showed that the water deprivation in the pre- and postoperative periods caused a delay in the alveolar bone healing process. The use of the fibrin adhesive (TISSUCOL™) produced an improvement in the fibrinolytic picture caused by dehydration.Surgery Department State University of São Paulo, São PauloDental Materials Department State University of São Paulo, São PauloSurgery Department School of Dentistry of Araçatuba State University of São Paulo, São PauloUniversidade Estadual Paulista (Unesp)Okamoto, TetuoRezende, Maria Cristina Rosifini Alves [UNESP]Cláudio, Carolina ChiantelliRodrigues, Thaís da SilveiraOkamoto, Roberta [UNESP]2014-05-27T11:21:52Z2014-05-27T11:21:52Z2006-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article33-39application/pdfhttp://dx.doi.org/10.1590/S1806-83242006000100007Brazilian Oral Research, v. 20, n. 1, p. 33-39, 2006.1806-83241807-3107http://hdl.handle.net/11449/6890210.1590/S1806-83242006000100007S1806-832420060001000072-s2.0-337447921052-s2.0-33744792105.pdf016995536396809715669282198280560000-0002-1327-9667Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Oral Research1.223info:eu-repo/semantics/openAccess2023-11-28T06:14:36Zoai:repositorio.unesp.br:11449/68902Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-28T06:14:36Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Effects of tissucol™ and epsilon aminocaproic acid in the healing process following dental extraction in dehydrated rats |
title |
Effects of tissucol™ and epsilon aminocaproic acid in the healing process following dental extraction in dehydrated rats |
spellingShingle |
Effects of tissucol™ and epsilon aminocaproic acid in the healing process following dental extraction in dehydrated rats Okamoto, Tetuo Dehydration Fibrin tissue adhesive Tooth socket |
title_short |
Effects of tissucol™ and epsilon aminocaproic acid in the healing process following dental extraction in dehydrated rats |
title_full |
Effects of tissucol™ and epsilon aminocaproic acid in the healing process following dental extraction in dehydrated rats |
title_fullStr |
Effects of tissucol™ and epsilon aminocaproic acid in the healing process following dental extraction in dehydrated rats |
title_full_unstemmed |
Effects of tissucol™ and epsilon aminocaproic acid in the healing process following dental extraction in dehydrated rats |
title_sort |
Effects of tissucol™ and epsilon aminocaproic acid in the healing process following dental extraction in dehydrated rats |
author |
Okamoto, Tetuo |
author_facet |
Okamoto, Tetuo Rezende, Maria Cristina Rosifini Alves [UNESP] Cláudio, Carolina Chiantelli Rodrigues, Thaís da Silveira Okamoto, Roberta [UNESP] |
author_role |
author |
author2 |
Rezende, Maria Cristina Rosifini Alves [UNESP] Cláudio, Carolina Chiantelli Rodrigues, Thaís da Silveira Okamoto, Roberta [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Okamoto, Tetuo Rezende, Maria Cristina Rosifini Alves [UNESP] Cláudio, Carolina Chiantelli Rodrigues, Thaís da Silveira Okamoto, Roberta [UNESP] |
dc.subject.por.fl_str_mv |
Dehydration Fibrin tissue adhesive Tooth socket |
topic |
Dehydration Fibrin tissue adhesive Tooth socket |
description |
A histological study was conducted of the alveolar bone healing process following tooth extraction of dehydrated rats after the implantation of fibrin adhesive (TISSUCOL™) associated to previous irrigation of the wound with a 5% epsilon aminocaproic acid solution (EACA). Seventy two rats were used, divided into three groups receiving different treatments after the surgical procedure. In group I, the gingival mucosa was sutured after extraction of the right upper incisor. In groups II and III, chronic dehydration was produced by water deprivation for 9 days (3 days in the preoperative period and 6 days in the postoperative period). In the animals of Group II, after tooth extraction, the gingival mucosa was sutured in the same way as performed in group I. In group III, after extraction, the dental socket was irrigated with 5% EACA, followed by implantation of the fibrin adhesive (TISSUCOL™). The mucosa was sutured in the same way as performed in the other groups. At 3, 7, 15 and 21 postoperative days, the animals were sacrificed in number of 6 for each group. Specimens containing the dental socket were removed and fixed in 10% formalin and decalcified in an equal part formic acid and sodium citrate solution. After routine processing, the specimens were embedded in paraffin for microtomy. We obtained 6 μm semi-serial slices that were stained with hematoxylin and eosin for histological evaluation. The results showed that the water deprivation in the pre- and postoperative periods caused a delay in the alveolar bone healing process. The use of the fibrin adhesive (TISSUCOL™) produced an improvement in the fibrinolytic picture caused by dehydration. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-06-01 2014-05-27T11:21:52Z 2014-05-27T11:21:52Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1806-83242006000100007 Brazilian Oral Research, v. 20, n. 1, p. 33-39, 2006. 1806-8324 1807-3107 http://hdl.handle.net/11449/68902 10.1590/S1806-83242006000100007 S1806-83242006000100007 2-s2.0-33744792105 2-s2.0-33744792105.pdf 0169955363968097 1566928219828056 0000-0002-1327-9667 |
url |
http://dx.doi.org/10.1590/S1806-83242006000100007 http://hdl.handle.net/11449/68902 |
identifier_str_mv |
Brazilian Oral Research, v. 20, n. 1, p. 33-39, 2006. 1806-8324 1807-3107 10.1590/S1806-83242006000100007 S1806-83242006000100007 2-s2.0-33744792105 2-s2.0-33744792105.pdf 0169955363968097 1566928219828056 0000-0002-1327-9667 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Oral Research 1.223 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
33-39 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965098784063488 |