The relationship between training status, blood pressure and uric acid in adults and elderly

• Autor(a) principal: Trapé, Atila Alexandre
• Data de Publicação: 2013
• Outros Autores: Jacomini, AndréMourão, Muniz, Jaqueline Jóice, Sertorio, Jonas Tadeu Cau, Tanus-Santos, José Eduardo, Amaral, Sandra Lia do [UNESP], Zago, Anderson Saranz [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1186/1471-2261-13-44; http://hdl.handle.net/11449/75696
• topic: Blood pressure; Elderly; Nitric oxide; Oxidative stress; Training status; Uric acid; cholesterol; high density lipoprotein cholesterol; low density lipoprotein cholesterol; nitrite; oxygen; thiobarbituric acid reactive substance; triacylglycerol; uric acid; adult; aged; blood sampling; body mass; cholesterol blood level; clinical evaluation; correlation analysis; diastolic blood pressure; exercise; female; fitness; human; hypertension; major clinical study; male; oxidative stress; oxygen consumption; priority journal; systolic blood pressure; triacylglycerol blood level; uric acid blood level

Background: Hypertension can be generated by a great number of mechanisms including elevated uric acid (UA) that contribute to the anion superoxide production. However, physical exercise is recommended to prevent and/or control high blood pressure (BP). The purpose of this study was to investigate the relationship between BP and UA and whether this relationship may be mediated by the functional fitness index.Methods: All participants (n = 123) performed the following tests: indirect maximal oxygen uptake (VO2max), AAHPERD Functional Fitness Battery Test to determine the general fitness functional index (GFFI), systolic and diastolic blood pressure (SBP and DBP), body mass index (BMI) and blood sample collection to evaluate the total-cholesterol (CHOL), LDL-cholesterol (LDL-c), HDL-cholesterol (HDL-c), triglycerides (TG), uric acid (UA), nitrite (NO2) and thiobarbituric acid reactive substances (T-BARS). After the physical, hemodynamic and metabolic evaluations, all participants were allocated into three groups according to their GFFI: G1 (regular), G2 (good) and G3 (very good).Results: Baseline blood pressure was higher in G1 when compared to G3 (+12% and +11%, for SBP and DBP, respectively, p<0.05) and the subjects who had higher values of BP also presented higher values of UA. Although UA was not different among GFFI groups, it presented a significant correlation with GFFI and VO2max. Also, nitrite concentration was elevated in G3 compared to G1 (140±29 μM vs 111± 29 μM, for G3 and G1, respectively, p<0.0001). As far as the lipid profile, participants in G3 presented better values of CHOL and TG when compared to those in G1.Conclusions: Taking together the findings that subjects with higher BP had elevated values of UA and lower values of nitrite, it can be suggested that the relationship between blood pressure and the oxidative stress produced by acid uric may be mediated by training status. © 2013 Trapé et al.; licensee BioMed Central Ltd.