Synthesis and antitubercular evaluation of new 1,2,3-triazole derivatives of carbohydrates
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNESP |
| Texto Completo: | http://dx.doi.org/10.13171/mjc.1.6.2012.02.05.15 http://hdl.handle.net/11449/133718 |
Resumo: | We reported in this work the preparation of novel 1,4-disubstituted-1,2,3-triazoles derivatives from Dglucose and D-fructose and their in vitro antibacterial activity against Mycobacterium tuberculosis were evaluated. The chemical synthesis was performed based on the 1,3-dipolar cycloaddition reaction, and antimicrobial activity was determined based on Resazurin Microtiter Assay against Mycobacterium. None of the triazole glycoconjugates tested showed activity against these microorganisms. |
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Synthesis and antitubercular evaluation of new 1,2,3-triazole derivatives of carbohydratesCarbohydrateGlycoconjugates1,2,3-triazoleAntitubercular activityWe reported in this work the preparation of novel 1,4-disubstituted-1,2,3-triazoles derivatives from Dglucose and D-fructose and their in vitro antibacterial activity against Mycobacterium tuberculosis were evaluated. The chemical synthesis was performed based on the 1,3-dipolar cycloaddition reaction, and antimicrobial activity was determined based on Resazurin Microtiter Assay against Mycobacterium. None of the triazole glycoconjugates tested showed activity against these microorganisms.Coordenação de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Federal de Juiz de Fora, Departamento de Química, Instituto de Ciências ExatasUniversidade Estadual Paulista, Departamento de Ciências Biológicas, Faculdade de Ciências Farmacêuticas de AraraquaraFAPESP: 2008/10390-2FAPESP: 2009/06499-1Universidade Estadual Paulista (Unesp)Universidade Federal de Juiz de Fora (UFJF)Santos, Juliana Alves dosCorrales, Roberta Cristina Novaes ReisPavan, Fernando Rogério [UNESP]Leite, Clarice Queico Fujimura [UNESP]Dias, Rafael Mafra de PaulaSilva, Adilson David da2016-01-28T16:56:19Z2016-01-28T16:56:19Z2012info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article281-288application/pdfhttp://dx.doi.org/10.13171/mjc.1.6.2012.02.05.15Mediterranean Journal of Chemistry, v. 1, n. 6, p. 281-288, 2012.2028-3997http://hdl.handle.net/11449/13371810.13171/mjc.1.6.2012.02.05.15ISSN2028-3997-2012-01-06-281-288.pdf98185970769712272114570774349859Currículo Lattesreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMediterranean Journal of Chemistryinfo:eu-repo/semantics/openAccess2023-10-01T06:03:27Zoai:repositorio.unesp.br:11449/133718Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-10-01T06:03:27Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
| dc.title.none.fl_str_mv |
Synthesis and antitubercular evaluation of new 1,2,3-triazole derivatives of carbohydrates |
| title |
Synthesis and antitubercular evaluation of new 1,2,3-triazole derivatives of carbohydrates |
| spellingShingle |
Synthesis and antitubercular evaluation of new 1,2,3-triazole derivatives of carbohydrates Santos, Juliana Alves dos Carbohydrate Glycoconjugates 1,2,3-triazole Antitubercular activity |
| title_short |
Synthesis and antitubercular evaluation of new 1,2,3-triazole derivatives of carbohydrates |
| title_full |
Synthesis and antitubercular evaluation of new 1,2,3-triazole derivatives of carbohydrates |
| title_fullStr |
Synthesis and antitubercular evaluation of new 1,2,3-triazole derivatives of carbohydrates |
| title_full_unstemmed |
Synthesis and antitubercular evaluation of new 1,2,3-triazole derivatives of carbohydrates |
| title_sort |
Synthesis and antitubercular evaluation of new 1,2,3-triazole derivatives of carbohydrates |
| author |
Santos, Juliana Alves dos |
| author_facet |
Santos, Juliana Alves dos Corrales, Roberta Cristina Novaes Reis Pavan, Fernando Rogério [UNESP] Leite, Clarice Queico Fujimura [UNESP] Dias, Rafael Mafra de Paula Silva, Adilson David da |
| author_role |
author |
| author2 |
Corrales, Roberta Cristina Novaes Reis Pavan, Fernando Rogério [UNESP] Leite, Clarice Queico Fujimura [UNESP] Dias, Rafael Mafra de Paula Silva, Adilson David da |
| author2_role |
author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Federal de Juiz de Fora (UFJF) |
| dc.contributor.author.fl_str_mv |
Santos, Juliana Alves dos Corrales, Roberta Cristina Novaes Reis Pavan, Fernando Rogério [UNESP] Leite, Clarice Queico Fujimura [UNESP] Dias, Rafael Mafra de Paula Silva, Adilson David da |
| dc.subject.por.fl_str_mv |
Carbohydrate Glycoconjugates 1,2,3-triazole Antitubercular activity |
| topic |
Carbohydrate Glycoconjugates 1,2,3-triazole Antitubercular activity |
| description |
We reported in this work the preparation of novel 1,4-disubstituted-1,2,3-triazoles derivatives from Dglucose and D-fructose and their in vitro antibacterial activity against Mycobacterium tuberculosis were evaluated. The chemical synthesis was performed based on the 1,3-dipolar cycloaddition reaction, and antimicrobial activity was determined based on Resazurin Microtiter Assay against Mycobacterium. None of the triazole glycoconjugates tested showed activity against these microorganisms. |
| publishDate |
2012 |
| dc.date.none.fl_str_mv |
2012 2016-01-28T16:56:19Z 2016-01-28T16:56:19Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.13171/mjc.1.6.2012.02.05.15 Mediterranean Journal of Chemistry, v. 1, n. 6, p. 281-288, 2012. 2028-3997 http://hdl.handle.net/11449/133718 10.13171/mjc.1.6.2012.02.05.15 ISSN2028-3997-2012-01-06-281-288.pdf 9818597076971227 2114570774349859 |
| url |
http://dx.doi.org/10.13171/mjc.1.6.2012.02.05.15 http://hdl.handle.net/11449/133718 |
| identifier_str_mv |
Mediterranean Journal of Chemistry, v. 1, n. 6, p. 281-288, 2012. 2028-3997 10.13171/mjc.1.6.2012.02.05.15 ISSN2028-3997-2012-01-06-281-288.pdf 9818597076971227 2114570774349859 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Mediterranean Journal of Chemistry |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
281-288 application/pdf |
| dc.source.none.fl_str_mv |
Currículo Lattes reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
| instname_str |
Universidade Estadual Paulista (UNESP) |
| instacron_str |
UNESP |
| institution |
UNESP |
| reponame_str |
Repositório Institucional da UNESP |
| collection |
Repositório Institucional da UNESP |
| repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
| repository.mail.fl_str_mv |
|
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1797789253963350016 |