Nitric oxide and L-type calcium channel influences the changes in arterial blood pressure and heart rate induced by central angiotesin II
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1186/1744-9081-4-22 http://hdl.handle.net/11449/16327 |
Resumo: | We study the voltage dependent calcium channels and nitric oxide involvement in angiotensin II-induced pressor effect. The antipressor action of L-Type calcium channel antagonist, nifedipine, has been studied when it was injected into the third ventricle prior to angiotensin II. The influence of nitric oxide on nifedipine antipressor action has also been studied by utilizing N(W)-nitro-L-arginine methyl ester (LNAME) (40 mu g/0.2 mu l) a nitric oxide synthase inhibitor and L-arginine ( 20 mu g/0.2 mu l), a nitric oxide donor agent. Adult male Holtzman rats weighting 200-250 g, with cannulae implanted into the third ventricle were injected with angiotensin II. Angiotensin II produced an elevation in mean arterial pressure and a decreased in heart rate. Such effects were potentiated by the prior injection of LNAME. L-arginine and nifedipine blocked the effects of angiotensin II. These data showed the involvement of L-Type calcium channel and a free radical gas nitric oxide in the central control of angiotensin II-induced pressor effect. This suggested that L-Type calcium channel of the circunventricular structures of central nervous system participated in both short and long term neuronal actions of ANG II with the influence of nitrergic system. |
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Repositório Institucional da UNESP |
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Nitric oxide and L-type calcium channel influences the changes in arterial blood pressure and heart rate induced by central angiotesin IIWe study the voltage dependent calcium channels and nitric oxide involvement in angiotensin II-induced pressor effect. The antipressor action of L-Type calcium channel antagonist, nifedipine, has been studied when it was injected into the third ventricle prior to angiotensin II. The influence of nitric oxide on nifedipine antipressor action has also been studied by utilizing N(W)-nitro-L-arginine methyl ester (LNAME) (40 mu g/0.2 mu l) a nitric oxide synthase inhibitor and L-arginine ( 20 mu g/0.2 mu l), a nitric oxide donor agent. Adult male Holtzman rats weighting 200-250 g, with cannulae implanted into the third ventricle were injected with angiotensin II. Angiotensin II produced an elevation in mean arterial pressure and a decreased in heart rate. Such effects were potentiated by the prior injection of LNAME. L-arginine and nifedipine blocked the effects of angiotensin II. These data showed the involvement of L-Type calcium channel and a free radical gas nitric oxide in the central control of angiotensin II-induced pressor effect. This suggested that L-Type calcium channel of the circunventricular structures of central nervous system participated in both short and long term neuronal actions of ANG II with the influence of nitrergic system.Univ Taubate, Basic Inst Biosci, Taubate, BrazilAraraquara Univ Ctr, Dept Exact & Nat Sci, Araraquara, BrazilUniv Estadual Paulista, Dept Physiol & Pathol, Sch Dent, Araraquara, BrazilClin Hosp State São Paulo, Dept Anesthesiol, São Paulo, BrazilUniv Fed Sao Carlos, Dept Physiol, BR-13560 Sao Carlos, SP, BrazilUniv Estadual Paulista, Dept Physiol & Pathol, Sch Dent, Araraquara, BrazilBiomed Central Ltd.Univ TaubateAraraquara Univ CtrUniversidade Estadual Paulista (Unesp)Clin Hosp State São PauloUniversidade Federal de São Carlos (UFSCar)Saad, Wilson A. [UNESP]Guarda, Ismael F. M. S.Camargo, Luiz A. A. [UNESP]Santos, Talmir A. F. B.2014-05-20T13:46:12Z2014-05-20T13:46:12Z2008-05-24info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article6application/pdfhttp://dx.doi.org/10.1186/1744-9081-4-22Behavioral and Brain Functions. London: Biomed Central Ltd., v. 4, p. 6, 2008.1744-9081http://hdl.handle.net/11449/1632710.1186/1744-9081-4-22WOS:000256421300001WOS000256421300001.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBehavioral and Brain Functions2.4490,986info:eu-repo/semantics/openAccess2023-10-05T06:09:03Zoai:repositorio.unesp.br:11449/16327Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-10-05T06:09:03Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Nitric oxide and L-type calcium channel influences the changes in arterial blood pressure and heart rate induced by central angiotesin II |
title |
Nitric oxide and L-type calcium channel influences the changes in arterial blood pressure and heart rate induced by central angiotesin II |
spellingShingle |
Nitric oxide and L-type calcium channel influences the changes in arterial blood pressure and heart rate induced by central angiotesin II Saad, Wilson A. [UNESP] |
title_short |
Nitric oxide and L-type calcium channel influences the changes in arterial blood pressure and heart rate induced by central angiotesin II |
title_full |
Nitric oxide and L-type calcium channel influences the changes in arterial blood pressure and heart rate induced by central angiotesin II |
title_fullStr |
Nitric oxide and L-type calcium channel influences the changes in arterial blood pressure and heart rate induced by central angiotesin II |
title_full_unstemmed |
Nitric oxide and L-type calcium channel influences the changes in arterial blood pressure and heart rate induced by central angiotesin II |
title_sort |
Nitric oxide and L-type calcium channel influences the changes in arterial blood pressure and heart rate induced by central angiotesin II |
author |
Saad, Wilson A. [UNESP] |
author_facet |
Saad, Wilson A. [UNESP] Guarda, Ismael F. M. S. Camargo, Luiz A. A. [UNESP] Santos, Talmir A. F. B. |
author_role |
author |
author2 |
Guarda, Ismael F. M. S. Camargo, Luiz A. A. [UNESP] Santos, Talmir A. F. B. |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Univ Taubate Araraquara Univ Ctr Universidade Estadual Paulista (Unesp) Clin Hosp State São Paulo Universidade Federal de São Carlos (UFSCar) |
dc.contributor.author.fl_str_mv |
Saad, Wilson A. [UNESP] Guarda, Ismael F. M. S. Camargo, Luiz A. A. [UNESP] Santos, Talmir A. F. B. |
description |
We study the voltage dependent calcium channels and nitric oxide involvement in angiotensin II-induced pressor effect. The antipressor action of L-Type calcium channel antagonist, nifedipine, has been studied when it was injected into the third ventricle prior to angiotensin II. The influence of nitric oxide on nifedipine antipressor action has also been studied by utilizing N(W)-nitro-L-arginine methyl ester (LNAME) (40 mu g/0.2 mu l) a nitric oxide synthase inhibitor and L-arginine ( 20 mu g/0.2 mu l), a nitric oxide donor agent. Adult male Holtzman rats weighting 200-250 g, with cannulae implanted into the third ventricle were injected with angiotensin II. Angiotensin II produced an elevation in mean arterial pressure and a decreased in heart rate. Such effects were potentiated by the prior injection of LNAME. L-arginine and nifedipine blocked the effects of angiotensin II. These data showed the involvement of L-Type calcium channel and a free radical gas nitric oxide in the central control of angiotensin II-induced pressor effect. This suggested that L-Type calcium channel of the circunventricular structures of central nervous system participated in both short and long term neuronal actions of ANG II with the influence of nitrergic system. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-05-24 2014-05-20T13:46:12Z 2014-05-20T13:46:12Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1186/1744-9081-4-22 Behavioral and Brain Functions. London: Biomed Central Ltd., v. 4, p. 6, 2008. 1744-9081 http://hdl.handle.net/11449/16327 10.1186/1744-9081-4-22 WOS:000256421300001 WOS000256421300001.pdf |
url |
http://dx.doi.org/10.1186/1744-9081-4-22 http://hdl.handle.net/11449/16327 |
identifier_str_mv |
Behavioral and Brain Functions. London: Biomed Central Ltd., v. 4, p. 6, 2008. 1744-9081 10.1186/1744-9081-4-22 WOS:000256421300001 WOS000256421300001.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Behavioral and Brain Functions 2.449 0,986 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
6 application/pdf |
dc.publisher.none.fl_str_mv |
Biomed Central Ltd. |
publisher.none.fl_str_mv |
Biomed Central Ltd. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964448057720832 |