Hormonal and metabolic study of a case of adiposis dolorosa (Dercum's disease).
Autor(a) principal: | |
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Data de Publicação: | 1992 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/223947 |
Resumo: | A case of a 43-year-old nonobese woman with adiposis dolorosa (Dercum's disease) is reported. Muscle glucose uptake and oxidation before and after ingestion of 75 g of glucose were similar to control group values, although a greater insulin release (16,578 vs 6,242 +/- 1,136 microU/3 h) occurred simultaneously. In vitro studies of abdominal normal and painful subcutaneous adipose tissue of the patient revealed lower responsiveness to norepinephrine and lack of response to the antilipolytic effect of insulin in the painful adipose tissue (0.98 vs 1.43 microM FFA/10(6) cells at 5.0 microM of norepinephrine). The disease was not correlated with the HLA system and there were no alterations in hormonal secretion at the pituitary, adrenal, gonadal, and thyroid levels. These findings indicate the presence of peripheral insulin resistance in this patient with adiposis dolorosa. |
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Repositório Institucional da UNESP |
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2946 |
spelling |
Hormonal and metabolic study of a case of adiposis dolorosa (Dercum's disease).A case of a 43-year-old nonobese woman with adiposis dolorosa (Dercum's disease) is reported. Muscle glucose uptake and oxidation before and after ingestion of 75 g of glucose were similar to control group values, although a greater insulin release (16,578 vs 6,242 +/- 1,136 microU/3 h) occurred simultaneously. In vitro studies of abdominal normal and painful subcutaneous adipose tissue of the patient revealed lower responsiveness to norepinephrine and lack of response to the antilipolytic effect of insulin in the painful adipose tissue (0.98 vs 1.43 microM FFA/10(6) cells at 5.0 microM of norepinephrine). The disease was not correlated with the HLA system and there were no alterations in hormonal secretion at the pituitary, adrenal, gonadal, and thyroid levels. These findings indicate the presence of peripheral insulin resistance in this patient with adiposis dolorosa.Departamento de Clínica Médica Faculdade de Medicina de Botucatu Universidade Estadual Paulista SPDepartamento de Clínica Médica Faculdade de Medicina de Botucatu Universidade Estadual Paulista SPUniversidade Estadual Paulista (UNESP)Pimenta, W. P. [UNESP]Paula, F. J. [UNESP]Dick-de-Paula, I. [UNESP]Piccinato, C. E. [UNESP]Monteiro, C. M. [UNESP]Brandão-Neto, J. [UNESP]Kettelhut, I. C. [UNESP]Foss, M. C. [UNESP]2022-04-28T19:53:54Z2022-04-28T19:53:54Z1992-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article889-893Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.], v. 25, n. 9, p. 889-893, 1992.0100-879Xhttp://hdl.handle.net/11449/2239472-s2.0-0026959957Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.]info:eu-repo/semantics/openAccess2022-04-28T19:53:54Zoai:repositorio.unesp.br:11449/223947Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-28T19:53:54Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Hormonal and metabolic study of a case of adiposis dolorosa (Dercum's disease). |
title |
Hormonal and metabolic study of a case of adiposis dolorosa (Dercum's disease). |
spellingShingle |
Hormonal and metabolic study of a case of adiposis dolorosa (Dercum's disease). Pimenta, W. P. [UNESP] |
title_short |
Hormonal and metabolic study of a case of adiposis dolorosa (Dercum's disease). |
title_full |
Hormonal and metabolic study of a case of adiposis dolorosa (Dercum's disease). |
title_fullStr |
Hormonal and metabolic study of a case of adiposis dolorosa (Dercum's disease). |
title_full_unstemmed |
Hormonal and metabolic study of a case of adiposis dolorosa (Dercum's disease). |
title_sort |
Hormonal and metabolic study of a case of adiposis dolorosa (Dercum's disease). |
author |
Pimenta, W. P. [UNESP] |
author_facet |
Pimenta, W. P. [UNESP] Paula, F. J. [UNESP] Dick-de-Paula, I. [UNESP] Piccinato, C. E. [UNESP] Monteiro, C. M. [UNESP] Brandão-Neto, J. [UNESP] Kettelhut, I. C. [UNESP] Foss, M. C. [UNESP] |
author_role |
author |
author2 |
Paula, F. J. [UNESP] Dick-de-Paula, I. [UNESP] Piccinato, C. E. [UNESP] Monteiro, C. M. [UNESP] Brandão-Neto, J. [UNESP] Kettelhut, I. C. [UNESP] Foss, M. C. [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Pimenta, W. P. [UNESP] Paula, F. J. [UNESP] Dick-de-Paula, I. [UNESP] Piccinato, C. E. [UNESP] Monteiro, C. M. [UNESP] Brandão-Neto, J. [UNESP] Kettelhut, I. C. [UNESP] Foss, M. C. [UNESP] |
description |
A case of a 43-year-old nonobese woman with adiposis dolorosa (Dercum's disease) is reported. Muscle glucose uptake and oxidation before and after ingestion of 75 g of glucose were similar to control group values, although a greater insulin release (16,578 vs 6,242 +/- 1,136 microU/3 h) occurred simultaneously. In vitro studies of abdominal normal and painful subcutaneous adipose tissue of the patient revealed lower responsiveness to norepinephrine and lack of response to the antilipolytic effect of insulin in the painful adipose tissue (0.98 vs 1.43 microM FFA/10(6) cells at 5.0 microM of norepinephrine). The disease was not correlated with the HLA system and there were no alterations in hormonal secretion at the pituitary, adrenal, gonadal, and thyroid levels. These findings indicate the presence of peripheral insulin resistance in this patient with adiposis dolorosa. |
publishDate |
1992 |
dc.date.none.fl_str_mv |
1992-01-01 2022-04-28T19:53:54Z 2022-04-28T19:53:54Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.], v. 25, n. 9, p. 889-893, 1992. 0100-879X http://hdl.handle.net/11449/223947 2-s2.0-0026959957 |
identifier_str_mv |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.], v. 25, n. 9, p. 889-893, 1992. 0100-879X 2-s2.0-0026959957 |
url |
http://hdl.handle.net/11449/223947 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
889-893 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965760299204608 |